Ultrasound-Based Assessment of Preperitoneal Fat as a Surrogate Marker of Cardiovascular Risk: Comparative Study Between People Living With HIV and Controls

2021 ◽  
Author(s):  
Anna Bonjoch ◽  
Francisco de Cabo ◽  
Jordi Puig ◽  
Núria Pérez-Álvarez ◽  
Patricia Echeverría ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Comparative Study ◽  
Surrogate Marker ◽  
People Living With Hiv ◽  
Living With Hiv

scholarly journals Impact of switching to TAF/FTC/RPV, TAF/FTC/EVG/cobi and ABC/3TC/DTG on cardiovascular risk and lipid profile in people living with HIV: a retrospective cohort study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Andrea Giacomelli ◽  
Federico Conti ◽  
Laura Pezzati ◽  
Letizia Oreni ◽  
Anna Lisa Ridolfo ◽  
...  
Keyword(s):  
Body Weight ◽  
Cardiovascular Risk ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Risk Score ◽  
Rank Test ◽  
People Living With Hiv ◽  
Cholesterol Levels ◽  
Signed Rank Test ◽  
Living With Hiv

Abstract Background We aimed to assess the overall cardiovascular and metabolic effect of the switch to three different single tablet regimens (STRs) [tenofovir alafenamide/emtricitabine/rilpivirine (TAF/FTC/RPV), TAF/FTC/elvitegravir/cobi (TAF/FTC/EVG/cobi) and ABC/lamivudine/dolutegravir (ABC/3TC/DTG)] in a cohort of people living with HIV/AIDS (PLWH) under effective ART. Methods All PLWH aged above 18 years on antiretroviral treatment with an HIV-RNA < 50 cp/mL at the time of the switch to TAF/FTC/RPV, TAF/FTC/EVG/cobi and ABC/3TC/DTG were retrospectively included in the analysis. Framingham risk score modification after 12 months from the switch such as lipid profile and body weight modification were assessed. The change from baseline to 12 months in mean cardiovascular risk and body weight in each of the STR’s group were assessed by means of Wilcoxon signed-rank test whereas a mixed regression model was used to assess variation in lipid levels. Results Five-hundred and sixty PLWH were switched to an STR regimen of whom 170 (30.4%) to TAF/FTC/EVG/cobi, 191 (34.1%) to TAF/FTC/RPV and 199 (35.5%) to ABC/3TC/DTG. No difference in the Framingham cardiovascular risk score was observed after 12 months from the switch in each of the STR’s groups. No significant overtime variation in mean total cholesterol levels from baseline to 12 months was observed for PLWH switched to ABC/3TC/DTG [200 (SD 38) mg/dl vs 201 (SD 35) mg/dl; p = 0.610] whereas a significant increment was observed in PLWH switched to TAF/FTC/EVG/cobi [192 (SD 34) mg/dl vs 208 (SD 40) mg/dl; p < 0.0001] and TAF/FTC/RPV [187 (SD 34) mg/dl vs 195 (SD 35) mg/dl; p = 0.027]. In addition, a significant variation in the mean body weight from baseline to 12 months was observed in PLWH switched to TAF/FTC/EVG/cobi [72.2 (SD 13.5) kilograms vs 74.6 (SD 14.3) kilograms; p < 0.0001] and TAF/FTC/RPV [73.4 (SD 11.6) kilograms vs 75.6 (SD 11.8) kilograms; p < 0.0001] whereas no difference was observed in those switched to ABC/3TC/DTG [71.5 (SD 12.8) kilograms vs 72.1 (SD 12.6) kilograms; p = 0.478]. Conclusion No difference in the cardiovascular risk after 1 year from the switch to these STRs were observed. PLWH switched to TAF/FTC/EVG/cobi and TAF/FTC/RPV showed an increase in total cholesterol levels and body weight 12 months after the switch.

scholarly journals Managing cardiovascular risk in people living with HIV in Asia – where are we now?

HIV Medicine ◽  
2021 ◽  
Author(s):  
Jun Yong Choi ◽  
Grace Chung Yan Lui ◽  
Chia‐Te Liao ◽  
Chia‐Jui Yang
Keyword(s):  
Cardiovascular Risk ◽  
People Living With Hiv ◽  
Living With Hiv

scholarly journals Assessing Cardiovascular Risk in People Living with HIV: Current Tools and Limitations

2021 ◽  
Author(s):  
Amit C. Achhra ◽  
Asya Lyass ◽  
Leila Borowsky ◽  
Milana Bogorodskaya ◽  
Jorge Plutzky ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
People Living With Hiv ◽  
Living With Hiv

scholarly journals A Step Closer to the “Fourth 90”: A Practical Narrative Review of Diagnosis and Management of Nutritional Issues of People Living with HIV

Diagnostics ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 2047
Author(s):  
Davide Fiore Bavaro ◽  
Paola Laghetti ◽  
Mariacristina Poliseno ◽  
Nicolò De Gennaro ◽  
Francesco Di Gennaro ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Cardiovascular Risk ◽  
Kidney Disease ◽  
Current Knowledge ◽  
Disease Stage ◽  
Oral Glucose ◽  
People Living With Hiv ◽  
Diagnosis And Management ◽  
Increased Risk ◽  
Living With Hiv

