Peroxidase and Coupling Activities of Thyroid Peroxidase in Benign and Malignant Thyroid Tumor Tissues

Thyroid ◽  
1992 ◽  
Vol 2 (3) ◽  
pp. 193-196 ◽  
Author(s):  
JUNTA TAKAMATSU ◽  
TOICHIRO HOSOYA ◽  
MAYUMI TSUJI ◽  
MARIKO YAMADA ◽  
YASHUHIRO MURAKAMI ◽  
...  
Keyword(s):  
Thyroid Tumor ◽  
Thyroid Peroxidase ◽  
Malignant Thyroid Tumor ◽  
Tumor Tissues

scholarly journals Tensin3 is a novel thyroid-specific gene

2006 ◽  
Vol 36 (1) ◽  
pp. R1-R8 ◽  
Author(s):  
Ikuhiro Maeda ◽  
Toru Takano ◽  
Hiroshi Yoshida ◽  
Fumio Matsuzuka ◽  
Nobuyuki Amino ◽  
...  
Keyword(s):  
Thyroid Function ◽  
White Blood Cells ◽  
Thyroid Tumor ◽  
Pcr Analysis ◽  
Specific Gene ◽  
Thyroid Peroxidase ◽  
Sequencing Analysis ◽  
Normal Thyroid ◽  
Expression Levels ◽  
Tumor Tissues

Thyroid-specific genes, such as thyroid peroxidase, thyroglobulin, Na+/I− symporter and thyroid-stimulating hormone receptor, play fundamental roles in thyroid function and relate to many pathological conditions. Using sequence specific-differential display, we detected three genes that showed higher expression levels in normal thyroid tissues than in thyroid tumor tissues. After subcloning and sequencing analysis, one of the genes was revealed to be tensin3. The expression level of tensin3 was examined with real-time quantitative PCR analysis. Its expression levels were more depressed in thyroid tumor tissues than in normal thyroid tissues. The decrease was even more evident in two anaplastic carcinomas. High and moderate levels of tensin3 mRNA expression were observed in the thyroid and placenta respectively. Tensin3 mRNA was expressed only in low levels in other tissues, such as the brain, heart, lung, liver, pancreas, kidney, skeletal muscle, white blood cells and prostate. These results show that tensin3 is a novel thyroid-specific gene and further investigations may reveal its relation to thyroid function or thyroid disease.

scholarly journals A Case Report: A Third/Fourth Branchial Pouch Anomaly Presented by Solid Thyroid and Lateral Cervical Neck Masses

2016 ◽  
Vol 9 ◽  
pp. CPath.S31734 ◽  
Author(s):  
Magda H. A. Nasreldin ◽  
Eman A. Ibrahim ◽  
Somaia A. Saad El-Din
Keyword(s):  
Rare Case ◽  
Histopathological Examination ◽  
Parathyroid Tissue ◽  
Thyroid Tumor ◽  
Cervical Lymph Nodes ◽  
Neck Masses ◽  
Malignant Thyroid Tumor ◽  
Branchial Arches ◽  
Thyroid Swelling ◽  
Solid Cell

Branchial pouch-derived anomalies may arise from remnants of the first, second, or third/fourth branchial arches. Branchial pouch-related structures are found within the thyroid gland in the form of solid cell rests, epithelial lined cyst with or without an associated lymphoid component, thymic and/or parathyroid tissue, and less commonly in the form of heterotopic cartilage. We present a rare case of left solid thyroid swelling nearby two cervical nodules in a seven-year-old female with a clinical diagnosis suggestive of malignant thyroid tumor with metastasis to the cervical lymph nodes. Histopathological examination revealed that it was compatible with third/fourth branchial pouch-derived anomaly composed of mature cartilage and thymic and parathyroid tissues for clinical and radiological correlations.

scholarly journals Uncommon Site of Metastasis and Prolonged Survival in Patients with Anaplastic Thyroid Carcinoma: A Systematic Review of the Literature

Cancers ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2585
Author(s):  
Aurora Mirabile ◽  
Matteo Biafora ◽  
Leone Giordano ◽  
Gianluigi Arrigoni ◽  
Maria Giulia Cangi ◽  
...  
Keyword(s):  
Systematic Review ◽  
Overall Survival ◽  
Prognostic Factors ◽  
Thyroid Carcinoma ◽  
Thyroid Tumor ◽  
Anaplastic Thyroid Carcinoma ◽  
Review Of The Literature ◽  
Malignant Thyroid Tumor ◽  
One Year

Anaplastic thyroid carcinoma (ATC) is a very rare, highly aggressive malignant thyroid tumor with an overall survival from 3 to 5 months in most of the cases. Even the modern and intensive treatments seem not to be enough to provide a cure, also for the resectable ones, and the role of chemotherapy is still unclear but does not seem to prolong survival. Nevertheless, some patients survive longer and have a better outcome, even in the presence of metastasis, than what the literature reports. We present the case of a 64-year-old female affected by ATC, treated on February 2018 with surgery followed by chemoradiation. One year after surgery, the patient developed a subcutaneous recurrence that was radically resected and is still alive 29 months after the diagnosis. We propose a systematic review of the literature to deepen the knowledge of the prognostic factors of ATC with the aim to recognize and select the patients with a better outcome, even if metastatic, and to describe a very uncommon site of metastatization.

