scholarly journals Nutritional advice to increase soluble fibre intake does not change plasma folate or homocysteine in men with angina: a randomised controlled trial

2002 ◽  
Vol 5 (1) ◽  
pp. 47-53 ◽  
Author(s):  
Pauline AL Ashfield-Watt ◽  
Zoë E Clark ◽  
Pat Breay ◽  
Paul C Zotos ◽  
Sara B Cale ◽  
...  
Keyword(s):  
Methylenetetrahydrofolate Reductase ◽  
Randomised Trial ◽  
Intervention Group ◽  
Plasma Homocysteine ◽  
Fruit And Vegetables ◽  
Dietary Advice ◽  
Soluble Fibre ◽  
Fibre Intake ◽  
Plasma Folate

AbstractObjective:To study the effect of advice to increase dietary soluble fibre, including fruit and vegetables, on plasma folate and homocysteine in men with angina.Design:Data were collected on a subset of subjects from the Diet and Angina Randomised Trial (DART II). In a randomised (2 × 2) factorial design, subjects received advice on either, neither or both interventions to: (1) increase soluble fibre intake to 8.0 g day−1(fruit, vegetables and oats); (2) increase oily fish intake to 2 portions week−1. Those who received soluble fibre advice were compared with those who did not. Subjects were genotyped for C677T variant 5,10-methylenetetrahydrofolate reductase (MTHFR).Setting/subjects:Seven hundred and fifty-three male angina patients were recruited from general practice.Results:Plasma homocysteine concentrations were at the upper end of the normal range (median 11.5, 25% 9.4, 75% 14.0 μmol l−1). Baseline intake of fruit and vegetables was positively correlated with plasma folate (rs= 0.29,P< 0.01). Smokers had lower intakes of fruit and vegetables, lower plasma folate and higher homocysteine (allP< 0.01). Homozygotes for variant MTHFR had higher homocysteine concentrations at low plasma folate (P< 0.01). Reported intakes of fruit and vegetables and estimated dietary folate increased in the intervention group (ca.+75 g day−1,P< 0.01 andca.+20 g day−1,P< 0.05, respectively). However, neither plasma folate (baseline/follow-up 4.5 vs. 4.4 μg l−1,P= 0.40) nor homocysteine (baseline/follow-up 11.7 vs. 11.7 μmol l−1,P= 0.31) changed.Conclusions:Plasma homocysteine, a cardiovascular risk factor, is influenced by MTHFR genotype, plasma folate and smoking status. Dietary advice successfully led to changes in fruit and vegetable intake, but not to changes in plasma folate or homocysteine, possibly because the fruits and vegetables that were chosen were not those richest in folate.

scholarly journals Pharmacist Led Homeless Outreach Engagement and Non-Medical Independent Prescribing (Rx) (PHOENIx) Intervention for People Experiencing Homelessness: A Non- Randomised Feasibility Study

2020 ◽  
Author(s):  
Richard Lowrie ◽  
Kate Stock ◽  
Sharon Lucey ◽  
Megan Knapp ◽  
Andrea Williamson ◽  
...  
Keyword(s):  
Mental Health ◽  
Health Service ◽  
Randomised Trial ◽  
Intervention Group ◽  
City Centre ◽  
Health Board ◽  
Independent Prescribing ◽  
Comparator Group ◽  
The Phoenix

