Subjective memory loss in age-associated memory impairment: Family history and neuropsychological correlates

Abstract Aetiology of transient global amnesia (TGA) remains uncertain, though many have been proposed, including ischaemic, migrainous or epileptic pathologies. We attempted to determine risk factors for TGA, as well as prognostic factors that may cause recurrence. We evaluated clinical history, family history and magnetic resonance diffusion-weighted imaging (DWI) studies of 93 prospective patients with TGA. Patients were followed from 2004-2016. Fifteen of 93 (16%) patients experienced a recurrence of TGA. Among precipitating events, physical activities inducing Valsalva-like manoeuvres were most common, followed by emotional stress. Eighty-four patients had possible comorbidities or risk factors for TGA, though no single risk factor was ubiquitous. Risk factors associated with recurrence were head injury (isolated vs. recurrent, 16.7% vs. 53.5%, p < 0.01), depression (isolated vs. recurrent, 15.4% vs 46.7%, p = 0.01) and family history of dementia (isolated vs. recurrent, 20.5% vs. 46.7%, p = 0.03). Of 15 patients with confirmed recurrent TGA, two developed dementia and four subjective memory impairment. DWI lesions were observed in 24 patients and were located anywhere within the hippocampus. DWI lesions were not significantly associated with outcomes (recurrence, subjective memory impairment, dementia). We have found that depression, previous head injury and family history of dementia may predict TGA recurrence.

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Mnemonics Usage and Cognitive Decline in Age-Associated Memory Impairment

International Psychogeriatrics ◽

10.1017/s1041610297004195 ◽

1997 ◽

Vol 9 (1) ◽

pp. 47-56 ◽

Cited By ~ 10

Author(s):

Gary W. Small ◽

Asenath La Rue ◽

Scott Komo ◽

Andrea Kaplan

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Family History ◽

Cognitive Decline ◽

Memory Impairment ◽

Memory Function ◽

Subjective Memory ◽

Memory Measure ◽

History Of

To determine predictors of cognitive deterioration, the authors performed baseline and 1- to 5-year follow-up (mean ± SD = 2.5 ± 1.2 years) neuropsychological assessments on 36 persons (mean age ± SD = 62.1 ± 8.0; range = 50 to 81 years) with age-associated memory impairment. Subjects were recruited from a larger group of volunteers, had minimal medical comorbidity, and 25 of them had a family history of Alzheimer's disease. Baseline age and a subjective memory measure indicating reported frequency of mnemonics usage were significant decline predictors. Subjects reporting more frequent mnemonics use at baseline were more likely to show objective cognitive decline at follow-up. Baseline full-scale IQ, educational level, and family history of Alzheimer's disease failed to predict decline. These findings suggest that although age is the strongest decline predictor in some people with age-associated memory impairment, self-perception of memory function may also predict subsequent cognitive loss.

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Factors determining recurrence in transient global amnesia

10.21203/rs.2.14479/v3 ◽

2020 ◽

Author(s):

Rebecca Tynas ◽

Peter K Panegyres

Keyword(s):

Risk Factors ◽

Family History ◽

Head Injury ◽

Memory Impairment ◽

Transient Global Amnesia ◽

Clinical History ◽

Subjective Memory ◽

Subjective Memory Impairment ◽

History Of ◽

Global Amnesia

Abstract Background: Aetiology of transient global amnesia (TGA) remains uncertain, though many have been proposed, including ischaemic, migrainous or epileptic pathologies. Methods: We attempted to determine risk factors for TGA, as well as prognostic factors that may cause recurrence. We evaluated clinical history, family history and magnetic resonance diffusion-weighted imaging (DWI) studies of 93 prospective patients with TGA. Patients were followed from 2004-2016. Fifteen of 93 (16%) patients experienced a recurrence of TGA. Results: Among precipitating events, physical activities inducing Valsalva-like manoeuvres were most common, followed by emotional stress. Eighty-four patients had possible comorbidities or risk factors for TGA, though no single risk factor was ubiquitous. Risk factors associated with recurrence were head injury (isolated vs. recurrent, 16.7% vs. 53.5%, p < 0.01), depression (isolated vs. recurrent, 15.4% vs 46.7%, p = 0.01) and family history of dementia (isolated vs. recurrent, 20.5% vs. 46.7%, p = 0.03). Of 15 patients with confirmed recurrent TGA, two developed dementia and four subjective memory impairment. DWI lesions were observed in 24 patients and were located anywhere within the hippocampus. Conclusions: DWI lesions were not significantly associated with outcomes (recurrence, subjective memory impairment, dementia). We have found that depression, previous head injury and family history of dementia may predict TGA recurrence.

