scholarly journals THE PROTECTIVE ACTION OF COPPER AGAINST TRYPANOSOMA EQUIPERDUM INFECTION IN ALBINO RATS

1934 ◽  
Vol 60 (5) ◽  
pp. 541-546 ◽  
Author(s):  
David Perla
Keyword(s):  
Protective Action ◽  
Natural Resistance ◽  
Albino Rats ◽  
Adequate Diet ◽  
Elemental Copper ◽  
Trypanosoma Equiperdum

The effect was studied of additions of copper to an adequate diet on the course of infection with Trypanosoma equiperdum in rats. Copper in amounts equivalent to 0.2 mg. of elemental copper per rat per day during a period of 10 days prior to an induced infection with small numbers of trypanosomes raised the natural resistance of the rat to the infection. The infection was aborted in all instances when the rats were infected by the injection of 2,000 trypanosomes and in 75 per cent of instances when the rats were infected by the injection of 10,000 trypanosomes.

scholarly journals STUDIES ON BARTONELLA MURIS ANEMIA

1932 ◽  
Vol 56 (6) ◽  
pp. 783-792 ◽  
Author(s):  
David Perla ◽  
J. Marmorston-Gottesman
Keyword(s):  
Albino Rats ◽  
Adequate Diet

The effect on Bartonella muris anemia of adding copper or iron or both to an adequate diet was studied. The addition to the diet of copper (0.1 mg. per rat per day), or iron (1 mg. per day), or both during a period of 2 days prior to splenectomy and 1 month subsequent thereto failed to protect adult albino rats against Bartonella muris anemia. The addition of copper to an adequate diet for a period of 10 days prior to splenectomy and 1 month subsequent thereto protected 75 per cent of the rats against the anemia. The addition of iron (1 mg. per rat per day) for a period of 10 days prior to and 1 month subsequent to splenectomy protected 50 per cent of the rats against this anemia. The addition of both copper and iron for a period of 10 days prior to and 1 month subsequent to splenectomy protected 75 per cent of these rats against Bartonella muris anemia. The addition of copper alone for a period of 2 months prior to and 1 month subsequent to splenectomy protected 63 per cent of the rats against Bartonella muris anemia. The addition of iron, or of both copper and iron during a period of 2 months prior to splenectomy and 1 month subsequent thereto protected about one-third of the rats against Bartonella murisanemia.

scholarly journals Evaluation of the role of captopril on clozapine-induced cardiotoxicity and hematotoxicity in adult male albino rats

2017 ◽  
Vol 1 ◽  
pp. 239784731769653
Author(s):  
Omaima I Abdel Hamid ◽  
Marwa G Ahmed ◽  
Hanan MA Hassaneine ◽  
Hayam E Rashed
Keyword(s):  
Bone Marrow ◽  
Adult Male ◽  
Troponin I ◽  
Complete Blood Count ◽  
Enzyme Inhibitor ◽  
Protective Action ◽  
Antioxidant Properties ◽  
Control Group ◽  
Albino Rats ◽  
Group I

Clozapine (CLZ) is considered the most effective drug in treatment of resistant schizophrenia. However, its cardiotoxic effect has raised concerns about its safety. Captopril is a well-known angiotensin-converting enzyme inhibitor with unique antioxidant properties. The aim of this study was to investigate the protective effect of captopril against CLZ-induced myocarditis, and since both drugs have hematotoxic effects, this study aimed to clarify the effect of their combined use on the bone marrow. The study was conducted for 4 weeks on 50 adult male albino rats divided into five groups: group I (negative control), group II (positive control), group III treated with captopril 5 mg/kg/day, group IV treated with CLZ 25 mg/kg/day, and group V treated with captopril (5 mg/kg) 1 hour before CLZ (25 mg/kg/day). CLZ group showed a significant increase in serum troponin I, marked histopathological changes, and immunohistochemical staining of DNA degradation product 8-hydroxy-2-deoxy guanosine (8-OHdG). It significantly increased malondialdehyde level and decreased glutathione peroxidase. Captopril coadministration decreased the histopathological hallmarks and biochemical marker of myocarditis and attenuated CLZ effects on the oxidative stress parameters and 8-OHdG, suggesting its protective action against CLZ-induced myocarditis. Complete blood count and bone marrow evaluation was normal indicating that captopril, in the protective dose given, didn’t increase the risk of CLZ-induced hematotoxicity

