scholarly journals Cognitive control of orofacial motor and vocal responses in the ventrolateral and dorsomedial human frontal cortex

2020 ◽  
Vol 117 (9) ◽  
pp. 4994-5005 ◽  
Author(s):  
Kep Kee Loh ◽  
Emmanuel Procyk ◽  
Rémi Neveu ◽  
Franck Lamberton ◽  
William D. Hopkins ◽  
...  
Keyword(s):  
Cognitive Control ◽  
Human Brain ◽  
Language Production ◽  
Functional Neuroimaging ◽  
Learning Rule ◽  
Basic Function ◽  
Vocal Responses ◽  
Midcingulate Cortex ◽  
Cognitive Selection ◽  
Selection Of

In the primate brain, a set of areas in the ventrolateral frontal (VLF) cortex and the dorsomedial frontal (DMF) cortex appear to control vocalizations. The basic role of this network in the human brain and how it may have evolved to enable complex speech remain unknown. In the present functional neuroimaging study of the human brain, a multidomain protocol was utilized to investigate the roles of the various areas that comprise the VLF–DMF network in learning rule-based cognitive selections between different types of motor actions: manual, orofacial, nonspeech vocal, and speech vocal actions. Ventrolateral area 44 (a key component of the Broca’s language production region in the human brain) is involved in the cognitive selection of orofacial, as well as, speech and nonspeech vocal responses; and the midcingulate cortex is involved in the analysis of speech and nonspeech vocal feedback driving adaptation of these responses. By contrast, the cognitive selection of speech vocal information requires this former network and the additional recruitment of area 45 and the presupplementary motor area. We propose that the basic function expressed by the VLF–DMF network is to exert cognitive control of orofacial and vocal acts and, in the language dominant hemisphere of the human brain, has been adapted to serve higher speech function. These results pave the way to understand the potential changes that could have occurred in this network across primate evolution to enable speech production.

scholarly journals Cognitive control of orofacial and vocal responses in the human frontal cortex

2019 ◽  
Author(s):  
Kep Kee Loh ◽  
Emmanuel Procyk ◽  
Remi Neveu ◽  
Franck Lamberton ◽  
William Hopkins ◽  
...  
Keyword(s):  
Frontal Cortex ◽  
Functional Neuroimaging ◽  
Human Speech ◽  
Verbal Responses ◽  
Vocal Responses ◽  
Control Functions ◽  
Dorsomedial Frontal Cortex ◽  
Human Frontal Cortex ◽  
Neuroimaging Study ◽  
Cognitive Selection

AbstractThe frontal cortical areas critical for human speech production, i.e. the ventrolateral frontal cortex (cytoarchitectonic areas 44 and 45; VLF) and the dorsomedial frontal cortex (DMF) comprising the mid-cingulate cortex (MCC) and the pre-supplementary motor area (preSMA), exist in non-human primates and are implicated in cognitive vocal control functions. The present functional neuroimaging study seeks to define the basic roles of these VLF-DMF network regions in primate vocal production and how they might have been adapted for human speech. We demonstrate that area 44 and the MCC are respectively involved in the cognitive selection of orofacial, non-speech vocal and verbal responses, and the feedback-driven adaptation of these responses – roles that are likely preserved across primates. In contrast, area 45 and preSMA have roles that are specific to human speech: area 45 contributes to active verbal retrieval during learning, while preSMA is involved in processing verbal feedback during orofacial/vocal adaptations.

scholarly journals Standardizing human brain parcellations

2021 ◽  
Vol 8 (1) ◽  
Author(s):  
Ross M. Lawrence ◽  
Eric W. Bridgeford ◽  
Patrick E. Myers ◽  
Ganesh C. Arvapalli ◽  
Sandhya C. Ramachandran ◽  
...  
Keyword(s):  
Human Brain ◽  
Coordinate Space ◽  
The Past ◽  
File Storage ◽  
Statistical Inferences ◽  
Standardized Protocol ◽  
Storage Format ◽  
Labeling Scheme ◽  
Selection Of ◽  
Brain Atlases

AbstractUsing brain atlases to localize regions of interest is a requirement for making neuroscientifically valid statistical inferences. These atlases, represented in volumetric or surface coordinate spaces, can describe brain topology from a variety of perspectives. Although many human brain atlases have circulated the field over the past fifty years, limited effort has been devoted to their standardization. Standardization can facilitate consistency and transparency with respect to orientation, resolution, labeling scheme, file storage format, and coordinate space designation. Our group has worked to consolidate an extensive selection of popular human brain atlases into a single, curated, open-source library, where they are stored following a standardized protocol with accompanying metadata, which can serve as the basis for future atlases. The repository containing the atlases, the specification, as well as relevant transformation functions is available in the neuroparc OSF registered repository or https://github.com/neurodata/neuroparc.

scholarly journals Tackling Dysfunction of Mitochondrial Bioenergetics in the Brain

2021 ◽  
Vol 22 (15) ◽  
pp. 8325
Author(s):  
Paola Zanfardino ◽  
Stefano Doccini ◽  
Filippo M. Santorelli ◽  
Vittoria Petruzzella
Keyword(s):  
Human Brain ◽  
Basic Function ◽  
Mitochondrial Proteome ◽  
Novel Proteins ◽  
Mitochondrial Functions ◽  
Organ Specific ◽  
Oxphos System ◽  
Mitochondrial Defects ◽  
Energy Dependent ◽  
The Brain

