Evaluation of the metabolism, bioactivation and pharmacokinetics of triaminopyrimidine analogs toward selection of a potential candidate for antimalarial therapy

Xenobiotica ◽  
2016 ◽  
Vol 47 (11) ◽  
pp. 962-972
Author(s):  
Abhishek Srivastava ◽  
Vijender Panduga ◽  
Ramanatha Saralaya ◽  
Prabhakar K. R. ◽  
Shahul Hameed ◽  
...  
Keyword(s):  
Potential Candidate ◽  
Antimalarial Therapy ◽  
Selection Of

scholarly journals QTL Mapping for Gummy Stem Blight Resistance in Watermelon (Citrullus spp.)

Plants ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 500
Author(s):  
Eun Su Lee ◽  
Do-Sun Kim ◽  
Sang Gyu Kim ◽  
Yun-Chan Huh ◽  
Chang-Gi Back ◽  
...  
Keyword(s):  
Chromosome 8 ◽  
Chromosome 6 ◽  
Potential Candidate ◽  
Stem Blight ◽  
Gummy Stem Blight ◽  
F2 Population ◽  
Leaf Lesion ◽  
Phenotypic Variations ◽  
A Minor ◽  
Selection Of

Watermelon (Citrulluslanatus) is an economically important fruit crop worldwide. Gummy stem blight (GSB) is one of the most damaging diseases encountered during watermelon cultivation. In the present study, we identified quantitative trait loci (QTLs) associated with GSB resistance in an F2 population derived from a cross between maternal-susceptible line ‘920533’ (C. lanatus) and the paternal-resistant line ‘PI 189225’ (C. amarus). The resistance of 178 F2 plants was assessed by two different evaluation methods, including leaf lesion (LL) and stem blight (SB). To analyze the QTLs associated with GSB resistance, a linkage map was constructed covering a total genetic distance of 1070.2 cM. QTL analysis detected three QTLs associated with GSB resistance on chromosome 8 and 6. Among them, two QTLs, qLL8.1 and qSB8.1 on chromosome 8 identified as major QTLs, explaining 10.5 and 10.0% of the phenotypic variations localizing at same area and sharing the same top markers for both LL and SB traits, respectively. A minor QTL, qSB6.1, explains 9.7% of phenotypic variations detected on chromosome 6 only for the SB trait. High-throughput markers were developed and validated for the selection of resistant QTLs using watermelon accessions, and commercial cultivars. Four potential candidate genes were predicted associated with GSB resistance based on the physical location of flanking markers on chromosome 8. These findings will be helpful for the development of watermelon cultivars resistant to GSB.

scholarly journals Selecting Potential Moss Species for Green Roofs in the Mediterranean Basin

Urban Science ◽  
2019 ◽  
Vol 3 (2) ◽  
pp. 57 ◽  
Author(s):  
Ricardo Cruz de Carvalho ◽  
Zulema Varela ◽  
Teresa Afonso do Paço ◽  
Cristina Branquinho
Keyword(s):  
Climate Change ◽  
Mediterranean Basin ◽  
Vascular Plants ◽  
Green Roof ◽  
Green Roofs ◽  
Potential Candidate ◽  
Moss Species ◽  
The Mediterranean ◽  
The Mediterranean Basin ◽  
Selection Of

Green roofs are important infrastructures to address the effects of climate change in urban areas. However, most studies and applications have been done in cooler and wetter regions of the northern hemisphere. Climate change will lead to more extreme weather events, such as increased drought and decreased precipitation with intense flash rain events. Increase desertification is expected especially in the Mediterranean Basin, where in summer, radiation and temperature are high and water is scarce. Therefore, while vascular plants increase water consumption in green roofs during warmer periods, mosses present themselves as potential candidates due to their poikilohydric nature, responding to the environmental availability of water, completely drying out and recovering upon rehydration. Although criteria for the selection of vascular plants adapted to the Mediterranean and suitable for green roofs have been developed, no information is available regarding the selection of mosses based on scientific criteria. Here we propose selection criteria for moss species based on ecological preferences according to Ellenberg’s values and help to define moss traits suitable for a nonirrigated, nature-based green roof that tolerates the Mediterranean climate. The main result is a table of potential candidate mosses that can be either used as standalone or in conjunction with vascular plants to decrease water usage and/or manage stormwater through an easily applicable selection methodology. For green roof practitioners, we proposed that acrocarpous mosses exhibiting turf/cushion life forms and colonist or perennial life strategies best fit the requirements for such a green infrastructure in extreme climate regions with scarce water resources.

