scholarly journals Plasma metabolomics profiles suggest beneficial effects of a low–glycemic load dietary pattern on inflammation and energy metabolism

2019 ◽  
Vol 110 (4) ◽  
pp. 984-992 ◽  
Author(s):  
Sandi L Navarro ◽  
Aliasghar Tarkhan ◽  
Ali Shojaie ◽  
Timothy W Randolph ◽  
Haiwei Gu ◽  
...  
Keyword(s):  
Dietary Pattern ◽  
Fruits And Vegetables ◽  
Glycemic Load ◽  
Whole Grains ◽  
Data Driven ◽  
Metabolic Profiles ◽  
Plasma Samples ◽  
Refined Grains ◽  
Added Sugars ◽  
Beneficial Effects

ABSTRACT Background Low–glycemic load dietary patterns, characterized by consumption of whole grains, legumes, fruits, and vegetables, are associated with reduced risk of several chronic diseases. Methods Using samples from a randomized, controlled, crossover feeding trial, we evaluated the effects on metabolic profiles of a low-glycemic whole-grain dietary pattern (WG) compared with a dietary pattern high in refined grains and added sugars (RG) for 28 d. LC-MS-based targeted metabolomics analysis was performed on fasting plasma samples from 80 healthy participants (n = 40 men, n = 40 women) aged 18–45 y. Linear mixed models were used to evaluate differences in response between diets for individual metabolites. Kyoto Encyclopedia of Genes and Genomes (KEGG)–defined pathways and 2 novel data-driven analyses were conducted to consider differences at the pathway level. Results There were 121 metabolites with detectable signal in >98% of all plasma samples. Eighteen metabolites were significantly different between diets at day 28 [false discovery rate (FDR) < 0.05]. Inositol, hydroxyphenylpyruvate, citrulline, ornithine, 13-hydroxyoctadecadienoic acid, glutamine, and oxaloacetate were higher after the WG diet than after the RG diet, whereas melatonin, betaine, creatine, acetylcholine, aspartate, hydroxyproline, methylhistidine, tryptophan, cystamine, carnitine, and trimethylamine were lower. Analyses using KEGG-defined pathways revealed statistically significant differences in tryptophan metabolism between diets, with kynurenine and melatonin positively associated with serum C-reactive protein concentrations. Novel data-driven methods at the metabolite and network levels found correlations among metabolites involved in branched-chain amino acid (BCAA) degradation, trimethylamine-N-oxide production, and β oxidation of fatty acids (FDR < 0.1) that differed between diets, with more favorable metabolic profiles detected after the WG diet. Higher BCAAs and trimethylamine were positively associated with homeostasis model assessment-insulin resistance. Conclusions These exploratory metabolomics results support beneficial effects of a low–glycemic load dietary pattern characterized by whole grains, legumes, fruits, and vegetables, compared with a diet high in refined grains and added sugars on inflammation and energy metabolism pathways. This trial was registered at clinicaltrials.gov as NCT00622661.

scholarly journals High glycemic index and glycemic load diets as risk factors for insomnia: analyses from the Women's Health Initiative

2019 ◽  
Vol 111 (2) ◽  
pp. 429-439 ◽  
Author(s):  
James E Gangwisch ◽  
Lauren Hale ◽  
Marie-Pierre St-Onge ◽  
Lydia Choi ◽  
Erin S LeBlanc ◽  
...  
Keyword(s):  
Postmenopausal Women ◽  
Dietary Fiber ◽  
Glycemic Index ◽  
Glycemic Load ◽  
Whole Grains ◽  
Refined Grains ◽  
Added Sugars ◽  
Lower Odds ◽  
Health Initiative ◽  
The Women’S Health Initiative

