scholarly journals STUDIES ON TUBERCULIN FEVER

1961 ◽  
Vol 114 (6) ◽  
pp. 939-959 ◽  
Author(s):  
John M. Moses ◽  
Elisha Atkins
Keyword(s):  
Specific Resistance ◽  
Inhibitory Effect ◽  
Common Source ◽  
Endogenous Pyrogen ◽  
Sufficient Magnitude ◽  
Relationship Of ◽  
The Relationship ◽  
Specific Agent ◽  
Specific Tolerance ◽  
Host Tissues

Certain characteristics of tolerance which develops to the pyrogenic effects of old tuberculin (OT) in BCG-vaccinated rabbits have been described. Rabbits made tolerant by several injections of OT lost their ability to produce detectable amounts of endogenous pyrogen (EP) in response to the specific agent (OT) but mobilized normal amounts of EP when given a small unrelated stimulus. On the other hand, when this stimulus followed shortly after an initial tuberculin fever of sufficient magnitude, release of additional EP was suppressed, presumably due to an inhibitory effect of the EP previously mobilized by tuberculin. Similarly, a single large dose of endotoxin almost completely suppressed the response of sensitized rabbits to OT given several hours later. Since several spaced injections of the same dosage were ineffective, this phenomenon does not appear to be attributable to the known mechanisms by which endotoxins promote non-specific resistance to toxicity and infection. Tolerance to tuberculin could not be definitely shown following an injection of Newcastle disease virus which also produces a circulating EP, and it has been inferred that endotoxin blocks the pyrogenic action of antigen on host tissues directly rather than through mobilizing EP. On the basis of these observations, the relationship of specific to non-specific tolerance to tuberculin fever has been compared in terms of the ability of such tolerant animals to mobilize EP to heterologous stimuli and it is concluded that the two forms of tolerance are different. Furthermore, the fact that a number of unrelated agents produce tolerance non-specifically supports the concept that there may be a common source of EP released by a number of stimuli, including endotoxins and myxoviruses, as well as antigen in specifically sensitized hosts.

Reading Jeremiah 52 in Exile: Purpose in the Composition of Jeremiah

2019 ◽  
Vol 70 (2) ◽  
pp. 511-522
Author(s):  
Adam K Harger
Keyword(s):  
Original Position ◽  
Common Source ◽  
History Of ◽  
Composition History ◽  
Relationship Of ◽  
The Relationship

Abstract Jeremiah 52 is valued among scholars for the insight it provides into the composition history of the larger book and its relationship to 2 Kings. Beyond the text-critical clues it provides, however, little is said about the relationship of Jeremiah 52 to the rest of the book. The chapter has been added to Jeremiah from its original position in 2 Kings 24–5 (or a common source), but it has been edited in the process. What follows is an exploration of a possible motivation for the addition of Jeremiah 52 to the larger book. Using the characters of Jehoiachin and Zedekiah as representatives of those who did and did not listen to the exhortation of the prophet, the editor uses the material of Jeremiah 52 to indicate that any future for the nation of Israel was located in—and would come out of—Babylon.

scholarly journals Potential Role of Laccases in the Relationship of the Maize Late Wilt Causal Agent, Magnaporthiopsis maydis, and Its Host

2020 ◽  
Vol 6 (2) ◽  
pp. 63
Author(s):  
Ofir Degani ◽  
Yuval Goldblat
Keyword(s):  
Potential Role ◽  
Dry Weight ◽  
Maize Cultivars ◽  
Maize Plants ◽  
Relationship Of ◽  
The Relationship ◽  
Host Tissues ◽  
Adult Plants