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Factors determining recurrence in transient global amnesia

10.21203/rs.2.14479/v1 ◽

2019 ◽

Author(s):

Rebecca Tynas ◽

Peter K Panegyres

Keyword(s):

Risk Factors ◽

Risk Factor ◽

Family History ◽

Head Injury ◽

Memory Impairment ◽

Transient Global Amnesia ◽

Subjective Memory ◽

Subjective Memory Impairment ◽

History Of ◽

Global Amnesia

Abstract Aetiology of transient global amnesia (TGA) remains uncertain, though many have been proposed, including ischaemic, migrainous or epileptic pathologies. We attempted to determine risk factors for TGA, as well as prognostic factors that may cause recurrence. We evaluated clinical history, family history and magnetic resonance diffusion-weighted imaging (DWI) studies of 93 prospective patients with TGA. Patients were followed up regarding recurrence and prognostic factors. Fifteen of 93 (16%) patients experienced a recurrence of TGA. Among precipitating events, physical activities inducing Valsalva-like manoeuvres were most common, followed by emotional stress. Eighty-four patients had possible comorbidities or risk factor for TGA, though no single risk factor was ubiquitous. Risk factors associated with recurrence were head injury (isolated vs. recurrent, 16,7% vs. 53.5%, p < 0.01), depression (isolated vs. recurrent, 15.4% vs 46.7%, p = 0.01) and family history of dementia (isolated vs. recurrent, 20.5% vs 46.7%, p = 0.03). Of 15 patients with confirmed recurrent TGA, two developed dementia and four subjective memory impairment. DWI lesions were observed in 24 patients and located anywhere within the hippocampus. DWI lesions were not significantly associated with outcomes (recurrence, subjective memory impairment, dementia). Findings suggest TGA is a heterogeneous syndrome. Among those with recurrence, depression, previous head injury and family history of dementia may be predictive factors. Encouraging primary prevention of head injury, managing depression and assisting in development of adequate coping mechanisms may decrease incidence. Education of healthcare works will also increase diagnostic rates, allowing for improved education and comfort for patients and families.

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Family History of Alzheimer’s Disease and Subjective Memory Performance

American Journal of Alzheimer s Disease & Other Dementias® ◽

10.1177/1533317518775033 ◽

2018 ◽

Vol 33 (7) ◽

pp. 458-462 ◽

Cited By ~ 3

Author(s):

Robert Haussmann ◽

Steffi Ganske ◽

Antonia Gruschwitz ◽

Annett Werner ◽

Antje Osterrath ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Older Adults ◽

Alzheimer's Disease ◽

Family History ◽

Cognitive Deficits ◽

Memory Impairment ◽

Subjective Memory ◽

Healthy Older Adults ◽

Subjective Memory Impairment ◽

History Of

People with a first-degree family history of Alzheimer’s disease are at an increased risk of developing dementia. Subjective memory impairment among individuals with no measurable cognitive deficits may also indicate elevated dementia risk. It remains unclear whether nondemented people with a positive family history of Alzheimer’s disease are more likely to experience cognitive deficits and whether such an association reflects underlying neuropathology. We therefore investigated subjective memory impairment and hippocampal cortical thickness in 40 healthy older adults and 35 patients with amnestic mild cognitive impairment. We found greater subjective memory impairment and left hemispheric hippocampal cortical thinning associated with a first-degree family history of Alzheimer’s disease in healthy older adults. This suggests that subjective memory impairment could reflect preclinical stage neurodegeneration among individuals with the family history risk factor.

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The Anterior-posterior Functional Connectivity Disconnection in the Elderly with Subjective Memory Impairment and Amnestic Mild Cognitive Impairment

Current Alzheimer Research ◽

10.2174/1567205017666200525015017 ◽

2020 ◽

Vol 17 (4) ◽

pp. 373-381

Author(s):

Wuhai Tao ◽

Jinping Sun ◽

Xin Li ◽

Wen Shao ◽

Jing Pei ◽

...

Keyword(s):

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Functional Connectivity ◽

Memory Impairment ◽

Amnestic Mild Cognitive Impairment ◽

Magnetic Resonance Imaging Scan ◽

Subjective Memory ◽

Long Distance ◽

Whole Brain ◽

Subjective Memory Impairment

Background: Subjective Memory Impairment (SMI) may tremendously increase the risk of Alzheimer’s Disease (AD). The full understanding of the neuromechanism of SMI will shed light on the early intervention of AD. Methods: In the current study, 23 Healthy Controls (HC), 22 SMI subjects and 24 amnestic Mild Cognitive Impairment (aMCI) subjects underwent the comprehensive neuropsychological assessment and the resting-state functional magnetic resonance imaging scan. The difference in the connectivity of the Default Mode Network (DMN) and Functional Connectivity (FC) from the Region of Interest (ROI) to the whole brain were compared, respectively. Results: The results showed that HC and SMI subjects had significantly higher connectivity in the region of the precuneus area compared to aMCI subjects. However, from this region to the whole brain, SMI and aMCI subjects had significant FC decrease in the right anterior cingulum, left superior frontal and left medial superior frontal gyrus compared to HC. In addition, this FC change was significantly correlated with the cognitive function decline in participants. Conclusion: Our study indicated that SMI subjects had relatively intact DMN connectivity but impaired FC between the anterior and posterior brain. The findings suggest that long-distance FC is more vulnerable than the short ones in the people with SMI.

