The emergence of age-related changes in recognition memory in healthy middle-aged adults using the CVLT-II

2019 ◽  
Vol 27 (6) ◽  
pp. 854-863 ◽  
Author(s):  
Mckenna E. Williams ◽  
Lisa V. Graves ◽  
Emily J. Van Etten ◽  
Heather M. Holden ◽  
Lisa Delano-Wood ◽  
...  
Keyword(s):  
Recognition Memory ◽  
Middle Aged ◽  
Age Related ◽  
Middle Aged Adults ◽  
Age Related Changes

scholarly journals Age-related changes in MEG theta and alpha oscillatory signatures of attentional control

2018 ◽  
Author(s):  
Eleanor Huizeling ◽  
Hongfang Wang ◽  
Carol Holland ◽  
Klaus Kessler
Keyword(s):  
Attentional Control ◽  
Age Groups ◽  
Visual Presentation ◽  
Theta Oscillations ◽  
Older Individuals ◽  
Middle Aged ◽  
Attention Task ◽  
Age Related ◽  
Middle Aged Adults ◽  
Age Related Changes

AbstractIn our recent behavioural research (Callaghan et al., 2017), we reported age-related changes in the costs of switching between from a temporal (rapid serial visual presentation) to a spatial (visual search) attention task. Using magnetoencephalography, we have now compared the neural signatures of attention refocusing between three age groups (19-30, 40-49 and 60+ years) and found differences in task-related modulation and cortical localisation of alpha and theta oscillations. Efficient, faster switching between the temporal and spatial attention tasks in the youngest group compared to both older groups was reflected in parietal theta effects that were significantly reduced in the older groups. Residual parietal theta activity in older individuals was, however, beneficial to attentional switching, and could reflect the preservation of attention mechanisms. Difficulties in refocusing attention in the older and middle-aged adults (slowed response times) were accompanied by reduced theta power modulation in occipital and cerebellar regions. In addition to this posterior theta deficit, older and middle-aged adults presented with increased recruitment of frontal (both groups) and temporal (older group) areas. Theta oscillations therefore demonstrated a posterior to anterior processing shift, which may reflect the engagement of alternative strategies in older- and middle-age, such as top-down attentional control in an attempt to compensate for posterior processing deficits. Additional frontal theta recruitment indeed appeared to be beneficial for faster performance, as reflected by correlational analysis. Temporal theta (in older-age), however, did not correlate with performance, but could reflect strategies unrelated to speeded performance (e.g. silent vocalisation to maintain task goals). Alpha oscillations did not significantly correlate with task performance, possibly reflecting decreased neural precision or de-differentiation, but require further investigation.

Perceptions of Sex Roles of Young and Middle-Aged Women and Men

1982 ◽  
Vol 55 (2) ◽  
pp. 559-562
Author(s):  
Claire Etaugh ◽  
Sharon Weber
Keyword(s):  
College Students ◽  
Sex Roles ◽  
Sex Role ◽  
Middle Aged ◽  
Age Related ◽  
Aged Woman ◽  
Male College ◽  
Middle Aged Woman ◽  
Age Related Changes ◽  
Female Subjects

48 female and 48 male college students used the Bern Sex-role Inventory to describe either a young or middle-aged woman or man. Female subjects perceived that women become increasingly feminine and less androgynous with age. No age-related changes were perceived in men's sex-role behaviors.

A model to assess age-related changes in two-point discrimination of plantar skin

1999 ◽  
Vol 89 (8) ◽  
pp. 383-391 ◽  
Author(s):  
W Lynch ◽  
J Mooney
Keyword(s):  
Older Adults ◽  
Statistical Analysis ◽  
Linear Relationship ◽  
Middle Aged ◽  
Discrimination Accuracy ◽  
Discrimination Ability ◽  
Fixed Distance ◽  
Age Related ◽  
Older Subjects ◽  
Age Related Changes

A device was constructed to assess two-point discrimination in the plantar skin of younger, middle-aged, and older adults. The device consisted of paired filaments, each delivering a tip force of 4.56 log units (equivalent to 3.63 g), at a fixed distance apart. Statistical analysis showed significant differences in two-point discrimination accuracy between these groups of subjects. Younger subjects showed greater accuracy of plantar two-point discrimination than either middle-aged or older subjects, with an apparent inverse linear relationship between subject age and plantar two-point discrimination ability. A model to assess age-related changes in two-point discrimination is presented.

