scholarly journals Blinded Case-Control Study of the Relationship between Human Coronavirus NL63 and Kawasaki Syndrome

2006 ◽  
Vol 194 (12) ◽  
pp. 1697-1701 ◽  
Author(s):  
Samuel R.  Dominguez ◽  
Marsha S.  Anderson ◽  
Mary P.  Glodé ◽  
Christine C.  Robinson ◽  
Kathryn V.  Holmes
Keyword(s):  
Pediatric Patients ◽  
Case Control Study ◽  
Matched Control ◽  
Case Control ◽  
Kawasaki Syndrome ◽  
Human Coronavirus ◽  
Control Subjects ◽  
Polymerase Chain ◽  
The Relationship ◽  
Control Study

Abstract We conducted a blinded, case-control, retrospective study in pediatric patients hospitalized at The Children’s Hospital, Denver, Colorado, to determine whether human coronavirus (HCoV)–NL63 infection is associated with Kawasaki syndrome (KS). Over the course of a 7-month period, nasopharyngeal-wash samples from 2 (7.7%) of 26 consecutive children with KS and 4 (7.7%) of 52 matched control subjects tested positive for HCoV-NL63 by reverse transcription–polymerase chain reaction. These data suggest that, although HCoV-NL63 was circulating in children in our community during the time of the study, the prevalence of infection with HCoV-NL63 was not greater in patients with KS than in control subjects.

scholarly journals Case Control Study of Cerebrovascular Damage Defined by Magnetic Resonance Imaging in Patients with OSA and Normal Matched Control Subjects

SLEEP ◽  
2001 ◽  
Vol 24 (6) ◽  
pp. 715-720 ◽  
Author(s):  
Christopher W.H. Davies ◽  
Joy H. Crosby ◽  
Rebecca L. Mullins ◽  
Zoë C. Traill ◽  
Philip Anslow ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Case Control Study ◽  
Matched Control ◽  
Case Control ◽  
Resonance Imaging ◽  
Control Subjects ◽  
Control Study

scholarly journals Frequency of HLA-DRB1 Gene Alleles in Patients With Multiple Sclerosis in a Lithuanian Population

Medicina ◽  
2012 ◽  
Vol 48 (1) ◽  
pp. 2
Author(s):  
Renata Balnytė ◽  
Daiva Rastenytė ◽  
Dalia Mickevičienė ◽  
Antanas Vaitkus ◽  
Erika Skrodenienė ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Case Control Study ◽  
Case Control ◽  
Chain Reaction ◽  
Female Patients ◽  
History Of ◽  
Male Patients ◽  
Polymerase Chain ◽  
The Relationship ◽  
Control Study

The aim of the present study was to investigate the influence of HLA-DRB1 alleles on the genetic susceptibility to multiple sclerosis in the Lithuanian population. Material and Methods. A total of 120 patients with multiple sclerosis and 120 unrelated healthy controls were enrolled in this case-control study. Allelic frequencies were compared between the groups. HLA-DRB1 alleles were genotyped using the polymerase chain reaction. Results. HLA-DRB1*15 was present in 55.8% of the patients with multiple sclerosis and 10.0% of the controls (OR, 5.58; 95% CI, 3.19–9.77; P<0.0001). The protective alleles that were found to be more prevalent among the controls compared with the patients with multiple sclerosis were HLADRB1* 01 (26.7% vs. 7.5%, P<0.0001), *03 (17.5% vs. 8.3%, P=0.034), and *16 (11.7% vs. 3.3%, P=0.014). HLA-DRB1*15 was more common among the female patients with multiple sclerosis than among the male patients (68.4% vs. 34.1%; OR, 4.18; 95%, CI 1.90–9.22; P=0.001). The heterozygous inheritance of HLA-DRB1*15 allele was more common in the patients with a history of maternal multiple sclerosis than in those with a history of paternal multiple sclerosis (29.4% vs. 9.8%; P=0.045). Conclusions. HLA-DRB1*15 was found to be associated with multiple sclerosis in the Lithuanian population. This allele was more prevalent among the female patients with multiple sclerosis. Maternal multiple sclerosis was more common than paternal multiple sclerosis, but the relationship with HLA-DRB1*15 allele was not established. HLA-DRB1*01, *03, and *16 appeared to be the protective alleles in this series.

scholarly journals Is Gout Associated with Pyoderma Gangrenosum? A Population-Based Case-Control Study

