High level of pyridoxal 5′-phosphate in the cerebrospinal fluid of adult celiac patients

1982 ◽  
Vol 36 (5) ◽  
pp. 851-854 ◽  
Author(s):  
C Hallert ◽  
S Allenmark ◽  
U Larsson-Cohn ◽  
G Sedvall
Keyword(s):  
Cerebrospinal Fluid ◽  
High Level

CT-Guided Autologous Blood Patch for High-Level Cervical Cerebrospinal Fluid Leakage: Imaging Characteristics and Treatment Safety and Efficiency

2021 ◽  
pp. 1-7
Author(s):  
Xiaofeng He ◽  
Yueyong Xiao ◽  
Xiao Zhang ◽  
Xiaobo Zhang ◽  
Xin Zhang ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Epidural Space ◽  
Autologous Blood ◽  
Cerebrospinal Fluid Leakage ◽  
Imaging Features ◽  
Ct Guided ◽  
Iodinated Contrast ◽  
Blood Patch ◽  
Csf Leakage ◽  
High Level

<b><i>Introduction:</i></b> Epidural blood patches (EBPs) are rarely performed at the high-level cervical levels. The aim of the study was to investigate the imaging features, safety, and effectiveness of CT-guided percutaneous EBPs for high-level cervical cerebrospinal fluid (CSF) leakage. <b><i>Methods:</i></b> Twenty-five patients with spontaneous high-level (C1–C3) CSF leakage on MRI and CT imaging, including 2 patients with intracranial epidural hematoma caused by CSF, were treated with EBP. Two needles were inserted into the C1–3 bilateral epidural space. The needle location was confirmed by injection of both 3–5mL sterile air and a diluted iodinated contrast agent to delineate its spatial diffusion. The patient’s blood 11.1 ± 3.1 mL was slowly injected to make a patch; the distribution in epidural space was monitored with intermittent CT scanning. <b><i>Results:</i></b> The typical manifestation of CSF leakage was the high signal outside the C1–3 cervical dura on MR T2W fat inhibition images and low density in cervical muscle space on CT images. Twenty patients suffered from headaches and were able to sit and walk 24 h after the operation. Four patients, with partial relief of headache and a small but persistent CSF leakage, were re-treated with EBS. One patient underwent a third operation because of a persistent CSF leakage on MRI. <b><i>Conclusions:</i></b> Imaging of water at the surrounding epidural space of high cervical level is a typical feature of dural rupture on both MRI and CT. CT-guided EBP is safe and efficient for the high-level cervical CSF leakage, especially for cases in which conservative treatments failed.

Filamented Pseudomonas aeruginosa anda Markedly High Level of Endotoxin in Cerebrospinal Fluid

2000 ◽  
Vol 41 (1) ◽  
pp. 114-115
Author(s):  
C. Kawano ◽  
K. Muroi ◽  
M. Yozhizawa ◽  
T. Kirikae ◽  
K. Ozawa
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Cerebrospinal Fluid ◽  
High Level

Serum Immunoglobulin G level and Neutrophils to Lymphocytes Ratio Associated with the Prognosis of Neuromyelitis Optica Spectrum Disorder

2021 ◽  
Vol 18 ◽  
Author(s):  
Ying Tong ◽  
Li Wang ◽  
Kai Liu ◽  
Weishi Liu ◽  
Shen Li ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Neuromyelitis Optica ◽  
Immunoglobulin G ◽  
Peripheral Blood ◽  
Spectrum Disorder ◽  
Neuromyelitis Optica Spectrum Disorder ◽  
Positive Group ◽  
Serum Igg ◽  
High Level ◽  
Igg Level

Objective: To investigate the factors related to the prognosis of neuromyelitis optica spectrum disorder (NMOSD) in cerebrospinal fluid and peripheral blood examination. Methods: In this study, we collected 111 patients who were admitted to the First Affiliated Hospital of Zhengzhou University between January 2016 and January 2018 and diagnosed with NMOSD. The patients were divided into the relapse group (n=48) and remission group (n=67). Before treatment, all the patients underwent a routine cerebrospinal fluid (CSF) and peripheral blood test on the second morning of admission. The association between laboratory data and disease prognosis was evaluated. Results: The immunoglobulin G (IgG) level in the serum showed a strong correlation with the relapse of patients, especially in the aquaporin-4-Antibody (AQP4-Ab) positive group (p<0.01). A high level of serum IgG concentration was associated with the relapse of NMOSD, especially in the anti-AQP4 positive group. The area under the receiver operating characteristic (ROC) curve of serum IgG level was 0.888 (p0.001, 95%CI: 0.808-0.968). The ratio of neutrophils to lymphocytes (NLR) was associated with the disability degree of NMOSD patients in 3 years. The NLR value was a linear correlation with final Expanded Disability Status Scale (EDSS) scores. Patients with a high level of NLR value presented an increased degree of disability in the following three years (R2=0.053, p=0.015). Conclusion: The serum IgG level and NLR of first-attack patients were correlated with the prognosis of NMOSD.

