Therapeutic Potential of Zataria multiflora Boiss in Treatment of Irritable Bowel Syndrome (IBS)

Background: Gut flora have important trophic effects on intestinal epithelia and on immune structure and fonction.They also protect colonized host against invasion by alien microbes.Recent research suggests that an imbalance of the intestinal microbiota and a dysfunctional intestinal barrier might trigger irritable bowel syndrome (lBS). As probiotics have been reported to restore the intestinal microbiota and the gut barrier, the therapeutic potential of probiotics within IBS became of strong interest. Objectives: To assess the efficacy of probiotics in lBS. Methods: Patients of 15 to 60 years old and both sexes were included f om the out patient department (OPD) of gastroenterology, Bangabandhu Sheikh Mujib Medical University (BSMMU). A validated lBS-QOL instmment consisted of 34 questions used to assess improvement of quality of Iife before and after treatment. A total of 65 diarrhoea predominant LBS patients were randomised to receive either probiotics(n-33) or placebo(n-32) twice daily frir 6 weeks.Results: At the end of 6 weeks therapy, improvement in various symptoms(abclominal pain, stool frequency, consistency and 11atulence) in probiotics group was statistically significant. Mean QOL score before treatment was 103 in probiotics group and I 06 in placebo group. After 6 weeks of treatment mean QOL score was 82 in probiotics group and I 02.58 in placebo group. No side effects of the therapeutic agents were observed in any patient during the trial. Conclusions: Probiotics effectively alleviates global IBS and improves TBS symptoms simultaneously with an improvement of quality of life.

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Clinical evaluation of the effect of Zataria multiflora Boiss and Trachyspermum copticum (L.) on the patients with Irritable Bowel Syndrome

EXPLORE ◽

10.1016/j.explore.2021.12.004 ◽

2021 ◽

Author(s):

Hossein Jamalizadeh ◽

Bijan Ahmadi ◽

Fariba Shariffar ◽

Mehdi Ansari ◽

Mohammad Setayesh ◽

...

Keyword(s):

Irritable Bowel Syndrome ◽

Clinical Evaluation ◽

Zataria Multiflora ◽

Trachyspermum Copticum ◽

Irritable Bowel

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Therapeutic potential of ketotifen in irritable bowel syndrome (IBS) may involve changes in mast cells at sites beyond the rectum

Gut ◽

10.1136/gut.2010.225078 ◽

2010 ◽

Vol 60 (3) ◽

pp. 423-423 ◽

Cited By ~ 2

Author(s):

M. O'Sullivan

Keyword(s):

Irritable Bowel Syndrome ◽

Mast Cells ◽

Therapeutic Potential ◽

Irritable Bowel

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Effects of Diet Based on IgG Elimination Combined with Probiotics on Migraine Plus Irritable Bowel Syndrome

Pain Research and Management ◽

10.1155/2019/7890461 ◽

2019 ◽

Vol 2019 ◽

pp. 1-6 ◽

Cited By ~ 1

Author(s):

Yangzhi Xie ◽

Guijuan Zhou ◽

Yan Xu ◽

Bing He ◽

Yilin Wang ◽

...

Keyword(s):

Irritable Bowel Syndrome ◽

Therapeutic Potential ◽

Gastrointestinal Diseases ◽

Elimination Diet ◽

Serotonin Level ◽

Over The Counter ◽

Significant Difference ◽

Gut Function ◽

Irritable Bowel ◽

Serum Serotonin

Several research studies have revealed that migraine has a solid link with gastrointestinal diseases especially irritable bowel syndrome (IBS). This study was carried out to investigate therapeutic potential of diet based on IgG elimination combined with probiotics on migraine plus irritable bowel syndrome. A total of 60 patients diagnosed with migraine plus IBS were recruited for the study. IgG antibodies against 266 food varieties were detected by ELISA. Then, the subjects were randomized into three groups for treatment of IgG elimination diet or probiotics or diet combined with probiotics. Migraine symptom, gut function score, medication use, and serum serotonin level were measured at baseline, 7 weeks, and 14 weeks. Improvement of migraine and gut symptom was achieved at a certain time point. Reduced use of over-the-counter- (OTC−) analgesics was seen in all groups. However, use of triptans did not show significant difference. An increased serum serotonin level was seen in subjects treated with elimination diet and elimination diet combined with probiotics. IgG elimination diet combined with probiotics may be beneficial to migraine plus IBS. It may provide new insight by understanding the intricate relationship between migraine and gastrointestinal diseases.

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Irritable bowel syndrome: the problem and the problem of treating it – is there a role for probiotics?

Proceedings of The Nutrition Society ◽

10.1017/s0029665114000706 ◽

2014 ◽

Vol 73 (4) ◽

pp. 470-476 ◽

Cited By ~ 6

Author(s):

Antonieta R. Santos ◽

P. J. Whorwell

Keyword(s):

Irritable Bowel Syndrome ◽

Therapeutic Potential ◽

Medical Profession ◽

Treatment Options ◽

Bowel Dysfunction ◽

Poor Quality ◽

New Treatment ◽

Irritable Bowel ◽

Different Strains ◽

The Impact

The aim of this review is to highlight the impact of irritable bowel syndrome (IBS) in those patients who consult the medical profession and examine the therapeutic potential of probiotics in this condition, where there is a strong need for new treatment options. Traditionally, IBS is frequently regarded as a trivial condition which is certainly not life threatening and mainly psychological in origin. However, these preconceptions are misplaced, as in some patients the condition can be devastating with the pain being as severe as that of childbirth coupled with incapacitating bowel dysfunction. In addition, patients suffer from a variety of non-colonic symptoms such as low backache, constant lethargy, nausea and genito-urinary problems, all of which lead to these patients having extremely poor quality of life. Unfortunately, the treatment of IBS is very unsatisfactory with only one new medication being developed for this condition in the last 25 years. It is now recognised that IBS is a multifactorial condition with symptoms being triggered by a variety of factors, some of which appear to be influenced by probiotics, resulting in speculation that they may have therapeutic potential in this condition. There have been over thirty controlled clinical trials of probiotics in IBS with approximately two-thirds of these studies showing evidence of an improvement in symptoms. However, not all probiotics appear to be effective with different symptoms being improved by different strains and some improving symptoms more than others. Consequently, the ideal probiotic for the treatment of IBS has yet to be defined, but the evidence is good enough to encourage further research with the aim of identifying an optimal strain or strains.

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A Study on the Therapeutic Potential of Some Hathayogic Methods in the Management of Irritable Bowel Syndrome

International Journal of Yoga Therapy ◽

10.17761/ijyt.3.1.463634588nm66wh4 ◽

1992 ◽

Vol 3 (1) ◽

pp. 25-38

Author(s):

Virendra Kumar

Keyword(s):

Irritable Bowel Syndrome ◽

Side Effects ◽

Therapeutic Potential ◽

Irritable Bowel ◽

Modern Era ◽

Normal Health

In this modern era Allopathy and Ayurveda are two leading systems of medicine which have been advocated for maintaining normal health. Of the two,Allopathy has been widely used because it often provides instant relief. However,the high cost and side effects of modern drugs are often serious hazards in this approach.

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