Public knowledge of the influence of modifiable cardiovascular risk factors on dementia: a systematic literature review and meta-analysis

Background. Cardiovascular disease (CVD) is the major predictor of poor prognosis in rheumatoid arthritis (RA) patients. There is an increasing interest to identify “nontraditional” risk factors for this condition. Latin Americans (LA) are considered as a minority subpopulation and ethnically different due to admixture characteristics. To date, there are no systematic reviews of the literature published in LA and the Caribbean about CVD in RA patients. Methods. The systematic literature review was done by two blinded reviewers who independently assessed studies for eligibility. The search was completed through PubMed, LILACS, SciELO, and Virtual Health Library scientific databases. Results. The search retrieved 10,083 potential studies. A total of 16 articles concerning cardiovascular risk factors and measurement of any cardiovascular outcome in LA were included. The prevalence of CVD in LA patients with RA was 35.3%. Non-traditional risk factors associated to CVD in this population were HLA-DRB1 shared epitope alleles, rheumatoid factor, markers of chronic inflammation, long duration of RA, steroids, familial autoimmunity, and thrombogenic factors. Conclusions. There is limited data about CVD and RA in LA. We propose to evaluate cardiovascular risk factors comprehensively in the Latin RA patient and to generate specific public health policies in order to diminish morbi-mortality rates.

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The Impact of Biologics and Tofacitinib on Cardiovascular Risk Factors and Outcomes in Patients with Rheumatic Disease: A Systematic Literature Review

Drug Safety ◽

10.1007/s40264-017-0628-9 ◽

2018 ◽

Vol 41 (5) ◽

pp. 473-488 ◽

Cited By ~ 14

Author(s):

Michael Nurmohamed ◽

Ernest Choy ◽

Sadiq Lula ◽

Blerina Kola ◽

Ryan DeMasi ◽

...

Keyword(s):

Risk Factors ◽

Cardiovascular Risk ◽

Literature Review ◽

Rheumatic Disease ◽

Cardiovascular Risk Factors ◽

Systematic Literature Review ◽

The Impact

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Risk factors for orthodontic mini-implants in skeletal anchorage biological stability: a systematic literature review and meta-analysis

Scientific Reports ◽

10.1038/s41598-020-62838-7 ◽

2020 ◽

Vol 10 (1) ◽

Cited By ~ 2

Author(s):

María Dolores Casaña-Ruiz ◽

Carlos Bellot-Arcís ◽

Vanessa Paredes-Gallardo ◽

Verónica García-Sanz ◽

José Manuel Almerich-Silla ◽

...

Keyword(s):

Risk Factors ◽

Literature Review ◽

Systematic Literature Review ◽

Meta Analysis ◽

Skeletal Anchorage ◽

Biological Stability ◽

Mini Implants

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Efficacy of weight loss drugs on obesity and cardiovascular risk factors in obese adolescents: a meta-analysis of randomized controlled trials

Obesity Reviews ◽

10.1111/j.1467-789x.2009.00620.x ◽

2010 ◽

Vol 11 (2) ◽

pp. 150-158 ◽

Cited By ~ 25

Author(s):

S. Czernichow ◽

C. M. Y. Lee ◽

F. Barzi ◽

J. R. Greenfield ◽

L. A. Baur ◽

...

Keyword(s):

Risk Factors ◽

Weight Loss ◽

Cardiovascular Risk ◽

Randomized Controlled Trials ◽

Cardiovascular Risk Factors ◽

Meta Analysis ◽

Controlled Trials ◽

Obese Adolescents ◽

Randomized Controlled

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Prevalence of Polypharmacy and Risks of Potentially Inappropriate Medication Use in the Older Population in a Developing Country: A Systematic Review and Meta-Analysis

Gerontology ◽

10.1159/000516075 ◽

2021 ◽

pp. 1-10

Author(s):

Akshaya Srikanth Bhagavathula ◽

Eyob Alemayehu Gebreyohannes ◽

Daniela Fialova

Keyword(s):

Risk Factors ◽

Developing Countries ◽

Literature Review ◽

Developing Country ◽

Systematic Literature Review ◽

Meta Analysis ◽

Inappropriate Medication ◽

Older Age ◽

Potentially Inappropriate Medication ◽

Older Population

Background and Aim: Polypharmacy and potentially inappropriate medication (PIM) use in older populations (65+ years) have not yet been investigated by meta-analyses in developing countries. This systematic literature review and meta-analysis aimed to investigate the prevalence of polypharmacy and PIM use and major risk factors associated with PIM prescribing in older adults in Ethiopia. Methods: We searched PubMed/MEDLINE, Scopus, Embase, and Google Scholar databases to identify relevant studies published between January 1990 and October 2020. Observational studies reporting the prevalence and association of risk factors with polypharmacy and PIM use in the older population were meta-analyzed. A multilevel meta-analysis was conducted to pool the prevalence estimates, and the risk of PIM use was reported as a relative risk (RR) with a 95% confidence interval (CI). Results: We identified by systematic literature review 404 articles. Of those, 8 studies fulfilled inclusion criteria, comprising a total sample of 2,608 participants. The overall prevalence of polypharmacy and PIM use pooled by meta-analysis in the Ethiopian older population was 33 and 37%, respectively. The risk factors of PIM use were analyzed in the meta-analysis (particularly polymorbidity, polypharmacy, gender, and older age), and only older age of 65+ (RR: 1.71, 95% CI: 1.16–2.51) was significantly associated with PIM use. Conclusion: This first meta-analysis from a developing country revealed a high prevalence of polypharmacy and PIM use in the Ethiopian older population. There was no awareness about the risk of PIMs in patients with polypharmacy and polymorbidity, and older age significantly predicted PIM use. Interventions ensuring rational geriatric pharmacotherapy are essential in developing countries in order to reduce the expected burden of PIM-related geriatric morbidity, higher costs, and mortality.

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