scholarly journals Heritability of Simulated Wear and Traffic Tolerance in Three Fine Fescue Species

HortScience ◽  
2018 ◽  
Vol 53 (4) ◽  
pp. 416-420 ◽  
Author(s):  
Austin L. Grimshaw ◽  
Yuanshuo Qu ◽  
William A. Meyer ◽  
Eric Watkins ◽  
Stacy A. Bonos
Keyword(s):  
Broad Sense ◽  
Potential Candidate ◽  
Single Individual ◽  
Broad Sense Heritability ◽  
The North ◽  
Heritability Estimates ◽  
Traffic Tolerance ◽  
Fine Fescue ◽  
Selection Of ◽  
Wear Tolerance

In recent years, turfgrass breeders have given increased attention to the development of lower maintenance turfgrass cultivars. Fine fescues (Festuca spp.) have been identified as potential candidate species for low-maintenance lawns because of their reduced need for water, mowing, and fertilizer. Unfortunately, these species have some weaknesses that must be improved to facilitate their use; perhaps, the most important of these is tolerance to wear and traffic. For this trait to be improved in new cultivars, there must be sufficient heritable variation available for plant breeders to exploit; however, little is known about the heritability of this complex trait in fine fescue species. Therefore, the objective of this study was to determine the heritability of wear and traffic tolerance in three fine fescue species. Replicated field studies were established in North Brunswick, NJ, and St. Paul, MN, and each included 157 Chewing’s fescue (Festuca rubra L. subsp. fallax), 155 hard fescue (Festuca brevipilia), and 149 strong creeping red fescue (F. rubra L. subsp. rubra) genotypes. Wear tolerance was evaluated in North Brunswick and traffic tolerance was evaluated in St. Paul during 2015 and 2016 using different simulators to determine both plant performance and broad-sense heritability estimates for wear and traffic tolerance. Broad-sense heritability estimates for the three species when calculated on a clonal basis was between 0.69 and 0.82 for wear tolerance in the North Brunswick location and between 0.49 and 0.60 for traffic tolerance in the St. Paul location. On a single-plant basis, broad-sense heritability estimates for the three species were between 0.31 and 0.45 for wear tolerance in the North Brunswick location and 0.09 and 0.12 for traffic tolerance in St. Paul. However, this research does indicate that improvement of wear and traffic tolerance in fine fescues is possible through recurrent breeding methods based on selection of replicated clonally propagated genotypes rather than selection of single individual plants of a population. This was the first study to determine the genetic effects of wear and traffic tolerance in any turfgrass species.

scholarly journals Selection of uric acid oxidizing-Lactobacillus plantarum isolates based on their genetic determinant and uricase kinetics

2020 ◽  
Vol 11 (4) ◽  
pp. 6583-6588
Author(s):  
Desi Meriyanti ◽  
I Made Artika ◽  
Novik Nurhidayat
Keyword(s):  
Uric Acid ◽  
Lactobacillus Plantarum ◽  
Substrate Affinity ◽  
Potential Candidate ◽  
Genetic Determinant ◽  
Specific Primers ◽  
The People ◽  
Differential Medium ◽  
Uricase Activity ◽  
Selection Of

Hyperuricemia is a condition characterized by abnormally elevated levels of uric acid in the blood. It has been a leading morbidity disease. Microbial uricase can be used to oxidize uric acid into allantoin and hydrogen peroxide in the presence of oxygen and therefore has the potential to play an essential role in reducing uric acid in the people suffering from degenerative disease of hyperuricemia. The present study aims to select uric acid oxidizing-Lactobacillus plantarum isolates based on their genetic determinant and uricase kinetics. A collection of Lactobacillus plantarum isolates were grown on a selective differential medium followed by measuring their uricase activity spectrophotometrically. Specific primers for detection of uricase gene were designed. The uricase coding gene (uox) was then detected in all of the selected isolates by using a qPCR method employing the designed specific primers. The uricase kinetics was determined by the Lineweaver-Burk method. Results showed that all isolates had uricase activity and 4 potential isolates were selected based on their superior uricase activity. The uox gene was detected in all of the selected isolates. The kinetics analysis, however, revealed that only the L. plantarum K-Mar-A2 show strongest substrate affinity and was considered a potential candidate to be developed as a source of therapeutic agent for hyperuricemia.

