Baseline atrial fibrillation is a risk factor for erectile dysfunction: Systemic review and meta-analysis

Abstract Background and Aims: Serum uric acid can affect endothelial function, and hyperuricemia-induced endothelial dysfunction is involved in the pathogenesis of cardiovascular diseases. As endothelial dysfunction is also a main pathogenic mechanism of erectile dysfunction (ED), the present study aims to evaluate the relationship between hyperuricemia and ED via systemic review and meta-analysis.Methods: Five cohort studies and five cross-sectional studies on hyperuricemia and ED, including a total of 454256 participants, were recruited. Odds ratio (OR) and the 95% confidence intervals (CI) were adopted to estimate the relationship between hyperuricemia and ED. Overall risk were effects of urate-lowering therapy (ULT) analyzed. In addition, subgroup analyses on study design, populations, age stratification and the object were conducted.Results: In the patients with hyperuricemia, the risk of ED was 1.55-fold higher than (pooled OR=1.55, 95%CI (1.24,1.94)) the non-hyperuricemia counterparts. urate-lowing therapy (ULT) in these hyperuricemia patients reduced the risk of ED by 27% (OR=1.27, 95%CI (1.14,1.41)). After subgroup analysis and meta-regression, the association between hyperuricemia and ED remained significant apart from in the ≥55y subgroup.Conclusions: Hyperuricemia is an independent risk factor of ED, while ULT can reduce the risk of ED in hyperuricemia. This study suggests that hyperuricemia-associated endothelial dysfunction may also underlie the pathogenesis of ED in these patients.

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Greater cardiorespiratory fitness reduces incidence of atrial fibrillation: a meta-analysis

European Journal of Preventive Cardiology ◽

10.1093/eurjpc/zwab061.200 ◽

2021 ◽

Vol 28 (Supplement_1) ◽

Author(s):

C Verdicchio ◽

A Elliott ◽

R Mahajan ◽

D Linz ◽

D Lau ◽

...

Keyword(s):

Risk Factors ◽

Atrial Fibrillation ◽

Risk Factor ◽

Cardiorespiratory Fitness ◽

Meta Analysis ◽

Exercise Stress ◽

Inverse Association ◽

Exercise Interventions ◽

Increased Risk ◽

Statistical Heterogeneity

Abstract Funding Acknowledgements Type of funding sources: None. Introduction Atrial Fibrillation (AF) is the most common sustained cardiac arrhythmia affecting 1-2% of the global population, with the prevalence of AF increasing dramatically over the past two decades. Although low levels of cardiorespiratory fitness (CRF) and physical activity are predictive of cardiovascular disease onset and mortality, only recently has this emerged as a potential risk factor for AF. Purpose The aim of this meta-analysis was therefore to quantify the relationship between CRF, measured by a symptom limited exercise stress test, and incident AF. We hypothesised that there would be an inverse relationship between CRF and the incidence of AF. Methods The systematic literature review was conducted using PUBMED, MEDLINE and EMBASE databases, with seven studies meeting the inclusion criteria. A random-effects meta-analysis was then used to compare the multivariate risk estimates of the lowest CRF group from each cohort with the group of the highest CRF. Results Data from 206,925 individuals (55.8% males) was used for analysis with a mean age of 55 ± 2.5 years and a mean follow-up period of 10.3 ± 5 years. The total number of AF events across the studies was 19,913. The overall pooled risk of AF in the high-CRF group versus the low-CRF group showed a significant lower risk of incident AF in those with high-CRF (OR: 0.52, 95% CI, 0.44-0.605, p < 0.001). There was evidence of statistical heterogeneity between the studies (I2 = 81%, p < 0.001). AF incidence rates demonstrated an overall decline in rates across the CRF quartiles from low to high. The mean incidence rate for low-CRF was 21 ± 13.4 compared to 6.9 ± 0.7 per 1000 person-years for the high CRF group (p = 0.03). Conclusion There is an inverse association between a lower CRF and an increased risk of AF, with a higher level of CRF protective against AF. This study highlights that low-CRF may be an additional risk factor for AF along with already other established lifestyle-based risk factors such as obesity and hypertension. Exercise interventions should be promoted as a primary prevention strategy in those at risk of developing AF with known risk factors. Future studies are warranted to identify the mechanism(s) through which improved CRF confers a reduction in AF incidence. Abstract Figure. AF risk between high and low-CRF

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Baseline atrial fibrillation is associated with contrast-induced nephropathy after cardiac catheterization in coronary artery disease: Systemic review and meta-analysis

Clinical Cardiology ◽

10.1002/clc.23100 ◽

2018 ◽

Vol 41 (12) ◽

pp. 1555-1562 ◽

Cited By ~ 4

Author(s):

Narut Prasitlumkum ◽

Chanavuth Kanitsoraphan ◽

Veraprapas Kittipibul ◽

Pattara Rattanawong ◽

Pakawat Chongsathidkiet ◽

...

