The Relationship of Frequency of Follow-Up Visits to Asthma Outcomes in Patients with Moderate Persistent Asthma

Objective: As diabetes technology use in youth increases worldwide, inequalities in access may exacerbate disparities in hemoglobin A1c (HbA1c). We hypothesized an increasing gap in diabetes technology use by socioeconomic status (SES) would be associated with increased HbA1c disparities. Research Design and Methods: Participants aged <18 years with diabetes duration ≥1 year in the Type 1 Diabetes Exchange (T1DX, US, n=16,457) and Diabetes Prospective Follow-up (DPV, Germany, n=39,836) registries were categorized into lowest (Q1) to highest (Q5) SES quintiles. Multiple regression analyses compared the relationship of SES quintiles with diabetes technology use and HbA1c from 2010-2012 and 2016-2018. Results: HbA1c was higher in participants with lower SES (in 2010-2012 & 2016-2018, respectively: 8.0% & 7.8% in Q1 and 7.6% & 7.5% in Q5 for DPV; and 9.0% & 9.3% in Q1 and 7.8% & 8.0% in Q5 for T1DX). For DPV, the association between SES and HbA1c did not change between the two time periods, whereas for T1DX, disparities in HbA1c by SES increased significantly (p<0.001). After adjusting for technology use, results for DPV did not change whereas the increase in T1DX was no longer significant. Conclusions: Although causal conclusions cannot be drawn, diabetes technology use is lowest and HbA1c is highest in those of the lowest SES quintile in the T1DX and this difference for HbA1c broadened in the last decade. Associations of SES with technology use and HbA1c were weaker in the DPV registry.

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Investigation of the Correlation between Postherpetic Itch and Neuropathic Pain over Time

Pain Research and Management ◽

10.1155/2018/9305126 ◽

2018 ◽

Vol 2018 ◽

pp. 1-6 ◽

Cited By ~ 4

Author(s):

Rie Ishikawa ◽

Masako Iseki ◽

Rie Koga ◽

Eiichi Inada

Keyword(s):

Neuropathic Pain ◽

Herpes Zoster ◽

Pain Intensity ◽

Visual Analog Scale ◽

Analog Scale ◽

Paindetect Questionnaire ◽

Relationship Of ◽

The Relationship ◽

Over Time

Postherpetic itch (PHI), or herpes zoster itch, is an intractable and poorly understood disease. We targeted 94 herpes zoster patients to investigate their pain and itch intensities at three separate stages of the condition (acute, subacute, and chronic). We used painDETECT questionnaire (PDQ) scores to investigate the correlation between PHI and neuropathic pain. Seventy-six patients were able to complete follow-up surveys. The prevalence of PHI was 47/76 (62%), 28/76 (37%), and 34/76 (45%) at the acute, subacute, and chronic stages, respectively. PHI manifestation times and patterns varied. We investigated the relationship of PHI with neuropathic pain using the visual analog scale (VAS), which is a measure of pain intensity, and the PDQ, which is a questionnaire used to evaluate the elements of neuropathic pain. The VAS and PDQ scores did not differ significantly between PHI-positive and PHI-negative patients. A large neuropathic component was not found for herpes zoster itch, suggesting that neuropathic pain treatments may not able to adequately control the itch. Accordingly, we suggest that a more PHI-focused therapy is required to address this condition.

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The Relationship of Left Ventricular Trabeculation to Ventricular Function and Structure Over a 9.5-Year Follow-Up

Journal of the American College of Cardiology ◽

10.1016/j.jacc.2014.08.035 ◽

2014 ◽

Vol 64 (19) ◽

pp. 1971-1980 ◽

Cited By ~ 105

Author(s):

Filip Zemrak ◽

Mark A. Ahlman ◽

Gabriella Captur ◽

Saidi A. Mohiddin ◽

Nadine Kawel-Boehm ◽

...

Keyword(s):

Ventricular Function ◽

Left Ventricular ◽

Relationship Of ◽

The Relationship

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Influence of uric acid on the correlation between waist circumference and triglyceride glucose index: an analysis from CHARLS

Lipids in Health and Disease ◽

10.1186/s12944-021-01474-0 ◽

2021 ◽

Vol 20 (1) ◽

Author(s):

Jia Zheng ◽

Min Jiang ◽

Yanxia Xie

Keyword(s):