Abstract BackgroundHomelessness and associated mortality and multimorbidity rates are increasing. Systematic reviews have failed to identify complex interventions that decrease unscheduled emergency health services utilisation or increase scheduled care. Better evidence is needed to inform policy responses. We examined the feasibility of a complex intervention (PHOENIx: Pharmacist led Homeless Outreach Engagement Nonmedical Independent prescribing (Rx)) to inform a subsequent pilot randomised controlled trial (RCT).MethodsNon-randomised trial with comparator group set in Greater Glasgow and Clyde Health Board, Scotland. Participants were adult inpatients experiencing homelessness in a city centre Glasgow hospital, at the point of hospital discharge. All patients were offered and agreed to receive serial consultations with the PHOENIx team (NHS Pharmacist prescriber working with Simon Community Scotland (third sector homeless charity worker). Patients who could not be reached by the PHOENIx team were allocated to the usual care (UC) group. The PHOENIx intervention included assessment of physical/mental health, addictions, housing, benefits and social activities followed by pharmacist prescribing with referral to other health service specialities as necessary. All participants received primary (including specialist homelessness health service general practitioner care, mental health and addictions services) and secondary care. Main outcome measures were rates of: recruitment; retention; uptake of the intervention; and completeness of collected data, from recruitment to censor date.Results Twenty four patients were offered and agreed to participate; 12 were reached and received the intervention as planned with a median 7.5 consultations (IQR3.0-14.2) per patient. The pharmacist prescribed a median of 2 new (IQR0.3-3.8) and 2 repeat (1.3-7.0) prescriptions per patient; 10(83%) received support for benefits, housing or advocacy. Twelve patients were not subsequently contactable after leaving hospital, despite agreeing to participate, and were assigned to UC. Two patients in the UC group died of drug/alcohol overdose during follow up; no patients in the Intervention group died. All 24 patients were retained in the intervention or UC group until death or censor date and all patient records were accessible at follow up: 11(92%) visited ED in both groups, with 11(92%) hospitalisations in intervention group, 9(75%) comparator group. Eight (67%) intervention group patients and 3(25%) comparator group patients attended scheduled out patient appointments. Conclusions Feasibility testing of the PHOENIx intervention suggests merit in a subsequent pilot RCT.

scholarly journals Increasing dietary fibre intake in healthy adults using personalised dietary advice compared with general advice: a single-blind randomised controlled trial

2020 ◽  
pp. 1-12
Author(s):  
Iris Rijnaarts ◽  
Nicole M de Roos ◽  
Taojun Wang ◽  
Erwin G Zoetendal ◽  
Jan Top ◽  
...  
Keyword(s):  
Randomised Controlled Trial ◽  
Dietary Fibre ◽  
Controlled Trial ◽  
Healthy Adults ◽  
Dietary Advice ◽  
Fibre Intake ◽  
Dietary Fibre Intake ◽  
Randomised Controlled ◽  
Single Blind

Abstract Objective: A high-fibre diet is associated with a lower risk for diseases. However, few adults meet the dietary fibre recommendation. Therefore, the effects and acceptance of an algorithm-generated personalised dietary advice (PDA) compared with general advice (GA) on fibre intake were investigated. Design: A 6-week, single-blind randomised controlled trial with a 3-month follow-up. Setting: PDA was based on habitual intake and provided fibre-rich alternatives using a website; GA contained brochures. Dietary intake was assessed at baseline, week 1, week 6 and 3-month follow-up. Both groups evaluated their advice at week 6. All participants had access to PDA from week 7 until 3-month follow-up. Participants: Two groups of healthy adults: PDA (n 34) and GA (n 47). For 3-month follow-up analysis, participants were re-divided into visitors (n 52) and non-visitors (n 26) of the PDA. Results: At week 6, energy intake remained stable in both groups, but fibre intake per 1000 kcal increased non-significantly in both groups (PDA = Δ0·5 ± 2·8; GA = Δ0·8 ± 3·1, P = 0·128). Importantly, a significantly higher percentage of PDA participants adhered to the recommendation compared with week 1 (PDA = 21 % increase; GA = 4 % increase, P ≤ 0·001). PDA participants evaluated the advice significantly better compared with GA participants. At 3-month follow-up, fibre intake increased compared with baseline (visitors = Δ2·2 ± 2·6, P < 0·001; non-visitors = Δ1·5 ± 1·9, P = 0·001), but was insignificantly different between groups. Visitors had a decrease and non-visitors had an increase in energy intake (visitors =Δ − 132 ± 525; non-visitors = Δ109 ± 507, P = 0·055). Conclusions: The algorithm-generated PDA was well accepted and stimulated adherence to the recommendations more than GA, indicating to be a suitable and cost-efficient method for improving dietary fibre intake in healthy adults.

scholarly journals Non-fasting reference intervals for the Abbott IMxTM homocysteine and AxSYMTM plasma folate assays: influence of the methylenetetrahydrofolate reductase 677 C→T mutation on homocysteine

2000 ◽  
Vol 37 (3) ◽  
pp. 390-398 ◽  
Author(s):  
James G Donnelly ◽  
Phillip A Isotalo
Keyword(s):  
Methylenetetrahydrofolate Reductase ◽  
Mthfr C677t ◽  
Hospital Staff ◽  
Reference Intervals ◽  
Mean Value ◽  
Plasma Homocysteine ◽  
Healthy Individuals ◽  
Plasma Folate ◽  
The Mean ◽  
677T Allele

