scholarly journals Non-targeted effects of radiation: a personal perspective on the role of exosomes in an evolving paradigm

2021 ◽  
pp. 1-11
Author(s):  
Munira Kadhim ◽  
Seda Tuncay Cagatay ◽  
Eman Mohammed Elbakrawy
Keyword(s):  
Personal Perspective ◽  
Effects Of Radiation

Effects of radiation and role of plants in radioprotection: A critical review

2021 ◽  
pp. 146431
Author(s):  
Mohammed J.H. Dowlath ◽  
Sathish Kumar Karuppannan ◽  
Pamela Sinha ◽  
Nihala Sultana Dowlath ◽  
Kantha Deivi Arunachalam ◽  
...  
Keyword(s):  
Critical Review ◽  
Effects Of Radiation

The AIM2 and NLRP3 inflammasomes trigger IL-1–mediated antitumor effects during radiation

2021 ◽  
Vol 6 (59) ◽  
pp. eabc6998
Author(s):  
Chuanhui Han ◽  
Victoria Godfrey ◽  
Zhida Liu ◽  
Yanfei Han ◽  
Longchao Liu ◽  
...  
Keyword(s):  
Antitumor Immunity ◽  
Radiation Treatment ◽  
Wild Type ◽  
Antitumor Effects ◽  
Radiation Induced ◽  
Effects Of Radiation ◽  
Nlrp3 Inflammasomes ◽  
Priming Activity ◽  
Deficient Mice

The inflammasome promotes inflammation-associated diseases, including cancer, and contributes to the radiation-induced tissue damage. However, the role of inflammasome in radiation-induced antitumor effects is unclear. We observed that tumors transplanted in Casp1−/− mice were resistant to radiation treatment compared with tumors in wild-type (WT) mice. To map out which molecule in the inflammasome pathway contributed to this resistant, we investigated the antitumor effect of radiation in several inflammasome-deficient mice. Tumors grown in either Aim2−/− or Nlrp3−/− mice remained sensitive to radiation, like WT mice, whereas Aim2−/−Nlrp3−/− mice showed radioresistance. Mechanistically, extracellular vesicles (EVs) and EV-free supernatant derived from irradiated tumors activated both Aim2 and Nlrp3 inflammasomes in macrophages, leading to the production of interleukin-1β (IL-1β). IL-1β treatment helped overcome the radioresistance of tumors growing in Casp1−/− and Aim2−/−Nlrp3−/− mice. IL-1 signaling in dendritic cells (DCs) promoted radiation-induced antitumor immunity by enhancing the cross-priming activity of DCs. Overall, we demonstrated that radiation-induced activation of the AIM2 and NLRP3 inflammasomes coordinate to induce some of the antitumor effects of radiation by triggering IL-1 signaling in DCs, leading to their activation and cross-priming.

Radiological and Nuclear Incidents

2017 ◽  
Author(s):  
Ian Greaves ◽  
Paul Hunt
Keyword(s):  
Central Government ◽  
Incident Radiation ◽  
The Body ◽  
Radiation Physics ◽  
Government Response ◽  
The Media ◽  
The Government ◽  
Effects Of Radiation

Chapter 10 covers information on definitions and types of radiological incident, radiation units, classification of radiation and nuclear incidents, basic radiation physics, stochastic and deterministic effects of radiation, types of device, acute effects of a nuclear explosion (detonation), managing an incident, radiological triage, radiation and the body, management of acute radiation syndrome, chronic effects, planning the response to a nuclear or radiation incident, planning at civilian sites, principles of radiation protection, civil nuclear constabulary, emergency exposures, the police response, RADSAFE, the site operator, fire and rescue services response, role of local authorities and Public Health England, national arrangements, radiation monitoring units, the Government Decontamination Service, central government response, dealing with the media, recovery, nuclear incidents overseas, and RIMNET.

scholarly journals Historical perspective on astrophysical MHD simulations

2010 ◽  
Vol 6 (S270) ◽  
pp. 7-17
Author(s):  
Michael L. Norman
Keyword(s):  
Star Formation ◽  
Magnetic Fields ◽  
Numerical Simulations ◽  
Historical Development ◽  
Adaptive Mesh Refinement ◽  
Historical Perspective ◽  
Adaptive Mesh ◽  
Personal Perspective ◽  
Mhd Simulations

AbstractThis contribution contains the introductory remarks that I presented at IAU Symposium 270 on “Computational Star Formation” held in Barcelona, Spain, May 31–June 4, 2010. I discuss the historical development of numerical MHD methods in astrophysics from a personal perspective. The recent advent of robust, higher-order accurate MHD algorithms and adaptive mesh refinement numerical simulations promises to greatly improve our understanding of the role of magnetic fields in star formation.

scholarly journals Radio-protective role of antioxidant agents

2012 ◽  
pp. e16
Author(s):  
Alireza Shirazi ◽  
Ehsan Mihandoost ◽  
Seied Rabie Mahdavi ◽  
Mehran Mohseni
Keyword(s):  
Therapeutic Index ◽  
Past Research ◽  
Protective Role ◽  
Herbal Products ◽  
Antioxidant Agents ◽  
Effects Of Radiation ◽  
Cellular Components ◽  
Harmful Effects ◽  
Research Show

Ionizing radiation interacts with biological systems to produce reactive oxygen species and reactive nitrogen species which attack various cellular components. Radio-protectors act as prophylactic agents to shield healthy cells and tissues from the harmful effects of radiation. Past research on synthetic radio-protectors has brought little success, primarily due to the various toxicity-related problems. Results of experimental research show that antioxidant nutrients, such as vitamin E and herbal products and melatonin, are protective against the damaging effects of radiation, with less toxicity and side effects. Therefore, we propose that in the future, antioxidant radio-protective agents may improve the therapeutic index in radiation oncology treatments.

The role of Echinacea extract to protect the damage effects of gammaradiation on some biochemical constituents in male albino rats

2016 ◽  
Author(s):  
A. G. Ahmed ◽  
Nahed Abdelaziz ◽  
H. M. El-Shennawy ◽  
A. N. El Shahat ◽  
R. G. Hamza
Keyword(s):  
Tissue Damage ◽  
Male Rats ◽  
Albino Rats ◽  
Protective Effects ◽  
Severe Damage ◽  
Biochemical Alterations ◽  
Radiation Induced ◽  
Effects Of Radiation ◽  
Echinacea Extract

The present study was designed to determine the possible protective effects of E. purpurea extracts (EPE) against gamma (g-) radiation exposure (6Gy) induced biochemical alterations and oxidative tissue damage (liver and testes) in male rats given EPE (100 mg/kg/day for 8 weeks) prior to g-irradiation. It has been found that g-irradiation led to hepatic and testicular oxidative stress with concomitant increase in liver function enzymes. Serum lipid profile and hormone level has also been found altered. Rats dosed with EPE before exposure to g-rays showed significantly less severe damage and remarkable improvement in all of the measured parameters when compared to irradiated rats. It could be concluded that EPE attenuates the deleterious effects of radiation-induced biochemical disorders and tissue damage (liver and testes).

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