scholarly journals Hyperuricemia Is an Independent Risk Factor of the Erectile Dysfunction: a Systematic Review and Meta-analysis

2021 ◽  
Author(s):  
Wenting Wang ◽  
Zhaohai Jing ◽  
Wei Liu ◽  
Lin Zhu ◽  
Hongsheng Ren ◽  
...  
Keyword(s):  
Risk Factor ◽  
Erectile Dysfunction ◽  
Endothelial Dysfunction ◽  
Independent Risk Factor ◽  
Meta Analysis ◽  
Systemic Review ◽  
Cross Sectional ◽  
Lowering Therapy ◽  
The Relationship ◽  
Age Stratification

Abstract Background and Aims: Serum uric acid can affect endothelial function, and hyperuricemia-induced endothelial dysfunction is involved in the pathogenesis of cardiovascular diseases. As endothelial dysfunction is also a main pathogenic mechanism of erectile dysfunction (ED), the present study aims to evaluate the relationship between hyperuricemia and ED via systemic review and meta-analysis.Methods: Five cohort studies and five cross-sectional studies on hyperuricemia and ED, including a total of 454256 participants, were recruited. Odds ratio (OR) and the 95% confidence intervals (CI) were adopted to estimate the relationship between hyperuricemia and ED. Overall risk were effects of urate-lowering therapy (ULT) analyzed. In addition, subgroup analyses on study design, populations, age stratification and the object were conducted.Results: In the patients with hyperuricemia, the risk of ED was 1.55-fold higher than (pooled OR=1.55, 95%CI (1.24,1.94)) the non-hyperuricemia counterparts. urate-lowing therapy (ULT) in these hyperuricemia patients reduced the risk of ED by 27% (OR=1.27, 95%CI (1.14,1.41)). After subgroup analysis and meta-regression, the association between hyperuricemia and ED remained significant apart from in the ≥55y subgroup.Conclusions: Hyperuricemia is an independent risk factor of ED, while ULT can reduce the risk of ED in hyperuricemia. This study suggests that hyperuricemia-associated endothelial dysfunction may also underlie the pathogenesis of ED in these patients.

scholarly journals GAMBARAN DISFUNGSI EREKSI DAN HUBUNGAN DIABETES MELITUS DAN HIPERTENSI TERHADAP KEJADIAN DISFUNGSI EREKSI PADA PENDERITA STROKE DI POLI NEUROLOGI RSUP PROF. DR. R. D. KANDOU MANADO

e-CliniC ◽  
2014 ◽  
Vol 2 (1) ◽  
Author(s):  
Richie Irvanto Ciandra ◽  
Corry N. Mahama ◽  
Melke J. Tumboimbela
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factor ◽  
Erectile Dysfunction ◽  
Erectile Function ◽  
Stroke Patients ◽  
Cross Sectional ◽  
Consecutive Sampling ◽  
Risk Of Disease ◽  
The Relationship ◽  
Diabetes Melitus

ABSTRACT: Stroke is a big health problem in all industrial nations. In Indonesia, the prevalence of stroke keeps on increasing with each passing year. In addition to physical complaints suffered, sexual function may affect the patient’s. Erectile dysfunction is a problem that often arises in stroke patients. Purpose: This research is aimed in understanding describe of erectile dysfunction and the relationship between the risk factor namely diabetes mellitus and hypertension among stroke patients. Methods: The research method used is analytic descriptive with cross sectional approach. The study subjects were 40 men stroke patients, recruited by consecutive sampling in Polyclinic Neurology RSUP Prof. Dr. R. D. Kandou Manado during the period of November to December 2013. The measurement of erectile dysfunction used International Index of Erectile function/IIEF-5. Conclusion: Stroke patients who experience erectile dysfunction by 85%, with the highest amount on mild erectile dysfunction and mild to moderate erectile dysfunction at  35% dan 32,5%. Age most experienced erectile dysfunction are in the age group 35-44 years and >75 years. Low levels of education may suffer from erectile dysfunction is higher than the high education level. And the insiden of erectile dysfunction among stroke patients having risk factor of diabetes mellitus were higher than haven’t (OR=2,391). While hypertension risk factors correlated with a reduced risk of disease (OR=0,771). Keywords: Stroke, erectile dysfunction, diabetes mellitus, hypertension   ABSTRAK: Stroke merupakan masalah kesehatan yang besar di negara-negara industri, prevalensi stroke di Indonesia terus meningkat dari tahun ke tahun. Selain keluhan fisik yang diderita, keadaan fungsi seksual dapat mempengaruhi penderita. Disfungsi ereksi merupakan masalah yang sering timbul pada pasien stroke. Tujuan: Penelitian ini bertujuan untuk mengetahui gambaran disfungsi ereksi dan hubungan diabetes melitus dan hipertensi terhadap kejadian disfungsi ereksi pada pasien stroke. Metode: Jenis penelitian yang digunakan adalah deskriptif analitik dengan pendekatan cross sectional. Jumlah sampel sebanyak 40 pasien stroke laki-laki yang diambil secara consecutive sampling di Poliklinik Neurologi RSUP Prof. Dr. R. D. Kandou Manado selama bulan November - Desember 2013. Pengukuran disfungsi ereksi menggunakan International Index of Erectile Function/IIEF-5. Simpulan: Pasien stroke yang mengalami disfungsi ereksi sebesar 85% dengan jumlah terbanyak pada disfungsi ereksi ringan dan disfungsi ereksi ringan sampai sedang sebesar 35% dan 32,5%. Umur terbanyak mengalami disfungsi ereksi terletak pada kelompok umur 35-44 tahun dan >75 tahun. Tingkat pendidikan rendah dapat mengalami disfungsi ereksi lebih tinggi daripada yang tingkat pendidikannya tinggi. Dan insiden disfungsi ereksi diantara pasien stroke yang mempunyai faktor resiko diabetes melitus adalah lebih tinggi daripada yang tidak mempunyai faktor resiko tersebut (OR=2,391). Sedangkan faktor resiko hipertensi berkorelasi dengan berkurangnya resiko penyakit (OR=0,771). Kata Kunci: Stroke, disfungsi ereksi, diabetes melitus, hipertensi