Late wilt is a vascular disease of maize (Zea mays L.) caused by the soil-borne and seed-borne fungus Magnaporthiopsis maydis. The pathogen penetrates the roots of maize plants at the seedling stage, grows into the xylem vessels, and gradually spreads upwards. From the flowering stage to the kernel ripening, the fungal hyphae and secreted materials block the water supply in susceptible maize cultivars, leading to rapid dehydration and death. Laccase is an enzyme secreted by fungus for diverse purposes. The M. maydis laccase gene was identified in our laboratory, but under what conditions it is expressed and to what functions remain unknown. In the current study, we tested the influence of plant age and tissue source (roots or leaves) on M. maydis laccase secretion. The results show increasing laccase secretion as corn parts (as ground tissue) were added to the minimal medium (MM). Furthermore, roots stimulated laccase secretion more than leaves, and adult plants enhanced laccase secretion more than young plants. This implies the possibility that the richer lignin tissue of adult plants may cause increased secretion of the enzyme. In vitro pathogenicity assay proved the ability of M. maydis to develop inside detached roots of maize, barley, watermelon, and cotton but not peanut. Testing root powder from those plants in MM revealed a negative correlation between M. maydis growth (expressed as biomass) and laccase secretion. For example, while the addition of maize, barley, or cotton root powder led to increasing fungal dry weight, it also resulted in relatively lower laccase activity. Watermelon and peanut root powder led to opposite responses. These findings suggest a pivotal role of laccase in the ability of M. maydis to exploit and grow on different host tissues. The results encourage further examination and a deeper understanding of the laccase role in these interesting host–pathogen interactions.

scholarly journals The release of an endogenous pyrogen from guinea pig leukocytes in vitro: a new model for investigating the role of lymphocytes in fevers induced by antigen in hosts with delayed hypersensitivity.

1977 ◽  
Vol 145 (5) ◽  
pp. 1288-1298 ◽  
Author(s):  
P Chao ◽  
L Francis ◽  
E Atkins
Keyword(s):  
Guinea Pig ◽  
Guinea Pigs ◽  
Polymorphonuclear Leukocytes ◽  
Delayed Hypersensitivity ◽  
Endogenous Pyrogen ◽  
Phagocytic Cells ◽  
Relationship Of ◽  
The Relationship

Guinea pig periotoneal exudate (PE) cells incubated overnight in vitro with heat-killed Staphylococci released an endogenous pyrogen (EP) that could be assayed by intravenous injection in rabbits. The febrile responses were linearly related to the dosage of EP over an eightfold range. PE cells derived from guinea pigs with delayed hypersensitivity (DH) to bovine gamma globulin (BGG), also released EP when incubated with antigen in vitro. This reaction was specific and did not occur withe PE cells from normal or complete Freund's adjuvant-sensitized guinea pigs. Studies indicated that monos and/or polymorphonuclear leukocytes rather than lymphocytes were the source of EP. However, when incubated with BGG and sufficient dosages of BGG-sensitized lymphocytes, normal PE cells released EP over a 42 h period. These results suggest that antigen stimulates specifically sensitized lymphocytes to release an agent (perhaps a lymphokine) that activates phagocytic cells to release EP. This model offers unique advantages for investigating in vitro the role of the lymphocyte in antigen-induced fever in DH as well as the relationship of this lymphocyte-induced activity to other known biologic activities mediated by antigen stimulated lymphocytes.

ON MEASURING ELECTRICAL RESISTANCE IN SITU IN HIGHER PLANTS

1966 ◽  
Vol 46 (2) ◽  
pp. 169-175 ◽  
Author(s):  
D. S. Fensom
Keyword(s):  
Cell Wall ◽  
Ion Mobility ◽  
Plant Tissue ◽  
Electrical Resistance ◽  
Higher Plants ◽  
Specific Resistance ◽  
Relationship Of ◽  
The Relationship

Simple but fundamental electrical calculations for resistance are reviewed with a view to their application in studies of plant tissue. The relationship of resistance to ion mobility, to temperature, to specific resistance, and to complex tissue is discussed. It would appear that the specific resistance of complex tissue is largely a measure of the resistances of the cell-wall interstices under ordinary conditions.

