Evaluation of the Performance of the BD MAX MDR-TB Test in the diagnosis of Mycobacterium tuberculosis complex in Extrapulmonary and Pulmonary Samples

2021 ◽  
Author(s):  
Pınar saĞiroĞlu ◽  
Mustafa Altay atalay
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Mycobacterium Tuberculosis Complex ◽  
Tuberculosis Complex ◽  
Mdr Tb

scholarly journals Insights into transmission dynamics of Mycobacterium tuberculosis complex in Nepal

2022 ◽  
Vol 50 (1) ◽  
Author(s):  
Yogendra Shah ◽  
Sarad Paudel ◽  
Kishor Pandey ◽  
Govind Prasad Gupta ◽  
Eddie Samuneti Solo ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
One Health ◽  
Animal Species ◽  
Mycobacterium Tuberculosis Complex ◽  
Public Health Problem ◽  
Multi Drug Resistance ◽  
Major Public Health Problem ◽  
Tuberculosis Complex ◽  
Mdr Tb ◽  
The Government

AbstractTuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis complex (MTBC) in humans and animals. Numbers of multi drug resistance TB (MDR-TB), extrapulmonary TB (EPTB) and zoonotic TB cases are increasingly being reported every year in Nepal posing a major public health problem. Therefore, the Government of Nepal should act immediately to strengthen the screening facilities across the country to be able to identify and treat the TB infected patients as well as detect zoonotic TB in animal species. Endorsement of One Health Act by the Government of Nepal is an opportunity to initiate the joint programs for TB surveillance among human and animal species using one health approach to reduce the TB burden in Nepal.

scholarly journals Clinical Evaluation of BD MAX MDR-TB Assay for Direct Detection of Mycobacterium tuberculosis Complex and Resistance Markers

2020 ◽  
Vol 22 (10) ◽  
pp. 1280-1286
Author(s):  
Sabine Hofmann-Thiel ◽  
Sara Plesnik ◽  
Marina Mihalic ◽  
Marion Heiß-Neumann ◽  
Korkut Avsar ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Clinical Evaluation ◽  
Mycobacterium Tuberculosis Complex ◽  
Direct Detection ◽  
Tuberculosis Complex ◽  
Mdr Tb ◽  
Resistance Markers

scholarly journals Spatial and Temporal Distribution of Mycobacterium tuberculosis Complex Infection in Eurasian Badger (Meles meles) and Cattle in Asturias, Spain

Animals ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 1294
Author(s):  
Cristina Blanco Blanco Vázquez ◽  
Thiago Doria Barral ◽  
Beatriz Romero ◽  
Manuel Queipo ◽  
Isabel Merediz ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Road Traffic ◽  
Mycobacterium Tuberculosis Complex ◽  
Temporal Distribution ◽  
Meles Meles ◽  
Interspecies Transmission ◽  
Tuberculosis Complex ◽  
Serum Samples ◽  
Study Objective ◽  
Infection Pressure

The present work investigated the prevalence, spatial distribution, and temporal distribution of tuberculosis (TB) in free-ranging Eurasian badgers (Meles meles) and cattle in Asturias (Atlantic Spain) during a 13-year follow-up. The study objective was to assess the role of badgers as a TB reservoir for cattle and other sympatric wild species in the region. Between 2008 and 2020, 673 badgers (98 trapped and 575 killed in road traffic accidents) in Asturias were necropsied, and their tissue samples were cultured for the Mycobacterium tuberculosis complex (MTC) isolation. Serum samples were tested in an in-house indirect P22 ELISA to detect antibodies against the MTC. In parallel, data on MTC isolation and single intradermal tuberculin test results were extracted for cattle that were tested and culled as part of the Spanish National Program for the Eradication of Bovine TB. A total of 27/639 badgers (4.23%) were positive for MTC based on bacterial isolation, while 160/673 badgers (23.77%) were found to be positive with the P22 ELISA. The rate of seropositivity was higher among adult badgers than subadults. Badger TB status was spatially and temporally associated with cattle TB status. Our results cannot determine the direction of possible interspecies transmission, but they are consistent with the idea that the two hosts may exert infection pressure on each other. This study highlights the importance of the wildlife monitoring of infection and disease during epidemiological interventions in order to optimize outcomes.

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