scholarly journals The relationship between leukocyte level and hypertension in elderly patients with hyperuricemia.

2020 ◽  
Author(s):  
Lijin Shen ◽  
Wei Zhao ◽  
Mingzhen Li ◽  
Bei Sun ◽  
Zhichao Zhou ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Risk Factor ◽  
Elderly Patients ◽  
Independent Risk Factor ◽  
Serum Uric Acid Level ◽  
Control Group ◽  
Multiple Logistic Regression ◽  
Cross Sectional ◽  
Increased Risk ◽  
The Relationship

Abstract Background : This study was to evaluate the change of leukocyte level caused by hyperuricemia and explore the relationship between leukocyte level and hypertension in elderly patients with hyperuricemia. Methods: A cross-sectional study of serum uric acid level was conducted in 1352 elderly people over 65 years old . The study samples were divided into three categories according to the tertiles of leukocyte: Tertile 1, leukocyte≤5.2 × 10 9 /L; Tertile 2, leukocyte=5.3~6.3 × 10 9 /L; and Tertile 3, leukocyte≥6.4 × 10 9 /L. Multiple logistic regression models were used for modeling relationships between leukocyte, hyperuricemia and hypertension. In vitro, human vascular endothelial cells (HUVECs) were treated by different concentrations of UA (0, 4, 8, 16 mg/dl) for 24 h, then cells were collected. Some cytokines were measured. Reactive oxygen species (ROS) were analyzed with a fluorescence microscope. Results: The levels of leukocyte were higher in elderly patients with hyperuricemia than without hyperuricemia( P <0.01). In multiple logistic regression, hyperuricemia was an independent risk factor of leukocyte in Tertile 3 (OR=1.657, 95%CI: 1.180～2.328, P =0.004). The prevalences of hypertension were higher in elderly patients with hyperuricemia than without hyperuricemia (77.0% vs 63.5%, χ 2 =11.447, P =0.001). In multiple logistic regression (Model 1), hyperuricemia was an independent risk factor of hypertension (OR=1.536, 95%CI: 1.026～2.302, P =0.037). Leukocyte in Tertile 3 was an independent risk factor of hypertension in Model 2 (OR= 1.333, 95%CI: 1.031~1.724, P =0.028). Expression levels of IL-1β, iNOS and TNF-α were obviously higher in the 8mg/dl UA group and 16mg/dl UA group than that in the control group ( P <0.05). Expression level of eNOS was obviously lower in the 8mg/dl UA group and 16mg/dl UA group than that in the control group ( P <0.05). The production of ROS in the 8mg/dl UA group and in the 16mg/dl UA group were obviously higher than that in the control group ( P <0.05). Conclusion: The present study demonstrated that hyperuricemia was associated with an increased risk for hypertension. The chronic inflammation caused by hyperuricemia maybe one of important pathogenesis of incident hypertension in patients with hyperuricemia.

scholarly journals Baseline atrial fibrillation is a risk factor for erectile dysfunction: Systemic review and meta-analysis

