Scientific mapping of stem cells associated with Chagas disease : A bibliometric analysis

Abstract BackgroundMesenchymal stromal/stem cells have garnered much interest in the field of cancer biology. Bibliometric analysis of a scientific field has the potential to reveal insights pertaining to the maturity of the field, the hotspot sources of publication and temporal shifts in research subcategories within the field. Despite the benefits of such an analysis, one has not been conducted to date.MethodsThe Web of Science™database and VOSviewer software were used to analyse publication and citation data for all publications relating to Mesenchymal Stromal/Stem Cells in oncology. Contributions to the literature were also identified by country, journal and cancer type. Keyword analysis identified trends in developing research categories.Results9927 published articles were analysed. The current publication rate fits an exponential trend(r2 = 0.97). The U.S. and the People’s Republic of China have the highest overall publications but when corrected for population and citations per article, the most successful countries are Singapore, Luxembourg and Switzerland. In the past 15 years 74% of articles have been in cancer specific journals. Breast cancer publications account for 42% of common cancer articles. Most articles were published in journals that had a basic science focus (44%). Keyword analysis resulted in 3 distinct clusters aligned with 1. Characterisation and nomenclature, 2.Clinical and 3.Molecular function. The most recent publications favour topics on Molecular function. ConclusionsResearch on Mesenchymal Stromal/Stem Cells in oncology is experiencing exponential growth. There is widespread acceptance of basic science research on MSCs in cancer specific journals and a niche for more translational and clinically focused studies.

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A Bibliometric Analysis of Exosomes in Cardiovascular Diseases From 2001 to 2021

Frontiers in Cardiovascular Medicine ◽

10.3389/fcvm.2021.734514 ◽

2021 ◽

Vol 8 ◽

Author(s):

Dan Ma ◽

Baoyi Guan ◽

Luxia Song ◽

Qiyu Liu ◽

Yixuan Fan ◽

...

Keyword(s):

Stem Cells ◽

Cardiovascular Diseases ◽

Bibliometric Analysis ◽

Research Field ◽

Future Research ◽

Visual Methods ◽

Knowledge Maps ◽

Active Research ◽

Medical University ◽

Research Hotspots

Background: Exosomes in cardiovascular diseases (CVDs) have become an active research field with substantial value and potential. Nevertheless, there are few bibliometric studies in this field. We aimed to visualize the research hotspots and trends of exosomes in CVDs using a bibliometric analysis to help understand the future development of basic and clinical research.Methods: The articles and reviews regarding exosomes in the CVDs were culled from the Web of Science Core Collection, and knowledge maps were generated using CiteSpace and VOSviewer software.Results: A total of 1,039 articles were included. The number of exosome articles in the CVDs increased yearly. These publications came from 60 countries/regions, led by the US and China. The primary research institutions were Shanghai Jiao Tong University and Nanjing Medical University. Circulation Research was the journal and co-cited journal with the most studies. We identified 473 authors among which Lucio Barile had the most significant number of articles and Thery C was co-cited most often. After analysis, the most common keywords are myocardium infarction, microRNA and mesenchymal stem cells. Ischemic heart disease, pathogenesis, regeneration, stem cells, targeted therapy, biomarkers, cardiac protection, and others are current and developing areas of study.Conclusion: We identified the research hotspots and trends of exosomes in CVDs using bibliometric and visual methods. Research on exosomes is flourishing in the cardiovascular medicine. Regenerative medicine, exosome engineering, delivery vehicles, and biomarkers will likely become the focus of future research.

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Bibliometric analysis of global scientific activity on umbilical cord mesenchymal stem cells: a swiftly expanding and shifting focus

Stem Cell Research & Therapy ◽

10.1186/s13287-018-0785-5 ◽

2018 ◽

Vol 9 (1) ◽

Cited By ~ 12

Author(s):

Jian Zhao ◽

Guanyu Yu ◽

Mengxi Cai ◽

Xiao Lei ◽

Yanyong Yang ◽

...