Plasma homocysteine comes under both genetic and nutritional control. B vitamins and particularly folate are important factors in homocysteine metabolism. We have obtained reference intervals for total plasma homocysteine and plasma folate. We have also determined the influence of methylenetetrahydrofolate reductase (MTHFR) genotype on plasma homocysteine concentrations in healthy individuals. Reference intervals for Abbott IMxTM homocysteine and AxSYMTM plasma folate assays were established using 116 volunteers recruited from hospital staff. Exclusion criteria included cardiac, hepatic or renal disorders, and use of over-the-counter prescription medications. An exception was the inclusion of three women using oral contraceptives and one woman receiving post-menopausal oestrogen supplementation. Methylenetetrahydrofolate reductase 677C-T genotyping was performed on 101 of the volunteers to determine whether the MTHFR 677T allele influences homocysteine concentrations in healthy individuals. Reference intervals for homocysteine and folate were determined using the mean±2 standard deviations of the data. Folate/homocysteine ratios were sorted by MTHFR C677T genotype. Homocysteine correlated negatively with plasma folate. Mean male homocysteine concentrations were significantly higher (9· μmol/L; P<0·05) than the mean value (7·1 μmol/L) obtained for females. Mean homocysteine values were significantly higher in subjects who were homozygous for the MTHFR 677T allele when compared with the 677CC genotype ( P<0·05). Ratios of folate/homocysteine were 20% and 7·44% lower in the male and female 677TT group than in the 677CC group, respectively. The mean homocysteine value of 43 volunteers who were taking multivitamins was not significantly different from that of 73 who were not vitamin supplemented. Conversely, the mean folate value was slightly greater, and statistically significant, in the group taking vitamin supplements. The mean folate values and reference intervals were not significantly different when grouped by sex or age. MTHFR 677C T mutations influenced homocysteine values observed in our study of healthy volunteers, even though we did not observe outright folate-deficient individuals. Our random homocysteine values were similar to the fasting homocysteine values obtained in other studies.

scholarly journals Evaluation of benefit to patients of training mental health professionals in suicide guidelines: Cluster randomised trial

2016 ◽  
Vol 208 (5) ◽  
pp. 477-483 ◽  
Author(s):  
Derek P. de Beurs ◽  
Marieke H. de Groot ◽  
Jos de Keijser ◽  
Erik van Duijn ◽  
Remco F. P. de Winter ◽  
...  
Keyword(s):  
Mental Health Professionals ◽  
Suicide Ideation ◽  
Randomised Trial ◽  
Intervention Group ◽  
Cluster Randomised Trial ◽  
Train The Trainer ◽  
Intention To Treat ◽  
Training Professionals ◽  
Positive Score

BackgroundRandomised studies examining the effect on patients of training professionals in adherence to suicide guidelines are scarce.AimsTo assess whether patients benefited from the training of professionals in adherence to suicide guidelines.MethodIn total 45 psychiatric departments were randomised (Dutch trial register: NTR3092). In the intervention condition, all staff in the departments were trained with an e-learning supported train-the-trainer programme. After the intervention, patients were assessed at admission and at 3-month follow-up. Primary outcome was change in suicide ideation, assessed with the Beck Scale for Suicide Ideation.ResultsFor the total group of 566 patients with a positive score on the Beck Scale for Suicide Ideation at baseline, intention-to-treat analysis showed no effects of the intervention on patient outcomes at 3-month follow-up. Patients who were suicidal with a DSM-IV diagnosis of depression (n = 154) showed a significant decrease in suicide ideation when treated in the intervention group. Patients in the intervention group more often reported that suicidality was discussed during treatment.ConclusionsOverall, no effect of our intervention on patients was found. However, we did find a beneficial effect of the training of professionals on patients with depression.

