EVIDENCE THAT THE L-ASPARAGINASE OF GUINEA PIG SERUM IS RESPONSIBLE FOR ITS ANTILYMPHOMA EFFECTS
1963 ◽
Vol 118
(1)
◽
pp. 99-120
◽
Keyword(s):
A number of the properties of the L-asparaginase present in guinea pig serum have been examined and shown to be indistinguishable from those of the agent responsible for inhibiting cells of lymphoma 6C3HED in vivo. The patterns of instability of the enzyme to changes in temperature and pH were found to parallel closely those of the antilymphoma agent. L-Asparaginase activity was essentially absent from the serum of newborn guinea pigs and this failed to inhibit 6C3HED cells. On separating guinea pig serum proteins by salt precipitation, electrophoresis, and chromatography on DEAE cellulose, antilymphoma activity was found only in fractions which contained L-asparaginase.
1939 ◽
Vol 39
(5)
◽
pp. 471-497
◽
Keyword(s):
1976 ◽
Vol 36
(02)
◽
pp. 401-410
◽
Keyword(s):
1963 ◽
Vol 41
(1)
◽
pp. 1803-1809
Keyword(s):
Keyword(s):
1988 ◽
Vol 65
(6)
◽
pp. 2585-2591
◽
Keyword(s):
1964 ◽
Vol 120
(5)
◽
pp. 967-986
◽
Keyword(s):
1994 ◽
Vol 179
(3)
◽
pp. 881-887
◽
1966 ◽
Vol 123
(1)
◽
pp. 55-74
◽
Keyword(s):
2004 ◽
Vol 72
(1)
◽
pp. 489-497
◽
Keyword(s):