Drug nanocarriers: alternative therapy to fight oral biofilms

SummaryMedullary carcinoma of the thyroid gland is a rare tumor. Its prognosis is mainly linked to surgery, because there is no valid alternative therapy to improve patients outcome. In this report, we discuss the recurrence of such a tumor in a 64-year-old female, focusing on magnetic resonance imaging and positron emission tomography evaluation of this tumor.

Download Full-text

Attitude toward alternative therapy, compliance with standard treatment, and need for emotional support in patients with melanoma

Archives of Dermatology ◽

10.1001/archderm.133.3.316 ◽

1997 ◽

Vol 133 (3) ◽

pp. 316-321 ◽

Cited By ~ 15

Author(s):

W. Sollner

Keyword(s):

Emotional Support ◽

Standard Treatment ◽

Alternative Therapy ◽

Therapy Compliance

Download Full-text

Use of Alternative Therapy in Psoriasis Vulgaris Patients

Case Medical Research ◽

10.31525/ct1-nct04207216 ◽

2019 ◽

Author(s):

Keyword(s):

Psoriasis Vulgaris ◽

Alternative Therapy

Download Full-text

Cultivated and not-yet-cultivated bacteria in oral biofilms

Microbial Ecology in Health and Disease ◽

10.3402/mehd.v21i2.7562 ◽

2009 ◽

Vol 21 (2) ◽

Author(s):

Ingar Olsen ◽

Dorita Preza ◽

Jørn A. Aas ◽

Bruce J. Paster

Keyword(s):

Oral Biofilms

Download Full-text

PENGELUARAN KOLOSTRUM DENGAN PEMBERIAN PERAWATAN PAYUDARA DAN ENDORPHIN MASSAGE PADA IBU POST SEKSIO SESAREA

Jurnal Penelitian Kebidanan & Kespro ◽

10.36656/jpk2r.v2i1.186 ◽

2019 ◽

Vol 2 (1) ◽

pp. 34-40

Author(s):

Diah Evawanna Anuhgera ◽

Eka Fitria Panjaitan ◽

Desika Wali Pardede ◽

Nikmah Jalilah Ritonga ◽

...

Keyword(s):

Experimental Study ◽

Cesarean Section ◽

Alternative Therapy ◽

Control Group ◽

Control Group Design ◽

Group Design ◽

A Value ◽

Quasi Experimental ◽

Breast Care ◽

June July

Spending colostrum in post-cesarean section mothers is difficult in the first week postpartum. Efforts to overcome colostrum disruption can use non-pharmacological methods, namely breast care and endorphin massage. This study aims to determine the expenditure of colostrum by giving breast care and endorphin massage to post-cesarean mothers. This research is a quasi-experimental study with a nonequivalent design posttest control group design. This research was carried out in the midwifery room of the second floor of Grand Medistra Lubuk Pakam Hospital during the June-July 2019 period. There were 48 participants selected using purposive sampling, with 18 assigned in breast care, endorphin massage and combination of breast care and endorphin massage. The time of spending colostrum expenditure is assessed every day while the amount of colostrum expenditure is assessed after intervening. Analysis of the data used is one-way Annova. The results showed that the combination of breast care and endorphin massage was the most effective action in the time of spending colostrum and the amount of colostrum with a value of p = 0,000. The combination of breast care and endorphin massage could be applied as an alternative therapy post-cesarean mothers

Download Full-text

Challenges in the Design of Clinically Useful Brain-targeted Drug Nanocarriers

Current Medicinal Chemistry ◽

10.2174/0929867321666140716101921 ◽

2014 ◽

Vol 21 (37) ◽

pp. 4227-4246 ◽

Cited By ~ 6

Author(s):

L. Costantino ◽

D. Boraschi ◽

M. Eaton

Keyword(s):

Targeted Drug ◽

Drug Nanocarriers

Download Full-text

Lipid-based Nanoplatforms in Cancer Therapy: Recent Advances and Applications

Current Cancer Drug Targets ◽

10.2174/1568009620666200115160805 ◽

2020 ◽

Vol 20 (4) ◽

pp. 271-287 ◽

Cited By ~ 2

Author(s):

Kuldeep Rajpoot

Keyword(s):

Drug Delivery ◽

Cancer Therapy ◽

Adverse Effects ◽

Targeted Drug Delivery ◽

Tumor Therapy ◽

Cancer Therapies ◽

Medication Delivery ◽

Lipid Nanocarriers ◽

Targeted Drug ◽

Drug Nanocarriers

Though modern available cancer therapies are effective, they possess major adverse effects, causing non-compliance to patients. Furthermore, the majority of the polymeric-based medication platforms are certainly not universally acceptable, due to their several restrictions. With this juxtaposition, lipid-based medication delivery systems have appeared as promising drug nanocarriers to replace the majority of the polymer-based products because they are in a position to reverse polymer as well as, drug-associated restrictions. Furthermore, the amalgamation of the basic principle of nanotechnology in designing lipid nanocarriers, which are the latest form of lipid carriers, has tremendous chemotherapeutic possibilities as tumor-targeted drug-delivery pertaining to tumor therapy. Apart from this, it is reported that nearly 40% of the modern medication entities are lipophilic. Moreover, research continues to be efficient in attaining a significant understanding of the absorption and bioavailability of the developed lipids systems.

Download Full-text

Retrospective analysis on the effect of spinal cord stimulation on opioid consumption

Pain Management ◽

10.2217/pmt-2020-0016 ◽

2020 ◽

Author(s):

Awinita Barpujari ◽

Michael A Erdek

Keyword(s):

Spinal Cord ◽

Chronic Pain ◽

Retrospective Analysis ◽

Spinal Cord Stimulation ◽

Alternative Therapy ◽

Opioid Consumption ◽

Opioid Use ◽

Number Of Patients ◽

Chronic Pain Conditions ◽

Post Trial

Aim: Spinal cord stimulation (SCS) is used to clinically manage and/or treat several chronic pain etiologies. A limited amount is known about the influence on patients' use of opioid pain medication. This retrospective analysis evaluated SCS effect on opioid consumption in patients presenting with chronic pain conditions. Materials & methods: Sixty-seven patients underwent a temporary trial device, permanent implant or both. Patients were divided for assessment based on the nature of their procedure(s). Primary outcome was change in morphine equivalent dose (MED), ascertained from preoperative and postoperative medication reports. Results: Postoperative MED was significantly lower in patients who received some form of neuromodulation therapy. Pretrial patients reported an average MED of 41.01 ± 10.23 mg per day while post-trial patients reported an average of 13.30 ± 5.34 mg per day (p < 0.001). Pre-implant patients reported an average MED of 39.14 ± 13.52 mg per day while post-implant patients reported an average MED of 20.23 ± 9.01 mg per day (p < 0.001). There were no significant differences between pre-trial and pre-implant MED, nor between post-trial and post-implant MED. Of the 42 study subjects who reported some amount of pre-intervention opioid use, 78.57% indicated a lower MED (n = 33; p < 0.001), 16.67% indicated no change (n = 7) and 4.76% (n = 2) indicated a higher MED, following intervention. Moreover, SCS therapy resulted in a 26.83% reduction (p < 0.001) in the number of patients with MED >50 mg per day. Conclusion: Spinal cord stimulation may reduce opioid use when implemented appropriately. Neuromodulation may represent alternative therapy for alleviating chronic pain which may avoid a number of deleterious side effects commonly associated with opioid consumption.

Download Full-text