Uric Acid ◽

Waist Circumference ◽

Mediation Effects ◽

Panel Model ◽

Triglyceride Glucose Index ◽

Study Population ◽

Relationship Of ◽

The Relationship ◽

Longitudinal Relationships

Abstract Background Waist circumference (WC) and uric acid (UA) are significantly related. Still, their temporal sequence and how the sequence works on future risk of triglyceride glucose (TyG) are unknown, especially in the Chinese population. Methods Cross-lagged panel model was used to analyze the reciprocal, longitudinal relationships among a set of interrelated variables. The mediation model was constructed to test the effect of the relationship between WC and UA on TyG. Results A total of 5727 subjects were enrolled in our study population, of which 53.5% were women, and the mean age was 59.0 (standard deviation, 8.62) years. After adjusting for traditional confounding factors, the results showed that a higher level of baseline WC was significantly associated with a higher level of follow-up UA (β = 0.003, P = 0.031) and follow-up TyG (β = 0.003, P < 0.001);. Simultaneously, there was no statistical association between the level of baseline UA and the level of follow-up WC (β = − 0.009, P = 0.951). The mediation effects of UA on WC-TyG were estimated to be 18.1% in adults, and 36.2% in women. Conclusions The current study demonstrated that higher baseline level of WC probably preceded UA’ level in general population. In addition, UA mediated the relationship of WC to TyG, especially in females. And the possible mechanism would require further clarification.

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Prediction of Reproductive Success in Multiparous First Service Dairy Cows by Parameters from In-Line Sensors

Agriculture ◽

10.3390/agriculture11040334 ◽

2021 ◽

Vol 11 (4) ◽

pp. 334

Author(s):

Ramūnas Antanaitis ◽

Vida Juozaitienė ◽

Dovilė Malašauskienė ◽

Mindaugas Televičius ◽

Mingaudas Urbutis ◽

...

Keyword(s):

Electrical Conductivity ◽

Blood Parameters ◽

Negative Energy ◽

Hydroxybutyric Acid ◽

Pregnancy Status ◽

Group A ◽

Biochemical Indices ◽

Relationship Of ◽

The Relationship

The aim of the current study was to evaluate the relationship of different parameters from an automatic milking system (AMS) with the pregnancy status of multiparous cows at first service and to assess the accuracy of such a follow-up with regard to blood parameters. Before the insemination of cows, blood samples for measuring biochemical indices were taken from the coccygeal vessels and the concentrations of blood serum albumin (ALB), cortisol, non-esterified fatty acids (NEFA) and the activities of aspartate aminotransferase (AST) and gamma glutamyltransferase (GGT) were determined. From oestrus day to seven days after oestrus, the following parameters were registered: milk yield (MY), electric milk conductivity, lactate dehydrogenase (LDH) and β-hydroxybutyric acid (BHB). The pregnancy status was evaluated using ultrasound “Easy scan” 30–35 days after insemination. Cows were grouped by reproductive status: PG− (non-pregnant; n = 48) and PG+ (pregnant; n = 44). The BHB level in PG− cows was 1.2 times higher (p < 0.005). The electrical conductivity of milk was statistically significantly higher in all quarters of PG− cows (1.07 times) than of PG+ cows (p < 0.05). The arithmetic mean of blood GGT was 1.61 times higher in PG− cows and the NEFA value 1.23 times higher (p < 0.05) compared with the PG+ group. The liver function was affected, the average ALB of PG− cows was 1.19 times lower (p < 0.05) and the AST activity was 1.16 times lower (p < 0.05) compared with PG+ cows. The non-pregnant group had a negative energy balance demonstrated by high in-line milk BHB and high blood NEFA concentrations. We found a greater number of cows with cortisol >0.0.75 mg/dL in the non-pregnant group. A higher milk electrical conductivity in the non-pregnant cows pointed towards a greater risk of mastitis while higher GGT activities together with lower albumin concentrations indicated that the cows were more affected by oxidative stress.

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The relationship of severe health disorders with bone loss, grip strength, and mobility in postmenopausal women – a 15-year follow-up study

Disability and Rehabilitation ◽

10.3109/09638288.2015.1103789 ◽

2015 ◽

Vol 38 (14) ◽

pp. 1407-1414

Author(s):

Juha Suuronen ◽

Samu Sjöblom ◽

Risto Honkanen ◽

Heli Koivumaa-Honkanen ◽

Heikki Kröger ◽

...

Keyword(s):

Bone Loss ◽

Grip Strength ◽

Postmenopausal Women ◽

Follow Up Study ◽

Health Disorders ◽

Relationship Of ◽

The Relationship

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Frequency of post-traumatic osteoarthritis in dogs after repair of a humeral condylar fracture

Veterinary and Comparative Orthopaedics and Traumatology ◽

10.1055/s-0038-1632755 ◽

2003 ◽

Vol 16 (01) ◽

pp. 01-05 ◽

Cited By ~ 18

Author(s):

M. F. Besancon ◽

M. G. Conzemius ◽

K. G. Miles ◽

A. S. Kapatkin ◽

W. T. N. Culp ◽

...

