scholarly journals A Potential Paradigm Shift in Opioid Crisis Management: The Role of Pharmacogenomics

2021 ◽  
pp. 1-19
Author(s):  
David Eapen-John ◽  
Ayeshah G Mohiuddin ◽  
James L Kennedy1
Keyword(s):  
Crisis Management ◽  
Paradigm Shift ◽  
Opioid Crisis

Posttransplant CMV infection and the role of immunosuppression (Sponsor: Novartis Pharma GmbH, Nürnberg)

2016 ◽  
Vol 04 (01) ◽  
pp. 4-10
Keyword(s):  
Lower Incidence ◽  
Paradigm Shift ◽  
Mtor Inhibitor ◽  
De Novo ◽  
Expert Panel ◽  
Risk Of Infection ◽  
Cmv Infection ◽  
Expert Meeting ◽  
Selection Of

AbstractImmunosuppression permits graft survival after transplantation and consequently a longer and better life. On the other hand, it increases the risk of infection, for instance with cytomegalovirus (CMV). However, the various available immunosuppressive therapies differ in this regard. One of the first clinical trials using de novo everolimus after kidney transplantation [1] already revealed a considerably lower incidence of CMV infection in the everolimus arms than in the mycophenolate mofetil (MMF) arm. This result was repeatedly confirmed in later studies [2–4]. Everolimus is now considered a substance with antiviral properties. This article is based on the expert meeting “Posttransplant CMV infection and the role of immunosuppression”. The expert panel called for a paradigm shift: In a CMV prevention strategy the targeted selection of the immunosuppressive therapy is also a key element. For patients with elevated risk of CMV, mTOR inhibitor-based immunosuppression is advantageous as it is associated with a significantly lower incidence of CMV events.

E-Projects Challenges in India – Role of Human Resource Management and Technology

2018 ◽  
Vol 6 (8) ◽  
pp. 263
Author(s):  
Ramnik Kaur
Keyword(s):  
Developing Countries ◽  
Public Administration ◽  
Paradigm Shift ◽  
Successful Implementation ◽  
The Public ◽  
Government Services ◽  
The Past ◽  
The Government ◽  
Traditional Approaches

E-governance is a paradigm shift over the traditional approaches in Public Administration which means rendering of government services and information to the public by using electronic means. In the past decades, service quality and responsiveness of the government towards the citizens were least important but with the approach of E-Government the government activities are now well dealt. This paper withdraws experiences from various studies from different countries and projects facing similar challenges which need to be consigned for the successful implementation of e-governance projects. Developing countries like India face poverty and illiteracy as a major obstacle in any form of development which makes it difficult for its government to provide e-services to its people conveniently and fast. It also suggests few suggestions to cope up with the challenges faced while implementing e-projects in India.

scholarly journals Rural Emergency Medical Service Providers Perceptions on the Causes of and Solutions to the Opioid Crisis: A Qualitative Assessment

2021 ◽  
Vol 12 ◽  
pp. 215013272098771
Author(s):  
Heather Blue ◽  
Ashley Dahly ◽  
Susan Chhen ◽  
Julie Lee ◽  
Adam Shadiow ◽  
...  
Keyword(s):  
Pain Management ◽  
Rural Communities ◽  
Social Determinants Of Health ◽  
Emergency Medical Service ◽  
Social Determinants ◽  
Medical Service ◽  
Critical Role ◽  
Access To Treatment ◽  
Opioid Crisis

Introduction: The continuing opioid crisis poses unique challenges to remote and often under-resourced rural communities. Emergency medical service (EMS) providers serve a critical role in responding to opioid overdose for individuals living in rural or remote areas who experience opioid overdoses. They are often first at the scene of an overdose and are sometimes the only health care provider in contact with an overdose patient who either did not survive or refused additional care. As such, EMS providers have valuable perspectives to share on the causes and consequences of the opioid crisis in rural communities. Methods: EMS providers attending a statewide EMS conference serving those from greater Minnesota and surrounding states were invited to take a 2-question survey asking them to reflect upon what they believed to be the causes of the opioid crisis and what they saw as the solutions to the opioid crisis. Results were coded and categorized using a Consensual Qualitative Research approach. Results: EMS providers’ perceptions on causes of the opioid crisis were categorized into 5 main domains: overprescribing, ease of access, socioeconomic vulnerability, mental health concerns, and lack of resources and education. Responses focused on solutions to address the opioid crisis were categorized into 5 main domains: need for increased education, enhanced opioid oversight, increased access to treatment programs, alternative therapies for pain management, and addressing socioeconomic vulnerabilities. Conclusion: Along with the recognition that the opioid crisis was at least partially caused by overprescribing, rural EMS providers who participated in this study recognized the critical role of social determinants of health in perpetuating opioid-related harm. Participants in this study reported that education and increased access to treatment facilities and appropriate pain management, along with recognition of the role of social determinants of health in opioid dependency, were necessary steps to address the opioid crisis.

scholarly journals French Firms and COVID-19: Do the Debt Status, Crisis Management System, and Monetary Policy Play a Role?

