Measuring the Impact of Using Different Tools on Classification System Results

The purpose of this study was to develop an environmental database for construction finish materials organized by building element as part of an effort to develop an environmental effect assessment program for buildings. To this end, a classification system has been developed for building elements that satisfies the demands from construction project stakeholders to acquire environmental information. Furthermore, among the construction materials, an environmental database of the finish materials has been developed for each building element based on reference substances and the impact indexes of six environmental effect categories of the national LCI DB.

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The impact of impairment on kinematic and kinetic variables in Va’a paddling: Towards a sport-specific evidence-based classification system for Para Va’a

Journal of Sports Sciences ◽

10.1080/02640414.2019.1606763 ◽

2019 ◽

Vol 37 (17) ◽

pp. 1942-1950 ◽

Cited By ~ 2

Author(s):

Johanna S. Rosén ◽

Anton Arndt ◽

Victoria L. Goosey-Tolfrey ◽

Barry S. Mason ◽

Michael J. Hutchinson ◽

...

Keyword(s):

Classification System ◽

Evidence Based ◽

The Impact

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Abstract 038: A Novel Histology Based Classification System to Identify Patients at Risk for Postoperative Atrial Fibrillation

Circulation Research ◽

10.1161/res.113.suppl_1.a038 ◽

2013 ◽

Vol 113 (suppl_1) ◽

Author(s):

Mahek Mirza ◽

Anton Strunets ◽

Ekhson Holmuhamedov ◽

Jasbir Sra ◽

Paul H Werner ◽

...

Keyword(s):

Atrial Fibrillation ◽

At Risk ◽

Classification System ◽

Area Under The Curve ◽

Postoperative Atrial Fibrillation ◽

Right Atrial ◽

Class Iii ◽

Atrial Fibrosis ◽

Patients At Risk ◽

The Impact

Postoperative atrial fibrillation (PoAF) is a common complication in up to 40% of patients after cardiac surgery, increasing morbidity, hospital stay and costs. The myocardial substrate underlying PoAF is not fully characterized. The objective was to assess the impact of atrial fibrosis on incident AF and define the fibrosis threshold level predictive of PoAF. Methods: Right atrial appendages removed from patients undergoing elective CABG with no history of AF or class III/IV heart failure were used to characterize the ratio of collagen to myocardium (Masson’s trichrome; NIH ImageJ software; Fig A), which was correlated with incident AF. Percentage burden of fibrosis predictive of PoAF with high sensitivity and specificity was determined by ROC curve. Results: Of 28 patients (67±10 years, 64% males), 15 had PoAF. There were no age, gender or comorbidity differences between groups. Compared to the group that remained in sinus rhythm, patients with PoAF had a significantly higher ratio of extracellular collagen to myocardium (45±16% vs. 5±4%, p <0.001; Fig B). A threshold ratio of 12.7% collagen to myocardium (ROC area under the curve 0.997; z statistic 137; P<0.0001) with 96% sensitivity and 97% specificity identified those with PoAF (Fig C). A classification system based on histological extent of atrial fibrosis is proposed for identifying patients at risk for PoAF (Fig D). Conclusion: Ongoing studies will confirm the predictive value of this new classification system for identifying the atrial substrate predisposing PoAF and correlate with preoperative cardiac imaging and circulatory serum biomarkers to provide a novel noninvasive tool to stratify patients at risk for PoAF.

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A Classification System for Hospital-Based Infection Outbreaks

Computational and Mathematical Methods in Medicine ◽

10.1080/17486701003670833 ◽

2010 ◽

Vol 11 (4) ◽

pp. 297-311

Author(s):

Paul S. Ganney ◽

Maurice Madeo ◽

Roger Phillips

Keyword(s):

Staphylococcus Aureus ◽

Clostridium Difficile ◽

Classification System ◽

Goodness Of Fit ◽

Computer Models ◽

New Classification ◽

The Impact

Outbreaks of infection within semi-closed environments such as hospitals, whether inherent in the environment (such as Clostridium difficile (C.Diff) or Methicillinresistant Staphylococcus aureus (MRSA) or imported from the wider community (such as Norwalk-like viruses (NLVs)), are difficult to manage. As part of our work on modelling such outbreaks, we have developed a classification system to describe the impact of a particular outbreak upon an organization. This classification system may then be used in comparing appropriate computer models to real outbreaks, as well as in comparing different real outbreaks in, for example, the comparison of differing management and containment techniques and strategies. Data from NLV outbreaks in the Hull and East Yorkshire Hospitals NHS Trust (the Trust) over several previous years are analysed and classified, both for infection within staff (where the end of infection date may not be known) and within patients (where it generally is known). A classification system consisting of seven elements is described, along with a goodness-of-fit method for comparing a new classification to previously known ones, for use in evaluating a simulation against history and thereby determining how ‘realistic’ (or otherwise) it is.

