pH responsive metformin loaded zeolitic imidazolate framework (ZIF-8) for the treatment of lung cancer

2021 ◽  
pp. 1-9
Author(s):  
Vaidevi Sethuraman ◽  
Narra Kishore ◽  
Azeera Mohamed Saliq ◽  
Gayathri Loganathan ◽  
Ruckmani Kandasamy
Keyword(s):  
Lung Cancer ◽  
Ph Responsive ◽  
Zeolitic Imidazolate Framework

scholarly journals Combining Carbon Nanotubes and Chitosan for the Vectorization of Methotrexate to Lung Cancer Cells

Materials ◽  
2019 ◽  
Vol 12 (18) ◽  
pp. 2889 ◽  
Author(s):  
Giuseppe Cirillo ◽  
Orazio Vittorio ◽  
David Kunhardt ◽  
Emanuele Valli ◽  
Florida Voli ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Carbon Nanotubes ◽  
Photoelectron Spectroscopy ◽  
Ph Responsive ◽  
Carbon Nanostructure ◽  
X Ray ◽  
Transmission Electron ◽  
Multi Walled Carbon Nanotubes ◽  
Responsive Behavior ◽  
Walled Carbon Nanotubes

A hybrid system composed of multi-walled carbon nanotubes coated with chitosan was proposed as a pH-responsive carrier for the vectorization of methotrexate to lung cancer. The effective coating of the carbon nanostructure by chitosan, quantified (20% by weight) by thermogravimetric analysis, was assessed by combined scanning and transmission electron microscopy, and X-ray photoelectron spectroscopy (N1s signal), respectively. Furthermore, Raman spectroscopy was used to characterize the interaction between polysaccharide and carbon counterparts. Methotrexate was physically loaded onto the nanohybrid and the release profiles showed a pH-responsive behavior with higher and faster release in acidic (pH 5.0) vs. neutral (pH 7.4) environments. Empty nanoparticles were found to be highly biocompatible in either healthy (MRC-5) or cancerous (H1299) cells, with the nanocarrier being effective in reducing the drug toxicity on MRC-5 while enhancing the anticancer activity on H1299.

Reversal of Lung Cancer Multidrug Resistance by pH-Responsive Micelleplexes Mediating Co-Delivery of siRNA and Paclitaxel

2013 ◽  
Vol 14 (1) ◽  
pp. 100-109 ◽  
Author(s):  
Haijun Yu ◽  
Zhiai Xu ◽  
Xianzhi Chen ◽  
Leilei Xu ◽  
Qi Yin ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Multidrug Resistance ◽  
Ph Responsive
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