Effect of aging on tracheal mucociliary clearance in beagle dogs

1987 ◽  
Vol 62 (3) ◽  
pp. 1331-1334 ◽  
Author(s):  
S. L. Whaley ◽  
B. A. Muggenburg ◽  
F. A. Seiler ◽  
R. K. Wolff
Keyword(s):  
Young Adult ◽  
Gamma Camera ◽  
Mucociliary Clearance ◽  
Age Groups ◽  
Beagle Dogs ◽  
Velocity Measurements ◽  
Middle Aged ◽  
Age Related ◽  
Age Related Changes ◽  
Made In

Tracheal mucous velocity measurements were made in 24 beagle dogs in five age groups, using a gamma camera to detect movement of instilled 99mTc-macroaggregated albumin. Age groups were defined as immature (9–10 mo), young adult (2.8–3.0 yr), middle aged (6.7–6.9 yr), mature (9.6–9.8 yr), and aged dogs (13.6–16.2 yr). Mean velocities were 3.6 +/- 0.4 (SE) mm/min in the immature dogs, 9.7 +/- 0.6 mm/min in the young adults, 6.9 +/- 0.5 mm/min in the middle-aged dogs, 3.5 +/- 0.8 mm/min in the mature dogs, and 2.9 +/- 0.5 mm/min in the aged dogs. Tracheal mucous velocity was significantly (P less than 0.05) greater in the young adult and middle-aged groups compared with the immature, mature, and aged dogs. This pattern of age-related changes was noted to be similar to age-related changes described for certain pulmonary function measurements.

scholarly journals Microarray analysis of aging-associated immune system alterations in the rostral ventrolateral medulla of F344 rats

2017 ◽  
Vol 49 (8) ◽  
pp. 400-415 ◽  
Author(s):  
Sivasai Balivada ◽  
Chanran K. Ganta ◽  
Yongqing Zhang ◽  
Hitesh N. Pawar ◽  
Richard J. Ortiz ◽  
...  
Keyword(s):  
Gene Expression ◽  
Immune System ◽  
Neural Substrates ◽  
Rostral Ventrolateral Medulla ◽  
Ventrolateral Medulla ◽  
Middle Aged ◽  
Transcriptomic Profile ◽  
Age Related ◽  
F344 Rats ◽  
Age Related Changes

The rostral ventrolateral medulla (RVLM) is an area of the brain stem that contains diverse neural substrates that are involved in systems critical for physiological function. There is evidence that aging affects some neural substrates within the RVLM, although age-related changes in RVLM molecular mechanisms are not well established. The goal of the present study was to characterize the transcriptomic profile of the aging RVLM and to test the hypothesis that aging is associated with altered gene expression in the RVLM, with an emphasis on immune system associated gene transcripts. RVLM tissue punches from young, middle-aged, and aged F344 rats were analyzed with Agilent’s whole rat genome microarray. The RVLM gene expression profile varied with age, and an association between chronological age and specific RVLM gene expression patterns was observed [ P < 0.05, false discovery rate (FDR) < 0.3]. Functional analysis of RVLM microarray data via gene ontology profiling and pathway analysis identified upregulation of genes associated with immune- and stress-related responses and downregulation of genes associated with lipid biosynthesis and neurotransmission in aged compared with middle-aged and young rats. Differentially expressed genes associated with the complement system and microglial cells were further validated by quantitative PCR with separate RVLM samples ( P < 0.05, FDR < 0.1). The present results have identified age-related changes in the transcriptomic profile of the RVLM, modifications that may provide the molecular backdrop for understanding age-dependent changes in physiological regulation.

