Thimerosal exposure and disturbance of emotions specific to childhood and adolescence: A case-control study in the Vaccine Safety Datalink (VSD) database

Studies suggest a relationship between exposure to endocrine disrupters, such as mercury (Hg), and premature puberty. Hg exposure from Thimerosal-containing hepatitis B vaccine, administered at specific intervals within the first six months of life, and the child’s long-term risk of being diagnosed with premature puberty (ICD-9 code: 259.1), was retrospectively examined, using a hypothesis-testing, longitudinal case-control design on prospectively collected data, in the Vaccine Safety Datalink (VSD). Cases diagnosed with premature puberty were significantly more likely to have received increased exposure to Hg from hepatitis B vaccines preserved with Thimerosal given in the first month after birth (odds ratio (OR) = 1.803), first two months after birth (OR = 1.768), and first six months after birth (OR = 2.0955), compared to control subjects. When the data were separated by gender, the effects remained among females but not males. Female cases, as compared to female controls, were significantly more likely in a dose-dependent manner to have received a greater exposure to Hg from hepatitis B vaccines preserved with Thimerosal, given in the first six months after birth (OR = 1.0281 per µg Hg). The results of this study show a dose-dependent association between increasing organic Hg exposure from Thimerosal-containing hepatitis B vaccines administered within the first six months of life and the long-term risk of the child being diagnosed with premature puberty.

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A composição familiar e sua associação com a ocorrência da gravidez na adolescência: estudo caso-controle [The family composition and its association with the occurrence of pregnancy in adolescence: case-control study] [La composición familiar y su asociación con la ocurrencia del embarazo adolescente: estudio caso-control]

Revista Enfermagem UERJ ◽

10.12957/reuerj.2020.36283 ◽

2020 ◽

Vol 28 ◽

pp. e36283

Author(s):

Ana Luiza Rabello Silva ◽

Janete Tamami Tomiyoshi Nakagawa ◽

Marielle Jeani Prasnievski Silva

Keyword(s):

Family Income ◽

Case Control Study ◽

Case Control ◽

Childhood And Adolescence ◽

Structured Interviews ◽

Pregnancy In Adolescence ◽

Mato Grosso ◽

Nuclear Families ◽

Factores De Riesgo ◽

Control Study

Objetivo: analisar a influência das composições familiares na ocorrência da gravidez na adolescência. Método: estudo caso-controle, realizado com 74 gestantes adolescentes, grupo de casos, e 74 adultas jovens sem história pregressa de gravidez na adolescência, grupo controle, pareadas pela variável renda familiar. Os dados foram coletados por meio de entrevistas estruturadas realizadas no período de agosto a outubro de 2016 em Cuiabá, Mato Grosso, e em seguida analisados pelos métodos estatísticos descritivo e inferencial. Resultados: identificou-se associação entre a ocorrência do desfecho com pertencer a famílias não nucleares, não permanecer a mesma família durante a infância e adolescência, e a constituição de uma família própria no período da adolescência. Conclusão: verificou-se que adolescentes inseridas em famílias não nucleares estão mais expostas a fatores de risco para ocorrência da gravidez na adolescência, quando comparadas às jovens provenientes de famílias com ambos os pais.ABSTRACTObjective: to analyze the influence of family compositions in the occurrence of pregnancy in adolescence. Method: this is a case-control study performed with 74 pregnant adolescents, group of cases, and 74 young adults without background history of pregnancy during adolescence, group control, paired by family income. Data were collected through structured interviews conducted in the period from August to October 2016 in Cuiabá, Mato Grosso, and then analyzed by descriptive and inferential statistical methods. Results: we identified an association between the occurrence of the outcome and the belonging to non-nuclear families, as well as the non-belonging to the same family during childhood and adolescence, besides the constitution of an own family in the period of adolescence. Conclusion: checked that adolescents inserted in non-nuclear families are more exposed to risk factors for the occurrence of pregnancy in adolescence when compared to young people coming from families with both parents.RESUMENObjetivo: analizar la influencia de las composiciones familiares en la ocurrencia del embarazo adolescente. Método: estudio caso-control efectuado con 74 adolescentes embarazadas, grupo de casos, y 74 jóvenes adultas sin historia anterior de embarazo en la adolescencia, grupo de control, agrupadas por sus ingresos familiares. Los datos se recopilaron mediante entrevistas estructuradas conducidas en el periodo de agosto a octubre de 2016 en Cuiabá, Mato Grosso, y posteriormente analizados por los métodos estadísticos descriptivo e inferencial. Resultados: se identificó una asociación entre la ocurrencia del desenlace y la pertenencia a las familias no nucleares, no permanencia en la misma familia durante niñez y adolescencia, y la constitución de una familia propia en el periodo de la adolescencia. Conclusion: comprobado eso que las adolescentes insertadas en familias no nucleares están más expuestas a los factores de riesgo para la ocurrencia del embarazo adolescente en comparación con las jóvenes provenientes de familias con ambos padres biológicos.

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1814 Psychopathological Profile and Health Related Quality of Life in Narcolepsy with Cataplexy Across Childhood And Adolescence: A Case-Control Study

Archives of Disease in Childhood ◽

10.1136/archdischild-2012-302724.1814 ◽

2012 ◽

Vol 97 (Suppl 2) ◽

pp. A513-A514

Author(s):

E. Finotti ◽

F. Pizza ◽

F. Poli ◽

C. Franceschini ◽

O. Bruni ◽

...

Keyword(s):

Quality Of Life ◽

Case Control Study ◽

Case Control ◽

Childhood And Adolescence ◽

Health Related Quality ◽

Related Quality ◽

Health Related ◽

Control Study

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Lifestyle factors and breast cancer in a Moroccan population case-control study of the center Mohammed VI for cancer treatment

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20194343 ◽

2019 ◽

Vol 8 (10) ◽

pp. 3825

Author(s):

Drissi Houda ◽

Imad Fatima Ezzahra ◽

Bendahhou Karima ◽

Benider Abdelatif ◽

Radallah Driss

Keyword(s):

Breast Cancer ◽

Family History ◽

Cancer Treatment ◽

Case Control Study ◽

Case Control ◽

Childhood And Adolescence ◽

Overweight Women ◽

History Of ◽

Post Menopause ◽

Control Study

Background: The study aims to examine the association between lifestyle habits and breast cancer risk in a Moroccan population.Methods: This is a case-control study conducted at the Mohammed VI Centre for cancer treatment in Casablanca.Results: The results highlighted that family history of breast cancer (OR=5.73) and alcohol consumption (OR=3.76) were positively associated with breast cancer. Analysis of anthropometric parameters showed that the risk of developing breast cancer is estimated at 1.78 in overweight women and 2.39 in obese women compared to those of normal weight. The risk of developing breast cancer is estimated at 1.82 for women with a WC greater than 88 cm and 1.70 for women with a WHR greater than 0.85. At age 10, the risk is 1.60 for women with a large figure compared to women with a small figure. However, at age 40, the average body shape relative to the lean body was associated with a decreased risk of breast cancer. In addition, the data confirmed that physical activity participation decreases with age; in childhood and adolescence, women are more active while in post-menopause, women become moderately active. Being very active in childhood, peri-menopause and post-menopause seems to be a protective factor against the occurrence of breast cancer.Conclusions: The study showed that the risk of breast cancer is potentially high in elderly women, overweight women and women with a family history of cancer. This risk was increased by behavioral factors such as toxic habits and physical inactivity.

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