Keyword(s):

Stem Cells ◽

Mesenchymal Stem Cells ◽

Bibliometric Analysis ◽

Umbilical Cord ◽

Scientific Activity

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The 100 Most Cited Articles on the Applications of Stem Cells in Osteoarthritis: A Bibliometric Analysis

10.21203/rs.3.rs-95003/v1 ◽

2020 ◽

Author(s):

Keda Yang ◽

Siming Zhou ◽

Lin Tao

Keyword(s):

Stem Cells ◽

Stem Cell ◽

Cell Therapy ◽

Bibliometric Analysis ◽

Stem Cell Therapy ◽

Molecular Mechanisms ◽

The United States ◽

Research Area ◽

General Information ◽

Publication Number

Abstract Background: Stem cells have been applied in the treatment of OA, which had attracted wide attention. However, the research area is relatively extensive, and the research level is variable. In this study, we reviewed the mechanisms and clinical applications of stem cells in OA by using bibliometric analysis for the first time. We also revealed the characteristics, superior results and developmental trends in this field.Methods: The Web of Science core collection database was used to search articles related to the application of stem cells in OA. We collected the general information from the top 100 cited articles. We analyzed and evaluated the articles according to publication number, journals, institutions, countries, keywords and extended keywords.Results: The 100 most cited articles were cited from 129 to 1353 times mainly reviews and original articles. These articles were published from 2001 to 2017 and distributed evenly in America, East Asia and European countries. The United States contributed most in published number and international cooperation. The top ten institutions are mainly major universities and Duke University published a maximum of 10 articles. In terms of journals ,57 articles were published in the top ten journals. The keywords were divided into 8 categories from molecular mechanisms to clinical application.Conclusions: In our study, we found that mesenchymal stem cells (MSCs) which could repair articular cartilage and inhibit local inflammation, are the most widely applied in research and treatment of OA. TGF-βwas crucial during the process. Exosomes are regarded as the active ingredients in stem cell therapy for OA. Microtissue engineering will contribute to accurate and effective stem cell therapy. The findings of our study will contribute to the continuous development of research and direct the research of stem cells in OA.

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Granulocyte-Colony Stimulating Factor-Overexpressing Mesenchymal Stem Cells Exhibit Enhanced Immunomodulatory Actions Through the Recruitment of Suppressor Cells in Experimental Chagas Disease Cardiomyopathy

Frontiers in Immunology ◽

10.3389/fimmu.2018.01449 ◽

2018 ◽

Vol 9 ◽

Cited By ~ 5

Author(s):

Daniela N. Silva ◽

Bruno S. F. Souza ◽

Juliana F. Vasconcelos ◽

Carine M. Azevedo ◽

Clarissa X. R. Valim ◽

...

Keyword(s):

Stem Cells ◽

Mesenchymal Stem Cells ◽

Chagas Disease ◽

Suppressor Cells ◽

Granulocyte Colony Stimulating Factor ◽

Colony Stimulating Factor ◽

Stimulating Factor

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Therapy with Cardiomyocytes Derived from Pluripotent Cells in Chronic Chagasic Cardiomyopathy

Cells ◽

10.3390/cells9071629 ◽

2020 ◽

Vol 9 (7) ◽

pp. 1629

Author(s):

Guilherme Visconde Brasil ◽

Danúbia Silva dos Santos ◽

Elias Ataide Mendonça ◽

Fernanda Cristina Paccola Mesquita ◽

Tais Hanae Kasai-Brunswick ◽

...

Keyword(s):

Stem Cells ◽

Embryonic Stem Cells ◽

Chagas Disease ◽

Therapeutic Potential ◽

Embryonic Stem ◽

Mouse Embryonic Stem Cells ◽

Cardiac Differentiation ◽

Iron Oxide Particles ◽

Functional Changes ◽

Chagasic Cardiomyopathy

Chagas disease discovered more than a century ago remains an incurable disease. The objective of this work was to investigate the therapeutic potential of cardiomyocytes derived from mouse embryonic stem cells (CM-mESC) in a model of chronic Chagasic cardiomyopathy (CCC). Mouse embryonic stem cells (mESC) were characterized, transduced with luciferase, and submitted to cardiac differentiation. CM-mESC were labeled with superparamagnetic iron oxide particles. To induce CCC, mice were infected with Brazil strain trypomastigotes. At 150 days post-infection (dpi), infected animals were treated with CM-mESC or PBS. Cells were detected by magnetic resonance imaging (MRI) and bioluminescence. Cardiac function was evaluated by MRI and electrocardiogram at 150 and 196 dpi. CCC mice showed significant differences in MRI and ECG parameters compared to non-infected mice. However, no differences were observed in contractile and electrical parameters between cell and PBS injected groups, 45 days after cell transplantation. Cells were detected 24 h after transplantation by MRI. CM-mESC bioluminescence tracking demonstrated over 90% decrease in signal 8 days after treatment. Nevertheless, the Infected + CM-mESC group showed a significant reduction in the percentage of collagen fibers when compared to the Infected + PBS group. In conclusion, CM-mESC therapy was not effective in reversing cardiac functional changes induced by Chagas disease despite some improvement in myocardial fibrosis.

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