scholarly journals aP2 Protein Expression as a Diagnostic Marker in Soft Tissue Tumours

Sarcoma ◽  
2001 ◽  
Vol 5 (3) ◽  
pp. 139-142 ◽  
Author(s):  
T. T. Yang ◽  
A. C. C. Reed ◽  
N. A. Athanasou
Keyword(s):  
Soft Tissue ◽  
Protein Expression ◽  
Fat Cells ◽  
Soft Tissue Tumours ◽  
Pleomorphic Lipoma ◽  
Adipose Differentiation ◽  
Amino Acid Segment ◽  
Malignant Soft Tissue ◽  
Immunohistochemical Identification

Purpose/Methods:The aP2 gene product (aP2 protein) is known to be expressed by preadipocytes and other immature fat cells in vitro. A mouse monoclonal antibody raised against an 18 amino acid segment of the aP2 protein was found to react with lipoblasts and fetal fat cells in paraffin sections of soft tissue tumours of adipose differentiation. In this immunohistochemical study, we have further examined the diagnostic utility of aP2 expression in distinguishing tumours of adipose differentiation from other benign and malignant soft tissue tumours.Result and discussionaP2 was strongly expressed by lipoblasts in lipoblastomas and all types of liposarcoma as well as brown fat cells in hibernomas. Optimal conditions for immunohistochemical identification of lipoblasts in tumours of adipose differentiation was noted when the antibody was diluted 1:30 to 1:50. Small lipoblast-like fat cells in pleomorphic lipoma and spindle cell lipoma also showed variable staining for aP2 at this dilution of the antibody. Most benign and malignant soft tissue tumours were distinguished by their absence of staining for aP2 protein, but some cases of myxoma, malignant fibrous histiocytoma, synovial sarcoma and leiomyosarcoma contained tumour cells which reacted for aP2. aP2 protein expression is likely to prove a useful means of distinguishing lipoblasts in liposarcoma but it should be used as part of a tumour panel to exclude expression in other forms of mesenchymal tumour.

scholarly journals Soft tissue tumours of the elbow: current concepts

2019 ◽  
Vol 4 (12) ◽  
pp. 668-677 ◽  
Author(s):  
Olga D. Savvidou ◽  
Panagiotis Koutsouradis ◽  
Ioanna K. Bolia ◽  
Angelos Kaspiris ◽  
George D. Chloros ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Clinical Outcome ◽  
Delayed Diagnosis ◽  
Imaging Features ◽  
Malignant Tumours ◽  
Soft Tissue Tumours ◽  
Clinicopathological Findings ◽  
Therapeutic Concepts ◽  
Neurovascular Structures ◽  
Malignant Soft Tissue

Soft tissue tumours of the elbow are mostly benign. Malignant tumours in this area, although uncommon, often present unique clinical and histopathological characteristics that are helpful for diagnosis. Management of soft tissue tumours around the elbow may be challenging because of their rarity and the proximity to neurovascular structures. Careful staging, histological diagnosis and treatment are essential to optimize clinical outcome. A missed or delayed diagnosis or an improperly executed biopsy may have devastating consequences for the patient. This article reviews the most common benign and malignant soft tissue tumours of the elbow and discusses the clinicopathological findings, imaging features and current therapeutic concepts. Cite this article: EFORT Open Rev 2019;4:668-677. DOI: 10.1302/2058-5241.4.190002

Preoperatively determining the margins of subcutaneous malignant soft tissue tumours using contrast-enhanced ultrasonography

2017 ◽  
Vol 45 (2) ◽  
pp. 385-388
Author(s):  
Sota Oguro ◽  
Kazutaka Kikuta ◽  
Aya Sasaki ◽  
Kiyoshi Okuma ◽  
Shunsuke Matsumoto ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Tumours ◽  
Contrast Enhanced ◽  
Contrast Enhanced Ultrasonography ◽  
Malignant Soft Tissue

scholarly journals Soft tissue neoplasms: a clinicopathological study

2020 ◽  
Vol 8 (10) ◽  
pp. 3591
Author(s):  
Athulya Krishna Kumar K. T. ◽  
Ariya S.
Keyword(s):  
Soft Tissue ◽  
Tertiary Care ◽  
Common Type ◽  
Soft Tissue Neoplasms ◽  
Care Hospital ◽  
Malignant Tumours ◽  
Soft Tissue Tumours ◽  
Female Ratio ◽  
Presenting Symptoms ◽  
Malignant Soft Tissue