ABSTRACT Background Previous studies have shown mixed results on the association between carbohydrate intake and insomnia. However, any influence that refined carbohydrates have on risk of insomnia is likely commensurate with their relative contribution to the overall diet, so studies are needed that measure overall dietary glycemic index (GI), glycemic load, and intakes of specific types of carbohydrates. Objective We hypothesized that higher GI and glycemic load would be associated with greater odds of insomnia prevalence and incidence. Methods This was a prospective cohort study with postmenopausal women who participated in the Women's Health Initiative Observational Study, investigating the relations of GI, glycemic load, other carbohydrate measures (added sugars, starch, total carbohydrate), dietary fiber, and specific carbohydrate-containing foods (whole grains, nonwhole/refined grains, nonjuice fruits, vegetables, dairy products) with odds of insomnia at baseline (between 1994 and 1998; n = 77,860) and after 3 y of follow-up (between 1997 and 2001; n = 53,069). Results In cross-sectional and longitudinal analyses, higher dietary GI was associated with increasing odds of prevalent (fifth compared with first quintile OR: 1.11; CI: 1.05, 1.16; P-trend = 0.0014) and incident (fifth compared with first quintile OR: 1.16; CI: 1.08, 1.25; P-trend &lt; 0.0001) insomnia in fully adjusted models. Higher intakes of dietary added sugars, starch, and nonwhole/refined grains were each associated with higher odds of incident insomnia. By contrast, higher nonjuice fruit and vegetable intakes were significantly associated with lower odds of incident insomnia. Also, higher intakes of dietary fiber, whole grains, nonjuice fruit, and vegetables were significantly associated with lower odds of prevalent insomnia. Conclusions The results suggest that high-GI diets could be a risk factor for insomnia in postmenopausal women. Substitution of high-GI foods with minimally processed, whole, fiber-rich carbohydrates should be evaluated as potential treatments of, and primary preventive measures for, insomnia in postmenopausal women.

scholarly journals Do Refined Grains Have a Place in a Healthy Dietary Pattern: Perspectives from an Expert Panel Consensus Meeting

2020 ◽  
Vol 4 (10) ◽  
Author(s):  
Yanni Papanikolaou ◽  
Joanne L Slavin ◽  
Roger Clemens ◽  
J Thomas Brenna ◽  
Dayle Hayes ◽  
...  
Keyword(s):  
Dietary Pattern ◽  
Expert Panel ◽  
Scientific Evidence ◽  
Whole Grains ◽  
Overweight And Obesity ◽  
Published Data ◽  
Refined Grains ◽  
Nutrient Density ◽  
Grain Foods ◽  
Healthy Dietary Pattern

ABSTRACT Although dietary guidance recommends increasing consumption of whole grains and concurrently limiting consumption of refined and/or enriched grain foods, emerging research suggests that certain refined grains may be part of a healthy dietary pattern. A scientific expert panel was convened to review published data since the release of 2015 dietary guidance in defined areas of grain research, which included nutrient intakes, diet quality, enrichment/fortification, and associations with weight-related outcomes. Based on a 1-d roundtable discussion, the expert panel reached consensus that 1) whole grains and refined grains can make meaningful nutrient contributions to dietary patterns, 2) whole and refined grain foods contribute nutrient density, 3) fortification and enrichment of grains remain vital in delivering nutrient adequacy in the American diet, 4) there is inconclusive scientific evidence that refined grain foods are linked to overweight and obesity, and 5) gaps exist in the scientific literature with regard to grain foods and health.

scholarly journals Plasma Lipidomics Profiles After a Diet Characterized by Whole Grains Compared to a Diet High in Refined Grains and Added Sugars (FS03-07-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Sepideh Dibay Moghadam ◽  
Sandi Navarro ◽  
Ali Shojaie ◽  
Timothy Randolph ◽  
Lisa Bettcher ◽  
...  
Keyword(s):  
Missing Values ◽  
Density Lipoprotein ◽  
Whole Grains ◽  
Normal Weight ◽  
Lipid Profiles ◽  
Refined Grains ◽  
Added Sugars ◽  
Funding Sources ◽  
Lipid Species ◽  
Complex Models

Abstract Objectives Dietary patterns high in fiber from sources including whole grains, legumes, fruits, vegetables, nuts and seeds, are associated with lower risk of chronic disease, such as cardiovascular disease and cancer. We investigated how plasma lipidomics profiles differed between a diet high in whole grains (WG) versus a diet high in refined grains and added sugars (RG). Methods Using a randomized, crossover, controlled feeding study, 80 healthy participants (n = 40 men, n = 40 women, 40 normal weight, 40 overweight/obese), 18–45 y, were randomized to receive either a WG or RG diet for 28 days. After a 28-day washout period where participants resumed their habitual diet, they crossed over to the other diet. Targeted, differential mobility mass spectrometry was performed on fasting plasma samples collected at the baseline and end of each diet period and quantified the concentrations of 863 lipids from 13 classes. Paired t-tests and pairwise partial least squares-discriminant analysis (PLS-DA) were used to evaluate differences in lipid profiles between the two diets. Results At a class level, only ceramides were significantly different when comparing the two diets. After removing lipid species with > 20% missing values or CVs < 25%, 606 were retained for species analysis. Sixty-seven lipid species were significantly different between diets at day 28 (FDR < 0.05): 38 of 414 detected triglycerides, 9 of 59 phosphatidylethanolamines, 9 of 63 phosphatidylcholines, 4 of 22 cholesterol esters, 3 of 11 sphingomyelins, 2 of 13 lysophosphatidylcholines, and 1 of 5 ceramides. The majority of significant lipids were higher in plasma after the WG diet. PLSDA analysis showed the first and second components explaining 49% and 8.4%, respectively. Based on the selected components, lipidomic profiles showed fair separation for the two groups of diet. R2 values were 0.07 and 0.43, and Q2 values were -0.03 and 0.04 for components 1 and 2, respectively. Conclusions Higher concentrations of some lipid species such as cholesterol ester 12:0, a carrier of high-density lipoprotein, could indicate a favorable shift in lipid profiles. Further investigation using more complex models are being conducted. Funding Sources National Cancer Institute - National Institutes of Health.

