scholarly journals Leukocyte telomere length and epigenetic-based mortality risk score: associations with all-cause mortality among older adults

Epigenetics ◽  
2018 ◽  
Vol 13 (8) ◽  
pp. 846-857 ◽  
Author(s):  
Xu Gao ◽  
Yan Zhang ◽  
Ute Mons ◽  
Hermann Brenner
Keyword(s):  
Older Adults ◽  
Telomere Length ◽  
Risk Score ◽  
Mortality Risk ◽  
Leukocyte Telomere Length ◽  
All Cause Mortality

scholarly journals ‘Fat but powerful’ paradox: association of muscle power and adiposity markers with all-cause mortality in older adults from the EXERNET multicentre study

2021 ◽  
pp. bjsports-2020-103720
Author(s):  
Julian Alcazar ◽  
David Navarrete-Villanueva ◽  
Asier Mañas ◽  
Alba Gómez-Cabello ◽  
Raquel Pedrero-Chamizo ◽  
...  
Keyword(s):  
Older Adults ◽  
Waist Circumference ◽  
Older People ◽  
Multicentre Study ◽  
Mortality Risk ◽  
Muscle Power ◽  
Smoking Status ◽  
Relative Power ◽  
Fat Percentage ◽  
All Cause Mortality

ObjectivesTo assess the influence of muscle power and adiposity on all-cause mortality risk and to evaluate the ‘fat but powerful’ (F+P) (or ‘fat but fit’) paradox in older adults.MethodsA total of 2563 older adults (65‒91 years old) from the EXERNET multicentre study were included. Adiposity (body mass index (BMI), waist circumference, body fat percentage (BF%) and fat index), allometric and relative power (sit-to-stand muscle power test) and various covariates (age, sex, hypertension, smoking status and walking and sitting times per day) were registered at baseline. All-cause mortality was recorded during a median follow-up of 8.9 years. Participants were classified into four groups: lean and powerful (L+P), F+P, lean but weak and fat and weak (F+W). Cox proportional hazard regression models and adjusted HRs were calculated.ResultsAccording to BMI and waist circumference, all-cause mortality risk was reduced in the F+P (HR=0.55 and 0.63, p=0.044 and 0.049, respectively) and L+P (HR=0.57 and 0.58, p=0.043 and 0.025, respectively) groups. According to BF%, all-cause mortality decreased in the L+P group (HR=0.53; p=0.021), and a trend for a reduction was reported in the F+P group (HR=0.57; p=0.060). According to fat index, a survival benefit was only noted in the L+P group (HR=0.50; p=0.049). Higher levels of relative power reduced all-cause mortality risk among older people (HR=0.63 and 0.53, p=0.006 and 0.011, respectively).ConclusionPowerful older people exhibited a reduced 9-year all-cause mortality regardless of BMI, waist circumference and BF%. Obesity according to fat index blunted the survival benefits of being powerful.

Impact of relative muscle power on hospitalization and all-cause mortality in older adults

2021 ◽  
Author(s):  
Jose Losa-Reyna ◽  
Julian Alcazar ◽  
Jose Carnicero ◽  
Ana Alfaro-Acha ◽  
Carmen Castillo-Gallego ◽  
...  
Keyword(s):  
Older Adults ◽  
Mortality Risk ◽  
Healthy Aging ◽  
Muscle Power ◽  
Handgrip Strength ◽  
Relative Power ◽  
Men And Women ◽  
Adjusted Risk ◽  
Power Group ◽  
All Cause Mortality