Analysis of self-efficacy for stroke recognition and action from a cluster randomised trial evaluating the effects of stroke education pamphlets versus a 12-minute culturally tailored stroke film among Black and Hispanic churchgoers in New York

2021 ◽  
pp. 001789692110028
Author(s):  
Daudet Ilunga Tshiswaka ◽  
Jeanne Teresi ◽  
Joseph P. Eimicke ◽  
Jian Kong ◽  
James M. Noble ◽  
...  
Keyword(s):  
New York ◽  
Usual Care ◽  
Self Efficacy ◽  
Retention Rate ◽  
Randomised Trial ◽  
Intervention Group ◽  
Cluster Randomised Trial ◽  
Cluster Randomised ◽  
The Impact

Background: Because early recognition of symptoms and timely treatment of stroke can reduce mortality and the long-term effects of such events, efforts to make many people both aware of these symptoms and knowledgeable about what to do when recognising them are critical for reducing impacts from stroke. Objectives: To assess the impact of a stroke preparedness film (intervention) and stroke preparedness pamphlets (usual care) on self-efficacy for stroke recognition and action. Design: Two-arm cluster randomised trial conducted between July 2013 and August 2018. Setting: A total of 13 church sites located in economically disadvantaged urban neighbourhoods in New York. Of the 883 churchgoers approached, 503 expressed interest, 375 completed eligibility screening and 312 were randomised. Participant inclusion criteria were Black or Hispanic churchgoers, aged 34 years or older, without stroke history, but at a high risk for stroke. The intervention consisted of two 12-minute stroke films: Gospel of Stroke, in English for Black participants, and Derrame Cerebral, in Spanish for Hispanic participants. Method: Participants were pre–post-tested (at baseline, 6-month follow-up and 12-month follow-up) for self-efficacy. Descriptive analysis, a linear mixed model and t tests were used to assess the effects of a stroke preparedness film and stroke preparedness pamphlets on self-efficacy. Results: Findings are based on intention-to-treat analysis. A total of 310 participants completed the study (99% retention rate). About half (53.8%) of participants were Black and 46.2% Hispanic in the intervention group; 48.3% were Black and 51.7% were Hispanic in the usual care group. Overall, both groups evidenced higher self-efficacy (i.e. lower predicted means) over time ( p < .0001), although a significant benefit was not observed for the intervention relative to usual care. Conclusion: Both stroke preparedness films and stroke preparedness pamphlets improved self-efficacy with respect to stroke recognition and action among minority churchgoers.

scholarly journals Distress improves after mindfulness training for progressive MS: A pilot randomised trial

2015 ◽  
Vol 21 (9) ◽  
pp. 1184-1194 ◽  
Author(s):  
A Bogosian ◽  
P Chadwick ◽  
S Windgassen ◽  
S Norton ◽  
P McCrone ◽  
...  
Keyword(s):  
Randomised Trial ◽  
Intervention Group ◽  
Cost Effective ◽  
Control Group ◽  
Post Intervention ◽  
Mindfulness Intervention ◽  
Life Years ◽  
Anxiety Depression

Background: Mindfulness-based interventions have been shown to effectively reduce anxiety, depression and pain in patients with chronic physical illnesses. Objectives: We assessed the potential effectiveness and cost-effectiveness of a specially adapted Skype distant-delivered mindfulness intervention, designed to reduce distress for people affected by primary and secondary progressive MS. Methods Forty participants were randomly assigned to the eight-week intervention ( n = 19) or a waiting-list control group ( n = 21). Participants completed standardised questionnaires to measure mood, impact of MS and symptom severity, quality of life and service costs at baseline, post-intervention and three-month follow-up. Results: Distress scores were lower in the intervention group compared with the control group at post-intervention and follow-up ( p < 0.05), effect size −0.67 post-intervention and −0.97 at follow-up. Mean scores for pain, fatigue, anxiety, depression and impact of MS were reduced for the mindfulness group compared with control group at post-therapy and follow-up; effect sizes ranged from −0.27 to −0.99 post-intervention and −0.29 to −1.12 at follow-up. There were no differences in quality-adjusted life years, but an 87.4% probability that the intervention saves on service costs and improves outcome. Conclusions: A mindfulness intervention delivered through Skype video conferences appears accessible, feasible and potentially effective and cost-effective for people with progressive MS.

scholarly journals Condensed Internet-delivered prolonged exposure provided soon after trauma: a randomised trial

2021 ◽  
pp. 1-10
Author(s):  
Maria Bragesjö ◽  
Filip K. Arnberg ◽  
Klara Olofsdotter Lauri ◽  
Kristina Aspvall ◽  
Josefin Särnholm ◽  
...  
Keyword(s):  
Traumatic Stress ◽  
Prolonged Exposure ◽  
Negative Impact ◽  
Randomised Trial ◽  
Intervention Group ◽  
Control Group ◽  
Post Traumatic Stress ◽  
Stress Symptoms ◽  
Post Traumatic