Background: The current WHO classification has categorized soft tissue tumours into benign, malignant and so-called intermediate neoplasms. Soft tissue sarcoma comprises <1% of adult cancers. The aim of the study was to clinically correlate soft tissue neoplasms and study the histomorphological features of various malignant soft tissue tumors.Methods: This was a retrospective study conducted in a tertiary care hospital in Mangalore, India from January 2019 to June 2020. Clinical details of all cases of soft tissue neoplasms retrieved from the medical records of our institution. Data collected included age, gender, presenting symptoms, site and size of soft tissue neoplasms and clinical diagnosis. Pathological diagnosis of these tumours was made and details recorded.Results: A total of 113 cases of soft tissue neoplasms were collected. 94.4% benign and 18.6 %. malignant tumours were present. 77% cases presented with swelling whereas 23% presented with pain. Majority of benign soft tissue tumours were located in the trunk (36.9%) and the most common type was lipomas (66.38%). Malignant soft tissue tumours showed male to female ratio of 1.33:1. Most predilection was noted for the extremities (42.8%) and leiomyosarcomas were the most common type (38%).Conclusions: The incidence of malignant soft tissue tumours is rare. Majority of the cases were noted in the extremities. Leiomyosarcoma was the most common type, in our study. Lipomas were the most common benign soft tissue tumours, and majority of the benign tumours were located in the trunk. 

scholarly journals Pleomorphic lipoma: A rare entity

2021 ◽  
Vol 8 (4) ◽  
pp. 515-517
Author(s):  
Goutami Das Nayak ◽  
Shushruta Mohanty ◽  
Meenakshi Mohapatro
Keyword(s):  
Spindle Cell ◽  
Histopathological Diagnosis ◽  
Spindle Cell Lipoma ◽  
Soft Tissue Tumours ◽  
Pleomorphic Lipoma ◽  
Atypical Cells ◽  
Posterior Neck ◽  
Subcutaneous Mass ◽  
Slow Growing ◽  
Malignant Soft Tissue

Pleomorphic lipoma is a rare neoplasm that is considered as a variant of spindle cell lipoma. It predominantly occurs in the dermis or subcutis of the posterior neck, upper back, and shoulders. Pleomorphic lipoma may clinically present as a slow-growing and well-circumscribed subcutaneous mass. Though it is a benign tumour it may contain atypical cells for which it may mimick sarcoma or other malignant soft tissue tumours. So histopathological diagnosis is vital for preventing unnecessary surgery. Here we report a case of a pleomorphic lipoma on upper back in a 55yr old patient.

CASE REPORT : LIPOSARCOMA OF THE SHOULDER

2021 ◽  
pp. 35-36
Author(s):  
Tannistha Chakraborty ◽  
Vamsi Krishna ◽  
T. Raghupathy
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Tumor ◽  
Benign Neoplasm ◽  
Soft Tissue Tumours ◽  
Long Duration ◽  
Cutaneous Localization ◽  
History Of ◽  
Local Radiation ◽  
The Right ◽  
Malignant Soft Tissue

Lipoma, a benign neoplasm of adipocytes, is the most common mesenchymal soft tissue tumor of adulthood, but rarely present with huge sizes in their cutaneous localization. Liposarcomas are the second most common soft tissue sarcoma following malignant brous histiocytoma. They comprise approximately 16-18% of all malignant soft tissue tumours. It is most common in the trunk followed by lower extremity, upper extremity and head and neck.. While lipomas can be clinically diagnosed , transformation of lipomas into liposarcoma is rare. Here we report the case of a 55 gentleman, who came with a history of swelling over the right shoulder with a probable malignant transformation due to history of long duration of presence of swelling. Management is usually by wide excision. Local radiation and chemotherapy may be necessary for high grade lesions.

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