scholarly journals Culmination of a half-century quest reveals insight into mutant tRNA-mediated frameshifting after tRNA departure from the decoding site

2018 ◽  
Vol 115 (44) ◽  
pp. 11121-11123 ◽  
Author(s):  
John F. Atkins
Keyword(s):  
2021 ◽  
Vol 37 (2) ◽  
pp. 149-165
Author(s):  
Andrew Barrette ◽  

This paper investigates a moment in the history of the phenomenological movement and offers an argument for its enduring significance. To this end, it brings to light, for the first time in a half-century, Manfred Frings’ rejected and so unpublished translation of Edmund Husserl’s Ideas II. After considering the meaning of the term Leib, which Frings renders ‘lived-body’ and to which the editor suggests ‘organism,’ a brief argument for the living tradition of phenomenology is given. It is claimed that the enduring significance of the document is found in the elucidation of the need to renew the phenomenological tradition through a collaboration across generations. Thus, even in its supposed “failure,” Frings’ translation gives data to future thinkers for insight into both their own life and the life of the ideas of phenomenology itself.


Author(s):  
Louis de Paor

This chapter explores the parallels and disjunctions between Máirtín Ó Cadhain and Flann O’Brien, with particular reference to the extent to which formal experiment in both writers owes as much to the specific circumstances of Irish culture, politics, and language in the middle decades of the twentieth century as it does to European modernism and postmodernism. The chapter examines the centrality of both writers’ detailed knowledge of the Irish language and its narrative traditions to their experimental prose fictions. The chapter argues that Ó Cadhain’s insight into lives blighted by economic injustice and bureaucratic tyranny has lost little of its political urgency in the half-century since his death, while Ó Nualláin’s work continues to deride a world in which absurdity insists on being taken seriously and the distortion of language is a defining attribute of power.


2019 ◽  
Vol 44 (1) ◽  
pp. 58-66
Author(s):  
Dwight P. Baker

Boone Aldridge provides an insider’s perspective on the outsize role William Cameron Townsend played in shaping the ethos and objectives of the Wycliffe Bible Translators and Summer Institute of Linguistics. He gives particular attention to organizational challenges posed by the mission’s dual or blended structure and to WBT/SIL’s responses to internal and external pressures. Despite a tendency to triumphalism, the volume is richly informed and adds insight into WBT/SIL’s formative first half century.


2006 ◽  
Vol 6 ◽  
pp. 1-24
Author(s):  
Lyle Jenkins

For the last half-century, biolinguistics, the study of the biology of language, has focused on the classical “what” and “how” questions in biology: (1) What is knowledge of language?, (2) How does language develop in the child? and (3) How does language evolve in the species? The answers to questions (1)–(3) have in turn stimulated investigation into the deeper “why” question; viz., why are the principles of language what they are? (the basis for the “minimalist” program). The answers to all of these questions will provide insight into the “unification problem;” viz., how the study of language can be integrated with the rest of the natural sciences. We review some recent investigations into these questions.


Author(s):  
David J. Neumann

This chapter explores discipleship and conversion in SRF, Yogananda’s dramatic death, and the transfer of authority that transpired afterward. The chapter explores profiles of more than fifteen Yogananda disciples, employing a model of conversion to offer insight into common patterns of the spiritual seekers who chose to join a new religious movement, following a guru who claimed powers like clairvoyance and hinted at his own deity. The circumstances surrounding Yogananda’s death and his followers’ efforts to cope with the tragedy are considered next. Yogananda’s death produced a crisis in leadership. Max Weber’s model of the routinization of charisma, modified by subsequent scholars, offers insight into the common challenge faced by organizations led by charismatic individuals, particularly after their death. Yogananda spiritualized his own leadership by indicating that his writings were to become the “guru” after his departure, but this did not fully solve the problem of human leadership. After the short tenure of one leader, long-term female disciple Faye Wright was appointed. Her half-century tenure at SRF stabilized the organization and routinized its publications by and about Yogananda.


2016 ◽  
Vol 12 (23) ◽  
Author(s):  
Wayne B. Jonas ◽  
Daniel Moerman

We provide a new perspect ve with which to understand what for a half century has been known as the »placebo effect.« We argue that, as currently used, the concept includes much that has nothing to do with placebos, confusirig the most interesting and important aspects of the phenomenon. We propose a new way to understand those aspects of medical care, plus a broad range of additional human experiences, by focusing on the idea of »meaning,« to which people, when they are sick, often respond. We review several of the many areas in medicine in which meaning affects illness or healing and introduce the idea of the »meaning response.« We suggest that use of this formulation, rather than the fixation on inert placebos, will probably lead to far greater insight into how treatment works and perhaps to real improvements in human well-being.


1966 ◽  
Vol 24 ◽  
pp. 322-330
Author(s):  
A. Beer

The investigations which I should like to summarize in this paper concern recent photo-electric luminosity determinations of O and B stars. Their final aim has been the derivation of new stellar distances, and some insight into certain patterns of galactic structure.


1984 ◽  
Vol 75 ◽  
pp. 461-469 ◽  
Author(s):  
Robert W. Hart

ABSTRACTThis paper models maximum entropy configurations of idealized gravitational ring systems. Such configurations are of interest because systems generally evolve toward an ultimate state of maximum randomness. For simplicity, attention is confined to ultimate states for which interparticle interactions are no longer of first order importance. The planets, in their orbits about the sun, are one example of such a ring system. The extent to which the present approximation yields insight into ring systems such as Saturn's is explored briefly.


Author(s):  
D. F. Blake ◽  
L. F. Allard ◽  
D. R. Peacor

Echinodermata is a phylum of marine invertebrates which has been extant since Cambrian time (c.a. 500 m.y. before the present). Modern examples of echinoderms include sea urchins, sea stars, and sea lilies (crinoids). The endoskeletons of echinoderms are composed of plates or ossicles (Fig. 1) which are with few exceptions, porous, single crystals of high-magnesian calcite. Despite their single crystal nature, fracture surfaces do not exhibit the near-perfect {10.4} cleavage characteristic of inorganic calcite. This paradoxical mix of biogenic and inorganic features has prompted much recent work on echinoderm skeletal crystallography. Furthermore, fossil echinoderm hard parts comprise a volumetrically significant portion of some marine limestones sequences. The ultrastructural and microchemical characterization of modern skeletal material should lend insight into: 1). The nature of the biogenic processes involved, for example, the relationship of Mg heterogeneity to morphological and structural features in modern echinoderm material, and 2). The nature of the diagenetic changes undergone by their ancient, fossilized counterparts. In this study, high resolution TEM (HRTEM), high voltage TEM (HVTEM), and STEM microanalysis are used to characterize tha ultrastructural and microchemical composition of skeletal elements of the modern crinoid Neocrinus blakei.


Author(s):  
Peter Sterling

The synaptic connections in cat retina that link photoreceptors to ganglion cells have been analyzed quantitatively. Our approach has been to prepare serial, ultrathin sections and photograph en montage at low magnification (˜2000X) in the electron microscope. Six series, 100-300 sections long, have been prepared over the last decade. They derive from different cats but always from the same region of retina, about one degree from the center of the visual axis. The material has been analyzed by reconstructing adjacent neurons in each array and then identifying systematically the synaptic connections between arrays. Most reconstructions were done manually by tracing the outlines of processes in successive sections onto acetate sheets aligned on a cartoonist's jig. The tracings were then digitized, stacked by computer, and printed with the hidden lines removed. The results have provided rather than the usual one-dimensional account of pathways, a three-dimensional account of circuits. From this has emerged insight into the functional architecture.


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