scholarly journals Are cerebrospinal fluid protein levels and plasma neutrophil/lymphocyte ratio associated with prognosis of Guillain Barré syndrome?

2017 ◽  
Vol 9 (2) ◽  
Author(s):  
Sevki Sahin ◽  
Nilgun Cinar ◽  
Sibel Karsidag
Keyword(s):  
Cerebrospinal Fluid ◽  
Cell Count ◽  
Protein Level ◽  
Guillain Barre Syndrome ◽  
Positive Correlation ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Protein Levels ◽  
Facial Diplegia ◽  
High Level

Guillain Barré syndrome (GBS) is a post-infectious acute autoimmune polyradiculopathy. Cerebrospinal fluid (CSF) total protein level and plasma neutrophil/ lymphocyte ratio (NLR) are related with autoimmune response. We aimed to reach a prognostic indicator for GBS by using electrophysiological findings, protein level of CSF, and plasma NLR based on Medical Research Council (MRC) sum score data. Cases who met diagnostic criteria of GBS and followed at least six months were enrolled in the study. Nerve conduction study (NCS) and lumbar puncture were performed one week after symptom onset. Routine CSF findings and complete blood count were recorded. Plasma NLR was calculated as the ratio of neutrophil cell count to lymphocyte cell count. All patients received intravenous immunoglobulin. MRC sum scores were calculated on administration time (1st) and six months later (2nd) for evaluation of recovery. Mean values of baseline CSF protein level, NCS parameters and NLR were compared with mean scores of MRC1st and MRC2nd. Increased CSF protein levels showed negative correlation with MRC2nd scores but no correlation with NCS. Increased NLR levels were positively correlated with age, MRC2nd scores and NCS. Facial diplegia was observed in 42% of patients. A positive correlation was found between high level of NLR and MRC1st, and there was no relationship with MRC2nd. Regression analyses showed that only CSF protein level was an independent factor on both MRC1st and MRC2nd. A positive association was found between baseline data included young age high plasma NLR, low level of CSF protein and good prognosis in our study. Also a positive correlation was found between high level of NLR and baseline disability in GBS cases with facial diplegia. Calculation of NLR is an easy and inexpensive method. On the other hand it may be influenced by age and immunotherapy. Our results showed that CSF protein level is still a liable parameter for prognosis. NLR could be a candidate prognostic marker of GBS cases. Further investigations including more cases are needed.

Comparison of the Neutrophil/Lymphocyte Ratio and C-Reactive Protein Levels in Patients With Amputation for Diabetic Foot Ulcers

2017 ◽  
Vol 16 (1) ◽  
pp. 23-28 ◽  
Author(s):  
Hasan Metineren ◽  
Turan Cihan Dülgeroğlu
Keyword(s):  
Diabetic Foot ◽  
Inflammatory Marker ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
C Reactive Protein ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Protein Levels ◽  
Reactive Protein ◽  
Before And After

This study compared the effectiveness of the neutrophil/lymphocyte ratio (NLR) versus C-reactive protein (CRP) for evaluating the prognosis and degree of inflammation in patients with amputation for a diabetic foot ulcer (DFU). This study enrolled 56 patients with amputations for DFU with gangrene and compared the CRP levels and NLR measured before and after surgery. Overall, 24 patients (42%) died within 2 weeks postoperatively. Mortality increased with a preoperative/postoperative CRP difference ≤1.5 ( P < .001) and age 73 years or older ( P < .001). The postoperative NLR was lower than the preoperative value but was not significant as a prognostic or inflammatory marker ( P = .945). An increasing serum CRP level is a significant predictor of mortality. CRP and old age are reliable prognostic factors in patients with DFU.

Acute Impact of Recovery on the Restoration of Cellular Immunological Homeostasis

2019 ◽  
Vol 41 (01) ◽  
pp. 12-20 ◽  
Author(s):  
Patrick Wahl ◽  
Sebastian Mathes ◽  
Wilhelm Bloch ◽  
Philipp Zimmer
Keyword(s):  
Cell Count ◽  
Stress Responses ◽  
Metabolic Stress ◽  
Interval Training ◽  
Active Recovery ◽  
Mixed Cell ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Passive Recovery ◽  
Quick Recovery

AbstractIn view of the growing amount of (intense) training in competitive sports, quick recovery plays a superior role in performance restoration. The aim of the present study was to compare the effects of active versus passive recovery during high-intensity interval training (HIIT) and sprint interval training (SIT) protocols on acute alterations of circulating blood cells. Twelve male triathletes/cyclists performed 1) a HIIT consisting of 4×4 min intervals, 2) a SIT consisting of 4×30s intervals, separated by either active or passive recovery. Blood samples were collected immediately before and at 0’, 30’, 60’ and 180’ (minutes) post-exercise. Outcomes comprised leukocytes, lymphocytes, neutrophils, mixed cell count, platelets, cellular inflammation markers (neutrophil/lymphocyte-ratio (NLR), platelet/lymphocyte-ratio (PLR)), and the systemic immune-inflammation index (SII). In view of HIIT, passive recovery attenuated the changes in lymphocytes and neutrophils compared to active recovery. In view of SIT, active recovery attenuated the increase in leukocytes, lymphocytes and absolute mixed cell count compared to passive recovery. Both protocols, independent of recovery, significantly increased NLR, PLR and SII up to 3h of recovery compared to pre-exercise values. The mode of recovery influences short-term alterations in the circulating fraction of leukocytes, lymphocytes, neutrophils and the mixed cell count, which might be associated with different hormonal and metabolic stress responses due to the mode of recovery.

