Highly palatable food access during adolescence increased anxiety-/depression-like behaviors in male, but not in female, rats

2017 ◽  
Vol 21 (7) ◽  
pp. 502-510 ◽  
Author(s):  
Jin Young Kim ◽  
Doyun Kim ◽  
Kyungpyo Park ◽  
Jong-Ho Lee ◽  
Jeong Won Jahng
Keyword(s):  
Food Access ◽  
Female Rats ◽  
Palatable Food ◽  
Anxiety Depression

The Effects of Puberty and Ovarian Hormone Removal on Developmental Trajectories of Palatable Food and Chow Intake in Female Rats

2021 ◽  
pp. 113394
Author(s):  
Kelly L. Klump ◽  
Deborah A. Kashy ◽  
Kristen M. Culbert ◽  
Elaine B. Sinclair ◽  
Britny A. Hildebrandt ◽  
...  
Keyword(s):  
Developmental Trajectories ◽  
Female Rats ◽  
Ovarian Hormone ◽  
Palatable Food

scholarly journals Effects of Maternal Deprivation on Anxiety, Depression, and Empathy in Male and Female Offspring of Wistar Rats in the Face of Novel Objects

2019 ◽  
Vol 8 ◽  
pp. 1093
Author(s):  
Solmaz Khalifeh ◽  
Fariba Khodagholi ◽  
Mehrad Moghtadaei ◽  
Ali Behvarmanesh ◽  
Afshin Kheradmand ◽  
...  
Keyword(s):  
Life Stress ◽  
Wistar Rats ◽  
Female Offspring ◽  
Maternal Deprivation ◽  
Female Rats ◽  
Control Group ◽  
Male And Female ◽  
Male And Female Rats ◽  
Novel Objects ◽  
Anxiety Depression

Background: Early life stress (ELS) models such as maternal deprivation (MD) are used to in¬vestigate behavioral changes in rodents under stressful situations. MD is a situation in which rat pups are separated from the dam; MD has different paradigms. The purpose of this research is to evaluate the effects of maternal deprivation on anxiety, depression, and empathy in adult Wistar rats. Materials and Methods: MD was applied to pups as per specifically designed protocol to compare rats of the control group with maternal deprivation rats and also the group, which faced novel objects. Each group consisted of eight rats. In this study, separation started from postnatal day (PND) 14 for various periods up to PND 60. EPM test was undertaken to measure anxiety; moreover, FST was used to indicate levels of depression. Also, changes in the empathy ratio were also demonstrated. One-way analysis of variance (ANOVA), Tukey’s post hoc analysis, and t-test were applied to analyze the results. Results: MD-treated rats showed a significant decrease in anxiety and empathy indexes compared with those in the control group (P<0.05). However, MD significantly increased depression in both male and female rats (P<0.05). Final¬ly, exposure to novel objects decreased depression but did not have any effect on anxiety and empathy levels in MD rats (P<0.05). Conclusion: ELS may lead to various states of mood and behavior in adulthood. According to the findings of this study, depression increases due to MD, though both anxiety and empathy decrease in both male and female Wistar rats. Moreover, ex¬posure to novel objects decreases depression, while anxiety and empathy do not change signifi¬cantly with exposure to novel objects. [GMJ.2019;8:e1093]

scholarly journals Palatable food access impacts expression of amylin receptor components in the mesocorticolimbic system

2020 ◽  
Vol 105 (6) ◽  
pp. 1012-1024
Author(s):  
Houda Nashawi ◽  
Tyler J. Gustafson ◽  
Elizabeth G. Mietlicki‐Baase
Keyword(s):  
Food Access ◽  
Palatable Food ◽  
Mesocorticolimbic System

scholarly journals Sex Differences in Demand for Highly Palatable Foods: Role of the Orexin System

2020 ◽  
Author(s):  
Linnea R Freeman ◽  
Brandon S Bentzley ◽  
Morgan H James ◽  
Gary Aston-Jones
Keyword(s):  
Sex Differences ◽  
Demand Curve ◽  
Female Rats ◽  
Demand Elasticity ◽  
Male Rats ◽  
Neural Activation ◽  
Palatable Food ◽  
Behavioral Economic ◽  
Male And Female Rats

Abstract Background The prevalence of eating disorders, including binge eating disorder, is significantly higher in women. These findings are mirrored by preclinical studies, which indicate that female rats have a higher preference for palatable food and show greater binge-like eating compared with male rats. Methods Here, we describe a novel within-session behavioral-economic paradigm that allows for the simultaneous measurement of the intake at null cost (Q0) and normalized demand elasticity (α) of 3 types of palatable food (low fat, high fat, and chocolate sucrose pellets) via demand curve analysis. In light of evidence that the orexin (hypocretin) system is critically involved in reward and feeding behaviors, we also examined the role of orexin function in sex differences of economic demand for palatable foods. Results The novel within-session behavioral-economic approach revealed that female rats have higher intake (demand) than males for all palatable foods at low cost (normalized to body weight) but no difference in intake at higher prices, indicating sex-dependent differences in the hedonic, but not motivational, aspects of palatable food. Immediately following behavioral-economic testing, we observed more orexin-expressing neurons and Fos expression (measure of recent neural activation) in these neurons in female rats compared with male rats. Moreover, the orexin-1 receptor antagonist SB334867 reduced both low- and high-cost intake for palatable food in both male and female rats. Conclusions These findings provide evidence of higher demand at low prices for palatable food in females and indicate that these behavioral differences may be associated with sexual dimorphism in orexin system function.