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Diffuse Large B-Cell Lymphoma Classification System That Associates Normal B-Cell Subset Phenotypes With Prognosis

Journal of Clinical Oncology ◽

10.1200/jco.2014.57.7080 ◽

2015 ◽

Vol 33 (12) ◽

pp. 1379-1388 ◽

Cited By ~ 52

Author(s):

Karen Dybkær ◽

Martin Bøgsted ◽

Steffen Falgreen ◽

Julie S. Bødker ◽

Malene K. Kjeldsen ◽

...

Keyword(s):

B Cell ◽

Classification System ◽

Cell Lymphoma ◽

Positive Impact ◽

Cell Subset ◽

Progression Free Survival ◽

B Cell Lymphoma ◽

Large B Cell Lymphoma ◽

The Impact ◽

Large B Cell

Purpose Current diagnostic tests for diffuse large B-cell lymphoma use the updated WHO criteria based on biologic, morphologic, and clinical heterogeneity. We propose a refined classification system based on subset-specific B-cell–associated gene signatures (BAGS) in the normal B-cell hierarchy, hypothesizing that it can provide new biologic insight and diagnostic and prognostic value. Patients and Methods We combined fluorescence-activated cell sorting, gene expression profiling, and statistical modeling to generate BAGS for naive, centrocyte, centroblast, memory, and plasmablast B cells from normal human tonsils. The impact of BAGS-assigned subtyping was analyzed using five clinical cohorts (treated with cyclophosphamide, doxorubicin, vincristine, and prednisone [CHOP], n = 270; treated with rituximab plus CHOP [R-CHOP], n = 869) gathered across geographic regions, time eras, and sampling methods. The analysis estimated subtype frequencies and drug-specific resistance and included a prognostic meta-analysis of patients treated with first-line R-CHOP therapy. Results Similar BAGS subtype frequencies were assigned across 1,139 samples from five different cohorts. Among R-CHOP–treated patients, BAGS assignment was significantly associated with overall survival and progression-free survival within the germinal center B-cell–like subclass; the centrocyte subtype had a superior prognosis compared with the centroblast subtype. In agreement with the observed therapeutic outcome, centrocyte subtypes were estimated as being less resistant than the centroblast subtype to doxorubicin and vincristine. The centroblast subtype had a complex genotype, whereas the centrocyte subtype had high TP53 mutation and insertion/deletion frequencies and expressed LMO2, CD58, and stromal-1–signature and major histocompatibility complex class II–signature genes, which are known to have a positive impact on prognosis. Conclusion Further development of a diagnostic platform using BAGS-assigned subtypes may allow pathogenetic studies to improve disease management.

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A qualitative exploration of Bahrain and Kuwait herbal medicine registration systems: policy implementation and readiness to change

Journal of Pharmaceutical Policy and Practice ◽

10.1186/s40545-019-0189-7 ◽

2019 ◽

Vol 12 (1) ◽

Cited By ~ 2

Author(s):

Azhar H. Alostad ◽

Douglas T. Steinke ◽

Ellen I. Schafheutle

Keyword(s):

Classification System ◽

Policy Development ◽

Readiness To Change ◽

Implementation Process ◽

Arab Countries ◽

Successful Implementation ◽

Registration System ◽

Regulatory Policies ◽

Registration Process ◽

The Impact

Abstract Background The Kuwaiti drug regulatory authority (DRA) lack a structured classification system for the assessment of imported herbal medicines (HMs), which leads to ambiguity in the registration process. This study aimed to examine the policy development and implementation process in an established HM registration system (Bahrain) and harness lessons to inform recommendations for a suitable HM classification system and explore implementation readiness in Kuwait. Methods A sequential study design was chosen, with data collected in Bahrain (case 1), recommendations formed and readiness for implementation explored subsequently in Kuwait (case 2). With ethics and DRA approval in place, data sources were documentary review of regulatory policies, direct observations of HMs registration processes, and semi-structured interviews with twenty three key officials involved in the HMs registration processes. Data from all three sources were analysed thematically and findings triangulated. Results The classification policy in Bahrain was found to be based on evidence and extensive stakeholder engagement, resulting in a clear and organised HM registration process. The availability of HMs classification policies in other DRAs, officials’ dedication and teamwork, and support by higher authority, were identified as the main facilitators in policy development and successful implementation. Barriers were the diversity of HM classifications worldwide, a lack of staff and resultant workload, and lack of training. Proposed recommendations for Kuwait were to adopt a clear definition of what constituted HMs, and to introduce a Traditional Herbal Registration based on this definition and the product’s characteristics. Interviews in Kuwait showed that almost all participants were in favour of the proposed recommendations and were in support of timely implementation. Interviewees anticipated that consistency in the HM registration process would be the main benefit, increasing reviewer’s confidence in making regulatory decisions. Interviewees also identified potential challenges which may impede successful implementation, including staff shortages, resistance to change by internal and external stakeholders, and the impact of cultural and traditional ways of working. Conclusions Insights into the HM policy development and implementation process in Bahrain, and exploration of Kuwait’s readiness to implement resultant recommendations informed an effective implementation process for a well-designed HMs policy for Kuwait and other Arab countries.