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Parental dementia and subjective memory impairment in the health and retirement study

Aging & Mental Health ◽

10.1080/13607863.2021.1910790 ◽

2021 ◽

pp. 1-9

Author(s):

Tyler R. Bell ◽

Nikki L. Hill ◽

Sakshi Bhargava ◽

Jacqueline Mogle

Keyword(s):

Memory Impairment ◽

Health And Retirement Study ◽

Subjective Memory ◽

Subjective Memory Impairment ◽

Retirement Study

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Long-term subjective memory after electroconvulsive therapy

BJPsych Open ◽

10.1192/bjo.2020.9 ◽

2020 ◽

Vol 6 (2) ◽

Cited By ~ 6

Author(s):

Robert Sigström ◽

Axel Nordenskjöld ◽

Anders Juréus ◽

Caitlin Clements ◽

Erik Joas ◽

...

Keyword(s):

Electroconvulsive Therapy ◽

Memory Impairment ◽

Rating Scale ◽

Final Analysis ◽

Negative Effects ◽

Subjective Memory ◽

Subjective Memory Impairment ◽

Negative Effect ◽

Negative Expectations

Background There have been reports of long-term subjective memory worsening after electroconvulsive therapy (ECT). Aims To study the prevalence and risk factors of long-term subjective memory worsening among patients receiving ECT in routine clinical practice. Method Patients (n = 535, of whom 277 were included in the final analysis) were recruited from eight Swedish hospitals. Participants' subjective memory impairment was assessed before ECT and a median of 73 days after ECT using the memory item from the Comprehensive Psychopathological Rating Scale. Participants also rated their pre-ECT expectations and post-ECT evaluations of the effect of ECT on memory on a 7-point scale. We used ordinal regression to identify variables associated with subjective memory worsening and negative evaluations of the effect of ECT on memory. Results Comparisons of pre- and post-ECT assessments showed that subjective memory worsened in 16.2% of participants, remained unchanged in 52.3% and improved in 31.4%. By contrast, when asked to evaluate the effect of ECT on memory after treatment 54.6% reported a negative effect. Subjective memory worsening was associated with negative expectations before ECT, younger age and shorter duration of follow-up. Conclusions Although subjective memory improved more often than it worsened when assessed before and after ECT, a majority of patients reported that ECT had negative effects on their memory when retrospectively asked how ECT had affected it. This might suggest that some patients attribute pre-existing subjective memory impairment to ECT. Clinicians should be aware that negative expectations are associated with subjective worsening of memory after ECT.

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Interaction between Subjective Memory Decline and Depression Symptom Intensity in Older People. Results of the Second Wave of Cognition of Older People, Education, Recreational Activities, Nutrition, Comorbidities, and Functional Capacity Studies (COPERNICUS)

Journal of Clinical Medicine ◽

10.3390/jcm10071334 ◽

2021 ◽

Vol 10 (7) ◽

pp. 1334

Author(s):

Sławomir Kujawski ◽

Agnieszka Kujawska ◽

Radosław Perkowski ◽

Joanna Androsiuk-Perkowska ◽

Weronika Hajec ◽

...

Keyword(s):

Older People ◽

Memory Impairment ◽

Geriatric Depression Scale ◽

Depression Scale ◽

Depression Symptoms ◽

Depression Symptom ◽

Subjective Memory ◽

Delayed Recall ◽

Mediating Role ◽

Symptom Intensity

Background: Prevalence of subjective memory impairment (SMC), with or without objective memory impairment, and the mediating role of depression symptom intensity was examined in older people. Methods: n = 205 subjects (60 years old and older) were examined and followed up at two years. Cognitive function was examined using the Montreal Cognitive Assessment (MoCA) Delayed Recall (DR) subtest. Geriatric Depression Scale (GDS) was used as a screening tool for depression. Statistical analysis was performed using linear mixed models. Results: A total of 144 subjects (70.24%) had SMC. MoCA Delayed Recall scores were not significantly changed in relation to time and SMC. Dynamics of SMC significantly influenced changes in GDS score (p = 0.008). Conclusions: SMC and objective memory impairment do not fully overlap each other. Subjects without SMC for longer than two years noted less intensity of depression symptoms in comparison to subgroup with SMC. However, occurrence of SMC in subjects who were previously free of SMC, was not related to increase in depression symptom intensity.

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