scholarly journals Oleoylethanolamide decreases frustration stress-induced binge-like eating in female rats: a novel potential treatment for binge eating disorder

2020 ◽  
Vol 45 (11) ◽  
pp. 1931-1941 ◽  
Author(s):  
Adele Romano ◽  
Maria Vittoria Micioni Di Bonaventura ◽  
Cristina Anna Gallelli ◽  
Justyna Barbara Koczwara ◽  
Dorien Smeets ◽  
...  
Keyword(s):  
Eating Disorder ◽  
Nucleus Accumbens ◽  
Food Intake ◽  
Binge Eating ◽  
Binge Eating Disorder ◽  
Female Rats ◽  
Early Gene ◽  
Mrna Levels ◽  
Palatable Food ◽  
Brain Areas

Abstract Binge eating disorder (BED) is the most frequent eating disorder, for which current pharmacotherapies show poor response rates and safety concerns, thus highlighting the need for novel treatment options. The lipid-derived messenger oleoylethanolamide (OEA) acts as a satiety signal inhibiting food intake through the involvement of central noradrenergic and oxytocinergic neurons. We investigated the anti-binge effects of OEA in a rat model of binge-like eating, in which, after cycles of intermittent food restrictions/refeeding and palatable food consumptions, female rats show a binge-like intake of palatable food, following a 15-min exposure to their sight and smell (“frustration stress”). Systemically administered OEA dose-dependently (2.5, 5, and 10 mg kg−1) prevented binge-like eating. This behavioral effect was associated with a decreased activation (measured by mapping the expression of c-fos, an early gene widely used as a marker of cellular activation) of brain areas responding to stress (such as the nucleus accumbens and amygdala) and to a stimulation of areas involved in the control of food intake, such as the VTA and the PVN. These effects were paralleled, also, to the modulation of monoamine transmission in key brain areas involved in both homeostatic and hedonic control of eating. In particular, a decreased dopaminergic response to stress was observed by measuring dopamine extracellular concentrations in microdialysates from the nucleus accumbens shell, whereas an increased serotonergic and noradrenergic tone was detected in tissue homogenates of selected brain areas. Finally, a decrease in corticotropin-releasing factor (CRF) mRNA levels was induced by OEA in the central amygdala, while an increase in oxytocin mRNA levels was induced in the PVN. The restoration of a normal oxytocin receptor density in the striatum paralleled the oxytocinergic stimulation produced by OEA. In conclusion, we provide evidence suggesting that OEA might represent a novel potential pharmacological target for the treatment of binge-like eating behavior.

scholarly journals Neuronal activities during palatable food consumption in the reward system of binge-like eating female rats

2021 ◽  
pp. 113604
Author(s):  
Dr. Richard Quansah Amissah ◽  
Diellor Basha ◽  
Olga Bukhtiyarova ◽  
Elena Timofeeva ◽  
Prof. Igor Timofeev
Keyword(s):  
Food Consumption ◽  
Reward System ◽  
Female Rats ◽  
Palatable Food

Estradiol increases glucagon's satiating potency in ovariectomized rats

2001 ◽  
Vol 281 (4) ◽  
pp. R1290-R1294 ◽  
Author(s):  
Nori Geary ◽  
Lori Asarian
Keyword(s):  
Signaling Pathway ◽  
Food Access ◽  
Estradiol Benzoate ◽  
Inhibitory Effect ◽  
Sesame Oil ◽  
Female Rats ◽  
Ovariectomized Rats ◽  
Hepatic Portal Vein ◽  
Hepatic Portal

Estradiol decreases meal size, food intake, and body weight in female rats. To investigate whether these effects of estradiol involve a change in the sensitivity of the signaling pathway through which pancreatic glucagon released during meals contributes to meal termination (satiation), glucagon or glucagon antibodies were infused via the hepatic portal vein in ovariectomized rats that were chronically treated with estradiol benzoate (2 μg/day sc) or vehicle alone (100 μl sesame oil). Infusions began at 1 h after dark onset, as rats were refed after 7 h of food deprivation. Glucagon (3 μg/min for 30 min) decreased feeding during the initial 45 min of food access in both groups of rats, but the inhibition was significantly greater in estradiol- than in oil-treated rats. Similarly, antagonism of endogenous glucagon by infusion of glucagon antibodies (a dose neutralizing 3 ng of glucagon in vitro during the first 3 min of refeeding) increased feeding significantly more in estradiol- than in oil-treated rats. These data indicate that an increase in the activity of the endogenous glucagon satiation-signaling pathway may be part of the mechanism for estradiol's inhibitory effect on feeding.

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