scholarly journals Evaluation of the controlling nutritional status score and prognostic nutritional index in patients with familial Mediterranean fever

2022 ◽  
Vol 9 (1) ◽  
pp. 14-19
Author(s):  
Firdevs Ulutaş ◽  
◽  
Veli Çobankara ◽  
Uğur Karasu ◽  
Serdar Kaymaz ◽  
...  
Keyword(s):  
Familial Mediterranean Fever ◽  
Nutritional Status ◽  
Prognostic Nutritional Index ◽  
Nutritional Index ◽  
Status Score ◽  
Mediterranean Fever

scholarly journals Impact of Controlling Nutritional Status Score (CONUT) and Prognostic Nutritional Index (PIN) on Patients Undergoing Coronary Artery Bypass Graft Surgery

2019 ◽  
Vol 22 (4) ◽  
pp. E294-E297 ◽  
Author(s):  
Melike Elif Teker Açıkel ◽  
Ali Kubilay Korkut
Keyword(s):  
Coronary Artery ◽  
Nutritional Status ◽  
Coronary Artery Bypass Graft ◽  
Coronary Artery Bypass ◽  
Artery Bypass ◽  
Bypass Graft ◽  
Prognostic Nutritional Index ◽  
Artery Bypass Graft ◽  
Nutritional Index ◽  
Status Score

Background: The aim of this study is to evaluate the negative effect of malnutrition in patients with coronary artery disease who are undergoing coronary artery bypass graft surgery. Methods: In this study, we analyzed 149 patients, who underwent coronary artery bypass surgery. Nutritional status of the patients was classified using controlling nutritional status score (CONUT) and prognostic nutritional index (PNI). Statistical correlation between malnutrition and complication following operation was evaluated with the chi-square test. Statistical alpha significant level was accepted P < 0.05. Results: There were various complications in 38 patients. Renal failure was the predominant problem in 18 of them. There was statistical significance between malnutrition and complication (P < .001). There were more complications in the controlling nutritional status score and prognostic nutritional index groups. Renal complication (P < .001), hemorrhage (P < .05), and mortality (P < .05) were high in the severe controlling nutritional status score and prognostic nutritional index groups. Conclusion: There are manifest correlations between the severe controlling nutritional status score and prognostic nutritional index groups and morbidity and mortality after coronary artery bypass graft surgery. We found that renal complications, hemorrhage, and mortality rate

scholarly journals Baseline prognostic nutritional index and changes in pretreatment body mass index associate with immunotherapy response in patients with advanced cancer

2020 ◽  
Vol 8 (2) ◽  
pp. e001674
Author(s):  
Paul Johannet ◽  
Amelia Sawyers ◽  
Yingzhi Qian ◽  
Samuel Kozloff ◽  
Nicholas Gulati ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Nutritional Status ◽  
Body Mass ◽  
Advanced Cancer ◽  
Objective Response ◽  
Prognostic Nutritional Index ◽  
Baseline Body Mass Index ◽  
New York University ◽  
Nutritional Index ◽  
Baseline Bmi

BackgroundRecent research suggests that baseline body mass index (BMI) is associated with response to immunotherapy. In this study, we test the hypothesis that worsening nutritional status prior to the start of immunotherapy, rather than baseline BMI, negatively impacts immunotherapy response.MethodsWe studied 629 patients with advanced cancer who received immune checkpoint blockade at New York University. Patients had melanoma (n=268), lung cancer (n=128) or other primary malignancies (n=233). We tested the association between BMI changes prior to the start of treatment, baseline prognostic nutritional index (PNI), baseline BMI category and multiple clinical end points including best overall response (BOR), objective response rate (ORR), disease control rate (DCR), progression-free survival (PFS) and overall survival (OS).ResultsDecreasing pretreatment BMI and low PNI were associated with worse BOR (p=0.04 and p=0.0004), ORR (p=0.01 and p=0.0005), DCR (p=0.01 and p<0.0001), PFS (p=0.02 and p=0.01) and OS (p<0.001 and p<0.001). Baseline BMI category was not significantly associated with any treatment outcomes.ConclusionStandard of care measures of worsening nutritional status more accurately associate with immunotherapy outcomes than static measurements of BMI. Future studies should focus on determining whether optimizing pretreatment nutritional status, a modifiable variable, leads to improvement in immunotherapy response.

scholarly journals Association between the Prognostic Nutritional Index and Dietary Intake in Community-Dwelling Older Adults with Heart Failure: Findings from NHANES III