Abstract Background The purpose of this study was to evaluate the relationship of lower-limb muscle power with mortality and hospitalization. Methods A total of 1928 subjects from the Toledo Study for Healthy Aging were included. Muscle power was assessed with the 5-repetition STS test and subjects were classified into different groups of relative power (i.e. normalized to body mass) according to sex-specific tertiles and their inability to perform the test. Mean follow-up periods for hospitalization and all-cause mortality were 3.3 and 6.3 years, respectively. Results Compared to the high relative muscle power group, men with low (HR [95%CI]= 2.1 [1.2-3.6]) and women with very low and low (HR [95%CI]= 4.7 [3.0-7.4] and 1.8 [1.2-2.7]) relative power had an increased age-adjusted risk of hospitalization. After adjusting for several covariates (age, physical activity, BMI education, depression, comorbidities, disability and handgrip strength) these effects were attenuated (men and women with very low relative power: HR [95%CI]= 1.6 [0.9-2.9] and 2.8 [1.6-4.9]). The very low relative muscle power group had also an increased all-cause mortality risk (age-adjusted) in both men and women (HR [95%CI]= 2.3 [1.4-3.9] and 2.9 [1.6-5.3]). After adjusting for all the covariates, a significantly increased mortality risk was observed only in men (HR [95% CI]= 2.1 [1.1-3.8], (women HR [95% CI]= 1.6 [0.8-3.2]), with very low levels of relative power. Conclusion Relative muscle power was independently and negatively associated with mortality and hospitalization in older adults. An augmented all-cause mortality risk was noted in the lowest group of relative muscle power.

Leukocyte telomere length, cancer incidence and all‐cause mortality among Chinese adults: Singapore Chinese Health Study

2020 ◽  
Vol 148 (2) ◽  
pp. 352-362
Author(s):  
Hamed Samavat ◽  
Hung N. Luu ◽  
Kenneth B. Beckman ◽  
Aizhen Jin ◽  
Renwei Wang ◽  
...  
Keyword(s):  
Telomere Length ◽  
Cancer Incidence ◽  
Health Study ◽  
Leukocyte Telomere Length ◽  
Chinese Adults ◽  
All Cause Mortality ◽  
Singapore Chinese

scholarly journals Impact of Body Mass Index and Metabolic Health Status on All‐Cause Mortality Risk among Older Adults

2016 ◽  
Vol 30 (S1) ◽  
Author(s):  
Feon W. Cheng ◽  
Xiang Gao ◽  
Diane C. Mitchell ◽  
Craig Wood ◽  
Christopher Still ◽  
...  
Keyword(s):  
Older Adults ◽  
Body Mass Index ◽  
Health Status ◽  
Body Mass ◽  
Mortality Risk ◽  
Metabolic Health ◽  
All Cause Mortality

scholarly journals Relationship Between Multimorbidity, Combination and All-Cause Mortality Among Older Adults: A Retrospective Cohort Analysis

2020 ◽  
Author(s):  
Kun He ◽  
Wenli Zhang ◽  
Xueqi Hu ◽  
Hao Zhao ◽  
Bingxin Guo ◽  
...  
Keyword(s):  
Older Adults ◽  
Mortality Risk ◽  
Cox Regression ◽  
Cohort Analysis ◽  
Relative Effect ◽  
Long Term Conditions ◽  
Cox Models ◽  
Chinese Older Adults ◽  
All Cause Mortality ◽  
The Impact

Abstract Background: Previous studies have evaluated the association of multimorbidity with higher mortality, but epidemiologic data on the association between the combination of multimorbidity and all-cause mortality risk are rare. We aimed to examine the relationship between multimorbidity (number/combination) and all-cause mortality in Chinese older adults. Methods: We conducted a population-based study of 50,100 Chinese participants. Cox regression models were used to estimate the impact of long-term conditions (LTCs) on all-cause mortality. Results: The prevalence of multimorbidity was 31.35% and all-cause mortality was 8.01% (50,100 participants). In adjusted Cox models, the hazard rations (HRs) and 95% confidence intervals (CIs) of all-cause mortality risk for those with 1, 2, and ≥ 3 LTCs compared with those with no LTCs was 1.10 (1.01-1.20), 1.21 (1.10-1.33), and 1.46 (1.27-1.67), respectively (Ptrend <0.001). In the LTCs ≥ 2 category, the combination of chronic diseases that included hypertension, diabetes, CHD, COPD, and stroke had the greatest impact on mortality. In the stratified model by age and sex, absolute all-cause mortality was higher among the ≥ 75 age group with an increasing number of LTCs. However, the relative effect size of the increasing number of LTCs on higher mortality risk was larger among those < 75 years.Conclusions: The risk of all-cause mortality is increased with the number of multimorbidity among Chinese older adults, particularly combinations.

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