scholarly journals Characterization of a Laboratory-Derived, High-Level Ampicillin-Resistant Salmonella enterica Serovar Typhimurium Strain That Caused Meningitis in an Infant

2002 ◽  
Vol 46 (5) ◽  
pp. 1604-1606 ◽  
Author(s):  
Cheng-Hsun Chiu ◽  
Chishih Chu ◽  
Lin-Hui Su ◽  
Wan-Yu Wu ◽  
Tsu-Lan Wu
Keyword(s):  
Cerebrospinal Fluid ◽  
Salmonella Enterica ◽  
Salmonella Enterica Serovar Typhimurium ◽  
Cloning Vector ◽  
Typhimurium Strain ◽  
Serovar Typhimurium ◽  
High Level ◽  
Lactamase Gene

ABSTRACT A Salmonella enterica serovar Typhimurium strain that harbored a plasmid carrying a TEM-1-type β-lactamase gene was isolated from the blood and cerebrospinal fluid of an infant with meningitis. This 3.2-kb plasmid was further characterized to be a nonconjugative pGEM series cloning vector containing a foreign insert. The strain was likely laboratory derived and contaminated the environment before it caused the infection.

scholarly journals Comparative analysis of cerebrospinal fluid adenosine deaminase levels in infective meningitis of different aetiologies

2017 ◽  
Vol 4 (2) ◽  
pp. 608
Author(s):  
Mohsin Rashid ◽  
Sheikh Mushtaq ◽  
Junaid Manzoor ◽  
Javaid Ahmad Bhat ◽  
Shilakha Chaman ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Diagnostic Accuracy ◽  
Adenosine Deaminase ◽  
Aseptic Meningitis ◽  
Predictive Value ◽  
Cost Effective ◽  
Systemic Lupus Erythematosis ◽  
Pyogenic Meningitis ◽  
Tubercular Meningitis ◽  
High Level

Background: Meningitis can be caused by bacteria, viruses, parasites, and fungi as well as by non-infectious conditions including inflammatory disorders (e.g., systemic lupus erythematosis or Kawasaki disease) and neoplasia (e.g., leukemic meningitis). The objective of this study were to study cerebrospinal fluid (CSF) adenosine deaminase (ADA) levels in infective meningitis of different aetiologies. And to assess the role of cerebrospinal fluids (CSF) adenosine deaminase (ADA) levels in differentiating tubercular from non-tubercular meningitis.Methods: The study was conducted on 70 patients of meningitis at Postgraduate Department of Paediatrics, in G. B. Pant Hospital, an associated hospital of Government Medical College Srinagar. Out of 70 patients included in the study 27 cases were Aseptic Meningitis (AM), 14 cases partially treated pyogenic -meningitis (PTM), 19 cases pyogenic meningitis (PM), and 10 cases were tubercular meningitis (TBM). ADA activity of CSF was quantified by colorimetry.Results: In our study we observed a significant high level of ADA 30.0±3.2U/L (20.0, 54.0) among the tubercular meningitis (TBM) patients and its respective level among Aseptic Meningitis (AM), was 8.1±0.3U/L (4.0, 11.5), partially treated pyo -meningitis (PTM) was 7.6±0.4U/L (5.0, 11.0), pyogenic meningitis (PM) was 11.6±0.5U/L (8.0, 14.5). In total Non-TBM ADA level was 9.1±0.3U/L (4.0, 14.5) units/liter. At cut off of > or equal to 10U/L sensitivity was 100% specificity66.67% positive predictive value33.33% negative predictive value of 100% diagnostic accuracy 71.43%. At a higher cut off of > or equal to 12U/L sensitivity was 100% and specificity increased to 81.67% positive predictive value 47.62% negative predictive value100% diagnostic accuracy was 84.29%.Conclusions: The sensitivity and specificity of CSF ADA activity is markedly high in differentiating TBM from non-TBM. Hence CSF ADA activity may be used as a simple, cost-effective and reliable test for early diagnosis of TBM.

scholarly journals High Level of Serum and Cerebrospinal Fluid of Heparan Sulfate and Hyaluronic Acid Might Be a Biomarker of Severity of Neuromyelitis Optica

2021 ◽  
Vol 12 ◽  
Author(s):  
Qi Zhang ◽  
Shanshan Pei ◽  
Zheyi Zhou ◽  
Zhanhang Wang ◽  
Yu Peng ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Hyaluronic Acid ◽  
Heparan Sulfate ◽  
Neuromyelitis Optica ◽  
Neurological Diseases ◽  
Clinical Situation ◽  
Diagnostic Value ◽  
Demyelinating Diseases ◽  
Csf Levels ◽  
High Level