scholarly journals Hypolipidemia activity testing protocol or Guizotia Abyssinica Cass. seed oil: An Experimental study report

2021 ◽  
Vol 12 (4) ◽  
pp. 938-942
Author(s):  
Bani Shashikala B ◽  
Mallya Suma V ◽  
Bhat Sudhakara
Keyword(s):  
Seed Oil ◽  
Protective Action ◽  
Low Density Lipoprotein ◽  
Saturated Fat ◽  
Density Lipoprotein ◽  
Albino Rats ◽  
Histopathological Study ◽  
Guizotia Abyssinica ◽  
Compression Method ◽  
Wistar Albino Rats

Hyperlipidemia is characterized by increased level of cholesterol in the form of low-density lipoprotein (LDL), chylomicrons, VLDL. Guizotia abyssinica Cass (Ramtil) seeds are one among the sources for the edible oil, which are low in saturated fat, cultivated commonly in Northern part of Karnataka. Materials and Methods: Guizotia abyssinica Cass (Ramtil) seeds were collected authenticated seed oil extracted by Cold compression method. The experiment carried out in Wistar albino rats, inducing Hyperlipidemia by HFD, along with administration of test drugs (Guizotia abyssinica Cass. seed oil Single and double dose) and Standard Atorvastatin.  Results & Discussion: G. abyssinica Cass seed oil found to decrease total cholesterol and LDL. Even not showed significant increase in HDL. Protective action over the Liver, Kidney and heart through histopathological study exhibit its safety aspect. Conclusion: G. abyssinica Cass seed oil in HFD induced Hyperlipidemia found effective and safe.

scholarly journals FURTHER STUDIES ON T. LEWISI INFECTION IN ALBINO RATS

1930 ◽  
Vol 52 (4) ◽  
pp. 601-616 ◽  
Author(s):  
David Perla ◽  
J. Marmorston-Gottesman
Keyword(s):  
Severe Infection ◽  
Natural Resistance ◽  
Albino Rats ◽  
Subsequent Infection ◽  
Splenic Autotransplantation ◽  
Adult Rat ◽  
Quantitative Estimates ◽  
Protozoan Infection ◽  
Suprarenal Glands ◽  
Old Rats

T. lewisi infection in normal adult 3 month old albino rats raised from a single stock and maintained under identical conditions was studied. Daily quantitative estimates of the trypanosomes in the circulating blood were made and the course of the infection was studied. Bilateral suprarenalectomy in rats lowers the resistance to a subsequent infection with T. lewisi. About 70 per cent of these rats die in an average period of 5.8 days after injection. The multiplication of the parasites, in the circulating stream, however, is not more considerable in the suprarenalectomized than in the previously normal rats, nor is the duration of the disease in the surviving rats any longer than in the normal group. The removal of the suprarenal glands does not alter the immune reaction to the parasite, but lowers the natural resistance of the animal to the toxic effects of the protozoan infection. Bilateral suprarenalectomy does not lessen the immunity of rats recovered from T. lewisi infection to subsequent infection. Unilateral nephrectomy does not influence the course of a subsequent infection with T. lewisi infection. The mortality of splenectomized rats from Bartonella muris anemia increases from 30 to 100 per cent following the injection of T. lewisi at the height of the anemia 7 days after splenectomy. T. lewisi infection 48 days after splenectomy that is to say at a time when the Bartonella anemia is no longer present produces a more severe infection than in normal rats. The number of trypanosomes at the height of infection averages 3 times the ordinary and the infection endures twice as long. Both the immune substance that inhibits the reproduction of the parasite and the lytic factor are markedly depressed. Splenic autotransplantation performed 4 weeks prior to splenectomy raises the resistance of rats to a subsequent T. lewisi infection. Thymectomy in 6 week old rats diminishes the severity of a subsequent trypanosome infection and shortens its course. Both the formation of the immune substance which inhibits reproduction of the trypanosomes and formation of trypanolytic antibodies are stimulated by this procedure. In the adult rat thymectomy shortens the course of the infection but the severity is only slightly diminished. Bilateral gonadectomy in the adult increases the severity of the infection. The number of trypanosomes at the height of the infection is almost three times the normal. However, the duration of the infection is the same as in the normal rats. The reproduction-inhibiting factor is depressed by bilateral gonadectomy but not the trypanocidal factor. Unilateral gonadectomy does not influence the infection.