Abstract Background Exposure to trauma is common and can have a profoundly negative impact on mental health. Interventions based on trauma-focused cognitive behavioural therapy have shown promising results to facilitate recovery. The current trial evaluated whether a novel, scalable and digital early version of the intervention, Condensed Internet-Delivered Prolonged Exposure (CIPE), is effective in reducing post-traumatic stress symptoms. Method A single-site randomised controlled trial with self-referred adults (N = 102) exposed to trauma within the last 2 months. The participants were randomised to 3 weeks of CIPE or a waiting list (WL) for 7 weeks. Assessments were conducted at baseline, week 1–3 (primary endpoint), week 4–7 (secondary endpoint) and at 6-month follow-up. The primary outcome measure was PTSD Checklist for DSM-5 (PCL-5). Results The main analysis according to the intention-to-treat principle indicated statistically significant reductions in symptoms of post-traumatic stress in the CIPE group as compared to the WL group. The between-group effect size was moderate at week 3 (bootstrapped d = 0.70; 95% CI 0.33–1.06) and large at week 7 (bootstrapped d = 0.83; 95% CI 0.46–1.19). Results in the intervention group were maintained at the 6-month follow-up. No severe adverse events were found. Conclusions CIPE is a scalable intervention that may confer early benefits on post-traumatic stress symptoms in survivors of trauma. The next step is to compare this intervention to an active control group and also investigate its effects when implemented in regular care.

The Immunomodulating Effect of a Diet Consisting of Green Vegetables, Beef, Whole Milk and Full-Fat Butter for Children with Non-Specific Elevated IgE

2014 ◽  
Vol 84 (5-6) ◽  
pp. 310-319 ◽  
Author(s):  
Ellen Jose van der Gaag ◽  
Kristina Forbes
Keyword(s):  
Intervention Group ◽  
Considerable Improvement ◽  
Dietary Advice ◽  
Control Group ◽  
Immunomodulating Effect ◽  
Whole Milk ◽  
Significant Difference ◽  
Group A ◽  
Serum Total Ige

Abstract. Background: Non-specific elevated IgE and allergies are common in children, and their prevalence is increasing. Dietary changes could be an explanation for this increase. Zinc, iron, vitamins A, C and E, and polyunsaturated fatty acids all play possible roles in the etiology and possible treatment of allergies due to their numerous immunomodulating properties. Objectives: To investigate the immunomodulating effect of recommending a nutrient-rich diet consisting of green vegetables, beef, whole milk and full-fat butter. Methods: We conducted a case-controlled, non-randomized, retrospective study. Children between the ages of 1 and 18 years with non-specific elevated IgE were included. Baseline and follow-up measurements of serum total IgE and clinical outcomes were retrospectively collected and compared for 49 children who received the dietary advice (to eat green vegetables, beef, whole milk and full-fat butter) and 56 children who did not. Results: The initial analysis showed a significantly greater decrease in IgE in the intervention group compared to the control group; a 9.2 kU/l versus a 0.1 kU/l decrease, respectively (P = 0.02). When supplement (vitamin D) use was taken into account, however, no significant difference was produced by the dietary effect alone (unstandardized coefficient = 71.3 kU/l, P = 0.16). 53.2 % of participants in the intervention group reported considerable improvement in symptoms versus 28.6 % in the control group (P < 0.001). Conclusion: Overall, the effects of nutrients and vitamins on the decrease in IgE are promising. The separate contributions of dietary advice and/or supplements need to be investigated in the future.

scholarly journals Pharmacist led homeless outreach engagement and non-medical independent prescribing (Rx) (PHOENIx) intervention for people experiencing homelessness: a non- randomised feasibility study

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Richard Lowrie ◽  
Kate Stock ◽  
Sharon Lucey ◽  
Megan Knapp ◽  
Andrea Williamson ◽  
...  
Keyword(s):  
Mental Health ◽  
Health Service ◽  
Randomised Trial ◽  
Intervention Group ◽  
Complex Interventions ◽  
City Centre ◽  
Health Board ◽  
Independent Prescribing ◽  
The Phoenix

