scholarly journals Research on Design Electrode Channel in Microfluidic Chip

2021 ◽  
Vol 2065 (1) ◽  
pp. 012014
Author(s):  
Zhou yingmei ◽  
Lv Jian
Keyword(s):  
Food Safety ◽  
Clinical Diagnosis ◽  
Microfluidic Chip ◽  
Channel Height ◽  
Microfluidic Chips ◽  
Digital Microfluidic ◽  
Environment Detection ◽  
Method Of Design

Abstract In recent years, microfluidic chips have been widely used in food safety, environment detection, clinical diagnosis and biochemical. However, Digital microfluidic chips(DMF) are attracting more and more eyes because picoliter-microliter-sized sample droplets can be accurately and automatically manipulated. In this paper, a method of design electrode channel height is studied to improve the efficiency of the voltage driving.

Drop driving on digital microfluidic chip

2020 ◽  
Vol 28 (11) ◽  
pp. 2488-2496
Author(s):  
Hong WANG ◽  
◽  
Jie ZHENG ◽  
Yan-peng YAN ◽  
Song WANG ◽  
...  
Keyword(s):  
Microfluidic Chip ◽  
Digital Microfluidic

Study on the Manufacture of Microfluidic Chip with Coated Glass

2012 ◽  
Vol 548 ◽  
pp. 254-257 ◽  
Author(s):  
Yan He ◽  
Bai Ling Huang ◽  
Yong Lai Zhang ◽  
Li Gang Niu
Keyword(s):  
Microfluidic Chip ◽  
Low Cost ◽  
Microfluidic Channel ◽  
Critical Factor ◽  
Wet Etching ◽  
Microfluidic Chips ◽  
Etching Technique ◽  
Chip Quality ◽  
Wet Chemical ◽  
Wet Chemical Etching

In this paper, a simple and facile technique for manufacturing glass-based microfluidic chips was developed. Instead of using expensive dry etching technology, the standard UV lithography and wet chemical etching technique was used to fabricate microchannels on a K9 glass substrate. The fabrication process of microfluidic chip including vacuum evaporation, annealing, lithography, and BHF (HF-NH4F-H2O) wet etching were investigated. Through series experiments, we found that anneal was the critical factor for chip quality. As a representative example, a microfluidic channel with 20 m of depth, and 80 m of width was successfully prepared, and the channel surfaces are quite smooth. These results present a simple, low cost, flexible and easy way to fabricate glass-based microfluidic chips.

An integrated digital microfluidic chip for multiplexed proteomic sample preparation and analysis by MALDI-MS

Lab on a Chip ◽  
2006 ◽  
Vol 6 (9) ◽  
pp. 1213 ◽  
Author(s):  
Hyejin Moon ◽  
Aaron R. Wheeler ◽  
Robin L. Garrell ◽  
Joseph A. Loo ◽  
Chang-Jin ?CJ? Kim
Keyword(s):  
Sample Preparation ◽  
Microfluidic Chip ◽  
Maldi Ms ◽  
Digital Microfluidic

Design and Fabrication of Micro Hot Embossing Mold for Microfluidic Chip Used in Flow Cytometry

2007 ◽  
Vol 339 ◽  
pp. 246-251
Author(s):  
L.Q. Du ◽  
C. Liu ◽  
H.J. Liu ◽  
J. Qin ◽  
N. Li ◽  
...  
Keyword(s):  
Flow Cytometry ◽  
Microfluidic Chip ◽  
Low Cost ◽  
Hot Embossing ◽  
Microfluidic Chips ◽  
Metal Mold ◽  
Nickel Electroforming ◽  
Thick Photoresist ◽  
Nickel Base ◽  
Microfabrication Technology

Micro hot embossing mold of microfluidic chip used in flow cytometry is designed and microfabricated. After some kinds of microfabrication processes are tried, this paper presents a novel microfabrication technology of micro hot embossing metal mold. Micro metal mold is fabricated by low-cost UV-LIGA surface micro fabrication process using negative thick photoresist, SU-8. Different from other micro hot embossing molds, the micro mold with vertical sidewalls is fabricated by micro nickel electroforming directly on Nickel base. Based on the micro Nickel mold and automation fabrication system, high precision and mass-producing microfluidic chips have been fabricated and they have been used in flow cytometry

Surface Microfabrication of Conventional Glass Using Femtosecond Laser for Microfluidic Applications

2017 ◽  
Vol 11 (6) ◽  
pp. 878-882 ◽  
Author(s):  
Takuma Niioka ◽  
◽  
Yasutaka Hanada
Keyword(s):  
High Resolution ◽  
Microfluidic Chip ◽  
High Speed ◽  
Single Cell Analysis ◽  
Glass Slide ◽  
Cell Analysis ◽  
Microfluidic Chips ◽  
Direct Writing ◽  
Laser Direct Writing ◽  
Fs Laser

