The Association between the Preoperative Prognostic Nutritional Index and the Controlling Nutritional Status Score on Tumor Stage, Chemotherapeutic Response and Overall Survival in Ovarian Cancer

Background: The aim of this study is to evaluate the negative effect of malnutrition in patients with coronary artery disease who are undergoing coronary artery bypass graft surgery. Methods: In this study, we analyzed 149 patients, who underwent coronary artery bypass surgery. Nutritional status of the patients was classified using controlling nutritional status score (CONUT) and prognostic nutritional index (PNI). Statistical correlation between malnutrition and complication following operation was evaluated with the chi-square test. Statistical alpha significant level was accepted P < 0.05. Results: There were various complications in 38 patients. Renal failure was the predominant problem in 18 of them. There was statistical significance between malnutrition and complication (P < .001). There were more complications in the controlling nutritional status score and prognostic nutritional index groups. Renal complication (P < .001), hemorrhage (P < .05), and mortality (P < .05) were high in the severe controlling nutritional status score and prognostic nutritional index groups. Conclusion: There are manifest correlations between the severe controlling nutritional status score and prognostic nutritional index groups and morbidity and mortality after coronary artery bypass graft surgery. We found that renal complications, hemorrhage, and mortality rate

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Survival impact of perioperative changes in prognostic nutritional index levels after esophagectomy

Esophagus ◽

10.1007/s10388-021-00883-5 ◽

2021 ◽

Author(s):

Ryoma Haneda ◽

Yoshihiro Hiramatsu ◽

Sanshiro Kawata ◽

Junko Honke ◽

Wataru Soneda ◽

...

Keyword(s):

Overall Survival ◽

Confidence Interval ◽

Nutritional Status ◽

Multivariable Analysis ◽

Prognostic Nutritional Index ◽

Hazard Ratio ◽

High Group ◽

Nutritional Index ◽

Significant Difference ◽

The Impact

Abstract Background The correlation between perioperative changes in nutritional status during esophagectomy and prognosis remains unclear. This study aimed to evaluate the impact of changes in prognostic nutritional index levels during the perioperative period on esophageal cancer patient survivals. Methods From January 2009 to May 2019, 158 patients with esophageal squamous cell carcinoma were enrolled. From the time-dependent ROC analysis, the cutoff values of preoperative and postoperative prognostic nutritional index levels were 46.9 and 40.9. Patients were divided into preoperative-high group (Group H) and preoperative-low group (Group L). Then, patients in Group L were divided into preoperative-low and postoperative-high group (Group L–H) and preoperative-low and postoperative-low group (Group L–L). Long-term outcomes and prognostic factors were evaluated. Results Patients in Group L had significantly worse overall survival than those in Group H (p = 0.001). Patients in Group L–L had significantly worse overall survival than those in Group L–H (p = 0.023). However, there was no significant difference in overall survival between Groups H and L–H (p = 0.224). In multivariable analysis, advanced pathological stage (hazard ratio 10.947, 95% confidence interval 2.590–46.268, p = 0.001) and Group L–L (hazard ratio 2.171, 95% confidence interval 1.249–3.775, p = 0.006) were independent predictors of poor overall survival. Conclusions Patients in Group L–H had a good prognosis, similar to those in Group H. This result indicated that increasing the postoperative prognostic nutritional index level sufficiently using various intensive perioperative support methods could improve prognosis after esophagectomy in patients with poor preoperative nutritional status.

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Significance of Prognostic Nutritional Index in post-surgical outcomes after surgical management in gastric cancer patients.

Journal of Clinical Oncology ◽

10.1200/jco.2017.35.15_suppl.e15535 ◽

2017 ◽

Vol 35 (15_suppl) ◽

pp. e15535-e15535

Author(s):

Marytere Herrera ◽

Nora Sobrevilla-Moreno ◽

IVAN LYRA-GONZALEZ ◽

German Calderillo ◽

Consuelo Diaz ◽

...

