Pharmacokinetics, Pharmacodynamics, and Dose-Response Relationship of Repaglinide in Type 2 Diabetes

Objectives: To summarize evidence regarding the association between white rice consumption and risk of type 2 diabetes and to quantify the potential dose-response relationship. Design: Meta-analysis of prospective cohort studies. Data Sources: We searched MEDLINE and EMBASE databases for articles published through July 2011 using keywords that included both rice intake and diabetes. We further searched references of included original studies. Study Selection: Prospective cohort studies that reported risk estimates of type 2 diabetes by white rice intake levels were selected for inclusion. Data Synthesis: Relative risks were pooled using a fixed-effects model. We also modeled the dose-response relationship utilizing data from all white rice intake categories in each study. Results: We identified 4 articles that included 7 distinct prospective cohort analyses for this study. A total of 13,284 incident cases of type 2 diabetes were ascertained among 352,384 participants with follow-up periods ranging from 4 to 22 years. The pooled relative risk (RR) for type 2 diabetes was 1.21 (95% confidence interval [CI], 1.08-1.34) comparing the highest with the lowest category of white rice intake. In addition, the dose-response meta-analysis suggested a linear association between white rice consumption and risk of type 2 diabetes: the RR (95% CI) was 1.10 (1.07, 1.14; P <0.001) for each serving/d (∼158 grams for a serving of cooked rice) increased intake of white rice. Conclusion: Frequent consumption of white rice is associated with a moderately increased risk of type 2 diabetes. These findings support the recommendation that consumption of white rice should be reduced in place of healthier options such as brown rice and other whole grains to lower risk of diabetes.

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4.P.100 The dose response relationship of trolitazone in terms of triglycerides and glycaemic control in dyslipidaemic type 2 diabetic patients

Atherosclerosis ◽

10.1016/s0021-9150(97)89627-x ◽

1997 ◽

Vol 134 (1-2) ◽

pp. 317

Author(s):

M. Starkie ◽

P.M. Round ◽

P.D. Home

Keyword(s):

Glycaemic Control ◽

Dose Response ◽

Diabetic Patients ◽

Response Relationship ◽

Dose Response Relationship ◽

Type 2 Diabetic Patients ◽

Relationship Of ◽

Type 2 Diabetic

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Alendronate Use and Risk of Type 2 Diabetes: A Nationwide Danish Nested Case-Control Study

Frontiers in Endocrinology ◽

10.3389/fendo.2021.771426 ◽

2021 ◽

Vol 12 ◽

Author(s):

Rikke Viggers ◽

Zheer Al-Mashhadi ◽

Jakob Starup-Linde ◽

Peter Vestergaard

Keyword(s):

Type 2 Diabetes ◽

Dose Response ◽

Case Control Study ◽

Case Control ◽

Incidence Density ◽

Response Relationship ◽

Dose Response Relationship ◽

Nested Case Control ◽

Control Study

ObjectiveA link has been proposed between glucose homeostasis and bone metabolism. Bisphosphonates are first-line treatment of osteoporosis, and we aimed to investigate whether the risk of developing type 2 diabetes was associated with prior use of alendronate.Research Design and MethodsWe conducted a population-based nested case-control study through access to all discharge diagnoses (ICD-10 system) from the National Danish Patient Registry along with all redeemed drug prescriptions (ATC classification system) from the Health Service Prescription Registry. All cases with a diagnosis of type 2 diabetes between 2008 and 2018 were matched on sex and age with 3 randomly selected controls by incidence-density sampling. Exposure was defined as ever use of alendronate and further grouped as effective and compliant use. ORs were calculated by conditional logistic regression analysis with adjustment for several confounders and test for trend for dose-response relationship.ResultsWe included 163,588 patients with type 2 diabetes and 490,764 matched control subjects with a mean age of 67 years and 55% male subjects. The odds of developing type 2 diabetes were lower among ever users of alendronate (multiple adjusted OR: 0.64 [95% CI 0.62-0.66]). A test for trend suggested a dose-response relationship between longer effective use of alendronate and lower risk of type 2 diabetes.ConclusionThese results suggest a possible protective effect of alendronate in a dose-dependent manner against development of type 2 diabetes.

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Efficacy, safety and dose-response relationship of teneligliptin, a dipeptidyl peptidase-4 inhibitor, in Japanese patients with type 2 diabetes mellitus

Diabetes Obesity and Metabolism ◽

10.1111/dom.12092 ◽

2013 ◽

Vol 15 (9) ◽

pp. 810-818 ◽

Cited By ~ 50

Author(s):

T. Kadowaki ◽

K. Kondo

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Japanese Patients ◽

Response Relationship ◽

Dose Response Relationship ◽

Dipeptidyl Peptidase 4 ◽

Dipeptidyl Peptidase 4 Inhibitor ◽

Relationship Of

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Association between Obstructive Sleep Apnea and Type 2 Diabetes Mellitus: A Dose-Response Meta-Analysis

