Development and evaluation of lead(II) iodide-based polycrystalline digital dosimeter for quality assurance in brachytherapy

2021 ◽  
Vol 16 (11) ◽  
pp. P11021
Author(s):  
S.W. Yang ◽  
M.J. Han ◽  
S.K. Park

Abstract Brachytherapy is a cancer treatment that involves intensively irradiating a tumor by placing a sealed radioactive isotope inside the body. Determining the position of the source through accurate quality assurance (QA) is important, because brachytherapy uses radioactive isotope sources with high dose rates. However, in clinical practice, the source position is determined with the naked eye through the use of a ruler, autoradiograph, video monitor, etc., which yields inaccurate results. Therefore, in this study, a lead (II) iodide (PbI2) based polycrystalline digital dosimeter that can measure the relative dose was developed for the QA of the brachytherapy device, and its applicability was evaluated in terms of reproducibility, linearity, percentage interval distance (PID), and angular dependence. Reproducibility evaluation yielded a relative standard deviation value of 1.41%, which satisfied the evaluation criterion of 1.5%. The linearity evaluation yielded an R2 value of 0.9993, which satisfied the evaluation criterion of 0.9990. The PID evaluation revealed that, as the distance from the source increased, the signal decreased according to the inverse-square law. When the PbI2-based digital dosimeter was rotated up to 45°, a difference of up to 13.20% in the angular dependence was observed. Thus, the dosimeter fabricated in this experiment met all the criteria of the aforementioned evaluations. Therefore, it is considered to be highly applicable as a dosimeter for the QA of brachytherapy devices.

Author(s):  
Carla Winterhalter ◽  
Michele Togno ◽  
Konrad Pawel Nesteruk ◽  
Frank Emert ◽  
Serena Psoroulas ◽  
...  

2021 ◽  
Vol 16 (11) ◽  
pp. P11017
Author(s):  
S.W. Yang ◽  
M.J. Han ◽  
J.H. Jung ◽  
C.W Mun ◽  
H.L. Cho ◽  
...  

Abstract The source position of irradiation is identified using a method that uses rulers and films for quality assurance (QA) in brachytherapy. However, this method involves a high probability of errors, because the scales are checked using the naked eye, and QA is indirectly performed using photographs. Lead monoxide (PbO) is widely used as a semiconductor dosimeter, because it is a photoconductor that generates electrons in response to electromagnetic waves. Moreover, PbO has excellent sensitivity to reflected rays, owing to its high atomic number (Z Pb: 82, Z O: 8) and density (ρPbO: 9.53 g/cm3). We applied PbO to a dosimeter for QA in a brachytherapy device and attempted to increase the signal stability with a parylene coating for performance improvement. Subsequently, a comparative analysis was performed with a PbO dosimeter that was not coated with parylene to determine whether the fabricated dosimeter is applicable as a dosimeter for QA of the brachytherapy device, by analyzing the reproducibility, linearity, percentage interval distance (PID), and angular dependence in the 192Ir source used for brachytherapy. The RSD of the non-parylene PbO dosimeter was 0.85%, and the RSD of the parylene PbO dosimeter was 0.40% in the reproducibility results. In the linearity evaluation results, the R 2 value of the non-parylene PbO dosimeter was 0.9996, and that of the parylene PbO dosimeter was 0.9997 In the PID evaluation results, the difference in the intensity distribution measured according to the distance due to the dose was attenuated at the coated parylene in the case of the parylene PbO dosimeter. Therefore, adjustments using correction coefficients are required for suitable performance. In the angular dependence evaluation results, the parylene PbO dosimeter had 3.44% less angular dependence than the non-parylene dosimeter at an angle of 45°. The parylene-coated PbO dosimeter showed better performance than the non-parylene-coated PbO dosimeter in terms of the reproducibility, linearity, and angular dependence. Therefore, it is considered that the parylene-coated PbO dosimeter can be implemented for QA of brachytherapy devices.


Author(s):  
M. Isaacson ◽  
M.L. Collins ◽  
M. Listvan

Over the past five years it has become evident that radiation damage provides the fundamental limit to the study of blomolecular structure by electron microscopy. In some special cases structural determinations at very low doses can be achieved through superposition techniques to study periodic (Unwin & Henderson, 1975) and nonperiodic (Saxton & Frank, 1977) specimens. In addition, protection methods such as glucose embedding (Unwin & Henderson, 1975) and maintenance of specimen hydration at low temperatures (Taylor & Glaeser, 1976) have also shown promise. Despite these successes, the basic nature of radiation damage in the electron microscope is far from clear. In general we cannot predict exactly how different structures will behave during electron Irradiation at high dose rates. Moreover, with the rapid rise of analytical electron microscopy over the last few years, nvicroscopists are becoming concerned with questions of compositional as well as structural integrity. It is important to measure changes in elemental composition arising from atom migration in or loss from the specimen as a result of electron bombardment.


Author(s):  
D.T. Grubb

Diffraction studies in polymeric and other beam sensitive materials may bring to mind the many experiments where diffracted intensity has been used as a measure of the electron dose required to destroy fine structure in the TEM. But this paper is concerned with a range of cases where the diffraction pattern itself contains the important information.In the first case, electron diffraction from paraffins, degraded polyethylene and polyethylene single crystals, all the samples are highly ordered, and their crystallographic structure is well known. The diffraction patterns fade on irradiation and may also change considerably in a-spacing, increasing the unit cell volume on irradiation. The effect is large and continuous far C94H190 paraffin and for PE, while for shorter chains to C 28H58 the change is less, levelling off at high dose, Fig.l. It is also found that the change in a-spacing increases at higher dose rates and at higher irradiation temperatures.


2021 ◽  
pp. 1-5
Author(s):  
Vitaliy Sazonov ◽  
Zaure Tobylbayeva ◽  
Askhat Saparov ◽  
Bolatbek Jubaniyazov ◽  
Samat Issakov ◽  
...  

Background: High-dose methotrexate (HDMTX) is likely to cause a number of side effects and manifest itself as hepatotoxicity, nephrotoxicity, mucositis, and neurotoxicity. A several studies demonstrated the efficacy of extracorporeal detoxification methods such as plasma exchange, hemodialysis (HD), HD filtration, and hemoperfusion for the treatment of MTX delayed clearance. However, none of the existing methods as effective as expected and limited for general implementation due to a procedure-related complication. Case Report: Here, we report a successful implementation of HA-230 hemoadsorption procedure to remove cumulated MTX from the body and reduce its toxicity in a child with ALL after high-dose chemotherapy. Results and Conclusion: Based on our results, single-hemoadsorption procedure with the HA-230 adsorber in case of delayed methotrexate clearance was safe and well-tolerated in a pediatric patient with ALL and would significantly improve the patient’s condition. Further studies need to demonstrate its safety and efficacy in a large number of pediatric patients.


2021 ◽  
Author(s):  
Konrad P. Nesteruk ◽  
Michele Togno ◽  
Martin Grossmann ◽  
Anthony J. Lomax ◽  
Damien C. Weber ◽  
...  

2020 ◽  
Vol 152 ◽  
pp. S353-S354
Author(s):  
E. Konradsson ◽  
M. Lempart ◽  
B. Blad ◽  
C. Ceberg ◽  
K. Petersson

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