Keyword(s):

Gastric Cancer ◽

Overall Survival ◽

Nutritional Status ◽

Advanced Gastric Cancer ◽

Cancer Patients ◽

Locally Advanced ◽

Prognostic Nutritional Index ◽

Locally Advanced Gastric Cancer ◽

Nutritional Index ◽

Gastric Cancer Patients

e15535 Background: Preoperative nutritional status in gastric cancer patients is not only correlated with postoperative complications, also, prognostic nutritional index or Onodera´s nutritional index (PNI) may relate with overall survival (OS) after gastrectomy. There is no available data of preoperative nutritional status in Mexican population. We decide to explore these variables and analyze its impact in outcomes reported in our population. Methods: This is a retrospective included a total of 91 patients patients with locally advanced gastric cancer confirmed by laparoscopy treated in the National Cancer Institute in México between January 2010 and June 2016. The PNI level was determined according the following formula: 10 x serum albumin (g/dl) + 0.005 x total lymphocyte count (per mm3). The optimal cutoff value of PNI in our population was set at 38.7 according the median, we stratified patients in high (PNI > 38.7) or low (PNI < 38.7) nutritional status, clinicopathologic features were compared. Results: We analyzed 91 patients, the mean patients age was 58, 61.5% were man, the 51.6% went to total gastrectomy with D2 dissection, 56% were pathologic stage III and 61.5% of the patients received adjuvant chemotherapy. The patients with high nutritional status had a OS of 46 months vs patients with low nutritional status with 25 months (p = 0.009). Patients with body mass index (BMI) > 23 had a OS of 41 months vs patients with BMI < 23 with 19 months of OS (p = 0.001), finally the patients with albumin > 3.75 had a 39 months of OS vs 23 months with albumin < 3.75 (p = 0.011) Conclusions: The low PNI group had worse OS than the high PNI group (46 months vs 25 months, p = 0.009). Preoperative is a simple and useful marker to predict overall survival in patients with locally advanced gastric cancer

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FA08.04: RELATIONSHIP BETWEEN PROGNOSTIC NUTRITIONAL INDEX AND PERITUMORAL IMMUNE SYSTEM DYNAMICS IN ESOPHAGEAL CANCER

Diseases of the Esophagus ◽

10.1093/dote/doy089.fa08.04 ◽

2018 ◽

Vol 31 (Supplement_1) ◽

pp. 17-17

Author(s):

Kazuo Okadome ◽

Yoshifumi Baba ◽

Taisuke Yagi ◽

Yuki Kiyozumi ◽

Kuroda Daisuke ◽

...

Keyword(s):

Overall Survival ◽

Esophageal Cancer ◽

Immune System ◽

Prognostic Factor ◽

Nutritional Status ◽

Prognostic Nutritional Index ◽

Immune Competence ◽

High Group ◽

Cancer Specific Survival ◽

Nutritional Index

Abstract Background There have been reported that nutritional status and tumor-infiltrating lymphocytes (TILs) are prognostic factor for esophageal cancer. Prognostic Nutritional Index (PNI) is one of the most widely used indicators for nutritional status and also shows systemic immune competence. Because TILs is related to peritumoral immune system, there may be relation between PNI and TILs. Methods Using a database of 300 curatively resected esophageal cancer from April 2005 to Jun 2013, we evaluated the relationship between PNI and TILs. PNI was calculated using serum albumin and total lymphocyte count. TILs were histologically estimated using postoperative samples. Studying the expression of CD8 and Foxp3 by immunohistochemical staining, we tried to reveal which subsets of lymphocyte were relevant to PNI. Results PNI high group (N = 198) experienced better overall survival (P < 0.001) and cancer specific survival (P < 0.001) compared with PNI low group (N = 102). PNI was significantly related to the TILs status (P < 0.01). CD8 positive lymphocyte was also significantly related to the PNI (P = 0.013) but Foxp3 wasn’t (P = 0.62). CD8 positive lymphocyte high group (N = 224) was significantly better in overall survival (P = 0.028) and cancer specific survival (P = 0.012) than low group (N = 76). There was no significant difference between Foxp3 high group (N = 225) and Foxp3 low group (N = 75) about overall survival (P = 0.87) and cancer specific survival (P = 0.90). Conclusion PNI was predictive prognostic marker for esophageal cancer and had relation to TILs status. It means systemic immune competence maybe affects peritumoral immune system. Among subsets of lymphocyte, CD8 positive lymphocyte had relation to PNI and was prognostic factor. In this study, Foxp3 didn’t have any relation to PNI and prognosis. Disclosure All authors have declared no conflicts of interest.

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