Neuroprotective effects of rutin on ASH neurons in Caenorhabditis elegans model of Huntington’s disease

2021 ◽  
pp. 1-14
Author(s):  
Larissa Marafiga Cordeiro ◽  
Marcell Valandro Soares ◽  
Aline Franzen da Silva ◽  
Marina Lopes Machado ◽  
Fabiane Bicca Obetine Baptista ◽  
...  
Keyword(s):  
Caenorhabditis Elegans ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Neuroprotective Effects

scholarly journals Esculetin Provides Neuroprotection against Mutant Huntingtin-Induced Toxicity in Huntington’s Disease Models

2021 ◽  
Vol 14 (10) ◽  
pp. 1044
Author(s):  
Letizia Pruccoli ◽  
Carlo Breda ◽  
Gabriella Teti ◽  
Mirella Falconi ◽  
Flaviano Giorgini ◽  
...  
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Neuronal Death ◽  
Trinucleotide Repeat ◽  
Neurodegenerative Disorder ◽  
Positive Impact ◽  
Neuroprotective Effects ◽  
Drosophila Model ◽  
Exon 1 ◽  
Transgenic Drosophila

Huntington’s disease (HD) is a neurodegenerative disorder caused by an abnormal CAG trinucleotide repeat expansion within exon 1 of the huntingtin (HTT) gene. This mutation leads to the production of mutant HTT (mHTT) protein which triggers neuronal death through several mechanisms. Here, we investigated the neuroprotective effects of esculetin (ESC), a bioactive phenolic compound, in an inducible PC12 model and a transgenic Drosophila melanogaster model of HD, both of which express mHTT fragments. ESC partially inhibited the progression of mHTT aggregation and reduced neuronal death through its ability to counteract the oxidative stress and mitochondria impairment elicited by mHTT in the PC12 model. The ability of ESC to counteract neuronal death was also confirmed in the transgenic Drosophila model. Although ESC did not modify the lifespan of the transgenic Drosophila, it still seemed to have a positive impact on the HD phenotype of this model. Based on our findings, ESC may be further studied as a potential neuroprotective agent in a rodent transgenic model of HD.

Rutin protects Huntington's disease through the insulin/IGF1 (IIS) signaling pathway and autophagy activity: Study in Caenorhabditis elegans model

2020 ◽  
Vol 141 ◽  
pp. 111323 ◽  
Author(s):  
Larissa Marafiga Cordeiro ◽  
Marina Lopes Machado ◽  
Aline Franzen da Silva ◽  
Fabiane Bicca Obetine Baptista ◽  
Tássia Limana da Silveira ◽  
...  
Keyword(s):  
Caenorhabditis Elegans ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Signaling Pathway ◽  
Autophagy Activity

scholarly journals Automated high-content phenotyping from the first larval stage till the onset of adulthood of the nematode Caenorhabditis elegans

Lab on a Chip ◽  
2019 ◽  
Vol 19 (1) ◽  
pp. 120-135 ◽  
Author(s):  
Huseyin Baris Atakan ◽  
Matteo Cornaglia ◽  
Laurent Mouchiroud ◽  
Johan Auwerx ◽  
Martin A. M. Gijs
Keyword(s):  
Caenorhabditis Elegans ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Dietary Restriction ◽  
Larval Stage ◽  
Disease Development ◽  
Nematode Caenorhabditis Elegans

We performed automated high-content phenotyping of Caenorhabditis elegans and demonstrated that dietary restriction slows down Huntington's disease development.

Neuroprotective effects of riluzole in Huntington’s disease

2007 ◽  
Vol 35 (1) ◽  
pp. 221-222 ◽  
Author(s):  
Ferdinando Squitieri ◽  
Andrea Ciammola ◽  
Claudio Colonnese ◽  
Andrea Ciarmiello
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Neuroprotective Effects

Neurodegenerative diseases and Flavonoids: Special reference to kaempferol

2021 ◽  
Vol 20 ◽  
Author(s):  
Rahul ◽  
Yasir Hasan Siddique
Keyword(s):  
Alzheimer’S Disease ◽  
Parkinson’S Disease ◽  
Alzheimer's Disease ◽  
Parkinson's Disease ◽  
Neurodegenerative Diseases ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Neuroprotective Effects ◽  
Major Health Problem ◽  
Beneficial Effects

: Neurodegenerative diseases like Alzheimer's disease, Parkinson's disease, Huntington’s disease, Multiple Sclerosis and Ischemic stroke have become a major health problem worldwide. Pre-clinical studies have demonstrated the beneficial effects of flavonoids on neurodegenerative diseases and suggesting them to be used as therapeutic agents. Kaempferol is found in many plants such as tea, beans, broccoli,strawberriesand has neuroprotective effects against the development of many neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease and Huntington's disease. The present study summarizesthe neuroprotective effects of kaempferol in various models of neurodegenerative diseases. Kaempferol delays the initiation as well as the progression of neurodegenerative disorders by acting as a scavenger of free radicals and preserving the activity of various antioxidant enzymes. Kaempferolcan crossthe blood-brain barrier (BBB), and therefore results inan enhanced protective effect. The multi-target property of kaempferol makes it a potential dietary supplement in preventing and treating neurodegenerative diseases.

scholarly journals Neuroprotective Effects of Synaptic Modulation in Huntington's Disease R6/2 Mice

2007 ◽  
Vol 27 (47) ◽  
pp. 12908-12915 ◽  
Author(s):  
E. C. Stack ◽  
A. Dedeoglu ◽  
K. M. Smith ◽  
K. Cormier ◽  
J. K. Kubilus ◽  
...  
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Neuroprotective Effects ◽  
Synaptic Modulation
Sign in / Sign up

Export Citation Format

Share Document