The quality of life of people living with HIV (PLWH) has remarkably increased thanks to the introduction of combined antiretroviral therapy. Still, PLWH are exposed to an increased risk of cardiovascular diseases, diabetes, chronic kidney disease, and liver disease. Hence, the purpose of this review is to summarize the current knowledge about diagnosis and nutritional management with specific indication of macro and micronutrients intake for the main comorbidities of PLWH. In fact, a prompt diagnosis and management of lifestyle behaviors are fundamental steps to reach the “fourth 90”. To achieve an early diagnosis of these comorbidities, clinicians have at their disposal algorithms such as the Framingham Score to assess cardiovascular risk; transient elastography and liver biopsy to detect NAFLD and NASH; and markers such as the oral glucose tolerance test and GFR to identify glucose impairment and renal failure, respectively. Furthermore, maintenance of ideal body weight is the goal for reducing cardiovascular risk and to improve diabetes, steatosis and fibrosis; while Mediterranean and low-carbohydrate diets are the dietetic approaches proposed for cardioprotective effects and for glycemic control, respectively. Conversely, diet management of chronic kidney disease requires different nutritional assessment, especially regarding protein intake, according to disease stage and eventually concomitant diabetes.

scholarly journals Level of agreement between frequently used cardiovascular risk calculators in people living with HIV

HIV Medicine ◽  
2019 ◽  
Vol 20 (5) ◽  
pp. 347-352 ◽  
Author(s):  
S Dhillon ◽  
CA Sabin ◽  
J Alagaratnam ◽  
E Bagkeris ◽  
FA Post ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
People Living With Hiv ◽  
Living With Hiv ◽  
Level Of Agreement

Progression of Subclinical Vascular Damage in People Living With HIV Is Not Predicted by Current Cardiovascular Risk Scores

2020 ◽  
Vol 83 (5) ◽  
pp. 504-512
Author(s):  
Chris J. Kapelios ◽  
Antonios A. Argyris ◽  
Athanase D. Protogerou ◽  
Ioannis Katsarolis ◽  
Aikaterini Arida ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Vascular Damage ◽  
Risk Scores ◽  
People Living With Hiv ◽  
Living With Hiv ◽  
Subclinical Vascular Damage

scholarly journals Mycobacterium tuberculosis co-infection is associated with increased surrogate marker of the HIV reservoir

2020 ◽  
Vol 17 (1) ◽  
Author(s):  
Jingna Xun ◽  
Tangkai Qi ◽  
Lei Zou ◽  
Qi Tang ◽  
Yinzhong Shen ◽  
...  
Keyword(s):  
Mononuclear Cells ◽  
Surrogate Marker ◽  
Baseline Viral Load ◽  
People Living With Hiv ◽  
Peripheral Blood Mononuclear ◽  
Hiv Reservoir ◽  
Hiv Dna ◽  
Interleukin 7 ◽  
Living With Hiv ◽  
The Impact

Abstract Background Tuberculosis (Tb) is the most frequent opportunistic infection among people living with HIV infection. The impact of Tb co-infection in the establishment and maintenance of the HIV reservoir is unclear. Method We enrolled 13 HIV-infected patients with microbiologically confirmed Tb and 10 matched mono-HIV infected controls. Total HIV DNA in peripheral blood mononuclear cells (PBMCs), plasma interleukin-7 (IL-7) concentrations and the activities of indoleamine 2,3-dioxygenase (IDO) were measured for all the participants prior to therapy and after antiretroviral therapy (ART). Results After a duration of 16 (12, 22) months’ ART, patients co-infected with Tb who were cured of Tb maintained higher levels of HIV DNA compared with mono-HIV infected patients [2.89 (2.65- 3.05) log10 copies/106 cells vs. 2.30 (2.11–2.84) log10 copies/106 cells, P = 0.008]. The levels of on-ART HIV DNA were positively correlated with the baseline viral load (r = 0.64, P = 0.02) in Tb co-infected group. However, neither plasma IL-7 concentration nor plasma IDO activity was correlated with the level of on-ART HIV DNA. Conclusions Tb co-infection was associated with the increased surrogate marker of the HIV reservoir, while its mechanism warrants further examination.

Metabolic changes and estimating cardiovascular risk of people living with HIV/AIDS twelve months after the start of HAART

2017 ◽  
Vol 27 ◽  
Author(s):  
Nathalia Sernizon Guimarães ◽  
Júlia Fonseca de Morais Caporali ◽  
Priscila Valeria do Carmo Carvalho Reis ◽  
Pedro Rezende Tanajura ◽  
André Ribeiro Guimarães ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Metabolic Changes ◽  
People Living With Hiv ◽  
Living With Hiv ◽  
Hiv Aids
Sign in / Sign up

Export Citation Format

Share Document