scholarly journals An experimental evaluation of gastro protective activity of paracetamol on ulcerogenicity of some NSAIDs in albino rats

2017 ◽  
Vol 6 (4) ◽  
pp. 774
Author(s):  
Rajashekar Y. R. ◽  
Shobha S. N.
Keyword(s):  
Gastric Juice ◽  
Protective Action ◽  
Mucosal Damage ◽  
Fixed Dose ◽  
Albino Rats ◽  
Protective Activity ◽  
Total Acid ◽  
Secretory Action ◽  
Uniform Manner ◽  
Therapeutic Doses

Background: Fixed dose combinations (FDCs) of NSAIDs are commonly prescribed and extensively sold over the counter. An indiscriminate usage of them leads to toxicity, mainly involving gastrointestinal system. Paracetamol appears to have controversial reputation regarding its gastro protective action. In this background, the study was planned to evaluate gastro protective effect of paracetamol on the ulcerogenicity of some relatively new NSAIDs in their therapeutic and sub therapeutic doses.Methods: Gatric toxicity and gastric juice analysis- Pyloric ligation method was adopted for assessing the ulcer index of 3 NSAIDs namely aceclofenac, nimesulide and lornoxicam individually and in combination with paracetamol. Gastric juice collected was subjected for total juice volume, free acidity, combined acidity and total acid output.Results: Paracetamol produced non significant gastric damage similar to that of control. When co administered with therapeutic doses of aceclofenac, nimesulide and lornoxicam, there was significant decrease in their gastric toxicity in a uniform manner and the ulcerogenicity of these NSAIDs in sub therapeutic doses was not affected by paracetamol. This upholds the uniform gastro protective activity of paracetamol in this study and this could be explained by its anti acid secretory action on gastric juice.Conclusions: Paracetamol, itself has least gastric damaging property. When co administered with other NSAIDs, their toxicity is rather reduced than enhancing the mucosal damage by them. Thus FDCs of various NSAIDs available in market are partially justifiable.

scholarly journals The relative natural resistance of rats and mice to experimental pulmonary tuberculosis

1961 ◽  
Vol 59 (4) ◽  
pp. 471-478 ◽  
Author(s):  
David F. Gray
Keyword(s):  
Pulmonary Tuberculosis ◽  
Detailed Comparison ◽  
Natural Resistance ◽  
Acquired Immunity ◽  
Albino Rats ◽  
Lung Involvement ◽  
Death Rates ◽  
Significant Difference ◽  
Wistar Albino Rats ◽  
Rats And Mice

1. Wistar-albino rats showed no significant difference from albino mice in their response to pulmonary tuberculosis. This conclusion was reached after a detailed comparison of bacillary multiplication, lung involvement, death rates and the rate of conversion to the immune state as determined by footpad reaction to tuberculin in the two species.2. These findings support the theory that the key to species differences in resistance to tuberculosis is the rate of onset of acquired immunity and it is therefore unrelated to natural resistance.

Sign in / Sign up

Export Citation Format

Share Document