scholarly journals Guar (Cyamopsis tetragonoloba L.): A Potential Candidate for the Rehabilitation of Feldspar Mine Spoil Amended with Bioinoculants

2020 ◽  
Author(s):  
R. Junia ◽  
R. C. Kasana ◽  
N. Jain ◽  
G. K. Aseri
Keyword(s):  
Glomus Mosseae ◽  
Biological Activities ◽  
Soil Health ◽  
Mine Spoil ◽  
Potential Candidate ◽  
Cyamopsis Tetragonoloba ◽  
Plant Metabolites ◽  
Fertility Status ◽  
Uninoculated Control ◽  
Selection Of

Excessive feldspar mining is becoming an alarming issue due to the untreated mine spoil. For the success in the remediation of mine spoil, selection of plant species is an important factor. Therefore being a nitrogen fixer, legumes can be an alternative and are needed to be broadcasted for the rehabilitation of mined lands. In this context guar (Cyamopsis tetragonoloba L.) can be preferred which excels in enhancing soil fertility and is already in cultivation but not experimented with feldspar due to not establishing its rhizosphere fertility. In this study to enhance the fertility status and biological activities of feldspar mine spoil plantation of guar is done with the inoculation of microbes Azotobacter Azospirillum and Glomus mosseae (AMF) and organic and inorganic amendments. This attempt has successfully enhanced the rhizosphere enzymes at the rate of 10-65% maximum with AMF+ OM+ NPK50% (T16), nutrient uptake 10-70% maximum with Azotobacter+ OM+ NPK 50% (T7) and plant metabolites 10-51% also observed maximum with T7 over the uninoculated control. Guar has also shown positive response towards the applied treatment and grown well. Based on the results it can be inferred that guar can tolerate detrimental effects of feldspar mining. Hence, it is concluded that guar can be a potential crop to restore soil health of feldspar mined land for sustainable development.

Selection of ILs for Separation of Benzene from n-Hexane Using COSMO-RS. A Quantum Chemical Approach

2013 ◽  
Vol 553 ◽  
pp. 35-40 ◽  
Author(s):  
Kiki A. Kurnia ◽  
Mohamed Ibrahim Abdul Mutalib ◽  
Zakaria Man ◽  
Mohammad Azmi Bustam
Keyword(s):  
Activity Coefficient ◽  
Performance Index ◽  
Quantum Chemical ◽  
Infinite Dilution ◽  
Aliphatic Hydrocarbon ◽  
Potential Candidate ◽  
Green Solvent ◽  
Chemical Approach ◽  
Quantum Chemical Approach ◽  
Selection Of

onic Liquids (ILs) provide an alternative green solvent for separating aromatic from its mixture with aliphatic hydrocarbon. The present work demonstrates the screening of potential IL for separation of benzene (aromatic) from n-hexane (aliphatic) using COSMO-RS. A total of 10 imidazolium based cations and 52 different anions resulting in 520 possible combinations of ILs were studied. The COSMO-RS was used to theoretically calculate the activity coefficient at infinite dilution (γ) for benzene and n-hexane in each of the ILs. Consequently, from the activity coefficient (γ) value, the capacity (C) and selectivity (S) at infinite dilution for each ILs with regards to the benzene/n-heptane separation were calculated. The Performance Index (PI) which is the product of the capacity (C) and selectivity (S) is then determined and compared against sulfolane as the benchmarking solvent, used widely by industry for the separation of benzene and aliphatic hydrocarbon. The result showed 20 ILs with C, S, and PI value higher than sulfolane thus making them as potential candidate for the separation application.

