Adapting to survive

2018 ◽  
Vol 25 (3) ◽  
pp. 363-391
Author(s):  
Nikki van de Pol
Keyword(s):  
Middle English ◽  
Opposite Direction ◽  
Additional Information ◽  
Range Of Functions ◽  
Corpus Data ◽  
The Absolute ◽  
Semantic Expansion ◽  
High Degree ◽  
Over Time

Abstract This paper traces the semantic development of the English absolute construction from Old to Present-day English on the basis of extensive corpus data. It is observed that the absolute construction developed from a solely adverbial, strictly subordinate construction into a construction with a much larger range of functions, including quasi-coordinate constructions whose ‘addition’ function comes close to that of and-coordinated finite clauses. This development involves an expansion of clausal status (from subordinate to anywhere between subordinate and quasi-coordinate) and a semantic expansion from typically adverbial meanings to any type of additional information. The process is claimed to have been facilitated by Middle English case loss and arguments for this facilitating role of case loss are adduced. It is then shown how these quasi-coordinate absolute constructions became more and more important as an absolute construction-function over time, as they were well-suited to the absolute construction’s high degree of syntactic independence. This evolution appears to have taken an opposite direction from the development of free adjuncts (Killie & Swann 2009: 339). This observation fits in well with the proposal that English ing-clauses form a network (Fonteyn & van de Pol 2015) in which each member maintains its own functional niche, rather than engaging in competition with one another.

Transisi Kepemimpinan Dalam Alkitab

2016 ◽  
Vol 1 (1) ◽  
pp. 16-38
Author(s):  
Jonathan Octavianus
Keyword(s):  
New Testament ◽  
Old Testament ◽  
Jesus Christ ◽  
Transition Time ◽  
People Of God ◽  
The Absolute

As every epoch there are there a transition time, on Old Testament like Moses with Joshua, Joshua selected by God an supported fully by Moses, Conversely Moses have liberally to be changed. Like Elijah to Elisha too.Pattern on New Testament there are an examples of transition time too, like Jesus Christ to His Disciples, an transition from Paul to his successor Timothy. This is a heart and soul a big leader, and shall all leadership owners shepherd in church, Christian institution, etc.Which most be remembered in transition of leadership, that people of God leadership, about who will lead, who continue leadership, like a principle in biblical, hence a role of God, is determinant an anoint man which be selected the absolute God choice and constitute all other, but a succession router leader is which have been selected His own. An can be anointed in front of believers.

Stability and Fluctuation of Personality Disorder Features in Daily Life

2018 ◽  
Author(s):  
Aidan G.C. Wright ◽  
Leonard Simms
Keyword(s):  
Personality Disorder ◽  
Daily Life ◽  
Daily Diary ◽  
Personality Pathology ◽  
Dynamic Processes ◽  
Diary Study ◽  
Daily Diary Study ◽  
Symptom Exacerbation ◽  
High Degree ◽  
Over Time

Very little is known about the daily stability and fluctuation of personality pathology. To address this gap in knowledge, we investigated the naturalistic manifestation of personality pathology over the course of 100 days. A group of individuals (N=101) diagnosed with any personality disorder (PD) completed a daily diary study over 100 consecutive days (Mdn = 94 days, Range = 33-101 days). Participants completed daily ratings of 30 manifestations of personality pathology. Patterns of stability and variability over the course of the study were then examined. Results indicated that individual PD manifestations and domains of PD manifestations were variable across days and differed widely in their frequency. Additionally, individual averages and level of variability in PD domains were highly stable across months, individual averages of PD domains were predicted by baseline dispositional ratings of PD traits with a high degree of specificity, and daily variability PD domains was associated with elevated levels of PD traits. This pattern of findings suggests that dynamic processes of symptom exacerbation and diminution that are stable in mean level and variability in expression over time characterizes personality pathology. Further, dispositional ratings are significant predictors of average daily expression of PD features.

Structure, Function and Interactions of Tau: Particular Focus on Potential Drug Targets for the Treatment of Tauopathies

2018 ◽  
Vol 17 (5) ◽  
pp. 325-337 ◽  
Author(s):  
Hojjat Borna ◽  
Kasim Assadoulahei ◽  
Gholamhossein Riazi ◽  
Asghar Beigi Harchegani ◽  
Alireza Shahriary
Keyword(s):  
Tau Protein ◽  
Drug Targets ◽  
Brain Injuries ◽  
Potential Drug ◽  
Microtubule Network ◽  
Wide Range ◽  
Potential Risk Factors ◽  
Range Of Functions ◽  
Potential Drug Targets

Background & Objective: Neurodegenrative diseases are among the most widespread lifethreatening disorders around the world in elderly ages. The common feature of a group of neurodegenerative disorders, called tauopathies, is an accumulation of microtubule associated protein tau inside the neurons. The exact mechanism underlying tauopathies is not well-understood but several factors such as traumatic brain injuries and genetics are considered as potential risk factors. Although tau protein is well-known for its key role in stabilizing and organization of axonal microtubule network, it bears a broad range of functions including DNA protection and participation in signaling pathways. Moreover, the flexible unfolded structure of tau facilitates modification of tau by a wide range of intracellular enzymes which in turn broadens tau function and interaction spectrum. The distinctive properties of tau protein concomitant with the crucial role of tau interaction partners in the progression of neurodegeneration suggest tau and its binding partners as potential drug targets for the treatment of neurodegenerative diseases. Conclusion: This review aims to give a detailed description of structure, functions and interactions of tau protein in order to provide insight into potential therapeutic targets for treatment of tauopathies.

