The clinicopathological and prognostic value of CD44 expression in bladder cancer: a study based on meta-analysis and TCGA data

Abstract Objective: Human Epidermal Growth Factor Receptor 2 (HER2) is highly expressed in a variety of tumors and associated with patients’ prognosis, but its role in bladder cancer remains unclear. We conducted this meta-analysis to explore the clinical significance and prognostic value of HER2 in bladder cancer and its potentiality as an immunotherapy target.Methods: PubMed was searched for studies published between January 1, 2000 and January 1, 2020. The odds ratios (ORs) and hazard ratios (HRs) with 95% confidence intervals (95%CIs) were used to investigate the relationship between HER2 and bladder cancer. UALCAN website was used to obtain TCGA (The cancer genome atlas) database.Results: Our study includes 14 articles, 1398 patients. HER2 expression was significantly higher in bladder cancer than in normal tissues. Our meta-analysis results did not reveal any effect of gender on the expression of HER2 levels in bladder cancer patients. However, HER2 expression in male patients was significantly higher than that in women according to TCGA databases. HER2 expression was also associated with carcinoma in situ, multifocal tumors, large tumor size, high tumor stage and grade, lymph node metastases, risk of recurrence and progression, low recurrence-free survival (RFS) rate. HER2 expression status had no effect on overall survival.Conclusions: Our meta-analysis showed that HER2 expression was related to pathological malignancy and poor prognosis in bladder cancer which indicated that it could be used as an effective biomarker and therapeutic target.

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Prognostic value of CD44 expression in renal cell carcinoma: a systematic review and meta-analysis

Scientific Reports ◽

10.1038/srep13157 ◽

2015 ◽

Vol 5 (1) ◽

Cited By ~ 31

Author(s):

Xintao Li ◽

Xin Ma ◽

Luyao Chen ◽

Liangyou Gu ◽

Yu Zhang ◽

...

Keyword(s):

Systematic Review ◽

Renal Cell Carcinoma ◽

Cell Carcinoma ◽

Renal Cell ◽

Prognostic Value ◽

Meta Analysis ◽

Cd44 Expression

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Prognostic value of concomitant carcinoma in situ in radical cystectomy specimens on patients with bladder cancer: A meta-analysis of 24,136 patients

European Urology Supplements ◽

10.1016/s1569-9056(18)31409-x ◽

2018 ◽

Vol 17 (2) ◽

pp. e828

Author(s):

S. Kimura ◽

A. Mari ◽

B. Foerster ◽

M. Vartolomei ◽

M. Abufaraj ◽

...

Keyword(s):

Bladder Cancer ◽

Radical Cystectomy ◽

Carcinoma In Situ ◽

Prognostic Value ◽

Meta Analysis

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The prognostic value of CD44 expression in gastric cancer: A meta-Analysis

Biomedicine & Pharmacotherapy ◽

10.1016/j.biopha.2014.08.001 ◽

2014 ◽

Vol 68 (6) ◽

pp. 693-697 ◽

Cited By ~ 25

Author(s):

Yansu Chen ◽

Ziyi Fu ◽

Sujuan Xu ◽

Ye Xu ◽

Pengfei Xu

Keyword(s):

Gastric Cancer ◽

Prognostic Value ◽

Meta Analysis ◽

Cd44 Expression

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Prognostic value of the miR-200 family in bladder cancer: a systematic review and meta-analysis

10.21203/rs.2.24463/v1 ◽

2020 ◽

Author(s):

Yanhui Mei ◽

Jianbo Zheng ◽

Ping Xiang ◽

Cheng Liu ◽

Yidong Fan

Keyword(s):

Bladder Cancer ◽

Confidence Interval ◽

Publication Bias ◽

Prognostic Value ◽

Meta Analysis ◽

Hazard Ratio ◽

High Expression ◽

Cancer Specific Survival ◽

Free Survival ◽

Hazard Ratios

Abstract Introduction : The association between the miR-200 family and the prognosis of patients with bladder cancer remains controversial. The aim of this study is to evaluate the prognostic value of the miR-200 family in patients with bladder cancer.Methods : Electronic databases were searched to identify the studies that had assessed the association between the miR-200 family and prognosis in patients with bladder cancer. Hazard ratios ( HRs ) and 95% confidence interval ( CI ) for overall survival (OS), cancer-specific survival (CSS) and recurrence-free survival (RFS) from eligible studies were used to calculate combined hazard ratios. The heterogeneity across the included studies was assessed by Cochrane´s Q test and I 2 statistic. The Begg´s funnel plot and Egger´s linear regression teats were used to evaluate the potential publication bias. The meta-analysis was performed with RevMan 5.3 and Stata SE12.0 according to the PRISMA guidelines.Results : A total of 1152 patients from 8 studies were included in this meta-analysis. The results showed that the high expression of the miR-200 family was associated with better OS (pooled hazard ratio: 0.50, 95% confidence interval: 0.40-0.62), CSS (pooled hazard ratio: 0.36, 95% confidence interval: 0.22-0.59) and RFS (pooled hazard ratio: 0.48, 95% confidence interval: 0.36-0.65). Both Begg's funnel plots test and Egger's test verified that there was no publication bias within the included cohorts. Conclusion : This study suggests that the high expression of the miR-200 family is significantly associated with better prognosis in patients with bladder cancer.

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The Clinical Significance and Prognostic Value of HER2 Expression in Bladder Cancer: A Meta-Analysis and a Bioinformatic Analysis

Frontiers in Oncology ◽

10.3389/fonc.2021.653491 ◽

2021 ◽

Vol 11 ◽

Author(s):

Kai Gan ◽

Yue Gao ◽

Kuangzheng Liu ◽

Bin Xu ◽

Weijun Qin

Keyword(s):

Bladder Cancer ◽

Clinical Significance ◽

Prognostic Value ◽

Meta Analysis ◽

Growth Factor Receptor ◽

Bioinformatic Analysis ◽

Tumor Stage ◽

Her2 Expression ◽

Large Tumor ◽

Normal Tissues

ObjectiveHuman Epidermal Growth Factor Receptor 2 (HER2) is highly expressed in multiple malignancies and associated with patients’ prognosis, but its role in bladder cancer (BCa) remains elusive. We conducted this meta-analysis to explore the clinical significance and prognostic value of HER2 in BCa.MethodsPubMed was searched for studies published between January 1, 2000 and January 1, 2020. The odds ratios (ORs) and hazard ratios (HRs) with 95% confidence intervals (95%CIs) were used to investigate the relationship between HER2 and BCa pathological features. TCGA was mined for the information regarding as well.ResultsOur study included 14 articles enrolling 1398 people. Expression of HER2 is higher in bladder cancer than in normal tissues. HER2 over-expression is associated with CIS, multifocal tumor, large tumor size, high tumor stage and grade, lymph node metastasis, progression, recurrence and papillary tumor. We could not find a significant association between HER2 expression and survival time in BCa patients.ConclusionsOur meta and bioinformatic analysis indicated that HER2 expression was related to pathological malignancy and poor prognosis in BCa.

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