scholarly journals Prognostic value of CD44 expression in patients with hepatocellular carcinoma: meta-analysis

2016 ◽  
Vol 16 (1) ◽  
Author(s):  
Yangkun Luo ◽  
Yan Tan
Keyword(s):  
Hepatocellular Carcinoma ◽  
Prognostic Value ◽  
Meta Analysis ◽  
Cd44 Expression

scholarly journals Prognostic value of plasma fibrinogen in hepatocellular carcinoma: a meta-analysis

2018 ◽  
Vol Volume 10 ◽  
pp. 5027-5041 ◽  
Author(s):  
Guanqun Huang ◽  
Hui Jiang ◽  
Ye Lin ◽  
Yanpeng Wu ◽  
Weilong Cai ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Prognostic Value ◽  
Meta Analysis ◽  
Plasma Fibrinogen

The prognostic value and clinicopathological significance of CD44 expression in ovarian cancer: a meta-analysis

2016 ◽  
Vol 294 (5) ◽  
pp. 1019-1029 ◽  
Author(s):  
Luyang Zhao ◽  
Chenglei Gu ◽  
Ke Huang ◽  
Zhe Zhang ◽  
Mingxia Ye ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Prognostic Value ◽  
Meta Analysis ◽  
Cd44 Expression ◽  
Clinicopathological Significance

scholarly journals The clinicopathological and prognostic value of HSP27 in hepatocellular carcinoma: a systematic review and meta-analysis

2018 ◽  
Vol Volume 11 ◽  
pp. 1293-1303 ◽  
Author(s):  
Chaojie Liang ◽  
Yingchen Xu ◽  
Hua Ge ◽  
Guangming Li ◽  
Jixiang Wu
Keyword(s):  
Hepatocellular Carcinoma ◽  
Systematic Review ◽  
Prognostic Value ◽  
Meta Analysis

scholarly journals Prognostic Value of Lactate Dehydrogenase in Patients with Hepatocellular Carcinoma: A Meta-Analysis

2018 ◽  
Vol 2018 ◽  
pp. 1-10 ◽  
Author(s):  
Weihao Kong ◽  
Xiaomin Zuo ◽  
Hao Liang ◽  
Jingxiong Hu ◽  
Huabing Zhang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Sensitivity Analysis ◽  
Lactate Dehydrogenase ◽  
Publication Bias ◽  
Subgroup Analysis ◽  
Prognostic Value ◽  
Meta Analysis ◽  
Progression Free Survival ◽  
Cochrane Library ◽  
Free Survival

Background. Previous studies have shown the prognostic value of lactate dehydrogenase (LDH) in hepatocellular carcinoma (HCC), but the results are not persuasive. Therefore, the purpose of our study was to quantitatively explore the prognostic value of LDH in hepatocellular carcinoma.Methods. We searched the Web of Science, Embase, PubMed, and the Cochrane Library for literature published before October 2018 on the prognostic value of LDH in patients with hepatocellular carcinoma. The combined hazard ratios (HRs) and 95% confidence intervals (CIs) were utilized to assess the prognostic value of LDH in overall survival (OS), recurrence-free survival (RFS), and progression-free survival (PFS) of HCC. Subgroup analysis, sensitivity analysis, and metaregression were used to explore the source of heterogeneity. Funnel plots with Begg’s test and Egger’s test were used to detect potential publication biases. Furthermore, combined odds ratios (ORs) were utilized to assess the correlation between LDH and clinicopathological features.Results. A total of 10 nonrandomized controlled studies were included in this meta-analysis. The combined effects of LDH on HCC patients’ OS, RFS/DFS, and PFS were HR = 2.07, 95% CI: 1.63-2.62, P < 0.001; HR = 1.62, 95% CI: 1.37-1.90, P < 0.001; and HR = 1.96, 95% CI: 1.14-3.36, P = 0.014, respectively. Subgroup analysis and sensitivity analysis showed that the outcome was stable, and the results of the metaregression also identified statistical models as an important source of heterogeneity. Potential publication bias was detected in the OS studies, so the trim-and-fill method was used to explore publication bias, and the results showed stability. Furthermore, the combined OR suggests that LDH was significantly correlated with gender, Child-Pugh grade, alpha-fetoprotein, vascular invasion, and tumor size.Conclusions. Preoperative LDH elevation is significantly associated with poor prognosis in patients with HCC, which may be a promising factor in assessing the prognosis of patients with HCC.

scholarly journals Prognostic value of Notch-1 expression in hepatocellular carcinoma: a meta-analysis

2015 ◽  
pp. 3105 ◽  
Author(s):  
Tao Wu ◽  
Min Jiao ◽  
Li Jing ◽  
Min-Cong Wang ◽  
Hai-Feng Sun ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Prognostic Value ◽  
Meta Analysis ◽  
Notch 1

scholarly journals A Comprehensive Evaluation of the Association between Polymorphisms in XRCC1, ERCC2, and XRCC3 and Prognosis in Hepatocellular Carcinoma: A Meta-Analysis

2019 ◽  
Vol 2019 ◽  
pp. 1-8 ◽  
Author(s):  
Yan Zhao ◽  
Erjiang Zhao ◽  
Junhui Zhang ◽  
Yuanyuan Chen ◽  
Junli Ma ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Gene Polymorphism ◽  
Prognostic Value ◽  
Literature Search ◽  
Comprehensive Evaluation ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Systematic Literature Search ◽  
The Cochrane Library ◽  
Larger Sample

Purpose. Associations between XRCC1, XRCC3, and ERCC2 gene polymorphism and prognosis have been investigated in several cancers. The aim of this meta-analysis was to assess the prognostic value of XRCC1, XRCC3, and ERCC2 gene polymorphism in hepatocellular carcinoma (HCC). Methods. A systematic literature search was performed to identify relevant studies in PubMed, Embase, and the Cochrane library up to December 2018. The prognostic values of XRCC1, XRCC3, and ERCC2 polymorphisms in HCC were estimated using crude HRs with 95% CIs. Results. Ten studies involving 2687 patients were included in the quantitative analysis. There were no statistically significant associations between XRCC1 rs1799782 C>T, XRCC1 rs25487 G>A, and ERCC2 rs1799793 G>A polymorphisms and overall survival (OS). OS was significantly longer for the ERCC2 rs13181 CC genotype than for AA (CC vs. AA: HR = 0.33, 95% CI = 0.15–0.72). A significantly lower OS was observed for patients with the CT genotype compared with the CC genotype at XRCC3 rs861539 (CT vs. CC: HR = 1.64, 95% CI = 1.11–2.42). Conclusion. The ERCC2 rs13181 A>C polymorphism and XRCC3 rs861539 C>T polymorphism may be predictive markers for prognosis in patients with HCC. Well-designed studies with larger sample sizes are needed to verify our findings.

scholarly journals The clinicopathological and prognostic value of CD44 expression in bladder cancer: a study based on meta-analysis and TCGA data

Bioengineered ◽  
2020 ◽  
Vol 11 (1) ◽  
pp. 572-581 ◽  
Author(s):  
Yu Hu ◽  
Yongrui Zhang ◽  
Jialin Gao ◽  
Xin Lian ◽  
Yuantao Wang
Keyword(s):  
Bladder Cancer ◽  
Prognostic Value ◽  
Meta Analysis ◽  
Cd44 Expression
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