2019 ◽  
Vol 17 (2) ◽  
pp. 98-105
Author(s):  
Narut Prasitlumkum ◽  
Jakrin Kewcharoen ◽  
Chanavuth Kanitsoraphan ◽  
Veraprapas Kittipibul ◽  
Pakawat Chongsathidkiet ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Risk Factor ◽  
Erectile Dysfunction ◽  
Meta Analysis ◽  
Systemic Review

Erectile Dysfunction Predicts Cardiovascular Events as an Independent Risk Factor: A Systematic Review and Meta-Analysis

2019 ◽  
Vol 16 (7) ◽  
pp. 1005-1017 ◽  
Author(s):  
Binghao Zhao ◽  
Zhengdong Hong ◽  
Yiping Wei ◽  
Dongliang Yu ◽  
Jianjun Xu ◽  
...  
Keyword(s):  
Systematic Review ◽  
Risk Factor ◽  
Erectile Dysfunction ◽  
Cardiovascular Events ◽  
Independent Risk Factor ◽  
Meta Analysis

scholarly journals Sleep apnoea is a risk factor for severe COVID-19

2021 ◽  
Vol 8 (1) ◽  
pp. e000845
Author(s):  
Satu Strausz ◽  
Tuomo Kiiskinen ◽  
Martin Broberg ◽  
Sanni Ruotsalainen ◽  
Jukka Koskela ◽  
...  
Keyword(s):  
Risk Factor ◽  
Independent Risk Factor ◽  
Causes Of Death ◽  
Meta Analysis ◽  
Sleep Apnoea ◽  
Male Gender ◽  
Multivariate Logistic Regression Model ◽  
Multivariate Logistic Regression ◽  
Obstructive Sleep ◽  
Positive Controls

BackgroundObstructive sleep apnoea (OSA) is associated with higher body mass index (BMI), diabetes, older age and male gender, which are all risk factors for severe COVID-19.We aimed to study if OSA is an independent risk factor for COVID-19 infection or for severe COVID-19.MethodsOSA diagnosis and COVID-19 infection were extracted from the hospital discharge, causes of death and infectious diseases registries in individuals who participated in the FinnGen study (n=260 405). Severe COVID-19 was defined as COVID-19 requiring hospitalisation. Multivariate logistic regression model was used to examine association. Comorbidities for either COVID-19 or OSA were selected as covariates. We performed a meta-analysis with previous studies.ResultsWe identified 445 individuals with COVID-19, and 38 (8.5%) of them with OSA of whom 19 out of 91 (20.9%) were hospitalised. OSA associated with COVID-19 hospitalisation independent from age, sex, BMI and comorbidities (p-unadjusted=5.13×10−5, OR-adjusted=2.93 (95% CI 1.02 to 8.39), p-adjusted=0.045). OSA was not associated with the risk of contracting COVID-19 (p=0.25). A meta-analysis of OSA and severe COVID-19 showed association across 15 835 COVID-19 positive controls, and n=1294 patients with OSA with severe COVID-19 (OR=2.37 (95% 1.14 to 4.95), p=0.021).ConclusionRisk for contracting COVID-19 was the same for patients with OSA and those without OSA. In contrast, among COVID-19 positive patients, OSA was associated with higher risk for hospitalisation. Our findings are in line with earlier works and suggest OSA as an independent risk factor for severe COVID-19.

scholarly journals Association between CYP3A5 Polymorphism and Statin-Induced Adverse Events: A Systemic Review and Meta-Analysis

2021 ◽  
Vol 11 (7) ◽  
pp. 677
Author(s):  
Jeong Yee ◽  
Hamin Kim ◽  
Yunhee Heo ◽  
Ha-Young Yoon ◽  
Gonjin Song ◽  
...  
Keyword(s):  
Adverse Events ◽  
Web Of Science ◽  
Meta Analysis ◽  
Statistical Significance ◽  
Systemic Review ◽  
Event Risk ◽  
Total Data ◽  
Lipophilic Statin ◽  
The Relationship ◽  
Review Manager