scholarly journals The associations between whole grain and refined grain intakes and serum C-reactive protein

2021 ◽  
Author(s):  
Riikka E. Taskinen ◽  
Sari Hantunen ◽  
Tomi-Pekka Tuomainen ◽  
Jyrki K. Virtanen
Keyword(s):  
Disease Risk ◽  
High Sensitivity ◽  
Epidemiological Studies ◽  
Whole Grains ◽  
Dietary Factors ◽  
Low Grade ◽  
Dietary Intakes ◽  
Whole Grain ◽  
Refined Grains ◽  
Hs Crp

Abstract Background/objectives Epidemiological studies suggest that whole grain intake has inverse associations with low-grade inflammation, but findings regarding refined grains are inconclusive. Our objective was to investigate whether consumption of whole or refined grains is associated with serum high sensitivity CRP (hs-CRP). Subjects/methods The study included 756 generally healthy men and women aged 53–73 years from the Kuopio Ischaemic Heart Disease Risk Factory Study, examined in 1999–2001. Dietary intakes were assessed using 4-day food records. ANCOVA and linear regression were used for analyses. Results The mean intake of whole and refined grains was 136 g/day (SD 80) and 84 g/day (SD 46), respectively. Higher whole grain intake was associated with lower hs-CRP concentration and higher refined grain intake with higher concentration after adjustment for lifestyle and dietary factors. Each 50 g/d higher whole grain intake was associated with 0.12 mg/L (95% Cl 0.02–0.21 mg/L) lower hs-CRP concentration and each 50 g/d higher refined grain intake with 0.23 mg/L (95% Cl 0.08–0.38) higher concentration. Adjustment for fibre from grains attenuated the associations especially with whole grains. There were no statistically significant interactions according to gender or BMI (P for interactions >0.065). Conclusions The results of this study suggest that higher intake of whole grains is associated with lower concentrations of hs-CRP and higher intake of refined grains is associated with higher concentrations. However, especially the association with whole grain intake was attenuated after adjusting for fibre intake from grains, suggesting that cereal fibre may partly explain the association.

scholarly journals Impact of Dietary Flavanols on Microbiota, Immunity and Inflammation in Metabolic Diseases

Nutrients ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 850
Author(s):  
María Ángeles Martín ◽  
Sonia Ramos
Keyword(s):  
Immune System ◽  
Fruits And Vegetables ◽  
Metabolic Diseases ◽  
Nuclear Factor Κb ◽  
Low Grade ◽  
Beneficial Effects ◽  
Health And Disease ◽  
Immunological Reactions ◽  
And Function ◽  
Positive Properties

Flavanols are natural occurring polyphenols abundant in fruits and vegetables to which have been attributed to beneficial effects on health, and also against metabolic diseases, such as diabetes, obesity and metabolic syndrome. These positive properties have been associated to the modulation of different molecular pathways, and importantly, to the regulation of immunological reactions (pro-inflammatory cytokines, chemokines, adhesion molecules, nuclear factor-κB [NF-κB], inducible enzymes), and the activity of cells of the immune system. In addition, flavanols can modulate the composition and function of gut microbiome in a prebiotic-like manner, resulting in the positive regulation of metabolic pathways and immune responses, and reduction of low-grade chronic inflammation. Moreover, the biotransformation of flavanols by gut bacteria increases their bioavailability generating a number of metabolites with potential to affect human metabolism, including during metabolic diseases. However, the exact mechanisms by which flavanols act on the microbiota and immune system to influence health and disease remain unclear, especially in humans where these connections have been scarcely explored. This review seeks to summarize recent advances on the complex interaction of flavanols with gut microbiota, immunity and inflammation focus on metabolic diseases.