Keyword(s):

Atrial Fibrillation ◽

Coronary Artery Disease ◽

Coronary Artery ◽

Cardiac Catheterization ◽

Meta Analysis ◽

Systemic Review ◽

Contrast Induced Nephropathy ◽

Artery Disease

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New Onset of Atrial Fibrillation" as an Outcome Predictor in Critically Ill Patients with Sepsis: A Systemic Review

QJM ◽

10.1093/qjmed/hcab086.071 ◽

2021 ◽

Vol 114 (Supplement_1) ◽

Author(s):

Mohamed W Mohamed ◽

Mostafa K Riyad ◽

Ahmed M Khamis ◽

Heba F Toulan

Keyword(s):

Atrial Fibrillation ◽

Critically Ill ◽

Critically Ill Patients ◽

Cardiac Arrhythmias ◽

Meta Analysis ◽

Systemic Review ◽

Common Occurrence ◽

Severity Of Disease ◽

Increased Risk ◽

New Onset

Abstract Background Evidence of various cardiac arrhythmias in septic patients has been demonstrated by multiple clinical reports and observations .Most cardiac arrhythmias in sepsis are new-onset and may be related to sepsis-induced myocardial dysfunction, autonomic dysfunction and, most likely also, by impairment and involvement of the cardiac conduction system. Aim of the Work to describe the incidence of NOAF and to determine the risk factors associated with its development, as well as its clinical course and its effect on the outcome of patients with sepsis admitted to the ICU. Patients and Methods A systematic search was conducted to retrieve articles that investigated the association of NOAF in patients diagnosed with sepsis. We identified potential Englishlanguage sources from the PubMed, Medline, and EMBASE databases. Keywords used were “atrial fibrillation” and (“sepsis” or “septic shock”). In addition, reference lists of any studies meeting inclusion criteria were reviewed manually to identify additional relevant publications. Results In our meta-analysis, we found that NOAF is a common occurrence in critically ill patients with sepsis, and its incidence rises with increasing severity of disease. Also, we found that NOAF in sepsis patients is significantly associated with increased risk of ICU. In hospital, and After hospital discharge mortality, as well as, increased risk of developing ischemic stroke. Conclusion NOAF is a common occurrence in critically ill patients with sepsis, and its incidence rises with increasing severity of disease. Our Meta-analysis suggests that it is independently associated with poor outcome. In view of these findings there is a need for better quality observational studies, because reliable identification of patients with sepsis who are prone for the development of AF may allow for early pharmacological interventions to prevent this complication.

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The Potential Role of Arginine Supplements on Erectile Dysfunction: A Systemic Review and Meta-Analysis

Journal of Sexual Medicine ◽

10.1016/j.jsxm.2018.12.002 ◽

2019 ◽

Vol 16 (2) ◽

pp. 223-234 ◽

Cited By ~ 1

Author(s):

Hye Chang Rhim ◽

Min Seo Kim ◽

Young-Jin Park ◽

Woo Suk Choi ◽

Hyoung Keun Park ◽

...

Keyword(s):

Erectile Dysfunction ◽

Potential Role ◽

Meta Analysis ◽

Systemic Review

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Is the History of Erectile Dysfunction a Reliable Risk Factor for New Onset Acute Myocardial Infarction? A Systematic Review and Meta-Analysis

Current Urology ◽

10.1159/000499249 ◽

2020 ◽

Vol 14 (3) ◽

pp. 122-129

Author(s):

Ahmed Adam ◽

Jared McDowall ◽

Sunday Joseph Aigbodion ◽

Callistus Enyuma ◽

Sean Buchanan ◽

...

Keyword(s):

Myocardial Infarction ◽

Systematic Review ◽

Acute Myocardial Infarction ◽

Risk Factor ◽

Erectile Dysfunction ◽

Meta Analysis ◽

Diagnostic Value ◽

True Negative ◽

History Of ◽

New Onset

Acute myocardial infarction (AMI) occurs as a manifestation of coronary atherosclerotic disease. The occurrence of erectile dysfunction (ED) following AMI is well documented and this association and pathophysiology is often interrelated. Few studies have objectively assessed the diagnostic value of ED as a risk factor for AMI, in general. In this review, we aimed to better outline the diagnostic predictability of ED as a precursor for ‘first/new onset' AMI. This review was performed using selective search terms, in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analysis guidelines. The Cochrane, Embase, PubMed, Scopus and Web of Science databases were searched (September 2018). Selected studies were further assessed for relevance and quality (Critical Appraisal Skills Program tool-Oxford). Four studies [573 participants; mean 143 (SD ± 76.3604) and median 141 participants] were eligible for analysis. Meta-analysis of the studies resulted in a pooled sensitivity of 51.36% (95% CI: 47.37-55.33%). For the single study which reported true negative and false positive cases, a specificity of 76.53% (95% CI: 68.57-83.00%) was calculated. The results of this systematic review and meta-analysis suggest that a history of ED should be used as a risk factor for new onset AMI.

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