scholarly journals Age-Related Changes in Gait Velocity and Leg Extension Power in Middle-Aged and Elderly People

2000 ◽  
Vol 10 (1sup) ◽  
pp. 77-81 ◽  
Author(s):  
Rumi Kozakai ◽  
Shigeki Tsuzuku ◽  
Kyonosuke Yabe ◽  
Fujiko Ando ◽  
Naoakira Niino ◽  
...  
Keyword(s):  
Elderly People ◽  
Gait Velocity ◽  
Middle Aged ◽  
Leg Extension ◽  
Age Related ◽  
Leg Extension Power ◽  
Age Related Changes

scholarly journals Age-related changes in body composition persons of middle age (letter 1)

2020 ◽  
pp. 31-41
Author(s):  
Антонина Владимировна Алексеева ◽  
Анатолий Яковлевич Рыжов ◽  
Данила Игоревич Игнатьев
Keyword(s):  
Body Composition ◽  
Middle Age ◽  
Middle Aged ◽  
Men And Women ◽  
Anthropometric Indicators ◽  
Aged People ◽  
Age Related ◽  
Positive Correlations ◽  
Age Related Changes

Исследованы антропометрические показатели и параметры состава тела у лиц среднего возраста. Установлено, что некоторые калиперометрические показатели испытывают различие у мужчин и женщин. Калиперометрические показатели величины кожных покровов спины, медиальной и латеральной поверхностей бедер характеризуются тесными положительными корреляциями. Anthropometric indicators and parameters of body composition in middle-aged people were studied. It is established that some caliperometric indicators experience a difference in men and women. Caliperometric indicators of the size of the skin of the back, medial and lateral surfaces of the thighs are characterized by close positive correlations.

scholarly journals Effects of Age on Dual Task Walking Performance as Measured Using a Smartphone Application in Middle-Aged Adults

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 168-168
Author(s):  
Junhong Zhou ◽  
Gabriele Cattaneo ◽  
Wanting Yu ◽  
Jose Tormos ◽  
Lewis Lipsitz ◽  
...  
Keyword(s):  
Dual Task ◽  
Age Group ◽  
Stride Time ◽  
Brain Health ◽  
Middle Aged ◽  
Single Task ◽  
Age Related ◽  
Walking Performance ◽  
The Mean ◽  
Middle Aged Adults

Abstract After the age of 65, one’s ability to walk while performing an additional cognitive task (i.e., dual-tasking) is predictive of both future falls and cognitive decline. However, while it is well-known that older adults exhibit diminished dual-task performance, the time course of age-related dual-task decline has not been established. We thus conducted an analysis of data collected within the ongoing Barcelona Brain Health Initiative, a prospective population-based study characterizing the determinants of brain health maintenance in middle-aged adults. Cognitively-unimpaired participants (n=655) aged 40-65 years without neuro-psychiatric disease completed laboratory-based trials of walking normally (single-task) and walking while performing a verbalized serial subtraction task (dual-task). A smartphone-based gait assessment application was used to capture data and derive both the mean stride time (ST) and stride time variability (STV, defined as the coefficient of variation about the mean stride time) of each trial. The dual-task costs (DTC) to each gait metric were obtained by calculating the percent change from single- to dual-task conditions. We categorized participants into five groups according to age (e.g. Group 1: 40-45 years; Group 5: 60-65 years). Age group did not have an effect on single-task gait outcomes (p&gt;0.51). However, the oldest age group, as compared to each of the other groups, exhibited greater DTC to both ST and STV (p&lt;0.03). These results indicate that dual-task walking performance in particular may begin to diminish in late middle age even in the absence of detectable cognitive issues, DTC may offer a sensitive metric to age-related change in cognitive function.

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