Demographic correlates of inflammatory and antiviral gene expression in the study of Midlife in the United States (MIDUS)

2021 ◽  
pp. 1-14
Author(s):  
Frank D. Mann ◽  
Robert F. Krueger ◽  
Sean Clouston ◽  
Steven Cole
Keyword(s):  
Gene Expression ◽  
United States ◽  
The United States ◽  
Demographic Correlates ◽  
Antiviral Gene

Septic shock and systemic inflammatory response syndrome patients' CD15+ granulocytes were subjected to global transcriptional profiling (SIRS)

2021 ◽  
Author(s):  
Marni Mack ◽  
Argo Easston
Keyword(s):  
Gene Expression ◽  
United States ◽  
Septic Shock ◽  
Immune Cells ◽  
Transcriptional Profiling ◽  
The United States ◽  
Transcriptional Level ◽  
Data Set ◽  
Transcriptional Alterations ◽  
Level I

In the United States, sepsis, the body's response to infection in a typically sterile circulation, is a leading causeof death (1). To assess the primary transcriptional alterations associated with each illness state, I utilized amicroarray data set from a cohort of thirtyone individuals with septic shock or systemic inflammatory responsesyndrome (2). At the transcriptional level, I discovered that the granulocytes of patients with SIRS weresimilar to those of patients with septic shock. SIRS showed a “intermediate” gene expression state betweenthat of control patients and that of septic shock patients for numerous genes expressed in the granulocyte. Thediscovery of the most differentially expressed genes in the granulocytic immune cells of patients with septicshock might aid the development of new therapies or diagnostics for an illness with a 14.7 percent to 29.9% inhospitaldeath rate despite decades of study (1).

scholarly journals Social, psychological, and demographic characteristics of dehumanization toward immigrants

2020 ◽  
Vol 117 (17) ◽  
pp. 9260-9269 ◽  
Author(s):  
David M. Markowitz ◽  
Paul Slovic
Keyword(s):  
United States ◽  
Death Penalty ◽  
Current Literature ◽  
The United States ◽  
Demographic Characteristics ◽  
Social Psychological ◽  
The Social ◽  
Demographic Correlates ◽  
Southern Border ◽  
Explained Variance

This study extends the current body of work on dehumanization by evaluating the social, psychological, and demographic correlates of blatant disregard for immigrants. Participants (n = 468) were randomly assigned to read a scenario where 1) an immigrant or 2) an immigrant and their child were caught illegally crossing the southern border of the United States, and then rated how long they should spend in jail if convicted. Participants reported that they would sentence the immigrant to more jail time than the immigrant and child. Those who sent immigrants to jail for more time also viewed them as socially distant and less human, described immigration in impersonal terms, and endorsed other social harms unrelated to immigration (e.g., the death penalty for convicted murderers). Crucially, endorsed social harms accounted for explained variance beyond simply holding conservative views. We position these data within the current literature on dehumanization theory and immigration issues.

scholarly journals An Ixodes scapularis protein required for survival of Anaplasma phagocytophilum in tick salivary glands

2006 ◽  
Vol 203 (6) ◽  
pp. 1507-1517 ◽  
Author(s):  
Bindu Sukumaran ◽  
Sukanya Narasimhan ◽  
John F. Anderson ◽  
Kathleen DePonte ◽  
Nancy Marcantonio ◽  
...  
Keyword(s):  
Gene Expression ◽  
United States ◽  
Salivary Glands ◽  
Anaplasma Phagocytophilum ◽  
Ixodes Scapularis ◽  
The United States ◽  
Salivary Protein ◽  
Specific Requirement ◽  
Obligate Intracellular ◽  
Tick Salivary Glands

Anaplasma phagocytophilum is the agent of human anaplasmosis, the second most common tick-borne illness in the United States. This pathogen, which is closely related to obligate intracellular organisms in the genera Rickettsia, Ehrlichia, and Anaplasma, persists in ticks and mammalian hosts; however, the mechanisms for survival in the arthropod are not known. We now show that A. phagocytophilum induces expression of the Ixodes scapularis salp16 gene in the arthropod salivary glands during vector engorgement. RNA interference–mediated silencing of salp16 gene expression interfered with the survival of A. phagocytophilum that entered ticks fed on A. phagocytophilum–infected mice. A. phagocytophilum migrated normally from A. phagocytophilum–infected mice to the gut of engorging salp16-deficient ticks, but up to 90% of the bacteria that entered the ticks were not able to successfully infect I. scapularis salivary glands. These data demonstrate the specific requirement of a pathogen for a tick salivary protein to persist within the arthropod and provide a paradigm for understanding how Rickettsia-like pathogens are maintained within vectors.

