An oncogenic form of the Flt-1 kinase has a tubulogenic potential in a sinusoidal endothelial cell line

2000 ◽  
Vol 79 (2) ◽  
pp. 130-143 ◽  
Author(s):  
Yoshiro Maru ◽  
Hiroshige Hirosawa ◽  
Masabumi Shibuya
Keyword(s):  
Endothelial Cell ◽  
Cell Line ◽  
Sinusoidal Endothelial Cell ◽  
Endothelial Cell Line ◽  
Oncogenic Form

CONSTRUCTION OF AN IMMORTALIZED LIVER SINUSOIDAL ENDOTHELIAL CELL LINE FOR LIVER-TARGETED TISSUE ENGINEERING

ASAIO Journal ◽  
2001 ◽  
Vol 47 (2) ◽  
pp. 166
Author(s):  
T. Matsumura ◽  
N. Kobayashi ◽  
H. Noguchi ◽  
T. Totsugawa ◽  
T. Watanabe ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Endothelial Cell ◽  
Cell Line ◽  
Sinusoidal Endothelial Cell ◽  
Liver Sinusoidal Endothelial Cell ◽  
Endothelial Cell Line

scholarly journals Endothelial and Vascular Health: A Tale of Honey, H2O2 and Calcium

Cells ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 1071
Author(s):  
Elia Ranzato ◽  
Gregorio Bonsignore ◽  
Mauro Patrone ◽  
Simona Martinotti
Keyword(s):  
Endothelial Cells ◽  
Endothelial Cell ◽  
Cell Line ◽  
Cellular Responses ◽  
Pivotal Role ◽  
Vascular Health ◽  
Endothelial Cell Line ◽  
Positive Effects

Intracellular Ca2+ regulation plays a pivotal role in endothelial biology as well as during endothelial restoration processes. Interest in honey utilization in wound approaches is rising in recent years. In order to evaluate the positive effects of buckwheat honey on endothelial responses, we utilized an immortalized endothelial cell line to evaluate cellular responses upon honey exposure, with particular interest in Ca2+ signaling involvement. The results highlight the positive effects of buckwheat honey on endothelial cells’ responses and the central role played by Ca2+ signaling as an encouraging target for more efficacious clinical treatments.

Endothelin-1 production by a microvascular endothelial cell line treated with Plasmodium falciparum parasitized red blood cells

2002 ◽  
Vol 103 (s2002) ◽  
pp. 464S-466S ◽  
Author(s):  
Nicoletta BASILICO ◽  
Livianna SPECIALE ◽  
Silvia PARAPINI ◽  
Pasquale FERRANTE ◽  
Donatella TARAMELLI
Keyword(s):  
Plasmodium Falciparum ◽  
Endothelial Cell ◽  
Red Blood Cells ◽  
Cell Line ◽  
Blood Cells ◽  
Microvascular Endothelial Cell ◽  
Microvascular Endothelium ◽  
Endothelial Cell Line ◽  
Endothelin 1 ◽  
Microvascular Endothelial

In this study, we investigated the production of endothelin 1 (ET-1) by a human microvascular endothelial cell line, HMEC-1, co-cultured with Plasmodium falciparum-parasitized red blood cells (pRBCs). The results indicate that hypoxia increased the basal level of ET-1 production by HMEC-1 cells after 24 or 48h of treatment. However, the co-incubation of HMEC-1 cells with pRBCs, but not with uninfected RBCs, induced a dose-dependent decrease of both constitutive and hypoxia-induced ET-1 production. The inhibition was not due to a decrease in cell viability, as lactate dehydrogenase release remained constant. These results indicate that pRBCs are able to interfere with both the constitutive and stimulated ET-1 release from the microvascular endothelium, thus inducing local modifications of the vascular tone and of the inflammatory response. This could be of relevance in the pathogenesis of the most severe forms of P. falciparum infections, such as cerebral malaria or malaria during pregnancy.

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