Raza, ciencia, sociedad

2015 ◽  
Vol 2 (4) ◽  
Author(s):  
Peter Wade
Keyword(s):  
Cultural Discourse ◽  
Human Biology ◽  
Science And Society ◽  
Race Science ◽  
And Behavior ◽  
Over Time

<p class="p1"><span class="s1"><strong>Resumen </strong></span>| En este trabajo quiero presentar una cronología convencional del concepto raza que marca un movimiento en el cual raza cambia de ser una idea basada en la cultura y el medio ambiente, a ser algo biológico, inflexible y determinante, para luego volver a ser una noción que habla de la cultura<span class="s2"><strong>.</strong></span>Resumo cómo la idea de raza ha cambiado a través del tiempo, mirando necesariamente el rol que ha desempeñado la ciencia, y enfocando los diferentes discursos de índole <em>natural-cultural </em>sobre los cuerpos, el medio ambiente y el comportamiento, en los cuales las dimensiones culturales y naturales siempre coexisten<span class="s2"><strong>.</strong></span>“La naturaleza” no puede ser entendida solamente como “la biología” y ni la naturaleza ni la biología necesariamente implican sólo el determinismo, la fijeza y la inmutabilidad Estar abiertos a la coexistencia de la cultura y la naturaleza y a la mutabilidad de la naturaleza nos permite ver mejor el ámbito de acción del pensamiento racial.</p><p class="p1"><strong><em>Race, Science and Society</em></strong></p><p class="p1"> </p><p class="p2"><span class="s1"><strong>Abstract </strong></span>| In this article I present and critique a standard chronology of race as, first, a concept rooted in culture and environment, and later in human biology and determinism, and finally back to culture alone<span class="s2"><strong><em>.</em></strong></span>I will outline changing understandings of race over time, with some attention to the role of science, broadly understood, and on the continuing but changing character of race as a natural-cultural discourse about organic bodies, environments and behavior, in which both cultural and natural dimensions always co-exist<span class="s2"><strong><em>.</em></strong></span>“Nature” is not to be understood simply as “biology,” and neither nature nor biology necessarily imply the fixity and determination that they are often assumed nowadays to involve<span class="s2"><strong><em>.</em></strong></span>Being open to the co-existence of culture and nature and the mutability of the latter allows us to better comprehend the whole range of action of racial thinking.</p>

The Role of the City in Merovingian Francia

2020 ◽  
pp. 581-610
Author(s):  
S. T. Loseby
Keyword(s):  
Roman Empire ◽  
Urban Communities ◽  
Late Antiquity ◽  
Building Blocks ◽  
Urban Network ◽  
City Councils ◽  
Royal Courts ◽  
Range Of Functions ◽  
Fierce Competition

The Merovingians inherited an urban network from the Roman Empire that remained substantially intact. Although Gallic cities had long been declining in extent and sophistication, during late antiquity their landscapes were adapted to contemporary priorities through the provision of walls and churches, and their politics was transformed by the emergence of bishops as leaders of urban communities. When the upper tiers of imperial administration disappeared, this equipped the vast majority of cities to survive as the basic building blocks of Merovingian kingdoms that were initially conceived as aggregations of city–territories. In ruling through their cities, the Merovingians expanded upon existing mechanisms for the extraction of taxes and services, while relying on centrally appointed bishops and counts rather than city councils for the projection of their authority. This generated fierce competition between kings for control of cities and among local elites for positions of power within them. In the later Merovingian period, however, the significance of cities diminished as stable territorial kingdoms emerged, political practice was centralized around the royal courts, and the Roman administrative legacy finally disintegrated. But the cities remained preeminent religious centers, and, with the beginnings of economic revival, continued to perform a range of functions unmatched by other categories of settlement.