scholarly journals Integrative Genome-Wide Gene Expression Profiling of Clear Cell Renal Cell Carcinoma in Czech Republic and in the United States

PLoS ONE ◽  
2013 ◽  
Vol 8 (3) ◽  
pp. e57886 ◽  
Author(s):  
Magdalena B. Wozniak ◽  
Florence Le Calvez-Kelm ◽  
Behnoush Abedi-Ardekani ◽  
Graham Byrnes ◽  
Geoffroy Durand ◽  
...  
Keyword(s):  
Gene Expression ◽  
United States ◽  
Renal Cell Carcinoma ◽  
Czech Republic ◽  
Expression Profiling ◽  
Clear Cell ◽  
The United States ◽  
Cell Renal Cell Carcinoma ◽  
Genome Wide ◽  
Genome Wide Gene Expression

Customized Oligonucleotide Microarray Gene Expression–Based Classification of Neuroblastoma Patients Outperforms Current Clinical Risk Stratification

2006 ◽  
Vol 24 (31) ◽  
pp. 5070-5078 ◽  
Author(s):  
André Oberthuer ◽  
Frank Berthold ◽  
Patrick Warnat ◽  
Barbara Hero ◽  
Yvonne Kahlert ◽  
...  
Keyword(s):  
Gene Expression ◽  
United States ◽  
Risk Stratification ◽  
Cox Regression ◽  
Risk Estimation ◽  
Risk Groups ◽  
The United States ◽  
Oligonucleotide Microarray ◽  
Microarray Gene Expression ◽  
Class Prediction

Purpose To develop a gene expression–based classifier for neuroblastoma patients that reliably predicts courses of the disease. Patients and Methods Two hundred fifty-one neuroblastoma specimens were analyzed using a customized oligonucleotide microarray comprising 10,163 probes for transcripts with differential expression in clinical subgroups of the disease. Subsequently, the prediction analysis for microarrays (PAM) was applied to a first set of patients with maximally divergent clinical courses (n = 77). The classification accuracy was estimated by a complete 10-times-repeated 10-fold cross validation, and a 144-gene predictor was constructed from this set. This classifier's predictive power was evaluated in an independent second set (n = 174) by comparing results of the gene expression–based classification with those of risk stratification systems of current trials from Germany, Japan, and the United States. Results The first set of patients was accurately predicted by PAM (cross-validated accuracy, 99%). Within the second set, the PAM classifier significantly separated cohorts with distinct courses (3-year event-free survival [EFS] 0.86 ± 0.03 [favorable; n = 115] v 0.52 ± 0.07 [unfavorable; n = 59] and 3-year overall survival 0.99 ± 0.01 v 0.84 ± 0.05; both P < .0001) and separated risk groups of current neuroblastoma trials into subgroups with divergent outcome (NB2004: low-risk 3-year EFS 0.86 ± 0.04 v 0.25 ± 0.15, P < .0001; intermediate-risk 1.00 v 0.57 ± 0.19, P = .018; high-risk 0.81 ± 0.10 v 0.56 ± 0.08, P = .06). In a multivariate Cox regression model, the PAM predictor classified patients of the second set more accurately than risk stratification of current trials from Germany, Japan, and the United States (P < .001; hazard ratio, 4.756 [95% CI, 2.544 to 8.893]). Conclusion Integration of gene expression–based class prediction of neuroblastoma patients may improve risk estimation of current neuroblastoma trials.

Social, Psychological, and Demographic Characteristics of Dehumanization: The Case of Immigration

2019 ◽  
Author(s):  
David Matthew Markowitz ◽  
Paul Slovic
Keyword(s):  
United States ◽  
Death Penalty ◽  
Current Literature ◽  
The United States ◽  
Demographic Characteristics ◽  
Social Psychological ◽  
The Social ◽  
Demographic Correlates ◽  
Southern Border ◽  
Explained Variance

This study extends the current body of work on dehumanization by evaluating the social, psychological, and demographic correlates of blatant disregard for immigrants. Participants (N = 468) were randomly assigned to read a scenario where (1) an immigrant or (2) an immigrant and their child were caught illegally crossing the southern border of the United States, and then rated how long they should spend in jail if convicted. Participants reported that they would sentence the immigrant to more jail time than the immigrant and child. Those who sent immigrants to jail for more time also viewed them as socially distant, less human, described immigration in impersonal terms, and endorsed other social harms unrelated to immigration (e.g., the death penalty for convicted murderers). Crucially, endorsed social harms accounted for explained variance beyond simply holding conservative views. We position these data within the current literature on dehumanization theory and immigration issues.

Sign in / Sign up

Export Citation Format

Share Document