Case–Control and Family-Based Association Studies of Novel Susceptibility Locus 8q24 in Nonsyndromic Cleft Lip With or Without Cleft Palate in a Southern Han Chinese Population Located in Guangdong Province

Objectives Non-syndromic cleft lip with or without cleft palate (NSCL ± P) is one of the most common birth malformations. Currently, numerous susceptibility SNPs have been reported by GWA studies, however, the replications of them among NSCL ± P from Han Chinese were very limited. Design In this study, we selected 16 SNPs around 1q32.2 based on the published GWA studies and replicated them among 302 trios with NSCL ± P from Han Chinese Population. The genotypic data was analyzed with FBAT, PLINK and R package. Setting The study was conducted in a tertiary medical center. Patients, participants 302 patients with CL ± P and their parents. Main outcome measures To ascertain the genetic variants in 1q32.2 in patients with CL ± P in Han Chinese Population. Interventions Blood samples were collected. Results We found T allele ( Z = 4.26, p = 0.00002) and T/T homozygotes ( Z = 4.4, p = 0.000011) at rs12063989 was significantly over-transmitted among non-syndromic cleft lip with or without cleft palate (NSCL ± P). Conclusions We found rs12063989 exhibited significant association with the occurrence of NSCL ± P, which would provide new evidence for the future study in the etiology of NSCL ± P.

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Relationship of genetic variants in IL33 gene and IL1RL1 gene with HBV-related liver cirrhosis in Han Chinese population: Three case-control studies

Infection Genetics and Evolution ◽

10.1016/j.meegid.2021.104983 ◽

2021 ◽

pp. 104983

Author(s):

Ning Ma ◽

Mengyuan Xu ◽

Yi Dong ◽

Fengxue Yu ◽

Xiaolin Zhang ◽

...

Keyword(s):

Liver Cirrhosis ◽

Genetic Variants ◽

Chinese Population ◽

Case Control ◽

Han Chinese ◽

Case Control Studies ◽

Han Chinese Population ◽

Relationship Of

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Interaction between interferon regulatory factor 6 and glycine receptor beta shows a protective effect on developing nonsyndromic cleft lip with or without cleft palate in the Han Chinese population

European Journal Of Oral Sciences ◽

10.1111/eos.12587 ◽

2018 ◽

Vol 127 (1) ◽

pp. 27-32 ◽

Cited By ~ 1

Author(s):

Di Wu ◽

Mei Wang ◽

Xingang Wang ◽

Yong-Biao Zhang ◽

Tao Song ◽

...

Keyword(s):

Cleft Palate ◽

Protective Effect ◽

Chinese Population ◽

Cleft Lip ◽

Glycine Receptor ◽

Interferon Regulatory Factor ◽

Regulatory Factor ◽

Han Chinese Population ◽

Interferon Regulatory Factor 6 ◽

Receptor Beta

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Replication of previous genome-wide association studies of HKDC1, BACE2, SLC16A11 and TMEM163 SNPs in a gestational diabetes mellitus case–control sample from Han Chinese population

Diabetes Metabolic Syndrome and Obesity Targets and Therapy ◽

10.2147/dmso.s207019 ◽

2019 ◽

Vol Volume 12 ◽

pp. 983-989 ◽

Cited By ~ 2

Author(s):

Yixiong Tan ◽

Shi-Min Hu ◽

Yi-Ping You ◽

Gui-Lian Yang ◽

Wei Wang

Keyword(s):

Diabetes Mellitus ◽

Gestational Diabetes ◽

Chinese Population ◽

Association Studies ◽

Control Sample ◽

Case Control ◽

Genome Wide Association ◽

Genome Wide Association Studies ◽

Han Chinese Population ◽

Genome Wide

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Association between Two Resistin Gene Polymorphisms and Metabolic Syndrome in Jilin, Northeast China: A Case-Control Study

Disease Markers ◽

10.1155/2017/1638769 ◽

2017 ◽

Vol 2017 ◽

pp. 1-7 ◽

Cited By ~ 1

Author(s):

Yingli Fu ◽

Yaqin Yu ◽

Yanhua Wu ◽

Yueyue You ◽

Yangyu Zhang ◽

...

Keyword(s):

Metabolic Syndrome ◽

Gene Polymorphisms ◽

Chinese Population ◽

Case Control Study ◽

International Diabetes Federation ◽

Case Control ◽

Han Chinese ◽

Jilin Province ◽

Han Chinese Population ◽

Control Study

Metabolic syndrome (MetS) is a significant health care problem worldwide and is characterized by increased fasting glucose and obesity. Resistin is a protein hormone produced both by adipocytes and immunocompetent cells, including those residing in adipose tissue, and is believed to modulate glucose tolerance and insulin action. This study examined the association of resistin gene polymorphisms, rs1862513 and rs3745368, and related haplotypes with the development of metabolic syndrome in a Han Chinese population. This case-control study was performed on 3792 subjects, including 1771 MetS cases and 2021 healthy controls from the Jilin province of China. Metabolic syndrome was defined according to the criteria of the International Diabetes Federation (IDF). Logistic regression analysis was used to estimate the relationship between gene polymorphism and MetS. Our results showed that there were no significant associations between MetS and the genotype distributions in four kinds of inheritance models, allele frequencies, and related haplotypes of resistin gene polymorphisms rs1862513 and rs3745368 (allpvalues > 0.05). Based on our study findings, we concluded that mutations in resistin genes are not associated with the presence of MetS in a Han Chinese population from Jilin province in China.

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