scholarly journals A Comparison of vitamin D deficiency with neutrophil lymphocyte ratio and CRP levels in Covid-19 patients

2021 ◽  
Vol 8 (5) ◽  
pp. 306-309
Author(s):  
Aslıhan Dilara Demir ◽  
Zeynep Hulya Durmaz
Keyword(s):  
Vitamin D ◽  
Retrospective Study ◽  
Moderate Correlation ◽  
C Reactive Protein ◽  
Positive Correlation ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Reactive Protein ◽  
Hospital Database ◽  
Vitamin D Levels

Objective: Objective: We aimed to evaluate the association of neutrophil-lymphocyte ratio (NLR) and C reactive protein (CRP), ferritin, sedimentation levels with vitamin D concentrations in Covid-19 patients and to investigate  their effect of  levels on Covid-19 patients. Materials and Methods: Forty-six patients aged 18-85 were included in our study. Our study is a retrospective study. Patients were divided into 2 groups with the first group consisting of those with vitamin D level 20 and below and 2nd group consisting of those with vitamin D level above 20. After Vitamin D, CRP, neutrophil, and lymphocyte values were retrospectively investigated with the hospital database, vitamin D levels were compared to CRP and neutrophil/lymphocyte ratio.  Results: A positive correlation between CRP and SED, CRP and ferritin, NLR, and ferritin was observed in Covid-19 positive patients with Vitamin D level > 20. A positive correlation between NLR and CRP was observed in Covid-19 positive patients with Vitamin D level ≤ 20. Conclusion: In patients with Vitamin D levels >20, there was a significant correlation between vitamin D and NLR and a moderate correlation between Vitamin D and CRP. In patients with Vitamin D levels <20, there was a positive correlation of Vitamin D with CRP and NLR.

scholarly journals The Neutrophil-Lymphocyte Ratio and its Relationship with Insulin Resistance in Obesity

2019 ◽  
Author(s):  
SERDAR KARAKAYA ◽  
MUSTAFA ALTAY ◽  
FATMA KAPLAN EFE ◽  
İBRAHİM KARADAĞ ◽  
OKTAY ÜNSAL ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Model Assessment ◽  
Obese Patients ◽  
Positive Correlation ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Insulin Levels ◽  
Glucose Levels ◽  
Key Words Neutrophil ◽  
The Relationship

Background and aim: In this study, we aimed to investigate the neutrophil/lymphocyte (N/L) ratio, variations in leukocytes and leukocyte subtypes, and the relationship between N/L ratio and insulin resistance (IR) in obesity. Materials and Methods: Ninety six patients and 40 healthy controls were included in this study. Patients’ blood glucose levels, insulin levels, and hemogram parameters upon 8 hours of fasting were determined. Body mass index (BMI) and homeostasis model assessment insulin resistance (HOMA-IR) values were calculated. Results: Neutrophil numbers were found to be higher among IR obese patients than among non-IR obese patients. The N/L ratio was, moreover, found to be higher among IR obese patients, when compared to non IR obese. A positive correlation was found between insulin resistance and both neutrophil and WBC counts. Another positive correlation was also found between insulin levels and the N/L ratio, WBC, and neutrophil counts. Discussion: In our study, leukocyte numbers and subtypes were determined to be higher among obese individuals than among healthy individuals. The N/L ratio had increased significantly only among obese patients who have insulin resistance. Further studies are needed in order to better demonstrate the relationship between the N/L ratio and insulin resistance/inflammation. Key Words: Neutrophil-Lymphocyte Ratio, Obesity, Insulin Resistance

scholarly journals Analysis of the albumin level, neutrophil-lymphocyte ratio, and platelet-lymphocyte ratio in Guillain-Barré syndrome

2016 ◽  
Vol 74 (9) ◽  
pp. 718-722 ◽  
Author(s):  
Hasan Huseyin Ozdemir
Keyword(s):  
Axonal Neuropathy ◽  
Albumin Level ◽  
Post Treatment ◽  
University Hospital ◽  
Guillain Barre Syndrome ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Platelet Lymphocyte Ratio ◽  
Guillain Barré Syndrome ◽  
Guillain Barré

ABSTRACT The purpose of this study was to investigate the prognostic value of the pretreatment and post-treatment albumin level, neutrophil-lymphocyte ratio (NLR), and platelet-lymphocyte ratio (PLR) in subtypes of Guillain-Barré syndrome (GBS). A retrospective analysis of 62 patients with GBS treated between 2011 and 2015 in Dicle University Hospital, Turkey, was carried out. The pretreatment and post-treatment albumin, NLR, and PLR were documented, together with acute inflammatory demyelinating polyradiculoneuropathy (AIDP), acute motor axonal neuropathy, motor sensory axonal neuropathy, and Hughes’ scores. Post-treatment albumin levels in GBS were significantly reduced, and albumin level was negatively correlated with the Hughes scores. Elevated pretreatment NLRs and PLRs were significantly associated with AIDP. There were no correlations between the Hughes scores, NLR, and PLR. The results point to a negative correlation between albumin levels and GBS disability and suggest that the NLR and PLR may be promising blood biomarkers of AIDP.

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