Polypeptide Growth Factors in the Regulation of Normal and Malignant Growth - Role of Transforming Growth Factor-β

1988 ◽  
Vol 48 (sup190) ◽  
pp. 24-25
Author(s):  
J. Keskl-Oja ◽  
M. Lalho
Keyword(s):  
Growth Factors ◽  
Growth Factor ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Malignant Growth ◽  
Polypeptide Growth Factors

Growth factors, stem cells, and stroke

2008 ◽  
Vol 24 (3-4) ◽  
pp. E14 ◽  
Author(s):  
Haviryaji S. G. Kalluri ◽  
Robert J. Dempsey
Keyword(s):  
Stem Cells ◽  
Growth Factors ◽  
Growth Factor ◽  
Neural Stem Cells ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Compensatory Mechanism ◽  
Ischemic Tissue ◽  
And Migration

✓ Postischemic neurogenesis has been identified as a compensatory mechanism to repair the damaged brain after stroke. Several factors are released by the ischemic tissue that are responsible for proliferation, differentiation, and migration of neural stem cells. An understanding of their roles may allow future therapies based on treatment with such factors. Although damaged cells release a variety of factors, some of them are stimulatory whereas some are inhibitory for neurogenesis. It is interesting to note that factors like insulin-like growth factor–I can induce proliferation in the presence of fibroblast growth factor–2 (FGF-2), and promote differentiation in the absence of FGF-2. Meanwhile, factors like transforming growth factor–β can induce the differentiation of neurons while inhibiting the proliferation of neural stem cells. Therefore, understanding the role of each factor in the process of neurogenesis will help physicians to enhance the endogenous response and improve the clinical outcome after stroke. In this article the authors discuss the role of growth factors and stem cells following stroke.

Metalloproteinase and growth factor interactions: do they play a role in pulmonary fibrosis?

2002 ◽  
Vol 283 (1) ◽  
pp. L1-L11 ◽  
Author(s):  
Margaret K. Winkler ◽  
John L. Fowlkes
Keyword(s):  
Acute Lung Injury ◽  
Growth Factors ◽  
Growth Factor ◽  
Pulmonary Fibrosis ◽  
Lung Injury ◽  
Transforming Growth Factor ◽  
Interstitial Fibrosis ◽  
Inflammatory Cells ◽  
Transforming Growth Factor Β ◽  
Target Cells

Chronic lung disease due to interstitial fibrosis can be a consequence of acute lung injury and inflammation. The inflammatory response is mediated through the migration of inflammatory cells, actions of proinflammatory cytokines, and the secretion of matrix-degrading proteinases. After the initial inflammatory insult, successful healing of the lung may occur, or alternatively, dysregulated tissue repair can result in scarring and fibrosis. On the basis of recent insights into the mechanisms underlying acute lung injury and its long-term consequences, data suggest that proteinases, such as the matrix metalloproteinases (MMPs), may not only be involved in the breakdown and remodeling that occurs during the injury but may also cause the release of growth factors and cytokines known to influence growth and differentiation of target cells within the lung. Through the release of and activation of fibrosis-promoting cytokines and growth factors such as transforming growth factor-β1, tumor necrosis factor-α, and insulin-like growth factors by MMPs, we propose that these metalloproteinases may be integral to the initiation and progression of pulmonary fibrosis.

The role of transforming growth factor β in glaucoma and the therapeutic implications

2013 ◽  
Vol 97 (6) ◽  
pp. 680-686 ◽  
Author(s):  
Mark A Prendes ◽  
Alon Harris ◽  
Barbara M Wirostko ◽  
Austin L Gerber ◽  
Brent Siesky
Keyword(s):  
Growth Factor ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Therapeutic Implications
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