Nutrients ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 2608
Author(s):  
Elisabeth L. P. Sattler ◽  
Yuta Ishikawa ◽  
Rupal Trivedi-Kapoor ◽  
Donglan Zhang ◽  
Arshed A. Quyyumi ◽  
...  
Keyword(s):  
Heart Failure ◽  
Older Adults ◽  
Nutritional Status ◽  
Dietary Intake ◽  
Prognostic Nutritional Index ◽  
Red Meat ◽  
Community Dwelling ◽  
Nhanes Iii ◽  
Nutritional Index ◽  
Community Dwelling Older Adults

The objective of this study was to examine the association between nutritional status and dietary intake in community-dwelling older adults with heart failure (HF). A cross-sectional analysis of NHANES III data was conducted. The analytic sample was comprised of n = 445 individuals aged 50+ years with congestive HF (54.4% male, 22.9% non-Hispanic Black, 43.8% low-income). Nutritional status was measured using the Prognostic Nutritional Index (PNI). Participants were classified by PNI quintiles with lower PNI scores indicating lower nutritional status. Participants in quintile 5 showed significantly greater intakes of energy, protein, vegetables, magnesium, zinc, copper, potassium, red meat, saturated fat, and sodium. In multivariate analyses, increased intake of red meat (β = 0.253, p = 0.040) and vegetables (β = 0.255, p = 0.038) was associated with significantly better nutritional status. In the absence of comprehensive nutritional guidance for HF patients, it appears that small increases in energy, protein (red meat), and vegetable consumption are associated with improved nutritional status.

343 EFFECTS OF PREOPERATIVE PNI (PROGNOSTIC NUTRITIONAL INDEX) AND POSTOPERATIVE INFLAMMATORY RESPONSE ON PROGNOSIS IN PATIENTS WITH ESOPHAGEAL CANCER

2021 ◽  
Vol 34 (Supplement_1) ◽  
Author(s):  
Yoshinori Fujiwara ◽  
Masaharu Higashida ◽  
Hisako Kubota ◽  
Yuko Okamoto ◽  
Syumei Mineta ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Blood Loss ◽  
Inflammatory Response ◽  
Nutritional Status ◽  
Cancer Patients ◽  
Inflammatory Responses ◽  
Cox Model ◽  
Prognostic Nutritional Index ◽  
Nutritional Index ◽  
Group 3

Abstract   The effects of preoperative nutritional status and postoperative inflammatory response on esophageal cancer patients on prognosis were unclear. In the present study, we evaluated the preoperative nutritional parameters and postoperative inflammatory responses and analyzed relationship between these parameters and cancer prognosis. Methods One hundred and eleven esophageal squamous cell carcinoma patients were analyzed with pathological TNM StageI-IV. Preoperative nutritional parameters: PNI (Prognostic Nutritional Index) was calculated from following formula:10 x Albumin(g/dl) +0.005 x peripheral lymphocyte counts (/mm3). Preoperative NLR (Neutrophil/Lymphocyte ratio) was defined as absolute neutrophil counts divided by the absolute lymphocyte counts. The highest CRP level was evaluated as postoperative inflammatory responses. Cut-off values of these continuous parameters were calculated by ROC, and univariate and multivariate analysis using Cox model for overall survival (OS) were examined in the parameters. Results Overall three or five years survivals were 60.9%, 56.28%, respectively. Cut-off value of PNI, CRP, NLR, Intraoperative blood loss were 44.8, 21.7 mg/dl,2.27,159 mL, respectively. High PNI group was significantly better survival than low group (3 years OS, 65.94 vs 45.82%, p &lt; 0.05). No association between PNI and prognosis was noted for patients with pStageI, but the low PNI patients of pStageII-IV were extremely poor prognosis (p &lt; 0.01). High CRP group was tendency to be worse survival than low group (3 years OS, 65.97 vs 38.82%, p = 0.062). The patients of low blood loss group was significantly better survival than high group (p &lt; 0.05).NLR was not associated with OS. Cox model showed that pTNM, tumor location, and PNI were independent prognostic factors. Conclusion Preoperative nutritional status affected the prognosis of esophageal cancer patients. But, postoperative inflammatory response was not affected the prognosis of these patients. Preoperative nutritional interventions may improve the prognosis of patients with esophageal cancer.