Abstract Background Homelessness and associated mortality and multimorbidity rates are increasing. Systematic reviews have demonstrated a lack of complex interventions that decrease unscheduled emergency health services utilisation or increase scheduled care. Better evidence is needed to inform policy responses. We examined the feasibility of a complex intervention (PHOENIx: Pharmacist led Homeless Outreach Engagement Nonmedical Independent prescribing (Rx)) to inform a subsequent pilot randomised controlled trial (RCT). Methods Non-randomised trial with Usual Care (UC) comparator group set in Greater Glasgow and Clyde Health Board, Scotland. Participants were adult inpatients experiencing homelessness in a city centre Glasgow hospital, referred to the PHOENIx team at the point of hospital discharge, from 19th March 2018 until 6th April 2019. The follow up period for each patient started on the day the patient was first seen (Intervention group) or first referred (UC), until 24th August 2019, the censor date for all patients. All patients were offered and agreed to receive serial consultations with the PHOENIx team (NHS Pharmacist prescriber working with Simon Community Scotland (third sector homeless charity worker)). Patients who could not be reached by the PHOENIx team were allocated to the UC group. The PHOENIx intervention included assessment of physical/mental health, addictions, housing, benefits and social activities followed by pharmacist prescribing with referral to other health service specialities as necessary. All participants received primary (including specialist homelessness health service based general practitioner care, mental health and addictions services) and secondary care. Main outcome measures were rates of: recruitment; retention; uptake of the intervention; and completeness of collected data, from recruitment to censor date. Results Twenty four patients were offered and agreed to participate; 12 were reached and received the intervention as planned with a median 7.5 consultations (IQR3.0–14.2) per patient. The pharmacist prescribed a median of 2 new (IQR0.3–3.8) and 2 repeat (1.3–7.0) prescriptions per patient; 10(83%) received support for benefits, housing or advocacy. Twelve patients were not subsequently contactable after leaving hospital, despite agreeing to participate, and were assigned to UC. Two patients in the UC group died of drug/alcohol overdose during follow up; no patients in the Intervention group died. All 24 patients were retained in the intervention or UC group until death or censor date and all patient records were accessible at follow up: 11(92%) visited ED in both groups, with 11(92%) hospitalisations in intervention group, 9(75%) UC. Eight (67%) intervention group patients and 3(25%) UC patients attended scheduled out patient appointments. Conclusions Feasibility testing of the PHOENIx intervention suggests merit in a subsequent pilot RCT.

scholarly journals Health in overweight children: 2-year follow-up of Finnmark Activity School—a randomised trial

2014 ◽  
Vol 100 (5) ◽  
pp. 441-448 ◽  
Author(s):  
Ane Kokkvoll ◽  
Sameline Grimsgaard ◽  
Silje Steinsbekk ◽  
Trond Flægstad ◽  
Inger Njølstad
Keyword(s):  
Waist Circumference ◽  
Outcome Measures ◽  
Randomised Trial ◽  
Intervention Group ◽  
Family Intervention ◽  
Overweight Children ◽  
Single Family ◽  
Psychological Outcome ◽  
Pooled Data

ObjectiveTo compare a comprehensive lifestyle intervention for overweight children performed in groups of families with a conventional single-family treatment. Two-year follow-up data on anthropometric and psychological outcome are presented.DesignOverweight and obese children aged 6–12 years with body mass index (BMI) corresponding to ≥27.5 kg/m2 in adults were randomised to multiple-family (n=48) or single-family intervention (n=49) in a parallel design. Multiple-family intervention comprised an inpatient programme with other families and a multidisciplinary team, follow-up visits in their hometown, weekly physical activity and a family camp. Single-family intervention included counselling by paediatric nurse, paediatric consultant and nutritionist at the hospital and follow-up by a community public health nurse. Primary outcome measures were change in BMI kg/m2 and BMI SD score after 2 years.ResultsBMI increased by 1.29 kg/m2 in the multiple-family intervention compared with 2.02 kg/m2 in the single-family intervention (p=0.075). BMI SD score decreased by 0.20 units in the multiple-family group and 0.08 units in the single-family intervention group (p=0.046). A between-group difference of 2.4 cm in waist circumference (p=0.038) was detected. Pooled data from both treatment groups showed a significant decrease in BMI SD score of 0.14 units and a significant decrease in parent-reported and self-reported Strength and Difficulty Questionnaire total score of 1.9 units.ConclusionsTwo-year outcome showed no between-group difference in BMI. A small between-group effect in BMI SD score and waist circumference favouring multiple-family intervention was detected. Pooled data showed an overall improvement in psychological outcome measures and BMI SD score.Trial registration numberNCT00872807, http://www.clinicaltrials.gov.

Sign in / Sign up

Export Citation Format

Share Document