Oxidative phosphorylation (OxPhos) is the basic function of mitochondria, although the landscape of mitochondrial functions is continuously growing to include more aspects of cellular homeostasis. Thanks to the application of -omics technologies to the study of the OxPhos system, novel features emerge from the cataloging of novel proteins as mitochondrial thus adding details to the mitochondrial proteome and defining novel metabolic cellular interrelations, especially in the human brain. We focussed on the diversity of bioenergetics demand and different aspects of mitochondrial structure, functions, and dysfunction in the brain. Definition such as ‘mitoexome’, ‘mitoproteome’ and ‘mitointeractome’ have entered the field of ‘mitochondrial medicine’. In this context, we reviewed several genetic defects that hamper the last step of aerobic metabolism, mostly involving the nervous tissue as one of the most prominent energy-dependent tissues and, as consequence, as a primary target of mitochondrial dysfunction. The dual genetic origin of the OxPhos complexes is one of the reasons for the complexity of the genotype-phenotype correlation when facing human diseases associated with mitochondrial defects. Such complexity clinically manifests with extremely heterogeneous symptoms, ranging from organ-specific to multisystemic dysfunction with different clinical courses. Finally, we briefly discuss the future directions of the multi-omics study of human brain disorders.

scholarly journals The neural representational space of social memory

2017 ◽  
Author(s):  
Sarah L. Dziura ◽  
James C. Thompson
Keyword(s):  
Social Networks ◽  
Human Brain ◽  
Incidental Learning ◽  
Functional Neuroimaging ◽  
Brain Activity ◽  
Temporoparietal Junction ◽  
Representational Space ◽  
Analysis Technique ◽  
The Social ◽  
Multivariate Pattern

AbstractSocial functioning involves learning about the social networks in which we live and interact; knowing not just our friends, but also who is friends with our friends. Here we utilized a novel incidental learning paradigm and representational similarity analysis (RSA), a functional MRI multivariate pattern analysis technique, to examine the relationship between learning social networks and the brain's response to the faces within the networks. We found that accuracy of learning face pair relationships through observation is correlated with neural similarity patterns to those pairs in the left temporoparietal junction (TPJ), the left fusiform gyrus, and the subcallosal ventromedial prefrontal cortex (vmPFC), all areas previously implicated in social cognition. This model was also significant in portions of the cerebellum and thalamus. These results show that the similarity of neural patterns represent how accurately we understand the closeness of any two faces within a network, regardless of their true relationship. Our findings indicate that these areas of the brain not only process knowledge and understanding of others, but also support learning relations between individuals in groups.Significance StatementKnowledge of the relationships between people is an important skill that helps us interact in a highly social world. While much is known about how the human brain represents the identity, goals, and intentions of others, less is known about how we represent knowledge about social relationships between others. In this study, we used functional neuroimaging to demonstrate that patterns in human brain activity represent memory for recently learned social connections.

scholarly journals How the human brain introspects about one's own episodes of cognitive control

Cortex ◽  
2018 ◽  
Vol 107 ◽  
pp. 110-120 ◽  
Author(s):  
David Soto ◽  
Mona Theodoraki ◽  
Pedro M. Paz-Alonso
Keyword(s):  
Cognitive Control ◽  
Human Brain

Word form retrieval in language production

2007 ◽  
pp. 470-488 ◽  
Author(s):  
Antje S. Meyer ◽  
Eva Belke
Keyword(s):  
Language Production ◽  
Knowledge Building ◽  
Word Production ◽  
Word Form ◽  
Lexical Selection ◽  
Single Word ◽  
Phonological Representations ◽  
Phonological Knowledge ◽  
Phonetic Code ◽  
Selection Of

Current models of word form retrieval converge on central assumptions. They all distinguish between morphological, phonological, and phonetic representations and processes; they all assume morphological and phonological decomposition, and agree on the main processing units at these levels. In addition, all current models of word form postulate the same basic retrieval mechanisms: activation and selection of units. Models of word production often distinguish between processes concerning the selection of a single word unit from the mental lexicon and the retrieval of the associated word form. This article explores lexical selection and word form retrieval in language production. Following the distinctions in linguistic theory, it discusses morphological encoding, phonological encoding, and phonetic encoding. The article also considers the representation of phonological knowledge, building of phonological representations, segmental retrieval, retrieval of metrical information, generating the phonetic code of words, and a model of word form retrieval.

scholarly journals Network Meta-Analysis of the Safety of Drug Therapy for Cardiogenic Shock

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Xianyong Liao ◽  
Lin Qian ◽  
Song Zhang ◽  
Xiang Chen ◽  
Jing Lei
Keyword(s):  
Cardiogenic Shock ◽  
Human Brain ◽  
Brain Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Adverse Reactions ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Cardiac Shock ◽  
Clinical Drugs ◽  
Selection Of

Objectives. (1) To conduct a network meta-analysis of clinical drugs used for cardiogenic shock and (2) provide evidence for the selection of medication for the treatment of this condition. Methods. PubMed, EMBASE, Cochrane library, China HowNet (CNKI), Wanfang database, and Weipu database were searched using keywords Dopamine, Dobutamine, Epinephrine, Adrenaline, Norepinephrine, Noradrenaline, Milrinone, Natriuretic peptide, Recombinant human brain natriuretic peptide, Levosimendan, Cardiac shock, and Cardiogenic shock. We select literature according to prespecified inclusion and exclusion criteria and record data such as drug type, mortality, and adverse reactions. Results. Twenty-eight of 1387 articles met inclusion criteria, comprising 1806 patients who suffered from cardiogenic shock. Dopamine, dobutamine, epinephrine, norepinephrine, milrinone, recombinant human brain natriuretic peptide, and levosimendan were all commonly used in the treatment of cardiogenic shock. Milrinone was most effective at reducing mortality and had the lowest incidence of adverse reactions. Conclusion. This network meta-analysis demonstrated that milrinone was the most effective medication at reducing mortality and adverse events in patients suffering from cardiogenic shock.

Sign in / Sign up

Export Citation Format

Share Document