scholarly journals Recruiting on SMART-principles

2020 ◽  
pp. 100-104
Author(s):  
Nataliia Pryvalova
Keyword(s):  
Job Search ◽  
Scientific Work ◽  
Potential Candidate ◽  
Senior Managers ◽  
Scientific Methods ◽  
Qualified Personnel ◽  
Analysis And Synthesis ◽  
Or Methodology ◽  
Recruitment And Selection ◽  
Selection Of

The relevance of the research topic due to socio-economic transformations in the Ukrainian economy and, as a result of particular importance for any enterprise is the problem of selection of qualified personnel. On the Ukrainian labor market has undergone significant changes: if earlier the problem was the job search by the worker, today the main problem was the search for a qualified employee by the company. Statement of the problem. New opportunities associated with rekrutinga and improvement of it principles given the SMART technology and to make certain conclusions. Analysis of recent researches and publications. Problems of personnel management, recruitment and selection of personnel, recruiting is dedicated to the work of such scientists-economists as A. Matusevich, T. Butynski, I. Zhilyaeva, E. Zotova, S. Kulakov, V. Kopeikin, V. Lysak, E. Orlova, V. Semenyak, A. Trunov and others. Highlighting unexplored aspects of the problem. In the operation and development of recruitment remains unanswered question about approaches to recruiting principles that justifies its relevance. Statement of the problem, purpose of the study. The purpose of this article is to study the nature of recruitment and its principles, given the SMART. Method or methodology of the study. The study used General scientific methods: dialectic, system-structural analysis and synthesis, generalization. The main material (the results). The article explores the nature of recruitment and the factors that influence it. It reveals the importance of recruiting for enterprise clients. Define the concept of «SMART» and its essence. It is proved that a modernized approach to recruiting, in modern conditions should be based on SMART principles, which takes into account the time factor, the needs of the enterprise client and his requirements to the potential candidate (employee) and the result (performance), which is expected from him. Recommended by the author recruiting at SMART-principles consists of specific, measurable, achievable, relevant and limited in time principles. The scope of the results. The findings and results of this paper can be used in educational and scientific process of economic faculties of higher educational institutions. However, the results can be used for recruiting, selection and hiring clients as well as business leaders, senior managers. Conclusions according to the article. On the basis of the study of the nature of recruitment and its principles, given the technology of SMART, the result of scientific work is that recruting SMART-principles contributes to a more accurate understanding of customer needs and a full view of the field of activity of the enterprise client as well as the ability to find clients and competent to work with them.

scholarly journals Gene Networks Driving Genetic Variation in Milk and Cheese-Making Traits of Spanish Assaf Sheep

Genes ◽  
2020 ◽  
Vol 11 (7) ◽  
pp. 715
Author(s):  
Héctor Marina ◽  
Antonio Reverter ◽  
Beatriz Gutiérrez-Gil ◽  
Pâmela Almeida Alexandre ◽  
Laercio R. Porto-Neto ◽  
...  
Keyword(s):  
Candidate Genes ◽  
Gene Networks ◽  
Genome Wide Association Study ◽  
Stepwise Multiple Regression ◽  
Potential Candidate ◽  
Cheese Making ◽  
Genome Wide ◽  
Regression Approach ◽  
Milk Coagulation ◽  
Selection Of

Most of the milk produced by sheep is used for the production of high-quality cheese. Consequently, traits related to milk coagulation properties and cheese yield are economically important to the Spanish dairy industry. The present study aims to identify candidate genes and their regulators related to 14 milk and cheese-making traits and to develop a low-density panel of markers that could be used to predict an individual’s genetic potential for cheese-making efficiency. In this study, we performed a combination of the classical genome-wide association study (GWAS) with a stepwise regression method and a pleiotropy analysis to determine the best combination of the variants located within the confidence intervals of the potential candidate genes that may explain the greatest genetic variance for milk and cheese-making traits. Two gene networks related to milk and cheese-making traits were created using the genomic relationship matrices built through a stepwise multiple regression approach. Several co-associated genes in these networks are involved in biological processes previously found to be associated with milk synthesis and cheese-making efficiency. The methodology applied in this study enabled the selection of a co-association network comprised of 374 variants located in the surrounding of genes showing a potential influence on milk synthesis and cheese-making efficiency.

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