Organophosphate pesticide exposure as a risk factor for attempted suicide in Cape Town, South Africa: A case-control study

2021 ◽  
pp. 1-11
Author(s):  
Tahira Kootbodien ◽  
Zelda Holtman ◽  
Laila Asmal ◽  
John Joska ◽  
Bonginkosi Chiliza ◽  
...  
Keyword(s):  
South Africa ◽  
Risk Factor ◽  
Attempted Suicide ◽  
Case Control Study ◽  
Pesticide Exposure ◽  
Cape Town ◽  
Case Control ◽  
Organophosphate Pesticide ◽  
Control Study

Environmental Pesticide Exposure as a Risk Factor for Alzheimer's Disease: A Case-Control Study

2001 ◽  
Vol 86 (1) ◽  
pp. 37-45 ◽  
Author(s):  
Eric Gauthier ◽  
Isabel Fortier ◽  
François Courchesne ◽  
Paul Pepin ◽  
Jim Mortimer ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Risk Factor ◽  
Case Control Study ◽  
Pesticide Exposure ◽  
Case Control ◽  
Control Study

scholarly journals Predictors of poor adherence among people on antiretroviral treatment in Cape Town, South Africa: a case-control study

AIDS Care ◽  
2015 ◽  
Vol 27 (3) ◽  
pp. 342-349 ◽  
Author(s):  
Sarah Dewing ◽  
Cathy Mathews ◽  
Mark Lurie ◽  
Ashraf Kagee ◽  
Trishanta Padayachee ◽  
...  
Keyword(s):  
South Africa ◽  
Antiretroviral Treatment ◽  
Case Control Study ◽  
Cape Town ◽  
Case Control ◽  
Poor Adherence ◽  
Control Study

scholarly journals Organochlorine pesticide exposure as a risk factor for breast cancer in young Indian women: A case–control study

2019 ◽  
Vol 08 (04) ◽  
pp. 212-214 ◽  
Author(s):  
Navneet Kaur ◽  
Srikant K Swain ◽  
Basudev D Banerjee ◽  
Tusha Sharma ◽  
Thammineni Krishnalata
Keyword(s):  
Breast Cancer ◽  
Risk Factor ◽  
Young Women ◽  
Case Control Study ◽  
Pesticide Exposure ◽  
Serum Levels ◽  
Case Control ◽  
Incidence Rates ◽  
Younger Women ◽  
Control Study

Abstract Background: Incidence rates of breast cancer are showing an increasing trend in young women (≤40 years) in India. Risk for breast cancer in this age group can be attributed only partially to various known risk factors. Environmental exposure to organochlorine (OC) compounds has been identified as a potential risk factor. However, the possible role of OC compounds in increasing breast cancer risk in young women has not been explored. This case–control study was planned with the objectives to assess the serum levels of OC compound in a North Indian population of young women. Materials and Methods: Forty-two patients of breast cancer ≤ 40 years age and 42 age-matched controls were evaluated for exposure to OC compounds by performing assays in blood samples for pesticides such as dichlorodiphenyltrichloroethane (DDT) and its metabolites DDD and DDE; dieldrin; aldrin; methoxychlor, heptachlor; α-endosulfan; β-endosulfan; and hexachlorocyclohexane and its isomers (α, β, and γ). Results: Young women with breast cancer were found to have significantly higher serum levels of all the OC compounds except aldrin, p, p’ DDT, and methoxychlor. Conclusions: Exposure to OC pesticides could be an important modifiable risk factor for breast cancer, especially in younger women.

scholarly journals SAT0077 CARDIOVASCULAR RISK ASSESSMENT WITH CAROTID ULTRASONOGRAPHY IN ADDITION TO THE TRADITIONAL CARDIOVASCULAR RISK FACTORS IN RHEUMATOID ARTHRITIS PATIENTS: A CASE CONTROL STUDY

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 973-973
Author(s):  
R. Gonzalez Mazario ◽  
J. J. Fragio-Gil ◽  
P. Martinez Calabuig ◽  
E. Grau García ◽  
M. De la Rubia Navarro ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Risk Factors ◽  
Risk Factor ◽  
Cardiovascular Risk ◽  
Disease Duration ◽  
Case Control Study ◽  
Case Control ◽  
Healthy Controls ◽  
Carotid Ultrasonography ◽  
Control Study

Background:Cardiovascular disease (CV) is the most frequent cause of death in rheumatoid arthritis (RA) patients. It is well known that RA acts as an independent cardiovascular risk factor.Objectives:To assess the CV risk in RA patients using carotid ultrasonography (US) additionally to the traditional CV risk factors.Methods:A prospective transversal case control study was performed, including adult RA patients who fulfilled ACR/EULAR 2010 criteria and healthy controls matched according to CV risk factors. Population over 75 years old, patients with established CV disease and/or chronic kidney failure (from III stage) were excluded. The US evaluator was blinded to the case/control condition and evaluated the presence of plaques and the intima-media thickness. Statistical analysis was performed with R (3.6.1 version) and included a multivariate variance analysis (MANOVA) and a negative binomial regression adjusted by confounding factors (age, sex and CV risk factors).Results:A total of 200 cases and 111 healthy controls were included in the study. Demographical, clinical and US data are exposed in table 1. Not any difference was detected in terms of CV risk factors between the cases and controls. In both groups a relationship between age, BMI and high blood pressure was detected (p<0.001).Table 1.Table 2.RA basal characteristicsDisease duration (years)16,98 (11,38)Erosions (X-Ray of hands/feet)163 (81,5%)Seropositive (RF/anti-CCP)146 (73%)Extra-articular symptoms44 (22%)Intersticial difusse lung disease10 (5%)Rheumatoid nodules14 (7%)Prednisone use103 (51,5%)Median dose of Prednisone last year (mg)2,34 (2,84)sDMARDsMethotrexate104 (52%)Leflunomide29 (14,5%)Hydroxycloroquine9 (4,5%)bDMARDs89 (44,5%) TNFi41 (20,5%) Abatacept15 (7,5%) IL6i22 (11%) RTX11 (5,5%)JAKi26 (13%) Baricitinib11 (5,5%) Tofacitinib15 (7,5%)DAS 28-ESR3,1 (2,3, 3,9)SDAI7,85 (4,04, 13,41)HAQ0,88 (0,22, 1,5)RF (U/mL)51 (15, 164,25)Anti-CCP (U/mL)173 (22, 340)Patients showed higher intima-media (both right and left) thickness compared to controls (p<0.006). Moreover it was also related to the disease duration and DAS28 score (p<0.001). A higher plaque account was noted in cases(p<0.004) and it was also related to the disease duration (p<0.001).Conclusion:RA implies a higher CV risk. Traditional CV risk factors explains only partially the global risk. These findings support that RA acts as an independent cardiovascular risk factor.Disclosure of Interests:None declared

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