IFT trains overcome an NPHP module barrier at the transition zone
Cilia harbor diffusion barriers for soluble and membrane proteins within their proximal-most transition zone (TZ) region and employ an intraflagellar transport (IFT) system to form dynamic motile and signaling compartments. In this issue, De-Castro and colleagues (2021. J. Cell Biol.https://doi.org/10.1083/jcb.202010178) uncover a long-suspected role for the TZ in gating IFT particles.
2005 ◽
Vol 169
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pp. 897-908
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2017 ◽
Vol 28
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pp. 233-239
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2017 ◽
Vol 216
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pp. 1659-1671
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2020 ◽
2021 ◽
2018 ◽
Vol 217
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pp. 1847-1868
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