Genetic significance of trace elements in certain rocks of Singhbhum, India

1968 ◽  
Vol 36 (281) ◽  
pp. 661-670 ◽  
Author(s):  
Bibhuti Mukherjee
Keyword(s):  
Trace Elements ◽  
Common Source ◽  
Sulphide Ore ◽  
Genetic Significance ◽  
Thrust Zone ◽  
Singhbhum Granite ◽  
Trace Constituents ◽  
Relationship Of ◽  
Basic Rocks ◽  
The Relationship

SummaryThe distribution of trace elements is studied in different acid and basic rocks, adjacent to the copper lodes in the Mosaboni mines, Singhbhum, and adjoining the thrust zone, as well as of areas far away from the mineralized zones. Specific differences in composition and trace constituents in these rocks especially as regards S, Cu, Ni, and Co, suggest that the relationship of the Singhbhum granite with the soda granite is most unlikely, and that there is a connection between the soda granite and the sulphide ore-fluid ; a genetic relationship of sulphide mineralization with the epidiorite is doubtful. The possibility of the existence of a common source for the Chotanagpur granite and the Singhbhum granite is inferred.

Suetonius' Tacitus

2014 ◽  
Vol 104 ◽  
pp. 205-225 ◽  
Author(s):  
Tristan Power
Keyword(s):  
Common Source ◽  
Widespread Belief ◽  
Relationship Of ◽  
The Relationship

AbstractThis article discusses the relationship of Tacitus to his younger contemporary Suetonius, challenging the view that Suetonius wrote a ‘supplement’ to the historian. Scholarly focus on this pair has led to the widespread belief that Suetonius had read Tacitus’Annals,which is unsupported by the evidence. The prevailing consensus that the biographer may at times be subtly criticizing the historian persists in commentaries on Suetonius’Caesars.It is argued that where their two accounts appear to meet, Suetonius is better seen as responding to the earlier common source or sources, or distinguishing himself from the conventions of historiography at large.

The relationship of the scleractinian corals to the rugose corals

Paleobiology ◽  
1980 ◽  
Vol 6 (02) ◽  
pp. 146-160 ◽  
Author(s):  
William A. Oliver
Keyword(s):  
Critical Points ◽  
Scleractinian Corals ◽  
Convincing Evidence ◽  
Early Triassic ◽  
Rugose Corals ◽  
History Of ◽  
The Subject ◽  
Relationship Of ◽  
The Relationship ◽  
Biologic Factors

The Mesozoic-Cenozoic coral Order Scleractinia has been suggested to have originated or evolved (1) by direct descent from the Paleozoic Order Rugosa or (2) by the development of a skeleton in members of one of the anemone groups that probably have existed throughout Phanerozoic time. In spite of much work on the subject, advocates of the direct descent hypothesis have failed to find convincing evidence of this relationship. Critical points are:(1) Rugosan septal insertion is serial; Scleractinian insertion is cyclic; no intermediate stages have been demonstrated. Apparent intermediates are Scleractinia having bilateral cyclic insertion or teratological Rugosa.(2) There is convincing evidence that the skeletons of many Rugosa were calcitic and none are known to be or to have been aragonitic. In contrast, the skeletons of all living Scleractinia are aragonitic and there is evidence that fossil Scleractinia were aragonitic also. The mineralogic difference is almost certainly due to intrinsic biologic factors.(3) No early Triassic corals of either group are known. This fact is not compelling (by itself) but is important in connection with points 1 and 2, because, given direct descent, both changes took place during this only stage in the history of the two groups in which there are no known corals.

