The ATM protein: The importance of being active
2012 ◽
Vol 198
(3)
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pp. 273-275
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Keyword(s):
The ataxia telangiectasia mutated (ATM) protein kinase regulates the cellular response to deoxyribonucleic acid (DNA) double-strand breaks by phosphorylating numerous players in the extensive DNA damage response network. Two papers in this issue (Daniel et al. 2012. J. Cell Biol. http://dx.doi.org/10.1083/jcb201204035; Yamamoto et al. 2012. J. Cell Biol. http://dx.doi.org/10.1083/jcb201204098) strikingly show that, in mice, the presence of a catalytically inactive version of ATM is embryonically lethal. This is surprising because mice completely lacking ATM have a much more moderate phenotype. The findings impact on basic cancer research and cancer therapeutics.
2009 ◽
Vol 187
(7)
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pp. 977-990
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2006 ◽
Vol 281
(25)
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pp. 17482-17491
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2008 ◽
Vol 28
(18)
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pp. 5724-5735
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2008 ◽
Vol 181
(5)
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pp. 727-735
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2006 ◽
Vol 26
(18)
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pp. 6819-6831
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2018 ◽
Vol 115
(51)
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pp. E11961-E11969
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