Nanoscaled Poly(l-glutamic acid)/Doxorubicin-Amphiphile Complex as pH-responsive Drug Delivery System for Effective Treatment of Nonsmall Cell Lung Cancer

The system is pH-responsive and redox-controlled release. And the charge reversal and size transitions of the system can enhance the targeted ability. Moreover, the system can recognize the cancer cells by the fluorescence imaging.

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pH-responsive mesoporous silica drug delivery system, its biocompatibility and co-adsorption/co-release of 5-Fluorouracil and Naproxen

Applied Surface Science ◽

10.1016/j.apsusc.2021.150011 ◽

2021 ◽

pp. 150011

Author(s):

Eva Benova ◽

Virginie Hornebecq ◽

Vladimír Zelenak ◽

Veronika Huntosova ◽

Miroslav Almasi ◽

...

Keyword(s):

Drug Delivery ◽

Mesoporous Silica ◽

Drug Delivery System ◽

Delivery System ◽

Co Adsorption ◽

Ph Responsive

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Biopolymer Hydrogel Scaffolds Containing Doxorubicin as A Localized Drug Delivery System for Inhibiting Lung Cancer Cell Proliferation

Polymers ◽

10.3390/polym13203580 ◽

2021 ◽

Vol 13 (20) ◽

pp. 3580

Author(s):

Chuda Chittasupho ◽

Jakrapong Angklomklew ◽

Thanu Thongnopkoon ◽

Wongwit Senavongse ◽

Pensak Jantrawut ◽

...

Keyword(s):

Lung Cancer ◽

Drug Delivery ◽

Drug Delivery System ◽

Delivery System ◽

Carboxymethyl Cellulose ◽

Encapsulation Efficiency ◽

Lung Cancer Cell ◽

Hydrogel Scaffold ◽

Hydrogel Scaffolds ◽

Localized Drug Delivery

A hydrogel scaffold is a localized drug delivery system that can maintain the therapeutic level of drug concentration at the tumor site. In this study, the biopolymer hydrogel scaffold encapsulating doxorubicin was fabricated from gelatin, sodium carboxymethyl cellulose, and gelatin/sodium carboxymethyl cellulose mixture using a lyophilization technique. The effects of a crosslinker on scaffold morphology and pore size were determined using scanning electron microscopy. The encapsulation efficiency and the release profile of doxorubicin from the hydrogel scaffolds were determined using UV-Vis spectrophotometry. The anti-proliferative effect of the scaffolds against the lung cancer cell line was investigated using an MTT assay. The results showed that scaffolds made from different types of natural polymer had different pore configurations and pore sizes. All scaffolds had high encapsulation efficiency and drug-controlled release profiles. The viability and proliferation of A549 cells, treated with gelatin, gelatin/SCMC, and SCMC scaffolds containing doxorubicin significantly decreased compared with control. These hydrogel scaffolds might provide a promising approach for developing a superior localized drug delivery system to kill lung cancer cells.

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FA-PEG decorated MOF nanoparticles as a targeted drug delivery system for controlled release of an autophagy inhibitor

Biomaterials Science ◽

10.1039/c8bm00625c ◽

2018 ◽

Vol 6 (10) ◽

pp. 2582-2590 ◽

Cited By ~ 31

Author(s):

Zheqi Shi ◽

Xuerui Chen ◽

Li Zhang ◽

Shiping Ding ◽

Xu Wang ◽

...

Keyword(s):

Drug Delivery ◽

Drug Delivery System ◽

Delivery System ◽

Targeted Drug Delivery ◽

Ph Responsive ◽

Specific Targeting ◽

Autophagy Inhibitor ◽

Novel Drug Delivery System ◽

Novel Drug ◽

Targeted Drug Delivery System

A novel drug delivery system with pH-responsive release and specific targeting identification was developed to control the release of an autophagy inhibitor.

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