Ocular Syphilis: Experience over 11 Years at a German Ophthalmology Reference Centre

IntroductionWomen have historically been under-represented in randomised controlled trials (RCTs), including many landmark RCTs that established standards of care. In light of this fact, some modern researchers are calling for replication of earlier landmark trials with women only. This approach is ethically concerning, in that it would require some enrolled women to be deprived of treatments that are currently considered standard of care.ObjectiveIn an attempt to better understand the justification of a women-only approach to designing clinical trials, this study looks to systematically categorise the number of women-only RCTs for conditions that affect both men and women and the reasons given within the medical and philosophical literatures to perform them.MethodologyThis scoping review of the literature will search, screen and select articles based on predetermined inclusion/exclusion criteria, after which a grounded theory approach will be used to synthesise the data. It is expected that there will be a variety of reasons given for why a women-only trial may be justified. Electronic databases that will be searched include MEDLINE, EMBASE, Cochrane Database of Systematic Reviews, Cochrane Clinical Trials Register, Web of Science Proceedings, ClinicalTrials.gov, Philosopher’s Index, Phil Papers, JSTOR, Periodicals Archive Online, Project MUSE and the National Reference Centre for Bioethics.SignificanceThe scope of this study is to determine published rationales used to justify women-only randomised trials, both in the case of new trials and in the repetition of landmark trials.Ethics and disseminationResearch ethics board approval is not required for this study as there is no participant involvement. Results will be published as a stand-alone manuscript and will inform a larger project related to the ethics of a women-only RCT of carotid intervention for women with symptomatic high-grade carotid stenosis.

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Access to patient oriented information—a baseline Endo-ERN survey among patients with rare endocrine disorders

Endocrine ◽

10.1007/s12020-021-02654-9 ◽

2021 ◽

Vol 71 (3) ◽

pp. 542-548

Author(s):

Violeta Iotova ◽

Camilla Schalin-Jäntti ◽

Petra Bruegmann ◽

Manuela Broesamle ◽

Johan De Graaf ◽

...

Keyword(s):

Mother Tongue ◽

Information Access ◽

Baseline Survey ◽

Endocrine Disorders ◽

Age Difference ◽

Specific Information ◽

Advocacy Groups ◽

Educational Materials ◽

Reference Centre ◽

Patient Advocacy Groups

Abstract Aim To perform a baseline survey on condition-specific information access among patients/parents/caregivers with rare endocrine disorders (RD) in Europe. Methods Electronic invitation to participate in a survey (19 questions) was sent to 120 patient advocacy groups (PAGs), and further distributed to 32 European countries. Results A total of 1138 respondents from 22 countries (74% women), aged between 1 year (parents) and 70 years, participated. The Netherlands, France, Germany, Italy and France had highest participation rates. All Main Thematic Groups (MTGs) were represented; the adrenal (32%), pituitary (26%) and thyroid (22%) were the most common. The majority of the respondents got information from their endocrinologist (75%), PAGs (37%) and expert reference centre (22%); 95% received information in their mother tongue. Leaflets (70%), infographics (65%), webinars (60%) and Internet films (55%) were preferred ways of learning. Respondents relied mostly on materials by PAGs and alliances (79%), rather than from specific international RD sites (15%). Fifty-six percent used Facebook, and 37% other social media, with a significant age difference (<40/>40 years) among non-users, 19% vs. 36%, p < 0.0001. Of all, 685 answered questions on informational materials for children−79% wanted materials that can be used by the children themselves. There was significant age difference (<40 years/>40 years) in the willingness to help create new educational materials; 49% vs. 34%, p < 0.001. Conclusions Our current patient information access survey provides a sound basis for further planning and execution of educational and teaching activities by Endo-ERN.

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Epidemiology unit recognised as an FAO reference centre

Veterinary Record ◽

10.1136/vr.f1781 ◽

2013 ◽

Vol 172 (13) ◽

pp. 326.2-326

Keyword(s):

Reference Centre

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Clinical features and therapeutic response in adult and pediatric patients with American tegumentary leishmaniasis in Rio de Janeiro

Transactions of the Royal Society of Tropical Medicine and Hygiene ◽

10.1093/trstmh/trz095 ◽

2019 ◽

Author(s):

Tatiana C R Senna ◽

Maria Inês F Pimentel ◽

Liliane F A Oliveira ◽

Marcelo R Lyra ◽

Mauricio N Saheki ◽

...