CT Findings in the Differential Diagnosis of Benign and Malignant Thyroid Tumor

1996 ◽  
Vol 34 (4) ◽  
pp. 457
Author(s):  
Hye Weon Jung ◽  
Moon Hee Han ◽  
Hong Dae Kim ◽  
Kee Hyun Chang ◽  
Heung Sik Kang ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Thyroid Tumor ◽  
Ct Findings ◽  
Malignant Thyroid Tumor

Characteristic Dynamic Enhancement Pattern of MR Imaging for Malignant Thyroid Tumor

2011 ◽  
Vol 24 (3) ◽  
pp. 392-394
Author(s):  
H. Hwang ◽  
Y.N. Park ◽  
Y.S. Shim ◽  
S.S. Byun ◽  
H.S. Kim
Keyword(s):  
Mr Imaging ◽  
Thyroid Tumor ◽  
Enhancement Pattern ◽  
Malignant Thyroid Tumor ◽  
Dynamic Enhancement ◽  
Characteristic Dynamic

scholarly journals Awake tracheotomy in a patient with stridor and dyspnoea caused by a sizeable malignant thyroid tumor: a case report and short review of the literature

2017 ◽  
Vol 5 (11) ◽  
pp. 1891-1895 ◽  
Author(s):  
Andreas Hohn ◽  
Tālis Kauliņš ◽  
Jochen Hinkelbein ◽  
Krista Kauliņa ◽  
Andreas Kopp ◽  
...  
Keyword(s):  
Case Report ◽  
Short Review ◽  
Thyroid Tumor ◽  
Review Of The Literature ◽  
Malignant Thyroid Tumor

scholarly journals Copper Isotopes and Copper to Zinc Ratio as Possible Biomarkers for Thyroid Cancer

2021 ◽  
Vol 8 ◽  
Author(s):  
Latifa Sarra Kazi Tani ◽  
Alexandra T. Gourlan ◽  
Nouria Dennouni-Medjati ◽  
Philippe Telouk ◽  
Majda Dali-Sahi ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Inductively Coupled Plasma ◽  
Plasma Concentrations ◽  
Thyroid Tumor ◽  
Healthy Controls ◽  
Systematic Screening ◽  
Inductively Coupled ◽  
Tumor Tissues ◽  
Icp Ms ◽  
Plasma Mass Spectrometry

Thyroid cancer is the most common endocrine cancer. There is no systematic screening for such cancer, and the current challenge is to find potential biomarkers to facilitate an early diagnosis. Copper (Cu) and zinc (Zn) are essential micronutrients involved in the proper functioning of the thyroid gland, and changes in their concentrations have been observed in the development of cancer. Previous studies have highlighted the potential 65Cu/63Cu ratio (δ65Cu) to be a cancer biomarker. This study tests its sensitivity on plasma samples (n = 46) of Algerian patients with papillary thyroid carcinoma and a set of corresponding biopsies (n = 11). The δ65Cu ratio in blood and tumor samples was determined using multi collector inductively coupled plasma-mass spectrometry (MC-ICP-MS), and their corresponding Cu and Zn plasma total concentrations using total reflection X-ray fluorescence (TXRF). Plasma concentrations of Cu were significantly higher (1346.1 ± 328.3 vs. 1060.5 ± 216.1 μg/L, p < 0.0001), and Zn significantly lower (942.1 ± 205.2 vs. 1027.9 ± 151.4 μg/L, p < 0.05) in thyroid cancer patients as compared to healthy controls (n = 50). Accordingly, the Cu/Zn ratio was significantly different between patients and controls (1.5 ± 0.4 vs. 1.0 ± 0.3, p < 0.0001). Furthermore, the δ65Cu plasma levels of patients were significantly lower than healthy controls (p < 0.0001), whereas thyroid tumor tissues presented high δ65Cu values. These results support the hypothesis that Cu isotopes and plasma trace elements may serve as suitable biomarkers of thyroid cancer diagnosis.

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