Biopsychosocial Patterning of Multimorbidity and Its Consequences

2018 ◽  
pp. 220-236
Author(s):  
Elliot Friedman ◽  
Beth LeBreton ◽  
Lindsay Fuzzell ◽  
Elizabeth Wehrpsann
Keyword(s):  
Quality Of Life ◽  
Older Adults ◽  
Functional Outcomes ◽  
The United States ◽  
Chronic Medical Conditions ◽  
Quality Of Life Research ◽  
Increased Risk ◽  
Over Time

By many estimates the majority of adults over age 65 have two or more chronic medical conditions (multimorbidity) and are consequently at increased risk of adverse functional outcomes. Nonetheless, many older adults with multimorbidity are able to maintain high levels of function and retain good quality of life. Research presented here is designed to understand the influences that help ensure better functional outcomes in these older adults. This chapter presents findings that draw on data from the Midlife in the United States study. The independent and interactive contributions of diverse factors to multimorbidity and changes in multimorbidity over time are reviewed. The degree that multimorbidity increases risk of cognitive impairment and disability is examined. The role of inflammation as a mediator is considered. Multimorbidity is increasingly the norm for older adults, so better understanding of factors contributing to variability in multimorbidity-related outcomes can lead to improved quality of life.

scholarly journals The role of faint population III supernovae in forming CEMP stars in ultra-faint dwarf galaxies

2021 ◽  
Author(s):  
Myoungwon Jeon ◽  
Volker Bromm ◽  
Gurtina Besla ◽  
Jinmi Yoon ◽  
Yumi Choi
Keyword(s):  
Milky Way ◽  
Dwarf Galaxies ◽  
Mass Resolution ◽  
Explosion Energy ◽  
High Carbon ◽  
Cosmological Simulations ◽  
Carbon Abundance ◽  
The Absolute ◽  
Zoom In

Abstract CEMP-no stars, a subset of carbon enhanced metal poor (CEMP) stars ($\rm [C/Fe]\ge 0.7$ and $\rm [Fe/H]\lesssim -1$) have been discovered in ultra-faint dwarf (UFD) galaxies, with Mvir ≈ 108 M⊙ and M* ≈ 103 − 104 M⊙ at z = 0, as well as in the halo of the Milky Way (MW). These CEMP-no stars are local fossils that may reflect the properties of the first (Pop III) and second (Pop II) generation of stars. However, cosmological simulations have struggled to reproduce the observed level of carbon enhancement of the known CEMP-no stars. Here we present new cosmological hydrodynamic zoom-in simulations of isolated UFDs that achieve a gas mass resolution of mgas ≈ 60 M⊙. We include enrichment from Pop III faint supernovae (SNe), with ESN = 0.6 × 1051 erg, to understand the origin of CEMP-no stars. We confirm that Pop III and Pop II stars are mainly responsible for the formation of CEMP and C-normal stars respectively. New to this study, we find that a majority of CEMP-no stars in the observed UFDs and the MW halo can be explained by Pop III SNe with normal explosion energy (ESN = 1.2 × 1051 erg) and Pop II enrichment, but faint SNe might also be needed to produce CEMP-no stars with $\rm [C/Fe]\gtrsim 2$, corresponding to the absolute carbon abundance of $\rm A(C)\gtrsim 6.0$. Furthermore, we find that while we create CEMP-no stars with high carbon ratio $\rm [C/Fe]\approx 3-4$, by adopting faint SNe, it is still challenging to reproduce CEMP-no stars with extreme level of carbon abundance of $\rm A(C)\approx 7.0-7.5$, observed both in the MW halo and UFDs.

scholarly journals Learning by Doing: The Use of Distance, Corners and Length in Rewarded Geometric Tasks by Zebrafish (Danio rerio)

Animals ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 2001
Author(s):  
Greta Baratti ◽  
Angelo Rizzo ◽  
Maria Elena Miletto Petrazzini ◽  
Valeria Anna Sovrano
Keyword(s):  
Danio Rerio ◽  
Three Dimensional ◽  
Reference Memory ◽  
Spatial Abilities ◽  
Learning By Doing ◽  
Surface Distance ◽  
Extended Surfaces ◽  
Unequal Length ◽  
Over Time

Zebrafish spontaneously use distance and directional relationships among three-dimensional extended surfaces to reorient within a rectangular arena. However, they fail to take advantage of either an array of freestanding corners or an array of unequal-length surfaces to search for a no-longer-present goal under a spontaneous cued memory procedure, being unable to use the information supplied by corners and length without some kind of rewarded training. The present study aimed to tease apart the geometric components characterizing a rectangular enclosure under a procedure recruiting the reference memory, thus training zebrafish in fragmented layouts that provided differences in surface distance, corners, and length. Results showed that fish, besides the distance, easily learned to use both corners and length if subjected to a rewarded exit task over time, suggesting that they can represent all the geometrically informative parts of a rectangular arena when consistently exposed to them. Altogether, these findings highlight crucially important issues apropos the employment of different behavioral protocols (spontaneous choice versus training over time) to assess spatial abilities of zebrafish, further paving the way to deepen the role of visual and nonvisual encodings of isolated geometric components in relation to macrostructural boundaries.

Sign in / Sign up

Export Citation Format

Share Document