Keyword(s):

Clinical Features ◽

Rio De Janeiro ◽

Pediatric Patients ◽

Therapeutic Response ◽

Age Groups ◽

Healing Time ◽

The Body ◽

Reference Centre ◽

Tegumentary Leishmaniasis ◽

American Tegumentary Leishmaniasis

Abstract Background American tegumentary leishmaniasis (ATL) is a neglected disease with wide territorial distribution. Knowledge is scarce in children and adolescents. This study aims to compare the clinical features and response to antimony treatment in pediatric and adult patients with cutaneous leishmaniasis. Methods A retrospective cohort study was performed with 659 patients who attended a reference centre in Rio de Janeiro, Brazil, from 2000 to 2015. The pediatric cohort consisted of 131 (20%) patients and the adult cohort consisted of 528 (80%) patients. Results The epidemiological profile, antimony therapeutic response and incidence of adverse events (AE) were different in the pediatric cohort compared with the adult cohort. Mucosal form was less frequent in the pediatric cohort (RR:0.49, p=0.011). Lesions in the head, neck and trunk were more frequent in the pediatric cohort (RR:1.49, p=0.043). The effectiveness of antimony treatment was superior in the pediatric cohort (88.3% vs 76.6%) with a shorter healing time (RR:0.49, p=0.009). Pediatric patients had lower proportions of moderate to severe AE compared with adults (RR:0.45, p=0.027). Clinical AE predominated in the adult cohort (RR:0.40, p=0.000) and laboratory AE in the pediatric cohort (RR:1.50, p=0.023). Conclusions This study adds to the body of knowledge on differences that exist between different age groups in ATL.

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Ocular Syphilis and Human Immunodeficiency Virus Coinfection Among Syphilis Patients in North Carolina, 2014–2016

Sexually Transmitted Diseases ◽

10.1097/olq.0000000000000910 ◽

2019 ◽

Vol 46 (2) ◽

pp. 80-85 ◽

Cited By ~ 2

Author(s):

Anna B. Cope ◽

Victoria L. Mobley ◽

Sara E. Oliver ◽

Mara Larson ◽

Nicole Dzialowy ◽

...

Keyword(s):

Human Immunodeficiency Virus ◽

North Carolina ◽

Ocular Syphilis ◽

Immunodeficiency Virus

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Interlaboratory Optimization and Evaluation of a Serological Assay for Diagnosis of Human Baylisascariasis

Clinical and Vaccine Immunology ◽

10.1128/cvi.00387-13 ◽

2013 ◽

Vol 20 (11) ◽

pp. 1758-1763 ◽

Cited By ~ 15

Author(s):

Lisa N. Rascoe ◽

Cynthia Santamaria ◽

Sukwan Handali ◽

Sriveny Dangoudoubiyam ◽

Kevin R. Kazacos ◽

...

Keyword(s):

Western Blot ◽

Cross Reactivity ◽

Western Blot Assay ◽

Content Type ◽

National Reference ◽

Baylisascaris Procyonis ◽

Reference Centre ◽

Assay Performance ◽

Positive Serum ◽

Control And Prevention

ABSTRACTA Western blot assay using a recombinant protein, recombinantBaylisascaris procyonisRAG1 protein (rBpRAG1), was developed for the diagnosis of human baylisascariasis concurrently by the Centers for Disease Control and Prevention (CDC) in Atlanta, Georgia, and the National Reference Centre for Parasitology (NRCP) in Montreal, Canada. Assay performance was assessed by testing 275 specimens at the CDC and 405 specimens at the NRCP. Twenty specimens from 16 cases of baylisascariasis were evaluated. Eighteen were positive, with the assay correctly identifying 14 of 16 patients. The rBpRAG1 Western blot assay showed no cross-reactivity withToxocara-positive serum and had an overall sensitivity of 88% and a specificity of 98%.

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