Purpose: Cytochrome P450 (CYP) is involved in the metabolism of statins; CYP3A5 is the main enzyme responsible for lipophilic statin metabolism. However, the evidence of the association between CYP3A5*3 polymorphism and the risk of statin-induced adverse events remains unclear. Therefore, this study aimed to perform a systematic review and meta-analysis to investigate the relationship between the CYP3A5*3 polymorphism and the risk of statin-induced adverse events. Methods: The PubMed, Web of Science, and EMBASE databases were searched for qualified studies published until August 2020. Observational studies that included the association between statin-induced adverse events and the CYP3A5*3 polymorphism were reviewed. The odds ratios (ORs) and 95% confidence intervals (CIs) were evaluated to assess the strength of the relationship. The Mantel–Haenszel method was used to provide the pooled ORs. Heterogeneity was estimated with I2 statistics and publication bias was determined by Begg’s and Egger’s test of the funnel plot. Data analysis was performed using Review Manager (version 5.4) and R Studio (version 3.6). Results: In total, data from 8 studies involving 1614 patients were included in this meta-analysis. The CYP3A5*3 polymorphism was found to be associated with the risk of statin-induced adverse events (*3/*3 vs. *1/*1 + *1/*3: OR = 1.40, 95% CI = 1.08–1.82). For myopathy, the pooled OR was 1.30 (95% CI: 0.96–1.75). The subgroup analysis of statin-induced myopathy revealed a trend, which did not achieve statistical significance. Conclusions: This meta-analysis demonstrated that the CYP3A5*3 polymorphism affected statin-induced adverse event risk. Therefore, CYP3A5 genotyping may be useful to predict statin toxicity.

scholarly journals Relationship between NAFLD and Periodontal Disease from the View of Clinical and Basic Research, and Immunological Response

2021 ◽  
Vol 22 (7) ◽  
pp. 3728
Author(s):  
Masahiro Hatasa ◽  
Sumiko Yoshida ◽  
Hirokazu Takahashi ◽  
Kenichi Tanaka ◽  
Yoshihito Kubotsu ◽  
...  
Keyword(s):  
Risk Factor ◽  
Periodontal Disease ◽  
Alveolar Bone ◽  
Basic Research ◽  
Epidemiological Studies ◽  
Cross Sectional ◽  
Periodontopathic Bacteria ◽  
In Vivo Animal Model ◽  
The Relationship

Periodontal disease is an inflammatory disease caused by pathogenic oral microorganisms that leads to the destruction of alveolar bone and connective tissues around the teeth. Although many studies have shown that periodontal disease is a risk factor for systemic diseases, such as type 2 diabetes and cardiovascular diseases, the relationship between nonalcoholic fatty liver disease (NAFLD) and periodontal disease has not yet been clarified. Thus, the purpose of this review was to reveal the relationship between NAFLD and periodontal disease based on epidemiological studies, basic research, and immunology. Many cross-sectional and prospective epidemiological studies have indicated that periodontal disease is a risk factor for NAFLD. An in vivo animal model revealed that infection with periodontopathic bacteria accelerates the progression of NAFLD accompanied by enhanced steatosis. Moreover, the detection of periodontopathic bacteria in the liver may demonstrate that the bacteria have a direct impact on NAFLD. Furthermore, Porphyromonas gingivalis lipopolysaccharide induces inflammation and accumulation of intracellular lipids in hepatocytes. Th17 may be a key molecule for explaining the relationship between periodontal disease and NAFLD. In this review, we attempted to establish that oral health is essential for systemic health, especially in patients with NAFLD.

Serum uric acid levels and risk of prehypertension: a meta-analysis

2017 ◽  
Vol 55 (3) ◽  
Author(s):  
Menglin Jiang ◽  
Dandan Gong ◽  
Yu Fan
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Meta Analysis ◽  
Elevated Serum ◽  
China National Knowledge Infrastructure ◽  
Cross Sectional ◽  
Knowledge Infrastructure ◽  
Increased Risk ◽  
Cross Sectional Studies ◽  
The Relationship

AbstractElevated serum uric acid (SUA) levels may increase the risk of prehypertension. However, the findings from these studies remain conflicting. The objective of this study was to determine the relationship between SUA levels and risk of prehypertension by conducting a meta-analysis. We conducted a comprehensive literature search of PubMed, Embase, China National Knowledge Infrastructure, VIP, and the Wangfang database without language restrictions through May 2015. Observational studies assessing the relationship between SUA levels and prevalence of prehypertension were included. Pooled adjust odds ratio (OR) and corresponding 95% confidence intervals (CI) of prehypertension were calculated for the highest vs. lowest SUA levels. Prehypertension was defined as systolic blood pressure (BP) ranging from 120 to 139 mmHg or diastolic BP ranging from 80 to 89 mmHg. Eight cross-sectional studies with a total of 21,832 prehypertensive individuals were included. Meta-analysis showed that elevated SUA levels were associated with increased risk of prehypertension (OR: 1.84; 95% CI: 1.42–2.38) comparing the highest vs. lowest level of SUA levels. Subgroup analyses showed that elevated SUA levels significantly increased the risk of prehypertension among men (OR: 1.60; 95% CI: 1.12–2.21) and women (OR: 1.59; 95% CI: 1.17–2.16). Elevated SUA levels are positively associated with the risk of prehypertension in the general population. However, more well-designed longitudinal studies are needed before a definitive conclusion can be drawn due to the cross-sectional studies included are susceptible to bias.

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