2020 ◽  
Vol 9 (6) ◽  
pp. 1626 ◽  
Author(s):  
Khalaf Kridin ◽  
Ralf J. Ludwig ◽  
Dana Tzur Bitan ◽  
Mouhammad Kridin ◽  
Giovanni Damiani ◽  
...  
Keyword(s):  
Pyoderma Gangrenosum ◽  
Regression Models ◽  
Case Control Study ◽  
Matched Control ◽  
Population Based ◽  
Case Control ◽  
Significant Independent Predictor ◽  
Logistic Regression Models ◽  
Control Subjects ◽  
Control Study

The coexistence of pyoderma gangrenosum (PG) and gout has been reported in individual patients; however, the association between these conditions has not been investigated. We aimed to assess the association between PG and gout and to examine whether the presence of gout predisposes to the development of PG. A population-based case-control study was conducted comparing PG patients (n = 302) with age-, sex-, and ethnicity-matched control subjects (n = 1497) with respect to the presence of preceding gout. Logistic regression models were utilized for univariate and multivariate analyses. The prevalence of preceding gout was greater in patients with PG than in control subjects (3.7% vs. 0.7%, respectively; p < 0.001). Gout was associated with a more than fivefold increase in the risk of PG (OR, 5.15; 95% CI, 2.21–11.98). After adjusting for confounding factors, gout emerged as a significant independent predictor of PG (adjusted OR, 4.08; 95% CI, 1.69–9.80). Gout preceded the diagnosis of PG by a median latency of 4.6 years. Patients with gout-associated PG were older, predominantly male, and had a higher prevalence of metabolic syndrome than other patients with PG. In conclusion, gout increases the risk of developing PG by more than fivefold. Physicians managing patients with gout and PG should be aware of this emerging association.

scholarly journals The Relationship between Stress and Severe Obesity: A Case-Control Study

2017 ◽  
Vol 2 (1) ◽  
pp. 1-13 ◽  
Author(s):  
Marja Koski ◽  
Hannu Naukkarinen
Keyword(s):  
Severe Obesity ◽  
Case Control Study ◽  
Case Control ◽  
Stress Factors ◽  
Control Group ◽  
Study Group ◽  
Valuable Insight ◽  
Control Subjects ◽  
The Relationship ◽  
Control Study

Background: Several etiological factors for obesity have been identified, whereas other factors related to obesity, such as stress, remain poorly understood. This study used psychiatric methods to examine the relationship between stress and obesity. Methods: Matched study and control groups were established, and the female and male control subjects were selected separately by random sampling. The control subjects were matched with the case subjects with respect to place of residence, sex, age, date that a pension was granted, and occupation. Psychiatric and psychological methods were assessed using a questionnaire and statistical analyses. Results: Psychiatric interviews indicated that stress was more prevalent in the study group than in the control group. Separation from parents was nearly significantly more frequently in the study group than in the control group. The questionnaire on coping mechanisms revealed that case subjects tended to resolve their problems in an active manner. Conclusions: The aim of this case-control study was to examine the relationship between stress and obesity in individuals receiving a disability pension. We identified stress factors that affect the development of obesity. We believe our study is both necessary and important, as these findings provide valuable insight into the relationship between severe obesity and stress.

scholarly journals Plasma BNP (B-Type Natriuretic Peptide) and Heart Failure: A Case-Control Study

1970 ◽  
Vol 11 (1) ◽  
pp. 46-50
Author(s):  
Parvin Sultana ◽  
Md Mozammel Hoque ◽  
Samina Shafiullah
Keyword(s):  
Heart Failure ◽  
Natriuretic Peptide ◽  
Case Control Study ◽  
Matched Control ◽  
Objective Evaluation ◽  
Case Control ◽  
Control Subjects ◽  
Median Plasma ◽  
Cardiac Ventricles ◽  
Control Study

Background: Accurate diagnosis of heart failure (HF) is essential for its proper management and logical drug therapy to reduce morbidity and mortality. In this perspective, researchers are in search of a good biomarker as complementary to the clinical parameters to improve the performance of HF diagnosis. B-type natriuretic peptide (BNP) secreted by cardiac ventricles in HF has emerged as a new promising biomarker in this regard. Objective: Evaluation of plasma BNP concentration in HF cases. Methods: In a hospital based case-control study, 100 HF cases and 80 age and sex matched control subjects without HF were enrolled by non random sampling. Plasma BNP was measured in all study subjects and then compared between cases and controls. Results: Median plasma BNP concentration in HF (446.5pg/ml, range 16.8-4000pg/ml) found to be significantly high compared to that in control subjects (69.5pg/ml, range 0.6-627.5pg/ml). Conclusion: In HF patients, plasma BNP is raised significantly. So it can be a promising biomarker for diagnosis of HF. Keywords: B-type natriuretic peptide, heart failure DOI:10.3329/jom.v11i1.4268 J Medicine 2010: 11: 46-50

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