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Mina Sami
Keyword(s):  
Monetary Policy ◽  
Stock Returns ◽  
Crisis Management ◽  
Management System ◽  
Daily Growth ◽  
Listed Firms ◽  
Study Results ◽  
Major Outbreak

Abstract This study has two main objectives: first, it assesses the effect of outbreak pandemic diseases on the French firms’ stock returns by considering the sector of activity as the main center of analysis. Second, it investigates the role of the crisis management system, firm debt strategy, and monetary policy in dealing with the adverse shocks of the major outbreak of the COVID-19. The study results can be summarized as follows: (1) the daily growth in COVID-19 cases and deaths are associated with lower stock returns of the listed firms, especially for the firms operating in the energy, industrial and health care sectors. In contrast, telecommunication and consumer sectors are not significantly affected. (2) The pandemic’s adverse effect is much more tolerant with the French firms with an efficient crisis management system and low long-term debt commitments than the firms that do not have such a system and engaged with long term debts. (3) Euribor rates and monetary policy are still playing an essential role during the pandemic period.

scholarly journals Can Blockchain Strengthen the Energy Internet?

Network ◽  
2021 ◽  
Vol 1 (2) ◽  
pp. 95-115
Author(s):  
Charithri Yapa ◽  
Chamitha de Alwis ◽  
Madhusanka Liyanage
Keyword(s):  
Distributed Generation ◽  
Paradigm Shift ◽  
Distribution Networks ◽  
Future Research ◽  
Disruptive Technology ◽  
Electricity Distribution ◽  
Energy Internet ◽  
Energy Delivery ◽  
Electricity Grids

Emergence of the Energy Internet (EI) demands restructuring of traditional electricity grids to integrate heterogeneous energy sources, distribution network management with grid intelligence and big data management. This paradigm shift is considered to be a breakthrough in the energy industry towards facilitating autonomous and decentralized grid operations while maximizing the utilization of Distributed Generation (DG). Blockchain has been identified as a disruptive technology enabler for the realization of EI to facilitate reliable, self-operated energy delivery. In this paper, we highlight six key directions towards utilizing blockchain capabilities to realize the envisaged EI. We elaborate the challenges in each direction and highlight the role of blockchain in addressing them. Furthermore, we summarize the future research directive in achieving fully autonomous and decentralized electricity distribution networks, which will be known as Energy Internet.

scholarly journals Herring and ICES: a historical sketch of a few ideas and their linkages

2009 ◽  
Vol 66 (8) ◽  
pp. 1652-1661 ◽  
Author(s):  
Mike Sinclair
Keyword(s):  
Paradigm Shift ◽  
Pelagic Fish ◽  
Marine Ecology ◽  
Effective Management ◽  
Paradigm Shifts ◽  
Population Thinking ◽  
Fish Stocks ◽  
Considerable Debate ◽  
Historical Sketch

Abstract Sinclair, M. 2009. Herring and ICES: a historical sketch of a few ideas and their linkages. – ICES Journal of Marine Science, 66: 1652–1661. This introduction to the Symposium on “Linking Herring” sketches the development of some ideas generated from herring research within an ICES context. The work of Committee A (1902–1908), under the leadership of Johan Hjort, led to a paradigm shift from “migration thinking” to “population thinking” as the interpretation of fluctuations in herring landings. From the 1920s to the 1950s, the focus on forecasting services for the herring fisheries, although ultimately unsuccessful, had the unintended consequence of generating ideas on recruitment overfishing and the match–mismatch hypothesis. The collapse of the East Anglian fishery led, in 1956, to considerable debate on its causes, but no consensus was reached. Three consecutive symposia dealing with herring (1961, 1968, and 1970) reveal a changing perspective on the role of fishing on recruitment dynamics, culminating in Cushing’s 1975 book (“Marine Ecology and Fisheries”, referred to here as the “Grand Synthesis”), which defined the concept of recruitment overfishing and established the future agenda for fisheries oceanography. The 1978 ICES “Symposium on the Assessment and Management of Pelagic Fish Stocks” is interpreted as the “Aberdeen Consensus” (i.e. without effective management, recruitment overfishing is to be expected). In conclusion, herring research within ICES has led to many ideas and two major paradigm shifts.

The Concept of the ‘Living Constitution’ in Russian Constitutional Theory and Practice

2021 ◽  
Vol 46 (3-4) ◽  
pp. 416-445
Author(s):  
Caroline von Gall
Keyword(s):  
Direct Effect ◽  
Paradigm Shift ◽  
Social Conditions ◽  
Theory And Practice ◽  
Constitutional Reform ◽  
Constitutional Theory ◽  
Constitutional Change ◽  
The Past ◽  
Margin Of Appreciation

Abstract In discussing the concept of the ‘living constitution’ in Russian constitutional theory and practice, this paper shows that the Russian concept of the living constitution differs from U.S. or European approaches to evolutive interpretation. The Russian concept has its roots in Soviet and pre-revolutionary Russian constitutional thinking. It reduces the normative power of the Constitution but allows an interpretation according to changing social conditions and gives the legislator a broad margin of appreciation. Whereas the 1993 Russian constitutional reform had been regarded as a paradigm shift with the intention to break with the past by declaring that the Constitution shall have supreme judicial force and direct effect, the paper also gives answers to the complexity of constitutional change and legal transplants and the role of constitutional theory and practice for the functioning of the current authoritarian regime in Russia.

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