Recently, a lot of attention has been paid to a single-cell analysis using microfluidic chips, since each cell is known to have several different characteristics. The microfluidic chip manipulates cells and performs high-speed and high-resolution analysis. In the meanwhile, femtosecond (fs) laser has become a versatile tool for the fabrication of microfluidic chips because the laser can modify internal volume solely at the focal area, resulting in three-dimensional (3D) microfabrication of glass materials. However, little research on surface microfabrication of materials using an fs laser has been conducted. Therefore, in this study, we demonstrate the surface microfabrication of a conventional glass slide using fs laser direct-writing for microfluidic applications. The fs laser modification, with successive wet etching using a diluted hydrofluoric (HF) acid solution, followed by annealing, results in rapid prototyping of microfluidics on a conventional glass slide for fluorescent microscopic cell analysis. Fundamental characteristics of the laser-irradiated regions in each experimental procedure were investigated. In addition, we developed a novel technique combining the fs laser direct-writing and the HF etching for high-speed and high-resolution microfabrication of the glass. After establishing the fs laser surface microfabrication technique, a 3D microfluidic chip was made by bonding the fabricated glass microfluidic chip with a polydimethylsiloxane (PDMS) polymer substrate for clear fluorescent microscopic observation in the microfluidics.

A Microfluidic Device for Sample Pretreatment by Laminar Flow Extraction

2014 ◽  
Vol 511-512 ◽  
pp. 8-11
Author(s):  
Da Lei Li ◽  
Xue Fei Lv ◽  
Yu Lin Deng
Keyword(s):  
Aqueous Solution ◽  
Laminar Flow ◽  
Microfluidic Device ◽  
Microfluidic Chip ◽  
Extraction Efficiency ◽  
Sample Pretreatment ◽  
Microfluidic Chips ◽  
Two Phase ◽  
Phase Fluid ◽  
Potential Tool

Microfluidic chip is the most active field and frontier of μTAS. In comparison to other aspects of researches on microfluidic chips, the work on sample pretreatment units are in the preliminary stage. In this study, a microfluidic device for extraction was devised and fabricated. The extraction efficiency of the microfluidic device was investigated by two phase fluid 0.1% Rhodamine-B aqueous solution and Hexyl alcohol. The results demonstrated that the microfluidic chip worked well in the first two days and might be integrated in a complex chip as a potential tool for sample pretreatment.

Paper-Based Digital Microfluidic Chip for Multiple Electrochemical Assay Operated by a Wireless Portable Control System

2017 ◽  
Vol 2 (3) ◽  
pp. 1600267 ◽  
Author(s):  
Nipapan Ruecha ◽  
Jumi Lee ◽  
Heedo Chae ◽  
Haena Cheong ◽  
Veasna Soum ◽  
...  
Keyword(s):  
Control System ◽  
Microfluidic Chip ◽  
Electrochemical Assay ◽  
Digital Microfluidic

An Inertia-Deformability Hybrid Circulating Tumor Cell Chip: Design, Clinical Test, and Numerical Analysis

2018 ◽  
Vol 12 (4) ◽  
Author(s):  
Hongmei Chen ◽  
Zhifeng Zhang
Keyword(s):  
Microfluidic Chip ◽  
Nonsmall Cell Lung Cancer ◽  
Circulating Tumor Cell ◽  
Capture Efficiency ◽  
Cancer Prognosis ◽  
Clinical Test ◽  
Microfluidic Chips ◽  
Dean Number ◽  
Chip Design ◽  
Cell Chip

Detection and capture of circulating tumor cells (CTCs) with microfluidic chips hold significance in cancer prognosis, diagnosis, and anti-cancer treatment. The counting of CTCs provides potential tools to evaluate cancer stages as well as treatment progress. However, facing the challenge of rareness in blood, the precise enumeration of CTCs is challenging. In the present research, we designed an inertial-deformability hybrid microfluidic chip using a long spiral channel with trapezoid-circular pillars and a capture zone. To clinically validate the device, the microfluidic chip has been tested for the whole blood and lysed blood with a small number of CTCs (colorectal and nonsmall-cell lung cancer) spiked in. The capture efficiency reaches over 90% for three types of cancer cell lines at the flow rate of 1.5 mL/h. Following numerical modeling was conducted to explain the working principle and working condition (Reynolds number below 10 and Dean number around 1). This design extended the effective capture length, improved the capture efficiency, and made the CTC enumeration much easier. We believe that this hybrid chip is promising clinically in the CTCs enumeration, evaluation of cancer therapy, and pharmacological responses.

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