scholarly journals Nutritional Quality of Undergraduate Student Meals in an All-You-Care-to-Eat Campus Dining Facility (P04-156-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Audrey Olson ◽  
Katie Vieyra ◽  
Alexandra Polasky ◽  
Amy Best ◽  
Lois Durant ◽  
...  
Keyword(s):  
Nutrition Education ◽  
Undergraduate Students ◽  
Nutritional Quality ◽  
Fruits And Vegetables ◽  
Saturated Fat ◽  
Whole Grains ◽  
Research Award ◽  
George Mason University ◽  
Reported Data

Abstract Objectives To assess the overall nutritional quality of meals chosen by undergraduate students during weekday lunches at campus all-you-care-to-eat dining halls. Methods A previously validated exit survey was used to collect self-reported data from undergraduate students on foods and beverages they consumed during a single visit to two all-you-care-to-eat dining halls on the George Mason University Fairfax campus, during 4 weeks. (n = 468) Nutritional quality of each meal was evaluated on a 7-point rubric, according to the ‘Wellness Meal’ standards from the Partnership for a Healthier America: ≤700 kilocalories, ≤10% calories from saturated fat, ≤800 mg sodium, ≥2 ounces whole grains, ≥1 cup lowfat dairy, ≥ 1.75 cups fruits and vegetables, and ≥ 2 ounces lean protein. Results Of the maximum score of 7 on the meal nutritional quality rubric, 4 participants earned the highest score of 5, whereas 43, 150, 132, 88, and 51 participants had scores of 4, 3, 2, 1, and 0, respectively. The most commonly attained rubric standard was saturated fat, where 60% of participants consumed ≤ 10% calories from saturated fat and average consumption was 9.1% (± 5.4%) of calories. The least achieved rubric category was lowfat dairy, where only 2% of students consumed 1 cup equivalent, followed by only 9% of participants having consumed the 2 ounce equivalent of whole grains. Approximately one-third of students met calorie, lean protein, sodium, and fruit/vegetable standards. Conclusions Despite a wide variety of food options in the campus all-you-care-to-eat dining halls during the lunch hours, most undergraduate students consumed meals of subpar nutritional quality, with the vast majority meeting fewer than half the categories on the meal nutritional quality rubric. All-you-care-to-eat university dining halls may be a prime location for nutrition education and interventions. Funding Sources This research was funded by the George Mason University Provost's Multidisciplinary Research Award.

scholarly journals Plasma alkylresorcinols, biomarkers of whole-grain intake, are not associated with progression of coronary artery atherosclerosis in postmenopausal women with coronary artery disease

2015 ◽  
Vol 19 (2) ◽  
pp. 326-331 ◽  
Author(s):  
Nicola M McKeown ◽  
Adela Hruby ◽  
Rikard Landberg ◽  
David M Herrington ◽  
Alice H Lichtenstein
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Postmenopausal Women ◽  
Vessel Diameter ◽  
Whole Grains ◽  
Plasma Samples ◽  
Whole Grain ◽  
Coronary Artery Atherosclerosis ◽  
Artery Disease ◽  
Change In Mean

AbstractObjectiveThe objective of the present study was to examine the relationship between plasma alkyresorcinol (AR) concentrations, which are biomarkers of whole-grain intake, and atherosclerotic progression over 3 years in postmenopausal women with coronary artery disease.DesignPlasma AR concentrations were measured by a validated GC–MS method in fasting plasma samples. Atherosclerosis progression was assessed using change in mean minimal coronary artery diameter (MCAD) and percentage diameter stenosis (%ST), based on mean proximal vessel diameter across up to ten coronary segments. Dietary intake was estimated using a 126-item interviewer-administered FFQ.SettingA prospective study of postmenopausal women participating in the Estrogen Replacement and Atherosclerosis trial.SubjectsFor the analysis of plasma AR concentrations and atherosclerotic progression, plasma samples and follow-up data on angiography were available for 182 women.ResultsMean whole-grain intake was 9·6 (se 0·6) servings per week. After multivariate adjustment, no significant associations were observed between plasma AR concentrations and change in mean MCAD or progression of %ST. Plasma AR concentrations were significantly correlated with dietary whole grains (r=0·35, P<0·001), cereal fibre (r=0·33, P<0·001), bran (r=0·15, P=0·05), total fibre (r=0·22, P=0·003) and legume fibre (r=0·15, P=0·04), but not refined grains, fruit fibre or vegetable fibre.ConclusionsPlasma AR concentrations were not significantly associated with coronary artery progression over a 3-year period in postmenopausal women with coronary artery disease. A moderate association was observed between plasma AR concentrations and dietary whole grains and cereal fibre, suggesting it may be a useful biomarker in observational studies.

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