scholarly journals Quantum Control of Electron Wavepacket Dynamics in Molecules by Trains of Half-Cycle Pulses

2012 ◽  
Vol 388 (1) ◽  
pp. 012033
Author(s):  
Georg Wachter ◽  
Emil Persson ◽  
Markus Pichler ◽  
Thomas Hisch ◽  
Joachim Burgdörfer ◽  
...  
2009 ◽  
Vol 11 (10) ◽  
pp. 105035 ◽  
Author(s):  
Emil Persson ◽  
Joachim Burgdörfer ◽  
Stefanie Gräfe

2011 ◽  
Vol 84 (4) ◽  
Author(s):  
Emil Persson ◽  
Markus Pichler ◽  
Georg Wachter ◽  
Thomas Hisch ◽  
Werner Jakubetz ◽  
...  

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Qiaoping Xu ◽  
Li Yuanyuan ◽  
Zhu Jiejing ◽  
Liu Jian ◽  
Li Qingyu ◽  
...  

Abstract Background Breast cancer is the most common cancer among women in China. Amplification of the Human epidermal growth factor receptor type 2 (HER2) gene is present and overexpressed in 18–20% of breast cancers and historically has been associated with inferior disease-related outcomes. There has been increasing interest in de-escalation of therapy for low-risk disease. This study analyzes the cost-effectiveness of Doxorubicin/ Cyclophosphamide/ Paclitaxel/ Trastuzumab (AC-TH) and Docetaxel/Carboplatin/Trastuzumab(TCH) from payer perspective over a 5 year time horizon. Methods A half-cycle corrected Markov model was built to simulate the process of breast cancer events and death occurred in both AC-TH and TCH armed patients. Cost data came from studies based on a Chinese hospital. One-way sensitivity analyses as well as second-order Monte Carlo and probabilistic sensitivity analyses were performed.The transition probabilities and utilities were extracted from published literature, and deterministic sensitivity analyses were conducted. Results We identified 41 breast cancer patients at Hangzhou First People’s Hospital, among whom 15 (60%) had a partial response for AC-TH treatment and 13 (81.25%) had a partial response for TCH treatment.No cardiac toxicity was observed. Hematologic grade 3 or 4 toxicities were observed in 1 of 28 patients.Nonhematologic grade 3 or 4 toxicities with a reverse pattern were observed in 6 of 29 patients. The mean QALY gain per patient compared with TCH was 0.25 with AC-TH, while the incremental costs were $US13,142. The incremental cost-effectiveness ratio (ICER) of AC-TH versus TCH was $US 52,565 per QALY gained. Conclusions This study concluded that TCH neoadjuvant chemotherapy was feasible and active in HER2-overexpressing breast cancer patients in terms of the pathological complete response, complete response, and partial response rates and manageable toxicities.


1999 ◽  
Vol 10 (07) ◽  
pp. 1205-1228 ◽  
Author(s):  
E. V. KRISHNAMURTHY

The important requirements are stated for the success of quantum computation. These requirements involve coherent preserving Hamiltonians as well as exact integrability of the corresponding Feynman path integrals. Also we explain the role of metric entropy in dynamical evolutionary system and outline some of the open problems in the design of quantum computational systems. Finally, we observe that unless we understand quantum nondemolition measurements, quantum integrability, quantum chaos and the direction of time arrow, the quantum control and computational paradigms will remain elusive and the design of systems based on quantum dynamical evolution may not be feasible.


2003 ◽  
Vol 118 (8) ◽  
pp. 3692-3701 ◽  
Author(s):  
T. Brixner ◽  
N. H. Damrauer ◽  
B. Kiefer ◽  
G. Gerber
Keyword(s):  

Author(s):  
Patrícia Tonon ◽  
Rodolfo André Kuche Sanches ◽  
Kenji Takizawa ◽  
Tayfun E. Tezduyar

AbstractGood mesh moving methods are always part of what makes moving-mesh methods good in computation of flow problems with moving boundaries and interfaces, including fluid–structure interaction. Moving-mesh methods, such as the space–time (ST) and arbitrary Lagrangian–Eulerian (ALE) methods, enable mesh-resolution control near solid surfaces and thus high-resolution representation of the boundary layers. Mesh moving based on linear elasticity and mesh-Jacobian-based stiffening (MJBS) has been in use with the ST and ALE methods since 1992. In the MJBS, the objective is to stiffen the smaller elements, which are typically placed near solid surfaces, more than the larger ones, and this is accomplished by altering the way we account for the Jacobian of the transformation from the element domain to the physical domain. In computing the mesh motion between time levels $$t_n$$ t n and $$t_{n+1}$$ t n + 1 with the linear-elasticity equations, the most common option is to compute the displacement from the configuration at $$t_n$$ t n . While this option works well for most problems, because the method is path-dependent, it involves cycle-to-cycle accumulated mesh distortion. The back-cycle-based mesh moving (BCBMM) method, introduced recently with two versions, can remedy that. In the BCBMM, there is no cycle-to-cycle accumulated distortion. In this article, for the first time, we present mesh moving test computations with the BCBMM. We also introduce a version we call “half-cycle-based mesh moving” (HCBMM) method, and that is for computations where the boundary or interface motion in the second half of the cycle consists of just reversing the steps in the first half and we want the mesh to behave the same way. We present detailed 2D and 3D test computations with finite element meshes, using as the test case the mesh motion associated with wing pitching. The computations show that all versions of the BCBMM perform well, with no cycle-to-cycle accumulated distortion, and with the HCBMM, as the wing in the second half of the cycle just reverses its motion steps in the first half, the mesh behaves the same way.


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