Prognostic nutritional index as indicator of immune nutritional status of patients with COVID-19

2021 ◽  
Author(s):  
Iskender Ekinci ◽  
Hafize Uzun ◽  
Irem Kirac Utku ◽  
Hanise Ozkan ◽  
Mitat Buyukkaba ◽  
...  
Keyword(s):  
Nutritional Status ◽  
Oxygen Saturation ◽  
White Blood Cells ◽  
Prognostic Nutritional Index ◽  
Multivariate Regression Analysis ◽  
Albumin Concentration ◽  
Reactive Protein ◽  
Nutritional Index ◽  
Failure Assessment ◽  
Group 2

Abstract. Purpose: This study aimed to investigate the effect of the nutritional status, as assessed by the prognostic nutritional index (PNI) on the disease prognosis of patients with COVID-19. Methods: This retrospective study included 282 patients with COVID-19. The PNI score of all patients, 147 of whom were male, with a mean age of 56.4±15.3 years, was calculated. According to the PNI score, the patients with normal and mild malnutrition constituted group-1 (n=159) and the patients with moderate-to-severe and serious malnutrition constituted group-2 (n=123). Results: The PNI score was correlated with age (r=−0.146, p=0.014); oxygen saturation (r=0.190, p=0.001); heart rate (r=−0.117, p=0.05); hospitalization duration (r=−0.266, p<0.001); white blood cells (r=0.156, p=0.009); hemoglobin (r=0.307, p<0.001); C-reactive protein (CRP) (r=−0.346, p<0.001); creatinine (r=−0.184, p=0.002); D-dimer (r=−0.304, p<0.001); ferritin (r=−0.283, p<0.001); procalcitonin (r=−0.287, p<0.001); the confusion, urea, respiratory rate, blood pressure, and age ≥65 years score (r=−0.217, p<0.001); and the quick sequential organ failure assessment score (r=−0.261, p<0.001) in patients with COVID-19. Mortality was significantly higher in Group 2 (p<0.001). Survival was significantly higher if PNI score was >41.2 (p<0.001, sensitivity: 78.7% and specificity: 84.2%). In multivariate regression analysis, among various other parameters, only PNI score and oxygen saturation had a significant effect on the disease course (p=0.02 and p=0.045, respectively). Conclusion: PNI, calculated from the serum albumin concentration and total lymphocyte count, is a simple and objective indicator that assesses the immune nutritional status of patients with COVID-19. The presence of malnutrition has a high predictive value in predicting the severity of COVID-19. Our data suggest that the PNI might be useful for risk stratification of patients with COVID-19 in clinical practice.

scholarly journals Association between a prognostic nutritional index less than 50 and the risk of medical complications after adult spinal deformity surgery

2020 ◽  
Vol 33 (2) ◽  
pp. 219-224 ◽  
Author(s):  
Shin Oe ◽  
Yu Yamato ◽  
Tomohiko Hasegawa ◽  
Go Yoshida ◽  
Sho Kobayashi ◽  
...  
Keyword(s):  
Nutritional Status ◽  
Spinal Deformity ◽  
Adult Spinal Deformity ◽  
Multiple Logistic Regression Analysis ◽  
Significant Risk ◽  
Prognostic Nutritional Index ◽  
Medical Complications ◽  
Complication Rates ◽  
Nutritional Index ◽  
Significant Difference

OBJECTIVEMany complications are likely to occur in patients with malnutrition. The prognostic nutritional index (PNI) is often used when evaluating a patient’s nutritional condition. However, no studies have investigated the association between nutritional status and postoperative medical complications or prognosis by using the PNI in the field of spinal surgery. The purpose of this retrospective study was to investigate postoperative medical complications and prognoses of patients who had undergone adult spinal deformity (ASD) surgery, according to their preoperative nutritional status.METHODSAll patients aged ≥ 40 years who had undergone scheduled ASD surgery in the authors’ hospital between March 2010 and June 2017 were eligible for study inclusion and were divided into groups according to their PNI (< 50, group L; ≥ 50, group H). Medical complications diagnosed within 30 days postoperatively were evaluated; however, surgical site infection and death were evaluated until 1 and 5 years after surgery, respectively.RESULTSAmong the 285 eligible patients, groups L and H consisted of 118 and 167 patients, whose mean ages were 68.6 and 68.3 years, respectively. There was a significant difference in body mass index (22 vs 24 mg/kg2, respectively, p = 0.000), PNI (46 vs 55, p = 0.000), comorbidity of osteoporosis (50% vs 32%, p = 0.005) and autoimmune disease (13% vs 5%, p = 0.036), medical history of malignant disorder (17% vs 6%, p = 0.007), and medical complications (49% vs 23%, p = 0.000) between groups L and H. Multiple logistic regression analysis suggested that significant risk factors for postoperative medical complications were male sex (p = 0.000, OR 3.5, 95% CI 1.78–6.96), PNI < 50 (p = 0.000, OR 2.9, 95% CI 1.69–4.93), and days to ambulation (p = 0.003, OR 1.1, 95% CI 1.02–1.09).CONCLUSIONSMedical complication rates are significantly higher in patients with PNI < 50, those with delayed ambulation, and male patients. In malnourished patients scheduled for ASD surgery, improvement of preoperative nutritional status and postoperative early ambulation are important to avoid medical complications.

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