BackgroundNeuromyelitis optica (NMO), multiple sclerosis (MS) and autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy are idiopathic inflammatory demyelinating diseases (IIDDs) that mainly present as encephalomyelitis. Heparan sulfate (HS) and hyaluronic acid (HA) are two components of glycocalyx, a carbohydrate-rich layer on the surface of blood vessels that mediates interaction with blood. Degradation of glycocalyx in NMO is poorly understood.PurposeTo detect the serum and cerebrospinal fluid (CSF) levels of shed HS and HA and to correlate these levels with disease severity to determine their diagnostic value.MethodsWe obtained serum and CSF samples from 24 NMO patients, 15 MS patients, 10 autoimmune GFAP astrocytopathy patients, and 18 controls without non-inflammatory neurological diseases. Soluble HS and HA, and IFNγ, IL17A, and matrix metalloproteinase (MMP) 1 were detected via ELISA.ResultsSerum and CSF levels of HS, HA and related cytokines but not of plasma MMP1 were significantly elevated in these diseases. Notably, HS and HA levels were positively correlated with Expanded Disability Status Scale scores.ConclusionsOur results indicate glycocalyx degradation and inflammation in NMO, MS and autoimmune GFAP astrocytopathy. Moreover, increased shedding of HS or HA may indicate a worse clinical situation. Furthermore, therapeutic strategies that protect glycocalyx may be effective in these diseases.

scholarly journals Mollaret Meningitis Associated with a High Level of Cytokines in Cerebrospinal Fluid.

1997 ◽  
Vol 34 (1) ◽  
pp. 65-69 ◽  
Author(s):  
Hitoshi Katayama ◽  
Katsuhiko Kohara ◽  
Michiya Igase ◽  
Motofumi Maguchi ◽  
Tomikazu Fukuoka ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
High Level

scholarly journals Are cerebrospinal fluid protein levels and plasma neutrophil/lymphocyte ratio associated with prognosis of Guillain Barré syndrome?

2017 ◽  
Vol 9 (2) ◽  
Author(s):  
Sevki Sahin ◽  
Nilgun Cinar ◽  
Sibel Karsidag
Keyword(s):  
Cerebrospinal Fluid ◽  
Cell Count ◽  
Protein Level ◽  
Guillain Barre Syndrome ◽  
Positive Correlation ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Protein Levels ◽  
Facial Diplegia ◽  
High Level

Guillain Barré syndrome (GBS) is a post-infectious acute autoimmune polyradiculopathy. Cerebrospinal fluid (CSF) total protein level and plasma neutrophil/ lymphocyte ratio (NLR) are related with autoimmune response. We aimed to reach a prognostic indicator for GBS by using electrophysiological findings, protein level of CSF, and plasma NLR based on Medical Research Council (MRC) sum score data. Cases who met diagnostic criteria of GBS and followed at least six months were enrolled in the study. Nerve conduction study (NCS) and lumbar puncture were performed one week after symptom onset. Routine CSF findings and complete blood count were recorded. Plasma NLR was calculated as the ratio of neutrophil cell count to lymphocyte cell count. All patients received intravenous immunoglobulin. MRC sum scores were calculated on administration time (1st) and six months later (2nd) for evaluation of recovery. Mean values of baseline CSF protein level, NCS parameters and NLR were compared with mean scores of MRC1st and MRC2nd. Increased CSF protein levels showed negative correlation with MRC2nd scores but no correlation with NCS. Increased NLR levels were positively correlated with age, MRC2nd scores and NCS. Facial diplegia was observed in 42% of patients. A positive correlation was found between high level of NLR and MRC1st, and there was no relationship with MRC2nd. Regression analyses showed that only CSF protein level was an independent factor on both MRC1st and MRC2nd. A positive association was found between baseline data included young age high plasma NLR, low level of CSF protein and good prognosis in our study. Also a positive correlation was found between high level of NLR and baseline disability in GBS cases with facial diplegia. Calculation of NLR is an easy and inexpensive method. On the other hand it may be influenced by age and immunotherapy. Our results showed that CSF protein level is still a liable parameter for prognosis. NLR could be a candidate prognostic marker of GBS cases. Further investigations including more cases are needed.

scholarly journals Mollaret Meningitis with a High Level of Cytokines in the Cerebrospinal Fluid Successfully Treated by Indomethacin

2019 ◽  
Vol 58 (8) ◽  
pp. 1163-1166
Author(s):  
Masahito Kawabori ◽  
Kota Kurisu ◽  
Yoshimasa Niiya ◽  
Yuzuru Ohta ◽  
Shoji Mabuchi ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
High Level
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