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2021/1337118 ◽

2021 ◽

Vol 2021 ◽

pp. 1-14

Author(s):

Zhixiang Yu ◽

Jin-Xiang Cheng ◽

Dong Zhang ◽

Fu Yi ◽

Qiuhe Ji

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Dose Response ◽

Odds Ratio ◽

Observational Studies ◽

Meta Analysis ◽

Response Relationship ◽

Dose Response Relationship ◽

Obstructive Sleep

Aim/Introduction. Obstructive sleep apnea (OSA) is a sleep-related breathing disorder that is characterized by repeated episodes of upper airway occlusion during sleep. The patients with OSA suffered from comprehensive oxidative stress in all systems. OSA might induce type 2 diabetes mellitus (T2DM), a kind of metabolism disorder. In this passage, we are exploring the dose-response relationship between OSA and T2DM. Materials and Methods. We screened four databases (PubMed, Embase, Cochran Library, and CNKI) for the observational studies about the OSA and T2DM. Studies were collected from database establishment to October 2020. We performed a traditional subgroup meta-analysis. What is more, linear and spline dose-response models were applied to assess the association between apnea-hypopnea index (AHI), an indicator to evaluate the severity of OSA, and the risk of T2DM. Review Manager, version 5.3, software and Stata 16.0 were used for the analysis. Result. Seven observational studies were included in the research. We excluded a study in the conventional meta-analysis. In the subgroup analysis, mild-dose AHI increased the risk of T2DM (odds ratio = 1.23, 95% confidence interval = 1.06–1.41, P < 0.05). Moderate-dose AHI increased the risk of T2DM with a higher odds ratio (OR = 1.35, 95% CI = 1.13–1.61, P < 0.05). Moderate-to-severe-dose AHI increased the risk of T2DM with a higher odds ratio (OR = 2.14, 95% CI = 1.72–2.67, P < 0.05). Severe-dose AHI increased the risk of T2DM with a higher odds ratio (OR = 2.19 95% CI = 1.30–3.68, P < 0.05). Furthermore, the spline and linear dose-response meta-analysis results revealed that the risk of T2DM increased with increasing AHI values. Conclusion. Through the dose-response meta-analysis, we found a potential dose-response relationship existed between the severity of OSA and the risk of T2DM. This relationship in our passage should be considered in the prevention of T2DM in the future.

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Dose-response relationship between statin therapy and glycaemia in community-based patients with type 2 diabetes: the Fremantle Diabetes Study

Diabetes Obesity and Metabolism ◽

10.1111/dom.12710 ◽

2016 ◽

Vol 18 (11) ◽

pp. 1143-1146 ◽

Cited By ~ 3

Author(s):

T. M. E. Davis ◽

I. Badshah ◽

S. A. P. Chubb ◽

W. A. Davis

Keyword(s):

Type 2 Diabetes ◽

Statin Therapy ◽

Dose Response ◽

Response Relationship ◽

Dose Response Relationship ◽

Community Based

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Analgesic and anti-inflammatory dose–response relationship of 7.5 and 15mg meloxicam after lower third molar removal: a double-blind, randomized, crossover study

International Journal of Oral and Maxillofacial Surgery ◽

10.1016/j.ijom.2006.09.006 ◽

2007 ◽

Vol 36 (1) ◽

pp. 26-31 ◽

Cited By ~ 24

Author(s):

A.M. Calvo ◽

V.T. Sakai ◽

F.P.M. Giglio ◽

K.C.S. Modena ◽

B.L. Colombini ◽

...

Keyword(s):

Crossover Study ◽

Dose Response ◽

Third Molar ◽

Response Relationship ◽

Dose Response Relationship ◽

Double Blind ◽

Anti Inflammatory ◽

Relationship Of ◽

Randomized Crossover Study

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Underestimation of Dose - Response Relationship with Particular Reference to the Relationship between the Dietary Intake of Mercury and its Concentration in Blood

Human Toxicology ◽

10.1177/096032718800700204 ◽

1988 ◽

Vol 7 (2) ◽

pp. 129-132 ◽

Cited By ~ 16

Author(s):

J.C. Sherlock ◽

M.J. Quinn

Keyword(s):

Linear Regression ◽

Dietary Intake ◽

Dose Response ◽

Mercury Concentration ◽

Response Relationship ◽

Dose Response Relationship ◽

Blood Mercury ◽

Relationship Of ◽

The Relationship ◽

Blood Mercury Concentration

Wide discrepancies have been observed between controlled and uncontrolled intake studies of the relationship of blood mercury concentration to intake of mercury. The probable reason for the apparent discrepancies is that the within-subject variation of mercury intake in the uncontrolled studies was almost certainly considerably larger than the within-subject variation in blood mercury concentration; in these circumstances, the apparent slope obtained from a linear regression of blood mercury on intake will invariably be much smaller than the true slope. Studies of the exposure or intake of any substance should therefore include a consideration of the likely within-subject variation in the exposure or intake relative to that in the effect.

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