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The impact of the latest classification system of benign vulvar diseases on the management of women with chronic vulvar pruritus

Indian Journal of Dermatology Venereology and Leprology ◽

10.4103/0378-6323.79698 ◽

2011 ◽

Vol 77 (3) ◽

pp. 294 ◽

Cited By ~ 2

Author(s):

KiymetHandan Kelekci ◽

Fulya Adamhasan ◽

Servet Gencdal ◽

Hamide Sayar ◽

Sefa Kelekci

Keyword(s):

Classification System ◽

Vulvar Diseases ◽

The Impact

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Morbidity profile following aggressive resection of parietal lobe gliomas

Journal of Neurosurgery ◽

10.3171/2012.2.jns111228 ◽

2012 ◽

Vol 116 (6) ◽

pp. 1182-1186 ◽

Cited By ~ 37

Author(s):

Nader Sanai ◽

Juan Martino ◽

Mitchel S. Berger

Keyword(s):

Classification System ◽

Tumor Volume ◽

Parietal Lobe ◽

Tumor Resection ◽

High Rate ◽

Low Grade ◽

High Grade ◽

Language Pathways ◽

The Impact ◽

Glioma Classification

Object The impact of parietal lobe gliomas is typically studied in the context of parietal lobe syndromes. However, critical language pathways traverse the parietal lobe and are susceptible during tumor resection. The authors of this study reviewed their experience with parietal gliomas to characterize the impact of resection and the morbidity associated with language. Methods The study population included adults who had undergone resection of parietal gliomas of all grades. Tumor location was identified according to a proposed classification system for parietal region gliomas. Low- and high-grade tumors were volumetrically analyzed using FLAIR and T1-weighted contrast-enhanced MR imaging. Results One hundred nineteen patients with parietal gliomas were identified—34 with low-grade gliomas and 85 with high-grade gliomas. The median patient age was 45 years, and most patients (53) presented with seizures, whereas only 4 patients had an appreciable parietal lobe syndrome. The median preoperative tumor volume was 31.3 cm3, the median extent of resection was 96%, and the median postoperative tumor volume was 0.9 cm3. Surprisingly, the most common early postoperative neurological deficit was dysphasia (16 patients), not weakness (12 patients), sensory deficits (14 patients), or parietal lobe syndrome (10 patients). A proposed parietal glioma classification system, based on surgical anatomy, was predictive of language deficits. Conclusions This is the largest reported experience with parietal lobe gliomas. The findings suggested that parietal language pathways are compromised at a surprisingly high rate. The proposed parietal glioma classification system is predictive of postoperative morbidity associated with language and can assist with preoperative planning. Taken together, these data emphasize the value of identifying language pathways when operating within the parietal lobe.

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MANAGEMENT OF PROJECTS FOR ORGANIZATION DEVELOPMENT ON THE BASIS OF ENTREPRENEURSHIP

International Journal of Computing ◽

10.47839/ijc.13.4.635 ◽

2014 ◽

pp. 221-226

Author(s):

Sergey D. Bushuyev ◽

Magomed Zh. Ozdoyev

Keyword(s):

Organization Development ◽

Classification System ◽

System Model ◽

Energy Sources ◽

Development Projects ◽

Successful Completion ◽

Mathematical Structures ◽

External Sources ◽

Main Factors ◽

The Impact

The success of organization development projects depends on the competence of organizations in managing of its projects and entrepreneurship that is formed by the leadership of the organization which support progress towards successful completion of the projects. Entrepreneurial energy is generated and reproduced through internal and external sources. Set of entrepreneurial energy sources mathematically modelled by means of a set equipped with additional mathematical structures (metrics, topology, etc.). The studies is formulated as a project management for the development of organizations through the creation and reproduction of entrepreneurial energy of the parties concerned under operational and project activities of the organization in order to build effective mechanisms for the development of the organization. System model of development projects in a general approach to the use of business energy that will include absolutely heterogeneous concept reflecting energy sources. The structure of entrepreneurial energy is multidimensional. The main factors that shape the classification system of entrepreneurial energy are: types of entrepreneurial energy, sources and types of energy carriers, catalysts and inhibitors of the application of entrepreneurial energy in development projects, as well as indicators of the impact of the projects context.

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