Keyword(s):

Fracture Repair ◽

Fracture Reduction ◽

Vertical Force ◽

Condylar Fracture ◽

Limb Function ◽

Anatomic Reduction ◽

Post Traumatic ◽

Relationship Of ◽

The Relationship

SummaryThe frequency of post-traumatic osteoarthritis (PTO) in the dog after repair of a humeral condylar fracture (HCF) and the relationship of fracture reduction to outcome is unknown. The objectives of this study were to determine the frequency of PTO in dogs after HCF repair and to determine the relationship between fracture reduction, limb function and follow-up osteoarthrosis (OA) score. All dogs were evaluated by physical and radiographic examinations and dogs with unilateral fracture repair were also examined by force platform gait analysis. Initial and follow-up radiographs were scored for reduction and evidence of osteoarthrosis using previously published grading scales. This study evaluated 15 fractures in 13 dogs with a mean follow-up time of 43 months. Osteoarthrosis developed or progressed radiographically in all elbows. Peak vertical force (PVF) was significantly reduced (p <0.01) in the affected limb, however vertical impulse (VI) did not differ (p = 0.12) when compared to the opposite normal limb. Pain-free range of motion was reduced in flexion (p <0.01), but not in extension (p = 0.98) when compared to the normal limb. Fracture reduction score did not correlate with follow-up OA score (p = 0.07), PVF (p = 0.40), VI (p = 0.72), flexion (p =0.50), or extension (p = 0.62). Due to the high incidence of PTO, owners should be warned of the possibility of declining limb function over time despite near anatomic reduction.

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Body Mass Index and Its Change from Adolescence to Adulthood Are Closely Related to the Risk of Adult Metabolic Syndrome in China

International Journal of Endocrinology ◽

10.1155/2021/8888862 ◽

2021 ◽

Vol 2021 ◽

pp. 1-7

Author(s):

Bingyang Liu ◽

Yue Li ◽

Jiamei Guo ◽

Yuting Fan ◽

Ling Li ◽

...

Keyword(s):

Metabolic Syndrome ◽

Body Mass Index ◽

Body Mass ◽

Glycosylated Hemoglobin ◽

Early Adulthood ◽

Study Groups ◽

Relationship Of ◽

Baseline Bmi ◽

The Relationship

Aims. To investigate the influence of body mass index (BMI) and its change from adolescence to adulthood (ΔBMI) on the risk of metabolic syndrome (MetS) in early adulthood. Methods. We selected 931 students from 12 to 16 years of age in Liaoyang City, China. Ninety-three participants from 18 to 22 years of age with complete baseline data were available for follow-up after 5 years. Statistical analysis determined the relationship of MetS at follow-up with baseline BMI (BMIb), ΔBMI, and follow-up BMI (BMIf). Results. ΔBMI was positively correlated with the change of waist circumference (ΔWC), systolic blood pressure (ΔSBP), triglycerides (ΔTG), uric acid, and glycosylated hemoglobin (ΔHbA1c) in follow-up ( p < 0.05 ). For every 1 kg/m2 increase in BMIb, ΔBMI, and BMIf, the risk of MetS at follow-up increased 1.201-fold, 1.406-fold, and 1.579-fold, respectively. Both BMIb and ΔBMI were predictive of MetS at follow-up, with prediction thresholds of 23.47 kg/m2 and 1.95 kg/m2. The participants were divided by the predicted BMIb and ΔBMI threshold values into four study groups. Interestingly, the group with lower BMI but a higher increase in BMI presented the same metabolic derangements and Mets% of the group with higher BMI but lower Δ BMI. Conclusion. Both BMI of adolescence and ΔBMI were predictive of MetS and cardiovascular risk factors in adulthood. Control of both variables in adolescents would be more effective in decreasing the risk of MetS in young adults than control of BMI alone.

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The Relationship of Untreated Borderline Infiltrates by the Banff Criteria to Acute Rejection in Renal Allograft Biopsies

Journal of the American Society of Nephrology ◽

10.1681/asn.v1081806 ◽

1999 ◽

Vol 10 (8) ◽

pp. 1806-1814

Author(s):

SHANE M. MEEHAN ◽

CHRISTOPHER T. SIEGEL ◽

ANDREW J. ARONSON ◽

SHARON M. BARTOSH ◽

J. RICHARD THISTLETHWAITE ◽

...