Skeletal elements of crinoid echinoderms: High-resolution structural and microanalytical results

1983 ◽  
Vol 41 ◽  
pp. 194-195
Author(s):  
D. F. Blake ◽  
L. F. Allard ◽  
D. R. Peacor
Keyword(s):  
High Resolution ◽  
Marine Invertebrates ◽  
Sea Urchins ◽  
Structural Features ◽  
Sea Stars ◽  
High Resolution Tem ◽  
Relationship Of ◽  
The Relationship ◽  
Insight Into

Echinodermata is a phylum of marine invertebrates which has been extant since Cambrian time (c.a. 500 m.y. before the present). Modern examples of echinoderms include sea urchins, sea stars, and sea lilies (crinoids). The endoskeletons of echinoderms are composed of plates or ossicles (Fig. 1) which are with few exceptions, porous, single crystals of high-magnesian calcite. Despite their single crystal nature, fracture surfaces do not exhibit the near-perfect {10.4} cleavage characteristic of inorganic calcite. This paradoxical mix of biogenic and inorganic features has prompted much recent work on echinoderm skeletal crystallography. Furthermore, fossil echinoderm hard parts comprise a volumetrically significant portion of some marine limestones sequences. The ultrastructural and microchemical characterization of modern skeletal material should lend insight into: 1). The nature of the biogenic processes involved, for example, the relationship of Mg heterogeneity to morphological and structural features in modern echinoderm material, and 2). The nature of the diagenetic changes undergone by their ancient, fossilized counterparts. In this study, high resolution TEM (HRTEM), high voltage TEM (HVTEM), and STEM microanalysis are used to characterize tha ultrastructural and microchemical composition of skeletal elements of the modern crinoid Neocrinus blakei.

Studies on Leukemogenic and Sarcomagenic Viruses

1970 ◽  
Vol 28 ◽  
pp. 156-157
Author(s):  
Leon Dmochowski
Keyword(s):  
Electron Microscopy ◽  
Electron Microscope ◽  
Morphological Properties ◽  
Mode Of Development ◽  
Relationship Of ◽  
The Relationship

Electron microscopy has proved to be an invaluable discipline in studies on the relationship of viruses to the origin of leukemia, sarcoma, and other types of tumors in animals and man. The successful cell-free transmission of leukemia and sarcoma in mice, rats, hamsters, and cats, interpreted as due to a virus or viruses, was proved to be due to a virus on the basis of electron microscope studies. These studies demonstrated that all the types of neoplasia in animals of the species examined are produced by a virus of certain characteristic morphological properties similar, if not identical, in the mode of development in all types of neoplasia in animals, as shown in Fig. 1.

The relationship of IGE receptor topography to signaling activity in RBL-2H3 mast cells

1991 ◽  
Vol 49 ◽  
pp. 236-237
Author(s):  
J.R. Pfeiffer ◽  
J.C. Seagrave ◽  
C. Wofsy ◽  
J.M. Oliver
Keyword(s):  
Mast Cells ◽  
Protein A ◽  
Scattered Electron ◽  
Ige Receptor ◽  
Receptor Complexes ◽  
Ige Binding ◽  
Electron Imaging ◽  
Small Clusters ◽  
Relationship Of ◽  
The Relationship

In RBL-2H3 rat leukemic mast cells, crosslinking IgE-receptor complexes with anti-IgE antibody leads to degranulation. Receptor crosslinking also stimulates the redistribution of receptors on the cell surface, a process that can be observed by labeling the anti-IgE with 15 nm protein A-gold particles as described in Stump et al. (1989), followed by back-scattered electron imaging (BEI) in the scanning electron microscope. We report that anti-IgE binding stimulates the redistribution of IgE-receptor complexes at 37“C from a dispersed topography (singlets and doublets; S/D) to distributions dominated sequentially by short chains, small clusters and large aggregates of crosslinked receptors. These patterns can be observed (Figure 1), quantified (Figure 2) and analyzed statistically. Cells incubated with 1 μg/ml anti-IgE, a concentration that stimulates maximum net secretion, redistribute receptors as far as chains and small clusters during a 15 min incubation period. At 3 and 10 μg/ml anti-IgE, net secretion is reduced and the majority of receptors redistribute rapidly into clusters and large aggregates.

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