Keyword(s):

Acute Rejection ◽

Serum Creatinine ◽

Renal Allograft ◽

Tubular Necrosis ◽

Maintenance Immunosuppression ◽

Initial Biopsy ◽

Elevated Creatinine ◽

Relationship Of ◽

The Relationship

Abstract. The relationship of borderline infiltrates to acute rejection by Banff criteria in renal allografts of patients receiving only maintenance immunosuppression is not clear. Renal allograft biopsies with borderline lesions that were not treated with additional anti-rejection therapy were retrospectively studied. Sixty-five such biopsies were identified from 50 patients, and their outcome was determined by serum creatinine and/or histologic findings in subsequent biopsies, up to 40 d after the initial biopsy. In addition to the borderline infiltrates, there was evidence of acute cyclosporine or tacrolimus toxicity (58%), acute tubular necrosis (12%), and urinary obstruction (12%). Forty-day follow-up after 30 (46%) biopsies revealed serum creatinine <110% of baseline, and repeat biopsies were not indicated. In 17 (26%), the serum creatinine initially decreased, then increased, and follow-up biopsies showed acute rejection in nine. In 18 (28%), the creatinine remained elevated and follow-up biopsies revealed acute rejection in nine. The untreated borderline infiltrates were thus nonprogressive after 47 biopsies (72%) and progressed to histologic acute rejection after 18 (28%). When there was increasing or persistently elevated creatinine after the initial biopsy, 51% of cases (18 of 35) progressed to acute rejection. Infiltrates that progressed to rejection had more frequent glomerulitis (7 of 18 versus 3 of 47, P = 0.003) and Banff acute score indices (i+t+v+g) >2 (16 of 18 versus 29 of 47, P = 0.03). A majority (72%) of borderline infiltrates not given additional anti-rejection therapy did not progress to acute rejection over 40 d of follow-up, suggesting that conservative management of these lesions, at least in the short term, may be more appropriate than routine treatment as acute rejection.

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A study of herpes zoster particularly in its relationship to chickenpox

Journal of Hygiene ◽

10.1017/s002217240001456x ◽

1949 ◽

Vol 47 (3) ◽

pp. 253-262 ◽

Cited By ~ 59

Author(s):

H. E. Seiler

Keyword(s):

Herpes Zoster ◽

Sex Differentiation ◽

Motor Paralysis ◽

Recurrent Herpes ◽

History Of ◽

The One ◽

Two Peaks ◽

Relationship Of ◽

The Relationship

The results of a field survey of herpes zoster over a period of 18 months are described and the difficulties of such a survey mentioned.A total of 246 patients with herpes zoster, only 16% of whom had attended hospital, is reported. It is calculated that the yearly incidence in the population was approximately 2 per 1000.Full investigation and ‘follow up’ was undertaken in 184 cases. These are classified according to the site of the zoster—the dorsal, supra-orbital and cervical regions being affected in almost 90%, the dorsal region alone accounting for 53·3%.Herpes generalisatus occurred in 7, or 38%, of the cases, recurrent herpes zoster in 6, or 3·3%, while there was one case of motor paralysis affecting lower limb.The majority of patients were apparently well at the onset of the zoster, but 27 had some associated disease; 5 gave a history of trauma prior to the onset and 2 were related to pregnancy.The seasonal and geographical distribution is given and, while the numbers are too small for statistical analysis, the disease in 1947 showed two peaks of higher incidence, the one in May and the other in October. Crowding or density of population did not appear to be important, and the disease occurred sporadically rather than in epidemic form.There was a higher proportion of female cases, but when related to the population as a whole no sex differentiation was observed. Of the patients 60% were over 45 years of age.There was no evidence that housing conditions or occupation were of aetiological significance or that the disease was more common among any particular section of the community.Eleven patients had been associated with other cases of herpes zoster before developing the disease, while 3 gave a suggestive history of prior contact with chickenpox.A condition indistinguishable from chickenpox occurred among the contacts of 10 patients, 12 individuals being affected, and there was one instance of concurrent herpes zoster and chickenpox. Other infections such as mumps, measles and rubella, while as common in association with the onset of herpes zoster, were not so frequently found as the chickenpox condition amongst contacts of the disease.The results of the survey as regards the relationship of chickenpox and herpes zoster are discussed. It is considered that the evidence does not favour a significant association with chickenpox prior to the onset of herpes zoster, but that the facts are consistent with the view that a condition indistinguishable from chickenpox may follow contact with herpes zoster. It is suggested, however, that this may be a generalized manifestation of the virus of zoster rather than true chickenpox.

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